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Clinical cancer research, ISSN 1557-3265, 2013, Volume 19, Issue 4, pp. 938 - 948
Journal Article
PloS one, ISSN 1932-6203, 2016, Volume 11, Issue 9, p. e0162901
Journal Article
Expert Opinion on Investigational Drugs, ISSN 1354-3784, 03/2011, Volume 20, Issue 3, pp. 343 - 359
Journal Article
Journal of Chromatography B, ISSN 1570-0232, 06/2016, Volume 1022, pp. 38 - 45
...′-deoxycytidine and 2′-deoxycytidine.•This method can be utilized to probe exposure-response relationships of nucleoside analog DNA methyltransferase inhibitors... 
DNA methyltransferase inhibitor | LC/MS/MS | Global DNA demethylation | 5-Methylcytosine | Genomic DNA | 5-Aza-2′-deoxycytidine | Decitabine | 5-Methyl-2′-deoxycytidine | 5-Aza-2'-deoxycytidine | 5-Methyl-2'-deoxycytidine | CHEMISTRY, ANALYTICAL | 5-Aza-2 '-deoxycytidine | 5-AZACYTIDINE | QUANTIFICATION | BIOCHEMICAL RESEARCH METHODS | MECHANISMS | AZACITIDINE | CANCER | BLOOD MONONUCLEAR-CELLS | PRODUCTS | 5-Methyl-2 '-deoxycytidine | TRIPHOSPHATE | DEGRADATION | Limit of Detection | Reproducibility of Results | Humans | Azacitidine - chemistry | Azacitidine - analogs & derivatives | Linear Models | DNA - metabolism | 5-Methylcytosine - chemistry | Azacitidine - analysis | DNA - chemistry | Animals | Methyltransferases - antagonists & inhibitors | 5-Methylcytosine - metabolism | DNA - analysis | Mice, Nude | Cell Line, Tumor | Mice | Azacitidine - metabolism | Chromatography, Liquid - methods | DNA Methylation - physiology | Tandem Mass Spectrometry - methods | Measurement | Medical colleges | Transferases | DNA | Nucleosides | Genetic research | Respiratory tract diseases | Liquid chromatography | Mass spectrometry | Methyltransferases | Analysis | Formic acid | Physiological aspects | Methylation | Enzymes | Inhibitors | Deoxyribonucleic acid | In vivo methods and tests | Exposure | Assaying | Chromatography | genomic DNA | global DNA demethylation | 5-methylcytosine | decitabine | 5-methyl-2′-deoxycytidine | 5-aza-2′-deoxycytidine
Journal Article
PloS one, ISSN 1932-6203, 2010, Volume 5, Issue 2, p. e9001
Background: The cytidine nucleoside analogs azacitidine (AZA) and decitabine (DAC) are used for the treatment of patients with myelodysplastic syndromes and acute myeloid leukemia... 
MULTIPLE-MYELOMA | APOPTOSIS | METHYLATION | 5-AZA-2'-DEOXYCYTIDINE | 5-AZACYTIDINE | PHASE-III | BIOLOGY | DNA METHYLTRANSFERASE INHIBITORS | CANCER | MYELODYSPLASTIC SYNDROMES | L1210 LEUKEMIA | Gene Expression - drug effects | Apoptosis - drug effects | Humans | Leukemia, Myeloid - genetics | Repressor Proteins - antagonists & inhibitors | Dose-Response Relationship, Drug | Leukemia, Myeloid - pathology | Flow Cytometry | Antimetabolites, Antineoplastic - pharmacology | Repressor Proteins - metabolism | Cell Line | Cell Survival - drug effects | Acute Disease | Oligonucleotide Array Sequence Analysis - methods | Repressor Proteins - genetics | Azacitidine - analogs & derivatives | Blotting, Western | Azacitidine - pharmacology | Leukemia, Myeloid - metabolism | Cell Line, Tumor | HL-60 Cells | Protein Biosynthesis - drug effects | DNA Damage | Cell Cycle - drug effects | DNA Methylation - drug effects | Medical research | RNA | Genes | DNA | Medicine, Experimental | Protein biosynthesis | Comparative analysis | Gene expression | Nucleoside analogs | Drugs | Biotechnology | Substance abuse treatment | Leukemia | DNA damage | Multiple myeloma | Biochemistry | Kinases | Cancer therapies | Experiments | Myelodysplastic syndrome | Proteins | Analogs | Cell cycle | DNA methylation | Deoxyribonucleic acid--DNA | Cytokines | Myeloid leukemia | Markers | Tumor cell lines | Ribonucleic acid--RNA | Protein synthesis | DNA methyltransferase | Acute myeloid leukemia | Apoptosis | 5-aza-2'-deoxycytidine | Deoxyribonucleic acid | Ribonucleic acid
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 10/2005, Volume 4, Issue 10, pp. 1515 - 1520
Journal Article
Experimental Hematology, ISSN 0301-472X, 2012, Volume 40, Issue 10, pp. 800 - 810
... and nucleoside analogs are commonly used in these regimens [3–6] . These drugs are used in various combinations, and sometimes radiation and/or antibodies are added as well... 
Hematology, Oncology and Palliative Medicine | Advanced Basic Science | CLOFARABINE | MEDICINE, RESEARCH & EXPERIMENTAL | RIBONUCLEOTIDE REDUCTASE | REPAIR | INHIBITION | DAILY INTRAVENOUS BUSULFAN | DOUBLE-STRAND BREAKS | ATM | HEMATOLOGY | FLUDARABINE | MOLECULAR-MECHANISMS | TRANSPLANTATION | Melphalan - agonists | Busulfan - agonists | Humans | Antineoplastic Agents, Alkylating - pharmacology | Deoxycytidine - pharmacology | Antineoplastic Agents, Alkylating - agonists | Deoxycytidine - agonists | Transplantation, Homologous | DNA (Cytosine-5-)-Methyltransferases - metabolism | DNA-Binding Proteins - metabolism | Dose-Response Relationship, Drug | Lymphoma - metabolism | Lymphoma - therapy | Lymphoma - pathology | Epigenesis, Genetic - drug effects | Melphalan - pharmacology | Transplantation Conditioning - methods | Hydroxamic Acids - pharmacology | Protein-Serine-Threonine Kinases - metabolism | Busulfan - pharmacology | Tumor Suppressor Proteins - metabolism | Drug Screening Assays, Antitumor - methods | Cell Cycle Proteins - metabolism | Hematopoietic Stem Cell Transplantation | Azacitidine - analogs & derivatives | Ataxia Telangiectasia Mutated Proteins | Azacitidine - agonists | Drug Synergism | Azacitidine - pharmacology | Cytotoxins | Hydroxamic Acids - agonists | Cell Line, Tumor | Checkpoint Kinase 2 | Cell Proliferation - drug effects | Deoxycytidine - analogs & derivatives | Antimitotic agents | Methyltransferases | Analysis | Nucleosides | Lymphomas | Transplantation | Antineoplastic agents | Methylation | Hematopoietic stem cells | SAHA | drug cytotoxicity Category | Hematological Malignancies or Stem Cell Transplantation | nucleoside analog | lymphoma | DNA alkylator
Journal Article
PloS one, ISSN 1932-6203, 2015, Volume 10, Issue 10, p. e0140131
Background The use of temozolomide (TMZ) has improved the prognosis for glioblastoma multiforme patients. However, TMZ resistance may be one of the main... 
SURVIVAL | APOPTOSIS | METHYLTRANSFERASE | MECHANISM | GENE | PROMOTER METHYLATION | MULTIDISCIPLINARY SCIENCES | PROTEIN EXPRESSION | MULTIDRUG-RESISTANCE | CANCER | MISMATCH REPAIR DEFICIENCY | Glioblastoma - enzymology | Guanine - analogs & derivatives | Epigenesis, Genetic | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | DNA Repair Enzymes - genetics | Glycoproteins - metabolism | Peptides - genetics | Antineoplastic Agents, Alkylating - pharmacology | Drug Resistance, Neoplasm | Antigens, CD - genetics | Antigens, CD - metabolism | DNA Methylation | Peptides - metabolism | Dacarbazine - pharmacology | Guanine - pharmacology | Tumor Suppressor Proteins - genetics | DNA Repair Enzymes - metabolism | Dacarbazine - analogs & derivatives | Inhibitory Concentration 50 | Gene Expression Regulation, Neoplastic - drug effects | Glycoproteins - genetics | Promoter Regions, Genetic | Gene Expression | Tumor Suppressor Proteins - metabolism | DNA Modification Methylases - metabolism | Azacitidine - analogs & derivatives | AC133 Antigen | Azacitidine - pharmacology | DNA Modification Methylases - genetics | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Cell Line, Tumor | Glioblastoma - drug therapy | Usage | Genetic aspects | Temozolomide | Research | Drug therapy | Gene expression | Health aspects | Glioblastoma multiforme | Biotechnology | Glioblastoma | Nervous system | Neuroblastoma | Drug resistance | Cancer therapies | O6-methylguanine-DNA methyltransferase | Proteins | Blood-brain barrier | Mismatch repair | Modulation | DNA methylation | P-Glycoprotein | Deoxyribonucleic acid--DNA | Tumor cells | Methylguanine | Glycoproteins | Exposure | Tumor cell lines | Patients | Medicine | Chemotherapy | Medical prognosis | Stem cells | DNA methyltransferase | Methylation | Cancer | Apoptosis | Tumors | Deoxyribonucleic acid | DNA
Journal Article
Journal Article
Radiation Oncology, ISSN 1748-717X, 03/2012, Volume 7, Issue 1, pp. 39 - 39
Background: Histone modifications and DNA methylation are two major factors in epigenetic phenomenon. Unlike the histone deacetylase inhibitors, which are... 
DNA methylation | Epigenetics | DNA methyltransferase inhibitor | Radiosensitization | Cancer | HISTONE DEACETYLASE INHIBITOR | METHYLATION | CHROMATIN-STRUCTURE | RADIATION SENSITIVITY | VALPROIC ACID | STRAND BREAKS | PSAMMAPLIN-A | LUNG-CANCER | GAMMA-H2AX FOCI | IN-VITRO | ONCOLOGY | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Tyrosine - pharmacology | Hydralazine - pharmacology | Humans | Caspase 3 - metabolism | Cytidine - pharmacology | Decitabine | Lung Neoplasms - pathology | Neoplasm Proteins - antagonists & inhibitors | Cell Line, Tumor - drug effects | Cytidine - analogs & derivatives | DNA (Cytosine-5-)-Methyltransferases - antagonists & inhibitors | Neoplasm Proteins - metabolism | Tyrosine - analogs & derivatives | DNA Breaks, Double-Stranded - drug effects | Enzyme Induction - drug effects | Inhibitory Concentration 50 | Disulfides - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Catechin - pharmacology | Cell Line, Tumor - radiation effects | DNA (Cytosine-5-)-Methyltransferases - biosynthesis | Tumor Stem Cell Assay | DNA Repair - drug effects | DNA (Cytosine-5-)-Methyltransferase 1 | Radiation-Sensitizing Agents - pharmacology | Azacitidine - analogs & derivatives | Azacitidine - pharmacology | DNA (Cytosine-5-)-Methyltransferases - genetics | Histones - analysis | Glioblastoma - pathology | Neoplasm Proteins - analysis | Catechin - analogs & derivatives | Enzyme inhibitors | Research | Analysis | Cancer cells | Studies | Medical research | Cell culture | Lung cancer | Cancer therapies | Deoxyribonucleic acid--DNA | Tumors | University colleges
Journal Article