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Cell Cycle, ISSN 1538-4101, 06/2019, Volume 18, Issue 11, pp. 1292 - 1294
Sezary Syndrome is an aggressive T-cell Lymphoma involving blood, skin and lymphonodes Involvement of the CXCR4-SDF1 has been previously shown. We here present... 
B-arrestin | Leukemia/lymphoma | CTCL | Copy Number Variation | CXCR4-SDF-1
Journal Article
Journal of Molecular Endocrinology, ISSN 0952-5041, 07/2014, Volume 53, Issue 2, pp. R71 - R92
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 341 - 16
Journal Article
Frontiers in Immunology, ISSN 1664-3224, 2014, Volume 5
Biased signaling or functional selectivity occurs when a 7TM receptor preferentially activates one of several available pathways. It can be divided into three... 
Biased signaling | Chemokine system | b-arrestin recruitment | Ligand/receptor/tissue bias | Pathway-specific drug development | 7TM-receptor | 7TM structure-function | G protein coupling | biased signaling | chemokine system | ligand/receptor/tissue bias
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 07/2018, Volume 115, Issue 27, p. 7051
Membrane receptors regulate numerous intracellular functions. However, the molecular underpinnings remain poorly understood because most receptors initiate... 
Molecular machines | Membranes | G protein-coupled receptors | Dopamine | Switches | Intracellular signalling | Arrestin | Selectivity | Cell surface | Membrane proteins | Proteins | b-Arrestin | Coupling (molecular) | Interfaces | Signal transduction | Receptors | Cellular biology | Pathways | Computation | Rewiring | Computer applications | Intracellular | Dopamine D2 receptors
Journal Article
FRONTIERS IN IMMUNOLOGY, ISSN 1664-3224, 06/2014, Volume 5
Journal Article
European Journal of Cancer, ISSN 0959-8049, 12/2016, Volume 69, p. S45
An abstract of a study by Madhukar et al on a big-data method to predict the targets of small molecules and accelerate drug discovery is presented. ONC201-DRD2... 
Immunohistochemistry | Research & development--R&D | Big Data | Arrestin | Molecular chains | b-Arrestin | Molecules | Learning algorithms | Data management | Machine learning | Drug discovery | Bayesian analysis | Dopamine D2 receptors | Cancer
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 6759 - 13
Aging-associated decrease in internal anal sphincter (IAS) tone (AADI) is a major contributor in the rectoanal incontinence (RI). To determine the pathogenesis... 
FECAL INCONTINENCE | ACTIVATION | BASAL TONE | RAT | PATHWAY | SMOOTH-MUSCLE TONE | MULTIDISCIPLINARY SCIENCES | RHO-KINASE | RHOA/ROCK | UP-REGULATION | EXPRESSION | G protein-coupled receptors | Biotinylation | Thromboxane A2 | Smooth muscle | Arrestin | Sphincter | Muscle contraction | Contraction | Protein turnover | b-Arrestin | Polymerase chain reaction | Internalization | Angiotensin | Aging | Colon | Angiotensin II | Regulatory proteins
Journal Article
Annals of the New York Academy of Sciences, ISSN 0077-8923, 08/2018, Volume 1425, Issue 1, pp. 82 - 93
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 4879 - 10
Renal Cell Carcinoma (RCC) is one of the most lethal urological cancers worldwide. The disease does not present early clinical symptoms and is commonly... 
ACTIVATION | INVASION | SRC | MULTIDISCIPLINARY SCIENCES | RECEPTOR | CANCER STATISTICS | VHL | IDENTIFICATION | PROGRESSION | TOOLS | b-Arrestin | Cell proliferation | G protein-coupled receptors | Allografts | Cyclin A | Cell cycle | Xenografts | Receptor mechanisms | Src protein | Protein transport | Cell migration | Clear cell-type renal cell carcinoma
Journal Article
Bioconjugate Chemistry, ISSN 1043-1802, 04/2017, Volume 28, Issue 4, p. 1291
The neuropeptide Y (NPY) Y4 receptor (Y4R) is involved in energy homeostasis and considered a potential drug target for the treatment of obesity. Only a few... 
Competition | Neuropeptide Y | Flow cytometry | Peptides | Osmolarity | Saturation | Methionine | Homeostasis | Radioisotopes | Fluorescence | Confocal microscopy | Arrestin | Fluorescent indicators | b-Arrestin | Energy balance | Sodium | Microscopy | Internalization | Ligands | Affinity | Oxidation | Kinetics | Probes
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2002, Volume 277, Issue 10, pp. 8121 - 8129
beta -Arrestins have been implicated in regulating internalization of the parathyroid hormone receptor (PTHR), but the structural features in the receptor... 
b-arrestin
Journal Article
Experimental & Molecular Medicine, ISSN 1226-3613, 06/2017, Volume 49, Issue 6
Little is known about the effects of chronic alcohol intake on the outcome of acute kidney injury (AKI). Hence, we examined the effects of chronic alcohol... 
Renal function | Kidneys | Glycogen | Glycogen synthase kinase 3 | AKT protein | Arrestin | Alcohol use | b-Arrestin | Reperfusion | Ischemia | Rodents | Fibrosis | Alcoholic beverages | Extracellular matrix
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 07/2017, Volume 114, Issue 27, p. 7154
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2001, Volume 276, Issue 40, pp. 37409 - 37414
The D sub(2) and D sub(3) receptors (D sub(2)R and D sub(3)R), which are potential targets for antipsychotic drugs, have a similar structural architecture and... 
b-Arrestin
Journal Article