X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (1142) 1142
Publication (213) 213
Patent (29) 29
Book Chapter (26) 26
Dissertation (7) 7
Book Review (6) 6
Conference Proceeding (5) 5
Newspaper Article (3) 3
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
apoptosis (859) 859
humans (696) 696
bak (601) 601
index medicus (520) 520
animals (410) 410
cell biology (358) 358
biochemistry & molecular biology (332) 332
bax (319) 319
mice (275) 275
mitochondria (274) 274
apoptosis - drug effects (256) 256
proteins (255) 255
oncology (242) 242
bcl-2 (237) 237
bcl-2 homologous antagonist-killer protein - metabolism (236) 236
proto-oncogene proteins c-bcl-2 - metabolism (212) 212
death (196) 196
cell-death (192) 192
cell line, tumor (191) 191
mitochondria - metabolism (186) 186
bak protein (175) 175
cancer (173) 173
female (158) 158
apoptosis - physiology (156) 156
activation (149) 149
bcl-2-associated x protein - metabolism (149) 149
expression (142) 142
cytochrome-c (138) 138
bcl-2 homologous antagonist-killer protein (136) 136
male (128) 128
bcl-2 homologous antagonist-killer protein - genetics (127) 127
cell death (127) 127
protein (124) 124
cytochrome-c release (122) 122
bcl-2-associated x protein (121) 121
in-vivo (112) 112
biological phenomena, cell phenomena, and immunity (111) 111
article (108) 108
membrane proteins - metabolism (108) 108
p53 (108) 108
bcl-2 homolog bak (106) 106
cytochrome c (106) 106
programmed cell-death (105) 105
proto-oncogene proteins c-bcl-2 - genetics (105) 105
signal transduction (102) 102
caspases - metabolism (98) 98
bcl-2 family (96) 96
mcl-1 (96) 96
proto-oncogene proteins - metabolism (95) 95
bax protein (92) 92
bcl-x (92) 92
apoptosis - genetics (91) 91
oligomerizes bak (91) 91
bcl-x protein (90) 90
caspase (88) 88
bcl-2 protein (87) 87
cell line (86) 86
gene expression (85) 85
research (84) 84
bh3-only proteins (81) 81
hela cells (77) 77
bcl-2-associated x protein - genetics (76) 76
family (75) 75
molecular sequence data (75) 75
cytochromes c - metabolism (74) 74
phosphorylation (74) 74
antineoplastic agents - pharmacology (73) 73
survival (73) 73
blotting, western (72) 72
amino acid sequence (69) 69
induced apoptosis (69) 69
multidisciplinary sciences (69) 69
middle aged (68) 68
membrane proteins - genetics (67) 67
mitochondria - drug effects (67) 67
immunohistochemistry (66) 66
protein binding (66) 66
apoptosis regulatory proteins - metabolism (64) 64
cells (64) 64
cells, cultured (64) 64
homolog bak (64) 64
tumor cells, cultured (63) 63
genetics & heredity (62) 62
inhibition (62) 62
chemotherapy (61) 61
mice, knockout (61) 61
research article (59) 59
tumor suppressor protein p53 - metabolism (59) 59
gene (58) 58
proto-oncogene proteins - genetics (58) 58
analysis (57) 57
flow cytometry (57) 57
myeloid cell leukemia sequence 1 protein (56) 56
transfection (56) 56
caspase-3 (55) 55
induction (55) 55
rats (55) 55
aged (54) 54
biochemistry (53) 53
tumors (53) 53
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (1157) 1157
Danish (28) 28
Japanese (7) 7
Chinese (4) 4
Turkish (3) 3
German (2) 2
French (1) 1
Korean (1) 1
Polish (1) 1
Portuguese (1) 1
Russian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Molecular Cell, ISSN 1097-2765, 11/2009, Volume 36, Issue 3, pp. 487 - 499
While activation of BAX/BAK by BH3-only molecules (BH3s) is essential for mitochondrial apoptosis, the underlying mechanisms remain unsettled. Here we... 
CELLCYCLE | CYTOCHROME-C | PROAPOPTOTIC BAX | OLIGOMERIZES BAK | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOPLASMIC-RETICULUM | SUBCELLULAR LOCATION | PROTEINS | BCL-2 FAMILY-MEMBERS | BH3 DOMAIN | CELL-DEATH | MEMBRANE PERMEABILIZATION | CELL BIOLOGY | bcl-2-Associated X Protein - chemistry | Immunoprecipitation | Apoptosis - drug effects | Protein Multimerization | bcl-2 Homologous Antagonist-Killer Protein - genetics | Immunoblotting | BH3 Interacting Domain Death Agonist Protein - genetics | Green Fluorescent Proteins - genetics | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Bcl-2-Like Protein 11 | Protein Binding - drug effects | Tumor Suppressor Proteins - genetics | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | BH3 Interacting Domain Death Agonist Protein - metabolism | bcl-2-Associated X Protein - genetics | Fibroblasts - metabolism | Proto-Oncogene Proteins - metabolism | Green Fluorescent Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Membrane Proteins - genetics | Cells, Cultured | bcl-2-Associated X Protein - metabolism | Etoposide - pharmacology | Proto-Oncogene Proteins - genetics | Mitochondria - metabolism | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Animals | Models, Biological | Tunicamycin - pharmacology | Fibroblasts - drug effects | Thapsigargin - pharmacology | Fibroblasts - cytology | Mice | Mutation | Microscopy, Fluorescence | Staurosporine - pharmacology | bcl-2 Homologous Antagonist-Killer Protein - chemistry | Monomers | Apoptosis | Oligomers
Journal Article
The FEBS Journal, ISSN 1742-464X, 02/2018, Volume 285, Issue 3, pp. 416 - 431
Bax and Bak are members of the Bcl‐2 family and core regulators of the intrinsic pathway of apoptosis. Upon apoptotic stimuli, they are activated and... 
BCL‐2 family | mitochondria | apoptosis | BAX | mitochondrial outer membrane permeabilization | BAK | DRP1 | BCL-2 family | OUTER-MEMBRANE | PROAPOPTOTIC BAX | BIOCHEMISTRY & MOLECULAR BIOLOGY | PORE FORMATION | BH3 DOMAINS | CELL-DEATH | PROSURVIVAL BCL-2 PROTEINS | CYTOCHROME-C | CONFORMATIONAL-CHANGES | BH3-ONLY PROTEINS | MEMBRANE PERMEABILIZATION | Mitochondrial Dynamics | Mitochondria - enzymology | bcl-2-Associated X Protein - chemistry | Proto-Oncogene Proteins c-bcl-2 - agonists | Humans | Protein Multimerization | bcl-2-Associated X Protein - agonists | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Mitochondrial Membranes - chemistry | Proto-Oncogene Proteins c-bcl-2 - chemistry | Mitochondrial Membranes - enzymology | Protein Interaction Domains and Motifs | Mitochondria - chemistry | Dimerization | Apoptosis Regulatory Proteins - chemistry | bcl-2-Associated X Protein - metabolism | Mitochondria - metabolism | Lipid Mobilization | Apoptosis Regulatory Proteins - metabolism | Mitochondrial Membranes - metabolism | Animals | Models, Biological | Apoptosis Regulatory Proteins - agonists | Protein Conformation | Lipid Bilayers - chemistry | Lipid Bilayers - metabolism | Porosity | bcl-2 Homologous Antagonist-Killer Protein - chemistry | Apoptosis | bcl-2 Homologous Antagonist-Killer Protein - agonists | Mitochondria | Regulators | Oligomerization | Bax protein | Bcl-2 protein | Spatial discrimination | Organelles
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2011, Volume 286, Issue 1, pp. 491 - 501
Bcl-2 family proteins regulate a critical step in apoptosis referred to as mitochondrial outer membrane permeabilization (MOMP). Members of a subgroup of the... 
MITOCHONDRIAL-MEMBRANE PERMEABILIZATION | ANTAGONIST ABT-737 | MCL-1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | MIMETIC ABT-737 | APOPTOTIC PROTEIN BAK | SENSITIVITY | OLIGOMERIZATION | BCL-2 FAMILY-MEMBERS | BH3-ONLY PROTEINS | CELL-DEATH | bcl-2-Associated X Protein - chemistry | Humans | Protein Multimerization | Cell Membrane Permeability | Molecular Sequence Data | Proto-Oncogene Proteins - chemistry | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Bcl-2-Like Protein 11 | BH3 Interacting Domain Death Agonist Protein - chemistry | HEK293 Cells | Protein Structure, Quaternary | Cell Membrane - metabolism | Membrane Proteins - metabolism | BH3 Interacting Domain Death Agonist Protein - metabolism | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | Peptide Fragments - metabolism | Cytochromes c - secretion | Apoptosis Regulatory Proteins - chemistry | bcl-2-Associated X Protein - metabolism | Apoptosis Regulatory Proteins - metabolism | Animals | Membrane Proteins - chemistry | Liposomes - metabolism | Mice | Adaptor Proteins, Signal Transducing - metabolism | bcl-X Protein - metabolism | bcl-2 Homologous Antagonist-Killer Protein - chemistry | Apoptosis | Cytochrome c | BH3 Peptides | Mitochondria | Cell Death | Liposomes | Cell Biology | Bcl-2 Family Proteins
Journal Article
Nature Communications, ISSN 2041-1723, 07/2017, Volume 8, Issue 1, p. 16078
BCL-2 family proteins are central regulators of mitochondrial apoptosis and validated anticancer targets. Using small cell lung cancer (SCLC) as a model, we... 
CELL LUNG-CANCER | SELECTIVE-INHIBITION | BAK ACTIVATION | POTENT | MULTIDISCIPLINARY SCIENCES | BIM | TRANSCRIPTION | DEATH | CDK INHIBITOR | ABT-263 | BH3 DOMAIN | Lung Neoplasms - drug therapy | Apoptosis - drug effects | Humans | Lung Neoplasms - metabolism | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | Drug Resistance, Neoplasm | Molecular Targeted Therapy | Apoptosis Regulatory Proteins - drug effects | Myeloid Cell Leukemia Sequence 1 Protein - drug effects | Small Cell Lung Carcinoma - drug therapy | Small Cell Lung Carcinoma - metabolism | bcl-X Protein - drug effects | Proto-Oncogene Proteins c-bcl-2 - metabolism | bcl-X Protein - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Myeloid Cell Leukemia Sequence 1 Protein - antagonists & inhibitors | Aniline Compounds - pharmacology | Cyclin-Dependent Kinase 9 - antagonists & inhibitors | Sulfonamides - pharmacology | Apoptosis Regulatory Proteins - metabolism | Drug Synergism | Pyridinium Compounds - pharmacology | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | High-Throughput Screening Assays | Apoptosis Regulatory Proteins - antagonists & inhibitors | Proto-Oncogene Proteins c-bcl-2 - drug effects | Cell Line, Tumor | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | bcl-X Protein - metabolism | Doxorubicin - pharmacology | Regulators | Bax protein | Bcl-2 protein | Small cell lung carcinoma | Lung cancer | High-throughput screening | Doxorubicin | BAK protein | Mcl-1 protein | Proteins | Mitochondria | Inhibitors | Bcl-x protein | Anthracycline | Addiction | Cell death | Sequestering | Cancer | Apoptosis
Journal Article
Oncogene, ISSN 0950-9232, 06/2012, Volume 31, Issue 26, pp. 3177 - 3189
The intrinsic mitochondrial apoptotic pathway acts through two core pro-apoptotic proteins Bax (Bcl2-associated X protein) and Bak (Bcl2-antagonist/killer 1).... 
Bax | apoptosis | DKO | HCT116 | Bak | BH3-only | TRAIL | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEATH | MEDIATED APOPTOSIS | BH3 MIMETIC ABT-737 | CELL BIOLOGY | NBK/BIK | GENE | ONCOLOGY | MITOCHONDRIAL PATHWAY | BCL-2 HOMOLOG BAX | GENETICS & HEREDITY | RESISTANCE | BH3-ONLY PROTEINS | Proto-Oncogene Proteins - metabolism | Apoptosis - drug effects | HCT116 Cells | Humans | bcl-2 Homologous Antagonist-Killer Protein - antagonists & inhibitors | bcl-2 Homologous Antagonist-Killer Protein - deficiency | bcl-2 Homologous Antagonist-Killer Protein - genetics | bcl-2-Associated X Protein - metabolism | Gene Knockout Techniques | Sulfonamides - pharmacology | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Piperazines - pharmacology | Apoptosis Regulatory Proteins - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Phenotype | Animals | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | Myeloid Cell Leukemia Sequence 1 Protein | Fluorouracil - pharmacology | Mice | Gene Expression Regulation, Neoplastic - drug effects | bcl-2-Associated X Protein - deficiency | bcl-2-Associated X Protein - genetics | Cellular proteins | Colon cancer | Cancer cells | Development and progression | Research | Properties | Health aspects | Apoptosis | Proteins | Oncology | Cellular biology | Gene expression | Colorectal cancer | Drugs | Camptothecin | Mitochondria | Bax protein | Bcl-2 protein | Data processing | Colon | X protein | BAK protein | Mcl-1 protein
Journal Article
FEBS Letters, ISSN 0014-5793, 2010, Volume 584, Issue 14, pp. 2981 - 2989
Apoptosis, an essential and basic biological phenomenon, is regulated in a complex manner by a multitude of factors. Myeloid cell leukemia 1 (Mcl-1), an... 
Post-translational modification | Phosphorylation | Myeloid cell leukemia 1 | Apoptosis | granzyme B | Bcl-2 homologous antagonist killer | MULE | JNK | HIF-1α | BFL-1/A1 | NF-κB | p53 upregulated modulator of apoptosis | CHX | GM-CSF | GrB | checkpoint 1 protein | cAMP response element binding protein | cyclin dependent kinase 1 | BCL-XL | Mir-29b | β-TrCP | Bcl-2 homology | proliferating cell nuclear antigen | extracellular regulated protein kinase | PEST | STAT response element | Bcl-2-associated protein X | CRE | micro inhibiting RNA 29b | BH3 interacting domain death agonist | proline/glutamic acid/serine/threonine | ERK | beta transducin-containing protein | Pin-1 | PCNA | MCL-1 | SRE | nuclear factor kappa B | C-Jun N-terminal kinase | peptidyl-prolyl cis-trans isomerase NIMA interacting protein 1 | BCL-2 | signal transducers and activators of transcription | CREB | BID | interleukin | B-cell lymphoma 2 | MCL-1 ubiquitin ligase | cAMP response element | hypoxia-inducible factor 1α | Bcl-2 like protein X | VEGF | BAK | Bcl-2 related protein A1 | cycloheximide | STAT | vascular endothelial growth factor | CHK-1 | granulocyte–macrophage colony-stimulating factor | BAX | PUMA | CDK-1 | MULTIPLE-MYELOMA | ANTIAPOPTOTIC MCL-1 | KINASE PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | BH3-ONLY LIGANDS | CELL-SURVIVAL | NEUTROPHIL APOPTOSIS | CELL BIOLOGY | BIOPHYSICS | SIGNALING PATHWAY | BCL-2 PROTEINS | ANTISENSE OLIGONUCLEOTIDES | TRANSCRIPTION FACTOR | Myeloid Progenitor Cells - metabolism | Humans | Leukemia, Myeloid - genetics | Apoptosis - genetics | Leukemia - metabolism | Protein Structure, Tertiary - genetics | Lymphoma, B-Cell - genetics | Proteins - genetics | Proteins - metabolism | Myeloid Cells - metabolism | Protein Processing, Post-Translational | Dimerization | B-Lymphocytes - metabolism | Leukemia - genetics | Ubiquitin | Ligases | Cyclohexane | Proline | Lymphomas | Macrophage colony stimulating factor | Tumor proteins | Glutamate | Vascular endothelial growth factor | Protein binding
Journal Article
The EMBO Journal, ISSN 0261-4189, 01/1998, Volume 17, Issue 2, pp. 384 - 395
Journal Article
Molecular Cell, ISSN 1097-2765, 09/2013, Volume 51, Issue 6, pp. 751 - 765
Journal Article