X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
bace-1 (176) 176
index medicus (171) 171
alzheimer's disease (170) 170
alzheimers-disease (138) 138
chemistry, medicinal (133) 133
amyloid precursor protein secretases - antagonists & inhibitors (109) 109
humans (108) 108
beta-secretase (88) 88
aspartic acid endopeptidases - antagonists & inhibitors (84) 84
amyloid precursor protein secretases - metabolism (80) 80
amyloid precursor protein (76) 76
bace-1 inhibitors (74) 74
alzheimer’s disease (71) 71
chemistry, organic (71) 71
structure-activity relationship (69) 69
biochemistry & molecular biology (64) 64
animals (61) 61
drug design (58) 58
models, molecular (56) 56
aspartic acid endopeptidases - metabolism (55) 55
design (52) 52
discovery (49) 49
alzheimer disease - drug therapy (48) 48
β-secretase (46) 46
crystallography, x-ray (45) 45
enzyme inhibitors - pharmacology (43) 43
pharmacology & pharmacy (42) 42
protease inhibitors - chemistry (40) 40
enzyme inhibitors - chemistry (36) 36
amyloid precursor protein secretases - chemistry (34) 34
molecular structure (34) 34
structure-based design (34) 34
inhibitors (33) 33
mice (33) 33
neurosciences (33) 33
binding sites (32) 32
drug discovery (31) 31
brain (30) 30
enzymes (30) 30
protease inhibitors - pharmacology (29) 29
protein binding (29) 29
alzheimer (28) 28
ligands (28) 28
docking (27) 27
identification (27) 27
progress (27) 27
amyloid beta-peptides - metabolism (26) 26
aspartic acid endopeptidases - chemistry (26) 26
protease inhibitors - chemical synthesis (26) 26
derivatives (25) 25
analysis (24) 24
potent (24) 24
amyloid beta-protein (23) 23
rats (21) 21
alzheimer disease - metabolism (20) 20
dose-response relationship, drug (20) 20
enzyme inhibitors - chemical synthesis (20) 20
site (20) 20
hydroxyethylamine (19) 19
molecular docking simulation (19) 19
protein (19) 19
secretase (19) 19
biophysics (18) 18
cell line (18) 18
in-vivo (18) 18
inhibitor (18) 18
oxidative stress (18) 18
precursor protein (18) 18
proteins (18) 18
alzheimer disease - enzymology (17) 17
alzheimers disease (17) 17
beta-secretase inhibitors (17) 17
chemistry (17) 17
generation (17) 17
medical and health sciences (17) 17
medicin och hälsovetenskap (17) 17
neurodegenerative diseases (17) 17
therapeutics (17) 17
acetylcholinesterase (16) 16
article (16) 16
binding (16) 16
catalytic domain (16) 16
cleavage (16) 16
computer science, interdisciplinary applications (16) 16
a-beta (15) 15
chemistry, multidisciplinary (15) 15
human brain (15) 15
potent inhibitors (15) 15
bace-1 inhibitor (14) 14
biochemical research methods (14) 14
cell biology (14) 14
computer simulation (14) 14
ethylamines - chemical synthesis (14) 14
ethylamines - chemistry (14) 14
natural sciences (14) 14
naturvetenskap (14) 14
peptidomimetic inhibitors (14) 14
permeability (14) 14
proteases (14) 14
virtual screening (14) 14
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Medicinal Research Reviews, ISSN 0198-6325, 01/2013, Volume 33, Issue 1, pp. 139 - 189
With 27 million cases worldwide documented in 2006, Alzheimer's disease (AD) constitutes an overwhelming health, social, economic, and political problem to... 
antioxidant drugs | CDK5 inhibitors | anti‐inflammatory drugs | AChE peripheral anionic site | CK‐1 inhibitors | ERK2‐inhibitors | Ca2+ dyshomeostasis | BACE‐1 inhibitors | amyloid–β antiaggregating agents | NSAIDs | neuroprotection | multitarget drugs | GSK‐3β inhibitors | dual AChE inhibitors | metal chelators | Alzheimer's disease | Ca2+ overload | oxidative stress | multiactive compounds | 1,4‐dihydropyridines | voltage‐dependent calcium channels | Neuroprotection | Oxidative stress | Dual AChE inhibitors | Anti-inflammatory drugs | GSK-3β inhibitors | Antioxidant drugs | overload | Metal chelators | Multitarget drugs | Voltage-dependent calcium channels | CK-1 inhibitors | BACE-1 inhibitors | dyshomeostasis | 1,4-dihydropyridines | ERK2-inhibitors | Multiactive compounds | Amyloid-β antiaggregating agents | GSK-3 ss inhibitors | anti-inflammatory drugs | voltage-dependent calcium channels | TYROSINE KINASE INHIBITOR | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | POTENT ACETYLCHOLINESTERASE INHIBITORS | amyloid-ss antiaggregating agents | M1 MUSCARINIC AGONISTS | CHEMISTRY, MEDICINAL | AMYLOID PRECURSOR PROTEIN | MOLECULAR MODELING INVESTIGATIONS | HERPES-SIMPLEX-VIRUS | TACRINE-DIHYDROPYRIDINE HYBRIDS | PERIPHERAL ANIONIC SITE | NMDA RECEPTOR ANTAGONIST | Calcium Channels - metabolism | Humans | Enzyme Inhibitors - pharmacology | Alzheimer Disease - drug therapy | tau Proteins - metabolism | Receptors, N-Methyl-D-Aspartate | Alzheimer Disease - enzymology | Enzyme Inhibitors - therapeutic use | Disease Progression | Alzheimer Disease - pathology | Amyloid Precursor Protein Secretases - metabolism | Butyrylcholinesterase - metabolism | Amyloid beta-Peptides - metabolism | Ligands | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Binding Sites | Acetylcholinesterase - metabolism | Care and treatment | Calcium channels | Glycogen | Development and progression | Glutamate | Target marketing | Antioxidants | Methyl aspartate | Enzyme inhibitors | Synthesis | Surface active agents | Drug therapy | Cancer
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2018, Volume 61, Issue 8, pp. 3491 - 3502
BACE1 is responsible for the first step in APP proteolysis, leading to toxic Aβ production, and has been indicated to play a key role in the pathogenesis of... 
BETA-SECRETASE | APP GENE | CHEMISTRY, MEDICINAL | SECRETASE BACE-1 INHIBITORS | ALZHEIMERS-DISEASE | CRYSTAL-STRUCTURE | DRUG DISCOVERY | MUTATION | A-BETA | OPTIMIZATION | AMYLOID PRECURSOR PROTEIN | Index Medicus
Journal Article
JOURNAL OF NEUROCHEMISTRY, ISSN 0022-3042, 01/2012, Volume 120, pp. 71 - 83
beta-Secretase (memapsin 2; BACE-1) is the first protease in the processing of amyloid precursor protein leading to the production of amyloid-beta (A beta) in... 
memapsin 2 | MEMAPSIN-2 BETA-SECRETASE | BACE 1 | inhibitors | drugs | BIOCHEMISTRY & MOLECULAR BIOLOGY | X-RAY-STRUCTURE | AMYLOID PRECURSOR PROTEIN | POTENT INHIBITORS | NEUROSCIENCES | HYDROXY ETHYLAMINES HEAS | beta-secretase | MOUSE MODEL | A-BETA | PEPTIDOMIMETIC INHIBITORS | Alzheimer's disease | BACE-1 INHIBITORS | STRUCTURE-BASED DESIGN
Journal Article
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2009, Volume 17, Issue 4, pp. 1600 - 1613
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2007, Volume 50, Issue 18, pp. 4261 - 4264
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 07/2018, Volume 28, Issue 12, pp. 2195 - 2200
Journal Article
Journal Article
Journal of Chromatography A, ISSN 0021-9673, 03/2017, Volume 1487, pp. 235 - 241
In this work a novel capillary electrophoresis-mass spectrometry (CE-MS) based method was developed and validated for the assay of β-secretase (BACE1) activity... 
β-secretase | Kinetics | Inhibition | Alzheimer’s disease | Capillary electrophoresis | Mass spectrometry detection | Alzheimer's disease | CHEMISTRY, ANALYTICAL | BIOCHEMICAL RESEARCH METHODS | AMYLOID PRECURSOR PROTEIN | PEPTIDE | PROTEASES | IMMOBILIZED ENZYME REACTOR | beta-secretase | SUBSTRATE | CELL | BACE-1 INHIBITORS
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2009, Volume 19, Issue 22, pp. 6386 - 6391
Journal Article