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1. Full Text Immunopharmacologic response of patients with B-lineage acute lymphoblastic leukemia to continuous infusion of T cell-engaging CD19/CD3-bispecific BiTE antibody blinatumomab
by Klinger, Matthias and Brandl, Christian and Zugmaier, Gerhard and Hijazi, Youssef and Bargou, Ralf C and Topp, Max S and Gökbuget, Nicola and Neumann, Svenja and Goebeler, Mariele and Viardot, Andreas and Stelljes, Matthias and Brüggemann, Monika and Hoelzer, Dieter and Degenhard, Evelyn and Nagorsen, Dirk and Baeuerle, Patrick A and Wolf, Andreas and Kufer, Peter
Blood, ISSN 0006-4971, 06/2012, Volume 119, Issue 26, pp. 6226 - 6233
Life Sciences & Biomedicine | Hematology | Science & Technology | Hematologic and hematopoietic diseases | Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis | Biological and medical sciences | Medical sciences | Immunotherapy - methods | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Humans | Antibodies, Bispecific - pharmacokinetics | Antilymphocyte Serum - metabolism | Antilymphocyte Serum - administration & dosage | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - immunology | Immunologic Factors - pharmacokinetics | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - diagnosis | T-Lymphocytes - drug effects | Antibodies, Bispecific - administration & dosage | Adult | Cytotoxicity, Immunologic - drug effects | Antigens, CD19 - immunology | Antilymphocyte Serum - adverse effects | Infusion Pumps | Immunologic Factors - administration & dosage | Treatment Outcome | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - therapy | Immunotherapy - adverse effects | Antibodies, Bispecific - adverse effects | Lymphocyte Activation - drug effects | Immune System - drug effects | CD3 Complex - immunology | T-Lymphocytes - immunology | Immunologic Factors - adverse effects | Index Medicus | Abridged Index Medicus
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2. Full Text Epigenetic evolution and lineage histories of chronic lymphocytic leukaemia
by Gaiti, Federico and Chaligne, Ronan and Gu, Hongcang and Brand, Ryan M and Kothen-Hill, Steven and Schulman, Rafael C and Grigorev, Kirill and Risso, Davide and Kim, Kyu-Tae and Pastore, Alessandro and Huang, Kevin Y and Alonso, Alicia and Sheridan, Caroline and Omans, Nathaniel D and Biederstedt, Evan and Clement, Kendell and Wang, Lili and Felsenfeld, Joshua A and Bhavsar, Erica B and Aryee, Martin J and Allan, John N and Furman, Richard and Gnirke, Andreas and Wu, Catherine J and Meissner, Alexander and Landau, Dan A
Nature (London), ISSN 0028-0836, 05/2019, Volume 569, Issue 7757, pp. 576 - 580
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Epigenesis, Genetic | Humans | Gene Expression Regulation, Neoplastic | Mutation Rate | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | DNA Methylation | Sequence Analysis, RNA | Epigenome - genetics | Base Sequence | Leukemia, Lymphocytic, Chronic, B-Cell - metabolism | Transcription, Genetic | Biological Clocks | Single-Cell Analysis | Cell Lineage - genetics | Evolution, Molecular | Epigenetic inheritance | Chronic lymphocytic leukemia | Genetic aspects | Health aspects | Sulfites | Analysis | Genetic research | Genetic transcription | B cells | Methylation | Cell differentiation | Therapy | Transformation | Transcription factors | Bisulfite | Populations | Transcription | Leukemia | Genomics | Biological evolution | Differentiation (biology) | Genomes | Mitochondrial DNA | Lymph nodes | Gene sequencing | Heterogeneity | DNA methylation | Phylogenetics | Evolution | Bioinformatics | Deoxyribonucleic acid--DNA | Immunoglobulins | Integration | Chronic lymphatic leukemia | Genetic diversity | Gene expression | Lymphocytes B | Genotyping | Epigenetics | Stochasticity | Mutation | Lymphocytosis | Binding sites | Cancer | DNA sequencing | Index Medicus | leukemia | single cell | cancer | somatic evolution | epigenetics
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3. Full Text A phylogenetic codon substitution model for antibody lineages
by Hoehn, Kenneth B and Lunter, Gerton and Pybus, Oliver G
Genetics (Austin), ISSN 0016-6731, 05/2017, Volume 206, Issue 1, pp. 417 - 427
Lineage | Evolution | Genetics of immunity | B-cell receptor | Antibody | Phylogenetic tree | Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Antibodies, Neutralizing - immunology | B-Lymphocytes - immunology | Humans | Antibodies, Neutralizing - genetics | Models, Genetic | Codon - genetics | Mutation | Phylogeny | Cell Lineage - genetics | Codon - immunology | Cell Lineage - immunology | Evolution, Molecular | Phylogenetic trees | Research | Immunoglobulins | Decay rate | Zoology | Hot spots | Colleges & universities | Antibodies | Infections | Genetic diversity | Mutation rates | Substitutes | Hypotheses | Somatic hypermutation | Lymphocytes B | Dependence | Phylogenetics | Index Medicus | lineage | phylogenetic tree | antibody | Genetics of Immunity | evolution | Investigations
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4. Full Text B-cell-lineage immunogen design in vaccine development with HIV-1 as a case study
by Haynes, Barton F and Kelsoe, Garnett and Harrison, Stephen C and Kepler, Thomas B
Nature biotechnology, ISSN 1087-0156, 05/2012, Volume 30, Issue 5, pp. 423 - 433
Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Fundamental and applied biological sciences. Psychology | Biotechnology | Health. Pharmaceutical industry | Industrial applications and implications. Economical aspects | Biological and medical sciences | Production of active biomolecules | Vaccins | HIV-1 - metabolism | B-Lymphocytes - cytology | Cell Proliferation | Antibodies - chemistry | Humans | Neutralization Tests | Vaccines - metabolism | AIDS Vaccines - chemistry | Biotechnology - methods | Cell Lineage | Immunogenetics | HIV Antibodies - immunology | Drug Design | Epitopes - chemistry | Mutation | Binding Sites | Dimerization | Antibodies, Monoclonal - chemistry | Antibody diversity | AIDS vaccines | Physiological aspects | Product development | B cells | Research | Health aspects | Monoclonal antibodies | Antigens | Immunology | Human immunodeficiency virus--HIV | Genomics | Index Medicus
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5. Full Text Philadelphia Chromosome-Positive Leukemia in the Lymphoid Lineage-Similarities and Differences with the Myeloid Lineage and Specific Vulnerabilities
by Komorowski, Lukasz and Fidyt, Klaudyna and Patkowska, Elzbieta and Firczuk, Malgorzata
International journal of molecular sciences, ISSN 1422-0067, 08/2020, Volume 21, Issue 16, p. 5776
Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Cell Lineage | Lymphocytes - pathology | Leukemia - pathology | Humans | Clinical Trials as Topic | Myeloid Cells - pathology | Philadelphia Chromosome | Leukemia - genetics | BCR protein | Disease | Leukemia | BCR gene | Drug resistance | Kinases | DNA repair | Molecular weight | DNA methylation | Tumor necrosis factor-TNF | Fusion protein | Chromosomes | Protein-tyrosine kinase | Deoxyribonucleic acid--DNA | Tyrosine | Acute lymphatic leukemia | Myeloid leukemia | Chronic myeloid leukemia | Lymphatic leukemia | Gene expression | Philadelphia chromosome | Chromosome 9 | Isoforms | Stem cells | Chromosome 22 | Mutation | Index Medicus | drug targets | leukemia | B-ALL | CML | p190 | TKIs
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6. Full Text Rituximab in B-Lineage Adult Acute Lymphoblastic Leukemia
by Maury, Sébastien and Chevret, Sylvie and Thomas, Xavier and Heim, Dominik and Leguay, Thibaut and Huguet, Françoise and Chevallier, Patrice and Hunault, Mathilde and Boissel, Nicolas and Escoffre-Barbe, Martine and Hess, Urs and Vey, Norbert and Pignon, Jean-Michel and Braun, Thorsten and Marolleau, Jean-Pierre and Cahn, Jean-Yves and Chalandon, Yves and Lhéritier, Véronique and Beldjord, Kheira and Béné, Marie C and Ifrah, Norbert and Dombret, Hervé and for GRAALL
The New England journal of medicine, ISSN 0028-4793, 09/2016, Volume 375, Issue 11, pp. 1044 - 1053
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Prognosis | Follow-Up Studies | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Remission Induction | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - immunology | Rituximab - administration & dosage | Young Adult | Disease-Free Survival | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Adolescent | Adult | Female | Antigens, CD20 - analysis | Rituximab - adverse effects | Treatment outcome | Care and treatment | Adults | Lymphocytic leukemia | Health aspects | Analysis | Antigens | Acute lymphatic leukemia | Leukemia | Hypersensitivity | Clinical trials | Rituximab | Lymphatic leukemia | Multivariate analysis | Lymphoma | Survival | Patients | Clinical outcomes | Philadelphia chromosome | Chemotherapy | CD20 antigen | Asparaginase | Index Medicus | Abridged Index Medicus | Life Sciences | Cancer
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7. Full Text Induction of HIV Neutralizing Antibody Lineages in Mice with Diverse Precursor Repertoires
by Tian, Ming and Cheng, Cheng and Chen, Xuejun and Duan, Hongying and Cheng, Hwei-Ling and Dao, Mai and Sheng, Zizhang and Kimble, Michael and Wang, Lingshu and Lin, Sherry and Schmidt, Stephen D and Du, Zhou and Joyce, M. Gordon and Chen, Yiwei and DeKosky, Brandon J and Chen, Yimin and Normandin, Erica and Cantor, Elizabeth and Chen, Rita E and Doria-Rose, Nicole A and Zhang, Yi and Shi, Wei and Kong, Wing-Pui and Choe, Misook and Henry, Amy R and Laboune, Farida and Georgiev, Ivelin S and Huang, Pei-Yi and Jain, Suvi and McGuire, Andrew T and Georgeson, Eric and Menis, Sergey and Douek, Daniel C and Schief, William R and Stamatatos, Leonidas and Kwong, Peter D and Shapiro, Lawrence and Haynes, Barton F and Mascola, John R and Alt, Frederick W
Cell (Cambridge), ISSN 0092-8674, 09/2016, Volume 166, Issue 6, pp. 1471 - 1484.e18
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Cell Line | Sequence Deletion | Immunization | Gene Expression Regulation - immunology | Immunoglobulin Heavy Chains - chemistry | Precursor Cells, B-Lymphoid - immunology | Antibodies, Monoclonal - genetics | Antibodies, Neutralizing - immunology | HIV-1 - immunology | Animals | B-Lymphocytes - immunology | Inhibitory Concentration 50 | T-Lymphocytes - immunology | Mice | Immunoglobulin Heavy Chains - immunology | Antibodies, Monoclonal - immunology | Immunoglobulin Heavy Chains - genetics | Disease Models, Animal | Viral antibodies | AIDS vaccines | Biological products | Analysis | Vaccination | Antibodies | Glycoproteins | B cells | HIV (Viruses) | Medical research | Medicine, Experimental | Index Medicus
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