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ctla-4 antigen (306) 306
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induction (249) 249
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antigens, cd - metabolism (238) 238
antigens, cd - immunology (236) 236
gene expression (236) 236
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cd28 antigens - immunology (221) 221
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ligands (211) 211
b7-h1 antigen (206) 206
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responses (205) 205
immunoconjugates (204) 204
dendritic cells - metabolism (199) 199
antigen-presenting cells - immunology (198) 198
cell biology (198) 198
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adult (189) 189
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cell line, tumor (180) 180
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Immunity, ISSN 1074-7613, 06/2015, Volume 42, Issue 6, pp. 1048 - 1061
Journal Article
Nature Medicine, ISSN 1078-8956, 12/2014, Volume 20, Issue 12, pp. 1410 - 1416
The protein cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential negative regulator of immune responses, and its loss causes fatal autoimmunity in mice.... 
PATHWAYS | MEDICINE, RESEARCH & EXPERIMENTAL | CLINICAL-PICTURE | HOMEOSTASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | AUTOIMMUNITY | REGULATORY T-CELLS | GERMLINE MUTATIONS | MICE | BLOCKADE | IMMUNODEFICIENCY | ABATACEPT | Recurrence | Agammaglobulinemia - immunology | Agammaglobulinemia - genetics | Purpura, Thrombocytopenic, Idiopathic - genetics | Exons | Immune System Diseases - genetics | Humans | Middle Aged | Male | Anemia, Hemolytic, Autoimmune - genetics | Mutation, Missense | Respiratory Tract Infections - genetics | T-Lymphocytes, Regulatory - immunology | Autoimmune Diseases - genetics | Young Adult | Purpura, Thrombocytopenic, Idiopathic - immunology | Adult | Female | Endocytosis - genetics | Polyendocrinopathies, Autoimmune - genetics | Child | Endocytosis - immunology | Granuloma - genetics | Autoimmune Diseases - immunology | CTLA-4 Antigen - genetics | B7-1 Antigen - metabolism | Codon, Nonsense | CTLA-4 Antigen - immunology | Syndrome | Polyendocrinopathies, Autoimmune - immunology | Lung Diseases, Interstitial - immunology | Animals | B-Lymphocytes - immunology | Lung Diseases, Interstitial - genetics | Pedigree | Anemia, Hemolytic, Autoimmune - immunology | Adolescent | Respiratory Tract Infections - immunology | Granuloma - immunology | Heterozygote | Mice | Antigens | Gene mutations | Physiological aspects | Genetic aspects | Immunologic diseases | Research | Risk factors | Proteins | Homeostasis | Cytotoxicity | Ligands | T cell receptors | Mutation | Immune system | Index Medicus
Journal Article
Journal of Immunology, ISSN 0022-1767, 03/2014, Volume 192, Issue 6, pp. 2699 - 2714
The long-held paradigm that B cells cannot uptake nonspecific particulate Ags for the initiation of primary adaptive immunity has been challenged by the recent... 
MICROBICIDAL ABILITIES | ZEBRAFISH | DENDRITIC CELLS | EARLY VERTEBRATES | INFECTION | IMMUNOLOGY | EXPRESSION | T-CELLS | RELEVANT GENES | ANTIGEN | LYMPHOCYTES | Antigens, CD - immunology | B7-2 Antigen - genetics | B7-1 Antigen - genetics | Zebrafish - immunology | Immunoglobulins - immunology | Membrane Glycoproteins - metabolism | Molecular Sequence Data | Male | B7 Antigens - immunology | Gene Expression Profiling | Immunoglobulins - genetics | Phylogeny | Antigens, CD - genetics | Adaptive Immunity - genetics | Antigens, CD - metabolism | CD4-Positive T-Lymphocytes - immunology | Immunoglobulins - metabolism | Lymphocyte Activation - immunology | B7 Antigens - genetics | Base Sequence | Zebrafish Proteins - immunology | B-Lymphocyte Subsets - immunology | Female | Membrane Glycoproteins - immunology | Adaptive Immunity - immunology | B7-2 Antigen - immunology | B-Lymphocytes - metabolism | Amino Acid Sequence | Antigen-Presenting Cells - metabolism | Vibrio alginolyticus - immunology | B7-1 Antigen - immunology | Zebrafish Proteins - metabolism | CD4-Positive T-Lymphocytes - metabolism | B7-1 Antigen - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Antigen-Presenting Cells - immunology | Blotting, Western | Zebrafish - genetics | B7 Antigens - metabolism | Membrane Glycoproteins - genetics | Sequence Homology, Amino Acid | B7-2 Antigen - metabolism | Animals | B-Lymphocytes - immunology | B-Lymphocyte Subsets - metabolism | Zebrafish Proteins - genetics | Evolution, Molecular | Index Medicus | Abridged Index Medicus
Journal Article
Nature, ISSN 0028-0836, 03/2011, Volume 471, Issue 7338, pp. 377 - +
Journal Article
Developmental and Comparative Immunology, ISSN 0145-305X, 03/2015, Volume 49, Issue 1, pp. 38 - 43
Dendritic cells (DCs) are among the most important professional antigen-presenting cells (APCs) that participate in various biological activities in mammals.... 
Zebrafish dendritic cells | Antigen presentation | Co-stimulatory signals | Surface phenotypic molecules | ZEBRAFISH | SUBSETS | INNATE | IMMUNOLOGY | IDENTIFICATION | MATURATION | ADAPTIVE IMMUNITY | ORIGIN | FISHERIES | ZOOLOGY | ANTIGEN-PRESENTATION | SUPERFAMILY | LINEAGE | Interleukin-12 Subunit p40 - genetics | Receptor, Macrophage Colony-Stimulating Factor - immunology | B7-1 Antigen - genetics | Zebrafish - immunology | Membrane Glycoproteins - metabolism | Dendritic Cells - immunology | Male | Immunoglobulins - genetics | Antigens, CD - genetics | Antigens, CD - metabolism | Immunoglobulins - metabolism | Lectins, C-Type - metabolism | Lymphocyte Activation - immunology | Gene Expression - immunology | Zebrafish Proteins - immunology | Receptors, Antigen, T-Cell - immunology | Cell Membrane - metabolism | Interleukin-12 Subunit p40 - immunology | GATA2 Transcription Factor - genetics | Interleukin-12 Subunit p40 - metabolism | Antigen-Presenting Cells - metabolism | Receptors, Antigen, T-Cell - metabolism | Receptor, Macrophage Colony-Stimulating Factor - genetics | Reverse Transcriptase Polymerase Chain Reaction | Cell Adhesion Molecules - metabolism | Receptors, Cell Surface - immunology | Zebrafish - genetics | Microscopy, Confocal | Histocompatibility Antigens Class II - immunology | Cell Membrane - immunology | Receptors, Antigen, T-Cell - genetics | Zebrafish Proteins - genetics | Receptors, Cell Surface - genetics | Antigens, CD - immunology | Cell Adhesion Molecules - genetics | Immunoglobulins - immunology | Lectins, C-Type - immunology | Cell Adhesion Molecules - immunology | Lectins, C-Type - genetics | Receptor, Macrophage Colony-Stimulating Factor - metabolism | Flow Cytometry | Female | Histocompatibility Antigens Class II - metabolism | Membrane Glycoproteins - immunology | Dendritic Cells - metabolism | B7-1 Antigen - immunology | Zebrafish Proteins - metabolism | Receptors, Cell Surface - metabolism | GATA2 Transcription Factor - immunology | Immunophenotyping | B7-1 Antigen - metabolism | Antigen-Presenting Cells - immunology | Membrane Glycoproteins - genetics | Animals | Zebrafish - metabolism | GATA2 Transcription Factor - metabolism | Histocompatibility Antigens Class II - genetics | Dendritic cells | Chemical properties | Index Medicus
Journal Article
Immunity, ISSN 1074-7613, 12/2014, Volume 41, Issue 6, pp. 1013 - 1025
Journal Article
Gene Therapy, ISSN 0007-0610, 03/2014, Volume 217, Issue 1, pp. 262 - 271
The release of cytokines by T cells strongly defines their functional activity in vivo. The ability to produce multiple cytokines has been associated with... 
CD4 | multifunctional | and CD8 | T cell | dendritic cell | PD-1/PD-L1 pathway | MEDICINE, RESEARCH & EXPERIMENTAL | VIRUS-INFECTION | CD4(+) and CD8(+) T cell | DENDRITIC CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | EFFECTOR FUNCTION | COSTIMULATORY MOLECULES | CANCER-IMMUNOTHERAPY | CHRONIC VIRAL-INFECTION | IMMUNE EVASION | DOWN-MODULATION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | LIGAND | PD-1 EXPRESSION | Tumor Necrosis Factor-alpha - metabolism | B7-1 Antigen - genetics | Dendritic Cells - immunology | Humans | Nucleoproteins - genetics | Tumor Necrosis Factor-alpha - genetics | B7 Antigens - immunology | RNA, Messenger - metabolism | Viral Proteins - metabolism | Antigen Presentation | T-Lymphocytes - metabolism | B7 Antigens - genetics | HEK293 Cells | Interleukin-10 - metabolism | Dendritic Cells - metabolism | RNA, Messenger - genetics | Programmed Cell Death 1 Receptor - metabolism | Viral Proteins - genetics | B7-1 Antigen - metabolism | B7 Antigens - metabolism | Nucleoproteins - metabolism | Interleukin-10 - genetics | T-Lymphocytes - immunology | Programmed Cell Death 1 Receptor - immunology | Programmed Cell Death 1 Receptor - genetics | Physiological aspects | Cell research | Research | T cells | Apoptosis | Antigen presentation | Ligands | T cell receptors | Cytokines | Immunotherapy | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2013, Volume 8, Issue 12, pp. e83139 - e83139
CD28, CTLA-4 and PD-L1, the three identified ligands for CD80/86, are pivotal positive and negative costimulatory molecules that, among other functions,... 
IN-VITRO | ACTIVATION | DENDRITIC CELLS | TCR STOP-SIGNAL | TOLERANCE | MULTIDISCIPLINARY SCIENCES | EXTRINSIC CONTROL | ANTI-CD28 ANTIBODY | UP-REGULATION | CUTTING EDGE | LYMPHOCYTES | B7-1 Antigen - antagonists & inhibitors | Cell Communication - immunology | B7-2 Antigen - genetics | B7-1 Antigen - genetics | Dendritic Cells - immunology | Humans | Molecular Targeted Therapy | T-Lymphocytes, Regulatory - immunology | T-Lymphocytes, Cytotoxic - drug effects | CD28 Antigens - genetics | Protein Binding - drug effects | CD28 Antigens - antagonists & inhibitors | T-Lymphocytes, Regulatory - cytology | Dendritic Cells - drug effects | B7-2 Antigen - immunology | T-Lymphocytes, Cytotoxic - immunology | Gene Expression | B7-2 Antigen - antagonists & inhibitors | B7-1 Antigen - immunology | Antibodies, Monoclonal - pharmacology | CTLA-4 Antigen - genetics | CD28 Antigens - immunology | CTLA-4 Antigen - immunology | B7-H1 Antigen - genetics | B7-H1 Antigen - immunology | Cell Movement - drug effects | T-Lymphocytes, Regulatory - drug effects | B7-H1 Antigen - antagonists & inhibitors | Lymphocyte Activation - drug effects | Cell Communication - drug effects | Dendritic Cells - cytology | CTLA-4 Antigen - antagonists & inhibitors | T-Lymphocytes, Cytotoxic - cytology | Viral antibodies | Antibodies | Antigens | B cells | T cells | Motility | Transplants & implants | Calcium | Blocking antibodies | Homeostasis | Effector cells | Reversing | Immunological synapses | Lymphocytes T | Kinases | CD28 antigen | T-cell receptor | CTLA-4 protein | Cell activation | Immunology | Lymphocytes | Dwell time | Cell cycle | Cytokines | Immunoregulation | CD80 antigen | T cell receptors | Costimulator | Microscopy | Antigen-presenting cells | PD-L1 protein | Ligands | Cell migration | Synapses | Apoptosis | Index Medicus | Life Sciences | Human health and pathology
Journal Article
Molecular Therapy, ISSN 1525-0016, 07/2017, Volume 25, Issue 7, pp. 1676 - 1685
Targeted approaches to treat autoimmune diseases would improve upon current therapies that broadly suppress the immune system and lead to detrimental side... 
tolerance induction mechanism | antigen-specific tolerance | immune tolerance | PLGA | PLG nanoparticles | MEDICINE, RESEARCH & EXPERIMENTAL | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | DENDRITIC CELLS | ANTIGENS | IL-10 | IMMUNOLOGICAL-TOLERANCE | DELIVERY | RESPONSES | MULTIPLE-SCLEROSIS | PATHWAY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | CROSS-PRESENTATION | B7-2 Antigen - genetics | Myelin Proteolipid Protein - immunology | B7-1 Antigen - genetics | Spleen - immunology | Nanoparticles - chemistry | Ovalbumin - immunology | Encephalomyelitis, Autoimmune, Experimental - immunology | Delayed-Action Preparations - chemistry | Spleen - drug effects | Polyglactin 910 - metabolism | T-Lymphocytes, Regulatory - pathology | Delayed-Action Preparations - administration & dosage | Myelin Proteolipid Protein - pharmacology | T-Lymphocytes, Regulatory - immunology | Antigen-Presenting Cells - pathology | Immunoconjugates - pharmacology | Female | CD40 Antigens - genetics | Encephalomyelitis, Autoimmune, Experimental - genetics | Polyglactin 910 - chemistry | B7-2 Antigen - immunology | Myelin Proteolipid Protein - chemistry | Spleen - pathology | Ovalbumin - chemistry | Immune Tolerance - drug effects | Gene Expression | Encephalomyelitis, Autoimmune, Experimental - pathology | B7-1 Antigen - immunology | Immunoconjugates - metabolism | Antigen-Presenting Cells - drug effects | Mice, Inbred C57BL | Ovalbumin - pharmacology | Antigen-Presenting Cells - immunology | Immunoconjugates - chemistry | Antigens - chemistry | Particle Size | Encephalomyelitis, Autoimmune, Experimental - therapy | T-Lymphocytes, Regulatory - drug effects | Animals | Antigens - immunology | Mice | Nanoparticles - administration & dosage | Primary Cell Culture | Antigens - pharmacology | CD40 Antigens - immunology | Cell proliferation | Multiple sclerosis | Transcription factors | CD40 antigen | Disease | Peptides | CD86 antigen | Lymphocytes T | Nanoparticles | Myelin proteolipid protein | Lymphocytes | Localization | Immune system | Antigen presentation | Cytokines | Dendritic cells | Myelin | CD80 antigen | Inflammation | T cell receptors | Immunological tolerance | Studies | Major histocompatibility complex | Antigen-presenting cells | Internalization | PD-L1 protein | Proteolipid protein | Poly(lactide-co-glycolide) | Autoimmune diseases | Apoptosis | Index Medicus | Original
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2008, Volume 105, Issue 52, pp. 20828 - 20833
Despite their common ability to activate intracellular signaling through CD80/CD86 molecules, cytotoxic T lymphocyte antigen 4 (CTLA-4)-Ig and CD28-Ig bias the... 
T lymphocytes | Messenger RNA | Reactivity | Dendritic cells | Cytokines | Antibodies | Catabolism | Physiological regulation | Immunity | Skin tests | CD28-Ig | Tryptophan catabolism | IL-6 | CD80/86 signaling | SOCS proteins | ACTIVATION | MULTIDISCIPLINARY SCIENCES | COMPETENT DENDRITIC CELLS | CUTTING EDGE | RESPONSES | REJECTION | IN-VIVO | REGULATORY T-CELLS | IMMUNE REGULATION | tryptophan catabolism | NF-KAPPA-B | Indoleamine-Pyrrole 2,3,-Dioxygenase - genetics | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Antigens, CD - immunology | B7-2 Antigen - genetics | B7-1 Antigen - genetics | Immune Tolerance - physiology | Dendritic Cells - immunology | Indoleamine-Pyrrole 2,3,-Dioxygenase - immunology | Antigens, CD - genetics | Antigens, CD - metabolism | CD28 Antigens - metabolism | CD28 Antigens - genetics | Mice, Inbred DBA | B7-2 Antigen - immunology | Proteasome Endopeptidase Complex - immunology | Interleukin-6 - genetics | B7-1 Antigen - immunology | Suppressor of Cytokine Signaling Proteins - immunology | Suppressor of Cytokine Signaling Proteins - genetics | Mice, Transgenic | B7-1 Antigen - metabolism | CD28 Antigens - immunology | Ubiquitination - immunology | CTLA-4 Antigen | Proteasome Endopeptidase Complex - genetics | B7-2 Antigen - metabolism | Suppressor of Cytokine Signaling 3 Protein | Animals | Amino Acid Motifs - immunology | Dendritic Cells - enzymology | Interleukin-6 - immunology | Interleukin-6 - biosynthesis | Dendritic Cells - cytology | Mice | Proteasome Endopeptidase Complex - metabolism | Amino Acid Motifs - genetics | Suppressor of Cytokine Signaling Proteins - biosynthesis | Ubiquitination - genetics | Cellular signal transduction | Research | T cells | Properties | Studies | Antigens | Gene expression | Lymphocytes | Rodents | Index Medicus | Biological Sciences | CD80 | 86 signaling
Journal Article