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Bioorganic Chemistry, ISSN 0045-2068, 08/2019, Volume 89, p. 102992
Alzheimer’s disease (AD) is the most prevalent disease of old age leading to dementia. Complex AD pathogenesis involves multiple factors amyloid plaque... 
Quinoxalines | Inflammation | Multitarget-directed ligands | BACE-1 | Thiazoles
Journal Article
Bioorganic chemistry, ISSN 0045-2068, 05/2019, Volume 89, pp. 102992 - 102992
Alzheimer's disease (AD) is the most prevalent disease of old age leading to dementia. Complex AD pathogenesis involves multiple factors viz. amyloid plaque... 
TARGET | DESIGN | MANAGEMENT | Multitarget-directed ligands | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | Quinoxalines | Inflammation | DISCOVERY | QUERCETIN | ANTIINFLAMMATORY AGENTS | BACE-1 | Thiazoles | CLINICAL CANDIDATE | DERIVATIVES | BACE-1 INHIBITORS | HYBRIDS | Index Medicus
Journal Article
CURRENT TOPICS IN MEDICINAL CHEMISTRY, ISSN 1568-0266, 2017, Volume 17, Issue 31, pp. 3361 - 3369
In industrialized countries, Alzheimer's disease represents the most devastating neurodegenerative disorder in elderly people and the search for a disease... 
CHEMISTRY, MEDICINAL | Neurofibrillary tangles (NFTs) | KINASE | TAU | AMYLOID PRECURSOR PROTEIN | IDENTIFICATION | Alzheimer | NEURODEGENERATIVE DISEASES | DISCOVERY | BETA | NQO1 enzyme | Dual BACE-1/GSK-3 beta | Neurodegenerative Diseases (ND) | BACE-1 | HYPOTHESIS | GSK-3-BETA INHIBITORS | Precursor protein
Journal Article
Bioorganic Chemistry, ISSN 0045-2068, 06/2019, Volume 87, pp. 474 - 483
BACE-1 is considered to be one of the targets for prevention and treatment of Alzheimer's disease (AD). We here report a novel class of semi-synthetic... 
In silico molecular docking | P-gp | Alzheimer's disease | β-Secretase(BACE-1) | Isoflavones | ETIOLOGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | beta-Secretase(BACE-1) | MACLURA-POMIFERA | FLAVONOIDS | PATHOLOGY | P-GLYCOPROTEIN | AGENT | OPTIMIZATION | GENERATION | EXTRACTS | Prevention | Adenosine triphosphatase | Cancer
Journal Article
Pharmaceuticals, ISSN 1424-8247, 03/2019, Volume 12, Issue 1, p. 41
Alzheimer's disease (AD) is a growing global health concern with a massive impact on affected individuals and society. Despite the considerable advances... 
Alzheimer’s disease | γ-secretase | Amyloid hypothesis | BACE-1 | amyloid hypothesis
Journal Article
Computational Biology and Chemistry, ISSN 1476-9271, 12/2017, Volume 71, pp. 1 - 9
Due to multifactorial nature of Alzheimer’s disease one target-one ligand hypothesis often looks insufficient. BACE-1 and GSK-3β are well established... 
Virtual screening | GSK-3β | Alzheimer’s disease | BACE-1 | Physicochemical properties
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 12/2018, Volume 19, Issue 12, p. 4112
A series of 2-aryl-3-hydroxy-6-iodo-4 -chromen-4-ones substituted at the 7-position with a halogen atom ( = F, Cl and Br) or methoxy group and their... 
7-substituted 6-iodoflavonols | X-ray | BACE-1 | Molecular docking | Cholinesterases | 4-substituted 2-hydroxy-5-iodochalcones | Index Medicus | molecular docking | cholinesterases
Journal Article
Life sciences, ISSN 0024-3205, 12/2012, Volume 91, Issue 23-24, pp. 1159 - 1168
Journal Article
Journal of Biomolecular Structure and Dynamics, ISSN 0739-1102, 01/2019, Volume 37, Issue 2, pp. 275 - 290
BACE-1 and GSK-3β both are potential therapeutic drug targets for Alzheimer's disease. Recently, both these targets received attention for designing dual... 
MM-PBSA | molecular dynamics | dual inhibitors | Alzheimer's disease | BACE-1 and GSK-3β | Alzheimer’s disease
Journal Article
JOURNAL OF NEUROCHEMISTRY, ISSN 0022-3042, 01/2012, Volume 120, pp. 71 - 83
beta-Secretase (memapsin 2; BACE-1) is the first protease in the processing of amyloid precursor protein leading to the production of amyloid-beta (A beta) in... 
memapsin 2 | BACE 1 | inhibitors | drugs | BIOCHEMISTRY & MOLECULAR BIOLOGY | HUMAN BETA-SECRETASE | X-RAY-STRUCTURE | AMYLOID PRECURSOR PROTEIN | POTENT INHIBITORS | NEUROSCIENCES | HYDROXY ETHYLAMINES HEAS | beta-secretase | WILD-TYPE MICE | IN-VIVO | A-BETA | Alzheimer's disease | CARBINAMINE BACE-1 INHIBITORS | STRUCTURE-BASED DESIGN
Journal Article
Current Bioactive Compounds, ISSN 1573-4072, 2013, Volume 9, Issue 1, pp. 14 - 20
Alzheimer's Disease (AD) is the major cause of senile dementia, flawing out 10% of 65 years old population and 50% of 85 years old, globally. The major... 
Virtual screening | Alzheimer | BACE-1
Journal Article
JOURNAL OF NUCLEAR MEDICINE, ISSN 0161-5505, 07/2019, Volume 60, Issue 7, pp. 992 - 997
beta-secretase 1 (BACE1) is a key enzyme in the generation of beta-amyloid, which is accumulated in the brain of Alzheimer disease patients. PF-06684511 was... 
POTENT | Alzheimer disease | IN-VIVO | nonhuman primate | AMYLOID PRECURSOR PROTEIN | BACE-1 INHIBITOR | BINDING | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | PET | BACE
Journal Article
Journal of Cerebral Blood Flow & Metabolism, ISSN 0271-678X, 7/2016, Volume 36, Issue 7, pp. 1281 - 1294
Endothelial cells of the blood–brain barrier form a structural and functional barrier maintaining brain homeostasis via paracellular tight junctions and... 
endothelium | blood–brain barrier | Alzheimer’s disease | Original | BACE-1 | β-amyloid
Journal Article
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