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Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 04/2018, Volume 28, Issue 6, pp. 1111 - 1115
The diastereoselective synthesis and structure activity relationship (SAR) of a series of fused cyclopropyl-3-amino-2,4-oxazine... 
BACE inhibitor | β-Secretase | Alzheimer’s disease (AD) | Structure-based design | Oxazine | Alzheimer's disease (AD) | CASCADE HYPOTHESIS | 2-ISOXAZOLINES | DESIGN | CHEMISTRY, MEDICINAL | beta-Secretase | BORON-TRIFLUORIDE | SERIES | ALZHEIMERS-DISEASE | CHEMISTRY, ORGANIC | PRECURSOR PROTEIN | Index Medicus
Journal Article
Journal Article
Journal Article
Journal Article
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 10/2014, Volume 75, pp. 48 - 59
Elevated total cholesterol in midlife has been associated with increased risk of dementia in later life. We have previously shown that low-density lipoprotein... 
BACE1 | Low-density lipoprotein | Lipid raft | Free radicals | Lipid oxidation | Redox | Aging | OxLDL | GSH | Cholesterol | COMMON VARIANTS | OXIDATIVE STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | INVOLVEMENT | 24-HYDROXYCHOLESTEROL | INHIBITION | ENDOCRINOLOGY & METABOLISM | 27-HYDROXYCHOLESTEROL | ACCUMULATION | ACID SPHINGOMYELINASE | ASSOCIATION | Free Radical Scavengers - pharmacology | Aspartic Acid Endopeptidases - biosynthesis | Glutathione - metabolism | Membrane Microdomains - metabolism | Humans | Amyloid beta-Peptides - secretion | Alzheimer Disease - pathology | Desipramine - pharmacology | Sphingomyelin Phosphodiesterase - biosynthesis | Aged, 80 and over | Cell Survival - drug effects | Oxidation-Reduction | Amyloid beta-Peptides - biosynthesis | Enzyme Inhibitors - pharmacology | Lipoproteins, LDL - pharmacology | Lipid Metabolism | Hydroxycholesterols - pharmacology | Amyloid Precursor Protein Secretases - metabolism | Sphingomyelin Phosphodiesterase - antagonists & inhibitors | Aspartic Acid Endopeptidases - metabolism | Acetylcysteine - pharmacology | Cell Line, Tumor | Cholesterol, LDL - metabolism | Aged | Glutathione - chemistry | Enzyme Activation | Glutathione Disulfide - chemistry | Lipoproteins, LDL - blood | Amyloid Precursor Protein Secretases - biosynthesis | Index Medicus | BACE, β-secretase β-site amyloid cleaving enzyme | GSH, glutathione | SM, sphingomyelin | EDTA, ethylenediamine tetraacetic acid | NAC, N-acetylcysteine | ELISA, enzyme-linked immunosorbent assay | GCL, glutamate–cysteinyl ligase | PVDF, polyvinylidene fluoride | E-64, proteinase inhibitor E-64 | PBS, phosphate-buffered saline | AD, Alzheimer disease | BSO, buthionine sulfoximine | LDL, low-density lipoprotein | CTB, cholera toxin B | GSSG, oxidized glutathione | BCA, bicinchoninic acid | Original Contribution | BBB, blood–brain barrier | BHT, butylated hydroxytoluene | ASMase, acid sphingomyelinase | ESI–MS, electrospray ionization mass spectrometry | Aβ, β-amyloid | SDS–PAGE, sodium dodecyl sulfate–polyacrylamide gel electrophoresis | MDA, malondialdehyde | oxLDL, oxidized low-density lipoprotein | 27OH-C, 27-hydroxycholesterol | PBST, phosphate-buffered saline with 1% Tween 20 | EGTA, ethylene glycol tetraacetic acid | CSF, cerebrospinal fluid | APP, amyloid precursor protein
Journal Article
FEBS Journal, ISSN 1742-464X, 09/2015, Volume 282, Issue 18, pp. 3618 - 3631
Journal Article
The Journal of neuroscience : the official journal of the Society for Neuroscience, ISSN 0270-6474, 1/2008, Volume 28, Issue 5, pp. 1213 - 1223
MicroRNAs (miRNAs) are small regulatory RNAs that participate in posttranscriptional gene regulation in a sequence-specific manner. However, little is... 
microarray | miRNAs | noncoding | Alzheimer’s | in situ | BACE
Journal Article
Archives of Biochemistry and Biophysics, ISSN 0003-9861, 2003, Volume 410, Issue 2, pp. 307 - 316
Journal Article
Journal of Neurotrauma, ISSN 0897-7151, 04/2009, Volume 26, Issue 4, pp. 613 - 625
In this study, we examined whether ischemia-induced amyloidogenesis could be modulated by environmental "experience,'' and whether this modulation is... 
b-secretase amyloid cleaving enzyme (BACE) | learning and Memory | enriched environment | water maze | Ab oligomers | beta-secretase amyloid cleaving enzyme (BACE) | AMYLOID PRECURSOR PROTEIN | SYNAPTIC PLASTICITY | NEUROSCIENCES | BETA PEPTIDE | CLINICAL NEUROLOGY | DELAYED NEURONAL DEATH | A beta oligomers | learning and memory | TRAUMATIC BRAIN-INJURY | CEREBRAL-ARTERY OCCLUSION | ENRICHMENT IMPROVES COGNITION | IN-VIVO | RAT-BRAIN | TRANSGENIC MICE | CRITICAL CARE MEDICINE | Memory Disorders - physiopathology | Rats, Wistar | Male | Environment, Controlled | Brain - metabolism | Cognition Disorders - etiology | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Recovery of Function - physiology | Hypoxia-Ischemia, Brain - therapy | Hypoxia-Ischemia, Brain - metabolism | Disease Models, Animal | Cognition Disorders - physiopathology | Maze Learning - physiology | Plaque, Amyloid - pathology | Brain - physiopathology | Rats | Treatment Outcome | Neprilysin - metabolism | Neuropsychological Tests | Animals | Memory Disorders - etiology | Memory Disorders - therapy | Brain - pathology | Plaque, Amyloid - metabolism | Cognition Disorders - therapy | Hypoxia-Ischemia, Brain - physiopathology | Enzymes | Brain damage | Ischemia | Peptides | Rodents | Animal cognition | Index Medicus | β-secretase amyloid cleaving enzyme (BACE) | Aβ oligomers
Journal Article
Biochemical Journal, ISSN 0264-6021, 10/2006, Volume 399, Issue 2, pp. 205 - 214
We have previously reported that protein lipidation in the form of palmitoylation and farnesylation is critical for the production of A beta (amyloid... 
Palmitoylation | β-secretase | Amyloid β-peptide (Aβ) | Statin | Alzheimer's disease | Dimerization | Cholesterol | COA REDUCTASE INHIBITORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | dimerization | AMYLOID PRECURSOR PROTEIN | CLEAVAGE | amyloid beta-peptide (A beta) | PEPTIDE | ENZYME | statin | beta-secretase | cholesterol | ALZHEIMERS-DISEASE PATIENTS | DOMAINS | palmitoylation | BRAIN | BACE | Mevalonic Acid - pharmacology | Endopeptidases - metabolism | Palmitic Acid - metabolism | Protein Prenylation - drug effects | Molecular Weight | Lovastatin - pharmacology | Humans | Cells, Cultured | Protein Transport - drug effects | Cholesterol - metabolism | Hypolipidemic Agents - pharmacology | Simvastatin - pharmacology | Endopeptidases - chemistry | Terpenes - metabolism | Models, Biological | Aspartic Acid Endopeptidases | Amyloid Precursor Protein Secretases | Amyloid beta-Peptides - metabolism | Index Medicus | HEK-293 cells, human embryonic kidney cells | bHEK cells, HEK-293 cells transfected with the Asp-2 gene plus a polyhistidine coding tag | SIMVA, simvastatin | HMG-CoA, 3-hydroxy-3-methylglutaryl-CoA | HRP, horseradish peroxidase | buffer R, reducing Laemmli sample buffer | ATORVA, atorvastatin | PA, palmitic acid | Aβ, amyloid β-peptide | amyloid β-peptide (Aβ) | buffer NR, non-reducing Laemmli sample buffer | TGN, trans-Golgi network | BACE, β-site amyloid-cleaving enzyme | GPI, glycosylphosphatidylinositol | LOVA, lovastatin | MA, mevalonate | AD, Alzheimer's disease | ER, endoplasmic reticulum | APP, amyloid precursor protein
Journal Article
동의신경정신과학회지, ISSN 1226-6396, 2010, Volume 21, Issue 2, p. 191
This experiment was designed to investigate the effect of Chongmyung-Tang Prescription Combination(CmTP-C1-10) extract on the production of amyloid β protein... 
β-site amyloid precursor protein-cleaving enzyme(BACE) | Chongmyung Tang | Amyloid β protein(Aβ) | Congmingtang Prescription Combination(CmTP-C1-10) | Alzheimer`s disease
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 01/2006, Volume 26, Issue 2, pp. 418 - 428
Journal Article
Biochemical Society Transactions, ISSN 0300-5127, 06/2007, Volume 35, Issue 3, pp. 571 - 573
Journal Article