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Bioorganic and Medicinal Chemistry Letters, ISSN 0960-894X, 02/2011, Volume 21, Issue 4, pp. 1243 - 1247
The development of inhibitors of B-Raf serine-threonine kinase is described. Various head-groups were examined to optimize inhibitor activity and ADME... 
Furopyridine | Indazole | B-Raf
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 07/2010, Volume 70, Issue 13, pp. 5518 - 5527
The BRAF(V600E) mutation is common in several human cancers, especially melanoma. RG7204 (PLX4032) is a small-molecule inhibitor of BRAF(V600E) kinase activity... 
ONCOGENE | EFFICACY | ONCOLOGY | BRAF | B-RAF | MUTATIONS | TUMORS | RAF/MEK/ERK PATHWAY | KINASES
Journal Article
CANCER CELL, ISSN 1535-6108, 09/2015, Volume 28, Issue 3, pp. 384 - 398
LY3009120 is a pan-RAF and RAF dimer inhibitor that inhibits all RAF isoforms and occupies both protomers in RAF dinners. Biochemical and cellular analyses... 
ACTIVATION | MELANOMA | MEK INHIBITION | ONCOLOGY | KINASE | C-RAF | IMPROVED SURVIVAL | B-RAF | MAPK PATHWAY | MEDIATES RESISTANCE | VEMURAFENIB | CELL BIOLOGY
Journal Article
Bioorganic and Medicinal Chemistry Letters, ISSN 0960-894X, 09/2011, Volume 21, Issue 18, pp. 5533 - 5537
Structure-activity relationships around a novel series of B-Raf inhibitors are reported. The enzymatic and cellular potencies of inhibitors derived from two... 
Pyrrolopyridine | Structure-activity relationship | B-Raf | Pyrazolopyridine
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 05/2018, Volume 26, Issue 9, pp. 2381 - 2391
Thioether and nicotinamide-containing sorafenib analogues with better anti-proliferative and anti-angiogenic activities than sorafenib were well designed and... 
Nicotinamide | B-Raf | Kinase inhibitor | VEGFR-2 | Antitumor
Journal Article
Oncogene, ISSN 0950-9232, 02/2008, Volume 27, Issue 7, pp. 877 - 895
  Of the RAF family of protein kinases, BRAF is the only member to be frequently activated by mutation in cancer. A single amino acid substitution (V600E)... 
Senescence | BRAF/B-RAF | Naevus/nevus | Melanoma | Cancer | Thyroid | Oncology | Genetics | Mutation | Kinases | Cell cycle | Tumors
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 04/2009, Volume 69, Issue 7, pp. 3042 - 3051
Oncogenic activation of the BRAF serine/threonine kinase has been associated with initiation and maintenance of melanoma tumors. As such, development of... 
BRAF GENE | POTENT | MELANOMA | MECHANISM | ONCOLOGY | PHOSPHORYLATION | BENIGN | PATTERNS | B-RAF | TUMORS | HUMAN CANCER
Journal Article
Lancet, The, ISSN 0140-6736, 2015, Volume 386, Issue 9992, pp. 444 - 451
Journal Article
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 05/2015, Volume 372, Issue 21, pp. 2006 - 2017
Journal Article
MOLECULAR CANCER THERAPEUTICS, ISSN 1535-7163, 03/2011, Volume 10, Issue 3, pp. 385 - 394
The mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) pathway is frequently mutated in human cancer. This pathway consists of... 
CPG ISLAND METHYLATION | SERRATED ADENOMAS | ONCOLOGY | BRAF MUTATION | MELANOCORTIN-1 RECEPTOR | NECROSIS-FACTOR-ALPHA | B-RAF | MC1R VARIANTS | RET/PTC REARRANGEMENTS | AZD6244 ARRY-142886 | DEPENDENT ACTIVATION
Journal Article
Lancet, The, ISSN 0140-6736, 2012, Volume 380, Issue 9839, pp. 358 - 365
Journal Article
Cell, ISSN 0092-8674, 07/2012, Volume 150, Issue 2, pp. 251 - 263
Journal Article