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Biomaterials, ISSN 0142-9612, 06/2015, Volume 53, pp. 437 - 452
Carbon nanotubes (CNTs) are a novel nanocarriers with interesting physical and chemical properties. Here we investigate the ability of amino-functionalized... 
Transcytosis | PBEC | TEM | Transwells | BBB model | STEM
Journal Article
by Booth, R and Kim, H
Annals of Biomedical Engineering, ISSN 0090-6964, 12/2014, Volume 42, Issue 12, pp. 2379 - 2391
Journal Article
Journal of Drug Targeting, ISSN 1061-186X, 07/2019, Volume 27, Issue 5-6, pp. 542 - 554
One of the major challenges in drug development is the delivery of therapeutics to the central nervous system (CNS). The blood-brain barrier (BBB), which... 
CNS; BBB; NPs; RVG; CTX
Journal Article
IEEE Transactions on Biomedical Engineering, ISSN 0018-9294, 02/2018, Volume 65, Issue 2, pp. 431 - 439
Objective: The blood-brain barrier (BBB) poses a unique challenge to the development of therapeutics against neurological disorders due to its impermeabi-lity... 
Impedance measurement | microphysiological systems | Tissue engineering | electrical impedance sensor array | Brain modeling | microfluidic blood–brain barrier (BBB) on a chip | Biosensors | Organ–on–a-chip | co-culture tissue chip | Blood | Microfluidics | Sensor arrays | Organ-on-a-chip | microfluidic blood-brain barrier (BBB) on a chip | CELL-CELL JUNCTIONS | BBB | VIVO | ENGINEERING, BIOMEDICAL | DRUG DISCOVERY | TOXICITY | ASTROCYTES | LINES | ON-A-CHIP | microfluidic bloodbrain barrier (BBB) on a chip | IN-VITRO MODEL | SHEAR-STRESS | Astrocytes - cytology | Coculture Techniques - instrumentation | Brain - cytology | Blood-Brain Barrier - cytology | Microfluidic Analytical Techniques - instrumentation | Lab-On-A-Chip Devices | Coculture Techniques - methods | Equipment Design | Animals | Endothelial Cells - cytology | Models, Biological | Blood-Brain Barrier - physiology | Mice | Mice, Inbred BALB C | Cell culture | Animal models | Toxicity | Membrane permeability | Shear stresses | Drug development | Mimicry | Microchannels | Blood-brain barrier | Biocompatibility | Polycarbonate | Culture | Astrocytes | Permeability | Chemical compounds | Endothelial cells | Neurological diseases | Dextran | Organic chemistry | Histamine | Shear stress | In vivo methods and tests | Electrical junctions | Three dimensional models | Index Medicus
Journal Article
European Journal of Pharmaceutical Sciences, ISSN 0928-0987, 01/2017, Volume 96, pp. 129 - 140
Glioma is the most frequent primary tumor, and the treatment efficiency is unsatisfactory for the obstacle of the blood brain barrier (BBB), the multidrug... 
Transferrin | Tetrandrine | MDR | BBB | Vincristine | Index Medicus
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 05/2012, Volume 159, Issue 3, pp. 429 - 434
The successful treatment of central nervous system (CNS) disorders is hampered by inefficient drug delivery across the blood–brain barrier (BBB). Transferrin... 
Micelle | Blood–brain barrier (BBB) | Transferrin | Glioma | Polyphosphoester | Blood-brain barrier (BBB) | VITRO | DRUG-DELIVERY | RATS | POLYMERIC MICELLES | CHEMISTRY, MULTIDISCIPLINARY | NANOPARTICLES | TRANSPORT | PHARMACOKINETICS | BARRIER BBB | PHARMACOLOGY & PHARMACY | Hemolysis - drug effects | Drug Carriers - toxicity | Paclitaxel - pharmacokinetics | Brain Neoplasms - metabolism | Drug Carriers - chemistry | Glioma - metabolism | Tissue Distribution | Antineoplastic Agents, Phytogenic - administration & dosage | Micelles | Chemical Phenomena | Drug Compounding | Antineoplastic Agents, Phytogenic - therapeutic use | Paclitaxel - administration & dosage | Antineoplastic Agents, Phytogenic - pharmacokinetics | Rats | Drug Carriers - chemical synthesis | Brain Neoplasms - drug therapy | Paclitaxel - therapeutic use | Rats, Sprague-Dawley | Mice, Inbred ICR | Blood-Brain Barrier - metabolism | Erythrocytes - drug effects | Polyesters - chemistry | Animals | Mice, Nude | Survival Analysis | Transferrin - chemistry | Cell Line, Tumor | Mice | Mice, Inbred BALB C | Glioma - drug therapy | Drugs | Antimitotic agents | Drug delivery systems | Antineoplastic agents | Gliomas | Vehicles | Index Medicus | Hemolysis | Brain | Hybrids | Blood-brain barrier | Brain tumors | Central nervous system | Paclitaxel | Drug delivery | Controlled release
Journal Article
Stem cells (Dayton, Ohio), ISSN 1066-5099, 5/2017, Volume 35, Issue 5, pp. 1246 - 1258
Stroke is a life threatening disease with limited therapeutic options. Cell therapy has emerged as an experimental stroke treatment. Blood-brain barrier (BBB)... 
MCAO | repair | BBB | rats | hBMEPC
Journal Article
Pharmaceutical Research, ISSN 0724-8741, 10/2013, Volume 30, Issue 10, pp. 2512 - 2522
To investigate the effects of the particle size and surface coating on the cellular uptake of the polymeric nanoparticles for drug delivery across the... 
Biochemistry, general | Biomedical Engineering | biodegradable polymers: blood–brain barrier (BBB) | pharmaceutical nanotechnology | Biomedicine | Pharmacy | Medical Law | chemotherapeutic engineering | Pharmacology/Toxicology | gastrointestinal barrier (GI barrier) | biodegradable polymers: blood-brain barrier (BBB) | CELLS | PERMEABILITY SCREEN | CONTROLLED-RELEASE | POLYSTYRENE MICROSPHERES | CHEMISTRY, MULTIDISCIPLINARY | PACLITAXEL | SOLID LIPID NANOPARTICLES | IN-VITRO | PHARMACOLOGY & PHARMACY | MDR-MDCK | PLGA NANOPARTICLES | BRAIN | Nanoparticles - chemistry | Humans | Vitamin E - analogs & derivatives | Male | Polyethylene Glycols - chemistry | Chromatography, High Pressure Liquid | Drug Carriers - chemistry | Polystyrenes - chemistry | Tissue Distribution | Surface Properties | Madin Darby Canine Kidney Cells | Vitamin E - chemistry | Caco-2 Cells | Fluorescent Dyes - chemistry | Vitamin E - pharmacokinetics | Administration, Oral | Polyethylene Glycols - pharmacokinetics | Rats | Rats, Sprague-Dawley | Gastrointestinal Tract - metabolism | Blood-Brain Barrier - metabolism | Endocytosis - physiology | Particle Size | Animals | Dogs | Drug Carriers - pharmacokinetics | Polystyrenes - pharmacokinetics | Drug Delivery Systems - methods | Drugs | Drug delivery systems | Vehicles | Biodegradable materials | Chemotherapy | Blood-brain barrier | Nanotechnology | Index Medicus
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 08/2019, Volume 377, pp. 114601 - 114601
High concentration of zinc has been reported to act as a critical mediator of neuronal death in the ischemic brain. Our previous studies showed that labile... 
Mitochondria | Reactive Oxygen Species (ROS) | Ischemia/reperfusion | Zinc | Blood–Brain Barrier (BBB) | Fission | BRAIN-INJURY | BARRIER | ASTROCYTES | PHARMACOLOGY & PHARMACY | TOXICOLOGY | DYSFUNCTION | CONTRIBUTES | Blood Brain Barrier (BBB) | ZN2
Journal Article
Progress in Neurobiology, ISSN 0301-0082, 09/2016, Volume 144, pp. 173 - 187
Astrocytes are a major constituent of the central nervous system. These glia play a major role in regulating blood-brain barrier function, the formation and... 
Proteoglycan | Astrogliosis | Heterogeneity | BBB | Disease | Astrocytes | Therapeutics | SCI | Transplantation | Glial scar | GFAP
Journal Article
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 11/2016, Volume 241, pp. 200 - 219
Carbon nanotubes (CNTs) have long been regarded as promising carriers in biomedicine. Due to their high surface area and unique needle-like structure, CNTs are... 
Carbon nanotubes (CNTs) | Cell toxicity | Biocompatibility | Brain delivery | Functionalisation | Blood-brain barrier (BBB)
Journal Article