X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
animals (14) 14
b-mediated transcription (12) 12
humans (11) 11
index medicus (11) 11
mice (8) 8
biochemistry & molecular biology (7) 7
male (7) 7
immunology (6) 6
cell biology (5) 5
cell line, tumor (5) 5
female (5) 5
activation (4) 4
expression (4) 4
inflammation (4) 4
kappa-b (4) 4
apoptosis (3) 3
b-mediated secretion (3) 3
biophysics (3) 3
blotting, western (3) 3
brain (3) 3
cell line (3) 3
cells (3) 3
cells, cultured (3) 3
dendritic cells (3) 3
disease models, animal (3) 3
endothelial-cells (3) 3
medicine (3) 3
mice, inbred c57bl (3) 3
necrosis-factor-alpha (3) 3
neoplasm invasiveness (3) 3
neurosciences (3) 3
nf-kappa-b (3) 3
phosphorylation (3) 3
protein-kinase (3) 3
receptors (3) 3
signal transduction (3) 3
t cells (3) 3
transcription factors (3) 3
allergy and immunology (2) 2
article (2) 2
atherosclerosis (2) 2
b-mediated apoptosis (2) 2
base sequence (2) 2
biological response modifiers (2) 2
biomarkers, tumor - genetics (2) 2
biomarkers, tumor - metabolism (2) 2
brain - metabolism (2) 2
breast neoplasms - genetics (2) 2
breast neoplasms - metabolism (2) 2
cell line, transformed (2) 2
cell movement (2) 2
cell proliferation (2) 2
cell-death (2) 2
cricetinae (2) 2
cyclic amp - metabolism (2) 2
cyclic-amp (2) 2
cytokines - metabolism (2) 2
dna - metabolism (2) 2
down-regulation (2) 2
element-binding protein (2) 2
enzyme-linked immunosorbent assay (2) 2
escherichia coli infections - microbiology (2) 2
estrogens - metabolism (2) 2
exposure (2) 2
gene expression regulation - drug effects (2) 2
health aspects (2) 2
human monocytic cells (2) 2
immunohistochemistry (2) 2
inflammation - physiopathology (2) 2
inhibition (2) 2
integrin alphavbeta3 - metabolism (2) 2
kinases (2) 2
matrix-metalloproteinase (2) 2
melanoma-cells (2) 2
mice, inbred c3h (2) 2
mitogen-activated protein kinase 1 - metabolism (2) 2
modulators (2) 2
multidisciplinary sciences (2) 2
oncology (2) 2
osteopontin (2) 2
pharmacology & pharmacy (2) 2
ppar-gamma (2) 2
protease inhibitors (2) 2
protein (2) 2
protein binding (2) 2
psychiatry (2) 2
rats (2) 2
receptors, estrogen - metabolism (2) 2
research (2) 2
reverse transcriptase polymerase chain reaction (2) 2
rna interference (2) 2
sialoglycoproteins - metabolism (2) 2
t-lymphocytes - immunology (2) 2
tamoxifen (2) 2
toxicology (2) 2
transfection (2) 2
up-regulation (2) 2
virology (2) 2
viruses (2) 2
4-hydroxytamoxifen (1) 1
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Cellular Signalling, ISSN 0898-6568, 09/2014, Volume 26, Issue 9, pp. 2016 - 2029
Apremilast, an oral small molecule inhibitor of phosphodiesterase 4 (PDE4), is in development for chronic inflammatory disorders, and has shown efficacy in... 
Phosphodiesterase inhibitor | Apremilast | Spondyloarthropathies | Psoriasis | Preclinical drug evaluation | Psoriatic arthritis | PROTEIN-KINASE-A | CONTROLLED-TRIAL | CAMP-SPECIFIC PHOSPHODIESTERASE | NECROSIS-FACTOR-ALPHA | KAPPA-B | PSORIATIC-ARTHRITIS | CELL BIOLOGY | ORAL PHOSPHODIESTERASE-4 INHIBITOR | CYCLIC-AMP | THALIDOMIDE ANALOGS | B-MEDIATED TRANSCRIPTION | Thalidomide - metabolism | Humans | Male | Thalidomide - pharmacology | Lung Diseases - drug therapy | Thalidomide - analogs & derivatives | T-Lymphocytes - metabolism | T-Lymphocytes - drug effects | Female | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Cyclic AMP - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - chemistry | Vomiting - prevention & control | B-Lymphocytes - metabolism | Disease Models, Animal | Cell Line | Cytokines - metabolism | Immunity, Innate - drug effects | Jurkat Cells | Phosphodiesterase 4 Inhibitors - therapeutic use | Mice, Transgenic | Phosphodiesterase 4 Inhibitors - metabolism | Ferrets | Phosphodiesterase 4 Inhibitors - pharmacology | B-Lymphocytes - drug effects | Adaptive Immunity - drug effects | Animals | B-Lymphocytes - immunology | Protein Binding | T-Lymphocytes - immunology | Mice | Thalidomide - therapeutic use | Dendritic cells | Analysis | Development and progression | Genetic engineering | B cells | Biological response modifiers | T cells
Journal Article
JOURNAL OF PHARMACY AND PHARMACOLOGY, ISSN 0022-3573, 06/2008, Volume 60, Issue 6, pp. 747 - 752
Histamine H-1 receptor (H1R) levels vary under various pathological conditions, and these changes may be responsible for some pathogenesis such as in allergic... 
SMOOTH-MUSCLE | ACTIVATION | PROTEIN | ENDOTHELIAL-CELLS | RECEPTOR MESSENGER-RNA | PHARMACOLOGY & PHARMACY | H-1 RECEPTOR | KAPPA-B | UP-REGULATION | EXPRESSION | B-MEDIATED TRANSCRIPTION
Journal Article
Phytotherapy Research, ISSN 0951-418X, 08/2007, Volume 21, Issue 8, pp. 741 - 745
Pimpinella essential oils and isolated compounds were screened for their inhibitory activity against NF‐κB mediated transcription in SW1353 cells. Twelve oils... 
phenylpropanoid | NF‐κB mediated transcription | Pimpinella species | essential oil | NF-κB mediated transcription | Essential oil | Phenylpropanoid | COLON-CANCER | CHEMISTRY, MEDICINAL | TURKEY | ESTERS | PHARMACOLOGY & PHARMACY | INHIBITORS | NF-kappa B mediated transcription
Journal Article
FEBS Letters, ISSN 0014-5793, 01/2016, Volume 590, Issue 1, pp. 43 - 52
Macrophages display heterogeneous phenotypes, including the classical M1 proinflammatory and the alternative M2 anti‐inflammatory polarization states. The... 
atherosclerosis | macrophage polarization | inflammation | transcription factors | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | GROUCHO | BIOPHYSICS | ADIPOSE-TISSUE MACROPHAGES | HUMAN HOMOLOGS | PPAR-GAMMA | DIFFERENTIATION | HUMAN ALTERNATIVE MACROPHAGES | POLARIZATION | ASSOCIATION | B-MEDIATED TRANSCRIPTION | Obesity - immunology | Humans | Co-Repressor Proteins - metabolism | Interleukin 1 Receptor Antagonist Protein - genetics | Male | Mice, 129 Strain | Obesity - blood | Co-Repressor Proteins - antagonists & inhibitors | Repressor Proteins - antagonists & inhibitors | Interleukin-4 - pharmacology | RNA Interference | Bone Marrow Cells - immunology | Interleukin 1 Receptor Antagonist Protein - metabolism | Interleukin-10 - metabolism | Bone Marrow Cells - drug effects | Female | Interleukin-4 - genetics | Plaque, Atherosclerotic - pathology | Macrophages - immunology | Repressor Proteins - metabolism | Biomarkers - metabolism | Body Mass Index | Intra-Abdominal Fat - immunology | Recombinant Proteins - metabolism | Macrophages - pathology | Plaque, Atherosclerotic - metabolism | Bone Marrow Cells - cytology | Interleukin-4 - metabolism | Cells, Cultured | Repressor Proteins - genetics | Recombinant Proteins - genetics | Plaque, Atherosclerotic - immunology | Recombinant Proteins - pharmacology | Intra-Abdominal Fat - metabolism | Co-Repressor Proteins - genetics | Obesity - metabolism | Obesity - pathology | Gene Expression Regulation - drug effects | Macrophages - metabolism | Animals | Interleukin 1 Receptor Antagonist Protein - antagonists & inhibitors | Interleukin-10 - antagonists & inhibitors | Interleukin-10 - genetics | Macrophages - drug effects | Intra-Abdominal Fat - pathology | Macrophage Activation - drug effects | Bone Marrow Cells - metabolism
Journal Article
NUCLEIC ACIDS RESEARCH, ISSN 0305-1048, 01/1993, Volume 21, Issue 2, pp. 289 - 294
The promoter regions of three IL-6 inducible genes, hemopexin (Hpx), haptoglobin (Hp) and C-reactive protein (CRP) contain cis-acting IL-6 responsive elements... 
RESPONSE ELEMENT | CELLS | B MEDIATED TRANSACTIVATION | CLONING | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-BINDING PROTEINS | NUCLEAR-PROTEIN | INTERLEUKIN-6 | HEPATOCYTE-STIMULATING FACTORS | EXPRESSION | FAMILY
Journal Article
Oncotarget, 2017, Volume 8, Issue 24, pp. 38743 - 38754
Journal Article
Glia, ISSN 0894-1491, 03/2001, Volume 33, Issue 4, pp. 324 - 333
Journal Article
OncoImmunology, ISSN 2162-4011, 05/2017, Volume 6, Issue 5, p. e1304336
Vasoactive intestinal peptide (VIP) is a neuroendocrine peptide hormone that has potent anti-inflammatory activities. VIP signaling through its receptor VPAC1... 
checkpoint blockade | leukemia | Antagonist | T cells | co-stimulation | DENDRITIC CELLS | RECEPTOR | ACUTE MYELOID-LEUKEMIA | IMMUNOLOGY | NEUROPEPTIDES | INHIBITION | ONCOLOGY | GRAFT-VERSUS-HOST | VIP | EXPRESSION | B-MEDIATED TRANSCRIPTION | POLYPEPTIDE
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2017, Volume 12, Issue 7, p. e0180319
The beta-1 adrenergic receptor (ADRB1) is a promising therapeutic target intrinsically involved in the cognitive deficits and pathological features associated... 
7-TRANSMEMBRANE RECEPTORS | ACTIVATION | INHIBITION | INTERFERON-GAMMA | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | FUNCTIONAL SELECTIVITY | NECROSIS-FACTOR-ALPHA | MICE | B-MEDIATED TRANSCRIPTION | Phenyl Ethers - pharmacokinetics | Cricetulus | Models, Chemical | Humans | Crystallography, X-Ray | Male | Adrenergic beta-1 Receptor Agonists - chemistry | Structure-Activity Relationship | Receptors, Adrenergic, beta-1 - chemistry | Propanolamines - pharmacokinetics | Brain - metabolism | Neurocognitive Disorders - drug therapy | Phenyl Ethers - chemistry | Propanolamines - therapeutic use | Adrenergic beta-1 Receptor Agonists - pharmacokinetics | Molecular Structure | Neurocognitive Disorders - metabolism | CHO Cells | Adrenergic beta-1 Receptor Agonists - therapeutic use | Cricetinae | Magnetic Resonance Spectroscopy | Mice, Inbred C57BL | Cells, Cultured | Alzheimer Disease - drug therapy | Models, Molecular | Receptors, Adrenergic, beta-1 - metabolism | Permeability | Drug Discovery | Rats, Sprague-Dawley | Animals | Phenyl Ethers - therapeutic use | Propanolamines - chemistry | Alzheimer Disease - metabolism | Cell Line, Tumor | Protein Binding | GTP-Binding Proteins - metabolism | Epinephrine | Care and treatment | Receptors | Usage | Cellular signal transduction | Research | Alzheimer's disease | Health aspects | Neuroprotection | Brain | Disorders | Cognitive ability | Cognition | Arrestin | Isoproterenol | Kinases | Neuromodulation | Modulators | Recruitment | Lipopolysaccharides | Signal transduction | Rodents | Tumor necrosis factor-TNF | Neurodegenerative diseases | Pharmacology | Inflammation | b-Arrestin | Pathology | Tumor necrosis factor | Adrenergic receptors | Transduction | In vitro methods and tests
Journal Article
PLOS ONE, ISSN 1932-6203, 09/2012, Volume 7, Issue 9
Background: Major basic protein released from eosinophils to airway parasympathetic nerves blocks inhibitory M-2 muscarinic receptors on the parasympathetic... 
CHOLINERGIC NERVES | CHALLENGED GUINEA-PIGS | INTERCELLULAR-ADHESION MOLECULE-1 | MULTIDISCIPLINARY SCIENCES | RACEMIC ALBUTEROL | ACETYLCHOLINE-RELEASE | MAJOR BASIC-PROTEIN | MUSCARINIC RECEPTOR FUNCTION | BETA-ADRENERGIC AGONISTS | EOSINOPHIL ADHESION | B-MEDIATED TRANSCRIPTION
Journal Article
Environmental Toxicology, ISSN 1520-4081, 10/2017, Volume 32, Issue 10, pp. 2234 - 2243
Titanium dioxide nanoparticles (TiO2 NPs) have been extensively used in industry, medicine, and daily life, and have shown potential toxic effects for animals... 
immunotoxicity | thymus | NF‐κB‐mediated MAPKs pathway | immune/inflammatory factors | titanium dioxide nanoparticles | NF-κB-mediated MAPKs pathway | OXIDATIVE STRESS | ACTIVATED RECEPTOR-GAMMA | PULMONARY TOXICITY | WATER RESOURCES | PROTEIN-KINASES | SIGNAL-TRANSDUCTION | ENVIRONMENTAL SCIENCES | INFLAMMATION | PPAR-GAMMA | TOXICOLOGY | NF-kappa B-mediated MAPKs pathway | SPLEEN INJURY | NF-KAPPA-B | TITANIUM-DIOXIDE NANOPARTICLES | COX-2 inhibitors | Killer cells | Interleukins | Prostaglandins E | Body weight | Hemoglobin | Interferon | Biological response modifiers | T cells | Mitogens | Titanium dioxide | Protein kinases | Transcription factors | CD8 antigen | Immunity | Blood | Thymus | Prostaglandin endoperoxide synthase | Proteins | Cell activation | Receptors | Titanium | Biocompatibility | Hemolysis | Cytokines | CD3 antigen | Exposure | Weight | Volume | Hypoxia | Mice | Body organs | Surgical implants | Necroses | Toxicity | Interleukin | Homeostasis | Lymphocytes T | Activation | Kinases | Macrophages | Bleeding | Nanoparticles | Lymphocytes | Interleukin 1 | Degeneration | Immune system | Blood cells | Organs | Extracellular signal-regulated kinase | c-Jun protein | Congestion | Gelatinase | Extracellular | CD4 antigen | Medicine | Animals | Lymphocytes B | Cyclooxygenase-2 | Platelets | Apoptosis | Index Medicus
Journal Article