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Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 1/2018, Volume 81, Issue 1, pp. 195 - 206
To evaluate the mass balance, metabolic disposition, and pharmacokinetics of a single dose of regorafenib in healthy volunteers. In addition, in vitro... 
Human | Regorafenib | Phase I | Medicine & Public Health | Biotransformation | Oncology | Cancer Research | Pharmacology/Toxicology | Metabolism | MULTICENTER | EFFICACY | SAFETY | BAY 73-4506 | HEPATOCELLULAR-CARCINOMA | ONCOLOGY | COLORECTAL-CANCER | IMATINIB | PHASE-3 TRIAL | DOUBLE-BLIND | SUNITINIB | PHARMACOLOGY & PHARMACY | Chromatography, High Pressure Liquid - methods | Humans | Middle Aged | Pyridines - pharmacokinetics | Male | Antineoplastic Agents - administration & dosage | Hepatocytes - metabolism | Healthy Volunteers | Pyridines - adverse effects | Antineoplastic Agents - adverse effects | Phenylurea Compounds - adverse effects | Adult | Antineoplastic Agents - pharmacokinetics | Phenylurea Compounds - pharmacokinetics | Scintillation Counting | Tandem Mass Spectrometry - methods | Pyridines - administration & dosage | Administration, Oral | Liver - metabolism | Phenylurea Compounds - blood | Urinalysis - methods | Pyridines - blood | Feces - chemistry | Phenylurea Compounds - administration & dosage | Antineoplastic Agents - blood | Metabolites | Analysis | Pyridine | Urine | Plasma | Pyridines | Excretion | Oxidative metabolism | Liver | Risk reduction | Pharmacology | Liquid chromatography | High-performance liquid chromatography | Hepatocytes | Scintillation counters | Collection | Feces | Pharmacokinetics | Drug dosages | Radioactivity | Original
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2015, Volume 10, Issue 12, p. e0145004
Journal Article
European Journal of Nuclear Medicine and Molecular Imaging, ISSN 1619-7070, 9/2016, Volume 43, Issue 10, pp. 1792 - 1801
The introduction of targeted drugs has had a significant impact on the approach to assessing tumour response. These drugs often induce a rapid cytostatic... 
Tumoral heterogeneity | Early metabolic response assessment | FDG PET-CT | Medicine & Public Health | Targeted therapy | Orthopedics | Oncology | Nuclear Medicine | Imaging / Radiology | Cardiology | Metastatic colorectal cancer | CRITERIA | 1ST-LINE CHEMOTHERAPY | GUIDELINES | TUMOR RESPONSE | REGORAFENIB BAY 73-4506 | LIVER METASTASES | POSITRON-EMISSION-TOMOGRAPHY | FLARE | LYMPHOMA | EARLY PREDICTION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Capecitabine - administration & dosage | Niacinamide - analogs & derivatives | Fluorodeoxyglucose F18 - pharmacokinetics | Reproducibility of Results | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Radiopharmaceuticals - pharmacokinetics | Humans | Middle Aged | Male | Treatment Outcome | Colorectal Neoplasms - diagnostic imaging | Drug Monitoring - methods | Niacinamide - administration & dosage | Phenylurea Compounds - administration & dosage | Colorectal Neoplasms - drug therapy | Sensitivity and Specificity | Adult | Colorectal Neoplasms - secondary | Female | Aged | Molecular Targeted Therapy - methods | Positron Emission Tomography Computed Tomography - methods | Pets | CT imaging | Care and treatment | PET imaging | Analysis | Colorectal cancer | Metastasis | Health aspects | Cancer | Medical imaging | Drug therapy | Metabolic disorders | Original
Journal Article
Cancer Science, ISSN 1347-9032, 05/2016, Volume 107, Issue 5, pp. 601 - 608
Interaction between tumor cells and stromal cells plays an important role in the growth and metastasis of colon cancer. We previously found that... 
molecular target therapy | Colon cancer | regorafenib | mesenchymal stem cells | stroma | Stroma | Regorafenib | Molecular target therapy | Mesenchymal stem cells | ANGIOGENESIS | TUMOR-CELLS | FACTOR RECEPTOR | MESENCHYMAL STEM-CELLS | BAY 73-4506 | POSITRON-EMISSION-TOMOGRAPHY | ONCOLOGY | PATHWAY | COLORECTAL-CANCER | BONE | EXPRESSION | Colonic Neoplasms - drug therapy | Antineoplastic Agents - therapeutic use | Stromal Cells - enzymology | Stromal Cells - drug effects | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Female | Antineoplastic Agents - pharmacology | Fibroblasts - metabolism | Pyridines - therapeutic use | Tumor Microenvironment - drug effects | Mesenchymal Stromal Cells - drug effects | Stromal Cells - metabolism | Mesenchymal Stromal Cells - metabolism | Phenylurea Compounds - therapeutic use | Receptor Protein-Tyrosine Kinases - metabolism | Xenograft Model Antitumor Assays | Animals | Lymphatic Metastasis - prevention & control | Mice, Nude | Protein Kinase Inhibitors - therapeutic use | Colonic Neoplasms - pathology | Fibroblasts - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Phenylurea Compounds - pharmacology | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Tyrosine | Growth | Stem cells | Transplantation | Metastasis | Growth factors | Mesenchyme | Colorectal cancer | Stem cell transplantation | Smooth muscle | Kinases | Cancer therapies | Lymph nodes | Metastases | Cell adhesion & migration | Angiogenesis | Cell growth | Fibroblasts | Bone marrow | Vascular endothelial growth factor | Imatinib | Tumor cells | Cecum | Studies | Chemotherapy | Stromal cells | Medical prognosis | Mutation | Laboratory animals | Cell migration | Tumors | Apoptosis | Index Medicus | Original
Journal Article
Cancer Medicine, ISSN 2045-7634, 11/2016, Volume 5, Issue 11, pp. 3176 - 3185
Journal Article
Future Oncology, ISSN 1479-6694, 09/2018, Volume 14, Issue 22, pp. 2239 - 2246
Regorafenib is an orally available multikinase inhibitor, currently approved in metastatic chemorefractory colorectal cancer patients. The results of two large... 
regorafenib adverse events | anti-angiogenic treatment | adherence to oral treatment | late lines of treatment | metastatic colorectal cancer | regorafenib | tyrosine-kinase inhibitor | targeted treatment | MULTICENTER | METABOLITES | MANAGEMENT | KINASE INHIBITORS | SORAFENIB | INDUCED HYPOTHYROIDISM | BAY 73-4506 | STRATEGIES | START LOW | ONCOLOGY | PLUS
Journal Article
IEEE/ACM Transactions on Computational Biology and Bioinformatics, ISSN 1545-5963, 07/2017, Volume 14, Issue 4, pp. 966 - 977
Computational approaches for predicting drug-disease associations by integrating gene expression and biological network provide great insights to the complex... 
Drugs | Proteins | multi-source random walk | Databases | Drug repositioning | hepatocellular carcinoma (HCC) | Electronic mail | Gene expression | Chemicals | Diseases | gene expression | BIOCHEMICAL RESEARCH METHODS | STATISTICS & PROBABILITY | VALPROIC ACID | KINASE INHIBITOR | CANCER | REGORAFENIB BAY 73-4506 | DISCOVERY | COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS | MATHEMATICS, INTERDISCIPLINARY APPLICATIONS | GAMMA-AMINOBUTYRIC-ACID | METHIONINE METABOLISM | HISTONE DEACETYLASE INHIBITORS | PHASE-I | DISEASE RELATIONSHIPS | Computational Biology - methods | Gene Regulatory Networks - genetics | Liver Neoplasms - genetics | Protein Interaction Maps - drug effects | Humans | Liver Neoplasms - drug therapy | Antineoplastic Agents - therapeutic use | Gene Expression Profiling | Transcriptome - drug effects | Transcriptome - genetics | Gene Regulatory Networks - drug effects | Carcinoma, Hepatocellular - drug therapy | Protein Interaction Maps - genetics | Carcinoma, Hepatocellular - genetics | Drug Repositioning - methods | Liver Neoplasms - metabolism | Antineoplastic Agents - pharmacology | Carcinoma, Hepatocellular - metabolism | Medical research | Similarity | Disease | Random walk | Clinical trials | Hepatocellular carcinoma | Carpets | Morbidity | Liver cancer | Computer applications | Predictions | Tumors
Journal Article
TARGETED ONCOLOGY, ISSN 1776-2596, 02/2016, Volume 11, Issue 1, pp. 123 - 125
To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s11523-015-0407-4 
ONCOLOGY | INHIBITOR | COLORECTAL-CANCER | BAY 73-4506 | Pyridines - adverse effects | Pyridines - administration & dosage | Drug Administration Schedule | Phenylurea Compounds - administration & dosage | Phenylurea Compounds - adverse effects | Colorectal Neoplasms - drug therapy | Humans
Journal Article
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