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Current bioactive compounds, ISSN 1573-4072, 2013, Volume 9, Issue 1, pp. 14 - 20
Alzheimer's Disease (AD) is the major cause of senile dementia, flawing out 10% of 65 years old population and 50% of 85 years old, globally. The major... 
Virtual screening | Alzheimer | BACE-1
Journal Article
Neuron (Cambridge, Mass.), ISSN 0896-6273, 08/2013, Volume 79, Issue 3, pp. 447 - 460
The convergence of APP (substrate) and BACE-1 (enzyme) is a rate-limiting, obligatory event triggering the amyloidogenic pathway—a key step in Alzheimer’s... 
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Amyloid Precursor Protein Secretases - genetics | Membrane Microdomains - metabolism | Protein Transport - physiology | Aspartic Acid Endopeptidases - genetics | rab5 GTP-Binding Proteins - metabolism | Case-Control Studies | Alzheimer Disease - pathology | Brain - metabolism | Neurons - ultrastructure | Amyloid beta-Protein Precursor - metabolism | Organ Culture Techniques | Animals, Newborn | Enzyme Inhibitors - pharmacology | Clathrin - genetics | Clathrin-Coated Vesicles - drug effects | Excitatory Amino Acid Antagonists - pharmacology | Hippocampus - cytology | Nerve Tissue Proteins - genetics | Clathrin - metabolism | Endocytosis - physiology | GABA Antagonists - pharmacology | Nerve Tissue Proteins - metabolism | Amyloid Precursor Protein Secretases - metabolism | Animals | Glycine - pharmacology | Aspartic Acid Endopeptidases - metabolism | Brain - pathology | Picrotoxin - pharmacology | Signal Transduction - physiology | Mice | Clathrin-Coated Vesicles - physiology | Hydrogen-Ion Concentration | Enzymes | Clathrin | Amyloidosis | Alzheimer's disease | Amyloid beta-protein | Proteins | Brain research | Sucrose | Neurons | Colleges & universities | Biosynthesis | Alzheimers disease | Convergence | Index Medicus | recycling endosomes | β-site APP cleaving enzyme (BACE-1) | amyloid precursor protein (APP) | neuronal activity | vesicle trafficking
Journal Article
Journal of Alzheimer's disease, ISSN 1387-2877, 2010, Volume 19, Issue 3, pp. 1007 - 1019
Accumulation of amyloid-beta (A beta) peptide and deposition of hyperphosphorylated tau protein are two major pathological hallmarks of Alzheimer's disease... 
GSK-3β | BACE-1 | Leptin | Tau | Organotypic slices | 27-hydroxycholesterol | Cholesterol | Hippocampus | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | hippocampus | organotypic slices | cholesterol | tau | leptin
Journal Article
Journal Article
Frontiers in physiology, ISSN 1664-042X, 2012, Volume 3, pp. 189 - 189
Lipid rafts are membrane domains, more ordered than the bulk membrane and enriched in cholesterol and sphingolipids. They represent a platform for... 
Ache | App | Bace-1 | Amyloid β peptide | Aicd | Neprilysin | Alzheimer's disease | Cholesterol | Life Sciences & Biomedicine | Physiology | Science & Technology | APP | Alzheimer’s disease | amyloid β peptide | AICD
Journal Article
Journal Article
European journal of medicinal chemistry, ISSN 0223-5234, 11/2018, Volume 159, pp. 104 - 125
Dysregulation of the Amyloid Precursor Protein (APP) processing leading to toxic species of amyloid β peptides (Aβ) is central to Alzheimer's disease (AD)... 
Chloroquine | BACE-1 | Lysosome | β-secretase | Alzheimer's disease | Autophagy | Indirect inhibitor | Amyloid precursor protein | Phenotypic | Index Medicus | Medicinal Chemistry | Life Sciences | Neurons and Cognition | Chemical Sciences | Neurobiology
Journal Article
Molecular neurodegeneration, ISSN 1750-1326, 09/2015, Volume 10, Issue 1, pp. 44 - 44
Background: Alzheimer's disease (AD) is the most common form of dementia, the number of affected individuals is rising, with significant impacts for healthcare... 
Neuroinflammation | Inhibitor | Amyloid-β | Alzheimer's disease | BACE-1 | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Aspartic Acid Endopeptidases - physiology | Neuroprotective Agents - therapeutic use | Thiazines - therapeutic use | Amyloid Precursor Protein Secretases - physiology | Cricetulus | Humans | Amyloid beta-Peptides - secretion | Astrocytes - pathology | Recombinant Fusion Proteins - metabolism | Brain - metabolism | Neuroprotective Agents - pharmacokinetics | Amyloid beta-Peptides - genetics | Amyloid beta-Peptides - metabolism | Microglia - pathology | Picolinic Acids - chemistry | Female | Drug Evaluation, Preclinical | CHO Cells | Thiazines - pharmacokinetics | Astrocytes - drug effects | Nerve Tissue Proteins - antagonists & inhibitors | Cricetinae | Nerve Tissue Proteins - physiology | Peptide Fragments - metabolism | Microglia - drug effects | Aspartic Acid Endopeptidases - antagonists & inhibitors | Peptide Fragments - secretion | Alzheimer Disease - drug therapy | Rats | Mice, Transgenic | Thiazines - chemistry | Brain - drug effects | Animals | Picolinic Acids - therapeutic use | Picolinic Acids - pharmacokinetics | Dogs | Brain - pathology | Hair Color - drug effects | Mice | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Mutation | Alzheimer Disease - genetics | Index Medicus
Journal Article