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The FEBS Journal, ISSN 1742-464X, 02/2014, Volume 281, Issue 3, pp. 787 - 801
The adenomatous polyposis coli (APC) membrane recruitment (Amer) family proteins Amer1/Wilms tumour gene on the X chromosome and Amer2 are binding partners... 
FAM123C | adenomatous polyposis coli membrane recruitment 3 | Wilms tumour gene on the X chromosome | Wnt signalling | adenomatous polyposis coli | Adenomatous polyposis coli membrane recruitment 3 | Adenomatous polyposis coli | AXIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | adenomatous polyposis coli membrane recruitment 3 | NUCLEAR EXPORT | WILMS-TUMOR | NEGATIVE REGULATOR | GENE | PATHWAY | TUMOR-SUPPRESSOR | UP-REGULATION | EXPRESSION | Adaptor Proteins, Signal Transducing - chemistry | Up-Regulation | Tumor Suppressor Proteins - antagonists & inhibitors | Humans | Cytoplasm - metabolism | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Recombinant Fusion Proteins - metabolism | Axin Protein - metabolism | Nerve Tissue Proteins - chemistry | Cell Nucleus - metabolism | Protein Isoforms - metabolism | RNA Interference | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Protein Isoforms - chemistry | Tumor Suppressor Proteins - chemistry | Tumor Suppressor Proteins - genetics | HEK293 Cells | Protein Interaction Domains and Motifs | Neoplasm Proteins - genetics | Adenomatous Polyposis Coli Protein - antagonists & inhibitors | Colorectal Neoplasms - metabolism | Wnt Signaling Pathway | Adenomatous Polyposis Coli Protein - genetics | Nerve Tissue Proteins - antagonists & inhibitors | Tumor Suppressor Proteins - metabolism | Armadillo Domain Proteins - chemistry | Neoplasm Proteins - chemistry | Recombinant Fusion Proteins - chemistry | Organ Specificity | Nerve Tissue Proteins - genetics | Protein Sorting Signals | Adenomatous Polyposis Coli - metabolism | Adenomatous Polyposis Coli Protein - chemistry | Protein Transport | Mutant Proteins | Nerve Tissue Proteins - metabolism | Adaptor Proteins, Signal Transducing - genetics | Adenomatous Polyposis Coli Protein - metabolism | Armadillo Domain Proteins - metabolism | Cell Line, Tumor | Adaptor Proteins, Signal Transducing - metabolism | Colorectal Neoplasms - pathology | Protein Isoforms - antagonists & inhibitors | Protein Isoforms - genetics
Journal Article
PLoS genetics, ISSN 1553-7404, 2018, Volume 14, Issue 4, p. e1007339
Wnt signaling provides a paradigm for cell-cell signals that regulate embryonic development and stem cell homeostasis and are inappropriately activated in... 
DISHEVELLED PROTEIN | PATHWAY ACTIVATION | AXIN | ADENOMATOUS POLYPOSIS-COLI | TUMOR-SUPPRESSOR APC | OVERLAPPING ROLES | DEP DOMAIN | NEGATIVE REGULATION | GENETICS & HEREDITY | DROSOPHILA APC2 | DIX DOMAIN | Wnt1 Protein - genetics | Drosophila melanogaster - embryology | Transcription Factors - chemistry | Axin Protein - genetics | Axin Protein - chemistry | Multiprotein Complexes - genetics | Wnt1 Protein - metabolism | Armadillo Domain Proteins - genetics | Drosophila Proteins - metabolism | RNA, Messenger - metabolism | Drosophila melanogaster - genetics | Recombinant Fusion Proteins - metabolism | Axin Protein - metabolism | Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome - metabolism | Drosophila melanogaster - metabolism | Multiprotein Complexes - metabolism | Proteolysis | Tumor Suppressor Proteins - chemistry | Tumor Suppressor Proteins - genetics | Transcription, Genetic | Wnt Signaling Pathway | Axin Signaling Complex - chemistry | Cell Line | Tumor Suppressor Proteins - metabolism | Animals, Genetically Modified | RNA, Messenger - genetics | Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome - genetics | Armadillo Domain Proteins - chemistry | Drosophila Proteins - chemistry | Recombinant Fusion Proteins - chemistry | Transcription Factors - genetics | Glycogen Synthase Kinase 3 - metabolism | Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome - chemistry | Transcription Factors - metabolism | Multiprotein Complexes - chemistry | Animals | Axin Signaling Complex - metabolism | Glycogen Synthase Kinase 3 - genetics | Axin Signaling Complex - genetics | Armadillo Domain Proteins - metabolism | Recombinant Fusion Proteins - genetics | Drosophila Proteins - genetics | Binding proteins | Wnt proteins | Health aspects | Stoichiometry | Phosphorylation | Wnt protein | Funding | Glycogen synthase | Genes | Homeostasis | Kinases | Proteins | β-catenin | Embryogenesis | Ubiquitination | Localization | Dishevelled protein | Glycogen | Polymerization | Curricula | Embryos | Adenomatous polyposis coli | Microscopy | Insects | Stem cells | Regulation | Genetic engineering | Molecular biology | Cancer
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2000, Volume 289, Issue 5481, pp. 950 - 953
Wnts are secreted signaling proteins that regulate developmental processes. Here we show that Wnt signaling, likely mediated by Wnt-10b, is a molecular switch that governs adipogenesis... 
3T3 L1 cells | NIH 3T3 cells | Genetic vectors | Cell lines | Retroviridae | Reports | Adipocytes | Lipogenesis | Cellular differentiation | Synapses | Myoblasts | BINDING-PROTEIN-ALPHA | 3T3-L1 ADIPOCYTES | FAT PADS | REGULATOR | TRANSCRIPTIONAL ACTIVATION | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | ADIPOCYTE DIFFERENTIATION | PPAR-GAMMA | BETA-CATENIN | FIBROBLASTS | Repressor Proteins | Adipocytes - cytology | Wnt Proteins | Mesoderm - cytology | CCAAT-Enhancer-Binding Proteins | DNA-Binding Proteins - metabolism | Retroviridae - genetics | TCF Transcription Factors | Cytoskeletal Proteins - metabolism | Cell Differentiation | Muscles - metabolism | Nuclear Proteins - genetics | Proto-Oncogene Proteins - metabolism | Gene Transfer Techniques | Retroviridae - physiology | DNA-Binding Proteins - antagonists & inhibitors | Signal Transduction | beta Catenin | Trans-Activators | Zebrafish Proteins | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Transcription Factors - antagonists & inhibitors | Receptors, Cytoplasmic and Nuclear - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Transcription Factor 7-Like 2 Protein | Proteins - genetics | Transcription Factors - metabolism | Cell Lineage | Animals | Proteins - metabolism | Mice, Nude | Adipocytes - metabolism | Nuclear Proteins - antagonists & inhibitors | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Axin Protein | Mice | Genetic Vectors | 3T3 Cells | Muscles - cytology | Receptors, Cytoplasmic and Nuclear - metabolism | Cell research | Fat cells | Research | Analysis | Wnt-10b protein | PPAR^g protein | adipogenesis | peroxisome proliferator-activated receptor ^g | CCAAT/enhancer binding protein ^a | C/EBP^a protein
Journal Article
Developmental Cell, ISSN 1534-5807, 2002, Volume 2, Issue 4, pp. 449 - 461
Journal Article
Genes and Development, ISSN 0890-9369, 2009, Volume 23, Issue 16, pp. 1910 - 1928
Journal Article
Scientific reports, ISSN 2045-2322, 2016, Volume 6, Issue 1, p. 22113
Journal Article
Biochemical Society transactions, ISSN 1470-8752, 2013, Volume 41, Issue 3, pp. 727 - 740
.... This modification creates a binding site for MBD (methyl-CpG-binding domain) proteins which target chromatin-modifying activities that are thought to contribute to transcriptional repression and maintain heterochromatic regions of the genome... 
DNA methylation | Epigenetics | DNA demethylation | Chromatin | Transcription | CpG island | transcription | BIOCHEMISTRY & MOLECULAR BIOLOGY | BINDING-PROTEIN | TRANSCRIPTIONAL REPRESSION | chromatin | H3-LYS METHYLTRANSFERASE COMPLEX | epigenetics | FINGER PROTEIN-1 | EMBRYONIC STEM-CELLS | MIXED-LINEAGE-LEUKEMIA | GENOME-WIDE ANALYSIS | POSTNATAL-DEVELOPMENT | HISTONE H3 ACETYLATION | Amino Acid Sequence | Chromatin - metabolism | DNA-Binding Proteins - physiology | Humans | Models, Molecular | Molecular Sequence Data | DNA Methylation - genetics | Protein Structure, Tertiary - genetics | DNA - metabolism | CpG Islands - physiology | DNA-Binding Proteins - genetics | DNA-Binding Proteins - chemistry | CpG Islands - genetics | Zinc Fingers - genetics | DNA Methylation - physiology | Protein Binding - physiology | MBD, methyl-CpG-binding domain | PRC, polycomb group repressive complex | IDAX, inhibition of the Dvl and axin complex protein | ESC, embryonic stem cell | RING, really interesting new gene | CFP1, CxxC finger protein 1 | JmjC, Jumonji C | PHD, plant homeodomain | Biochemical Society Annual Symposium No. 80 | 5mC, 5-methylcytosine | CGBP, CpG-binding protein | 5hmC, 5-hydroxymethylcytosine | DNMT1, DNA methyltransferase 1 | FBXL19, F-box and leucine-rich repeat protein 19 | RFTS, replication foci-targeting sequence | WDR, WD40 repeat | DPY-30, dosage compensation protein 30 | AF9, ALL1–fused gene from chromosome 9 protein | ChIP-seq, chromatin immunoprecipitation sequencing | HDAC, histone deacetylase | YY1, Yin and Yang 1 | RbBP5, retinoblastoma-binding protein 5 | ZF-CxxC, zinc finger-CxxC | BAH, bromo-adjacent homology | ASH2L, absent, small or homeotic 2-like | SETD1, SET domain 1 | TET, ten-eleven translocation | SEC, super-elongation complex | MLL, mixed lineage leukaemia protein | CGI, CpG island | ENL, eleven-nineteen leukaemia | shRNA, short hairpin RNA | KDM, lysine demethylase | RNAPII, RNA polymerase II
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 05/2016, Volume 7, Issue 5, pp. 508 - 513
...-catenin/B-cell lymphoma 9 (BCL9) protein–protein interaction interface. Inhibitor optimization led to a potent inhibitor that can disrupt the β... 
selectivity | B-cell lymphoma 9 | β-Catenin | Wnt signaling | inhibitor | protein-protein interactions | BCL9-2 | TARGET | SITE | ACTIVATION | AXIN | CHEMISTRY, MEDICINAL | BINDING PROTEIN | PORCUPINE | COLORECTAL-CANCER | PROGRESSION | Wnt signaling beta-Catenin
Journal Article
Cell metabolism, ISSN 1550-4131, 2013, Volume 18, Issue 4, pp. 546 - 555
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 2/2000, Volume 148, Issue 4, pp. 691 - 701
.... GSK-3 activity is regulated through the opposing activities of multiple proteins. Axin, GSK-3, and β-catenin form a complex that promotes the GSK-3-mediated phosphorylation and subsequent degradation... 
Phosphorylation | RNA | Glycogen | Natural satellites | Genes | Drosophila | Antibodies | Gene expression regulation | Embryos | Cells | Dorsal/ventral | β-catenin | Wnt pathway | beta-catenin | WNT SIGNALING PATHWAY | dorsal/ventral | DORSAL DETERMINANTS | CORTICAL ROTATION | GLYCOGEN-SYNTHASE KINASE-3 | NEGATIVE REGULATOR | CELL BIOLOGY | FIRST CELL-CYCLE | ADENOMATOUS POLYPOSIS-COLI | C-ELEGANS EMBRYOS | TUMOR-SUPPRESSOR PROTEIN | Cyclic AMP Response Element-Binding Protein - chemistry | Cytoskeletal Proteins - genetics | Repressor Proteins | Glycogen Synthase Kinase 3 | Wnt Proteins | Adenomatous Polyposis Coli Protein | Recombinant Fusion Proteins - metabolism | Glycogen Synthase Kinases | Calcium-Calmodulin-Dependent Protein Kinases - administration & dosage | Peptides - metabolism | Proteins - administration & dosage | Body Patterning | Carrier Proteins - administration & dosage | Cytoskeletal Proteins - metabolism | Xenopus laevis - genetics | Recombinant Fusion Proteins - administration & dosage | Xenopus laevis - embryology | Calcium-Calmodulin-Dependent Protein Kinases - genetics | Microinjections | Peptides - chemistry | Signal Transduction | beta Catenin | Trans-Activators | Zebrafish Proteins | Rats | Cytoskeletal Proteins - chemistry | Xenopus Proteins | Calcium-Calmodulin-Dependent Protein Kinases - antagonists & inhibitors | Mutation - genetics | Precipitin Tests | Proteins - genetics | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Proteins - metabolism | Models, Biological | Xenopus laevis - metabolism | Axin Protein | Cyclic AMP Response Element-Binding Protein - metabolism | Proto-Oncogene Proteins - physiology | Protein Binding | Enzyme Activation | Genes, Dominant - genetics | Proteins - antagonists & inhibitors | Calcium-Calmodulin-Dependent Protein Kinases - metabolism | Xenopus | Synthesis | Physiological aspects | Catenanes | Genetic aspects | Research | Protein kinases | dorsal | ventral | Original
Journal Article