X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (65184) 65184
Book Chapter (287) 287
Conference Proceeding (284) 284
Dissertation (205) 205
Magazine Article (157) 157
Publication (58) 58
Government Document (41) 41
Newspaper Article (8) 8
Web Resource (8) 8
Book / eBook (6) 6
Book Review (2) 2
Journal / eJournal (1) 1
Paper (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
apoptosis (38173) 38173
humans (34540) 34540
bcl-2 (24799) 24799
animals (22475) 22475
proto-oncogene proteins c-bcl-2 - metabolism (17751) 17751
apoptosis - drug effects (15372) 15372
oncology (12749) 12749
male (12295) 12295
female (11782) 11782
mice (11476) 11476
expression (11464) 11464
biochemistry & molecular biology (9843) 9843
cell biology (9479) 9479
proto-oncogene proteins c-bcl-2 - genetics (9163) 9163
proteins (8725) 8725
cancer (8588) 8588
cell line, tumor (8347) 8347
bax (7748) 7748
bcl-2 protein (7621) 7621
activation (7172) 7172
death (7049) 7049
rats (7026) 7026
apoptosis - physiology (6114) 6114
mitochondria (5963) 5963
immunohistochemistry (5716) 5716
middle aged (5694) 5694
p53 (5421) 5421
gene expression (5285) 5285
bcl-2-associated x protein - metabolism (5136) 5136
adult (5038) 5038
signal transduction (5015) 5015
bcl-2-associated x protein (4668) 4668
oxidative stress (4523) 4523
cell-death (4469) 4469
aged (4444) 4444
protein (4437) 4437
caspases - metabolism (4423) 4423
flow cytometry (4359) 4359
caspase-3 (4308) 4308
inhibition (4291) 4291
phosphorylation (4199) 4199
cell death (4177) 4177
antineoplastic agents - pharmacology (4101) 4101
pharmacology & pharmacy (4094) 4094
cells, cultured (4092) 4092
survival (4054) 4054
tumor cells, cultured (4024) 4024
bax protein (4014) 4014
mitochondria - metabolism (3931) 3931
proto-oncogene proteins c-bcl-2 - biosynthesis (3906) 3906
blotting, western (3797) 3797
apoptosis - genetics (3794) 3794
cell survival - drug effects (3768) 3768
proto-oncogene proteins c-bcl-2 (3735) 3735
caspase (3678) 3678
cell line (3638) 3638
research (3596) 3596
cells (3589) 3589
proto-oncogene proteins - metabolism (3579) 3579
bcl-x protein (3557) 3557
cell cycle (3501) 3501
caspase 3 - metabolism (3488) 3488
analysis (3430) 3430
medicine, research & experimental (3420) 3420
cell proliferation - drug effects (3368) 3368
proliferation (3365) 3365
cell proliferation (3357) 3357
bcl-2 family (3247) 3247
neurosciences (3244) 3244
chemotherapy (3199) 3199
hematology (3146) 3146
tumor suppressor protein p53 - metabolism (3124) 3124
in-vitro (3107) 3107
cytochrome-c (3048) 3048
in-vivo (3017) 3017
gene (3014) 3014
prognosis (2942) 2942
immunology (2931) 2931
dose-response relationship, drug (2910) 2910
induction (2904) 2904
pathology (2898) 2898
transfection (2869) 2869
down-regulation (2859) 2859
proto-oncogene proteins - genetics (2857) 2857
cell survival (2818) 2818
growth (2794) 2794
kinases (2779) 2779
signal transduction - drug effects (2772) 2772
tumors (2760) 2760
programmed cell-death (2673) 2673
rats, sprague-dawley (2568) 2568
research article (2548) 2548
time factors (2513) 2513
health aspects (2471) 2471
proto-oncogene proteins c-bcl-2 - analysis (2447) 2447
up-regulation (2412) 2412
mitochondria - drug effects (2377) 2377
reactive oxygen species - metabolism (2341) 2341
induced apoptosis (2268) 2268
caspase 3 (2254) 2254
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (59511) 59511
Chinese (6873) 6873
Japanese (537) 537
French (196) 196
Russian (180) 180
Korean (164) 164
Portuguese (125) 125
Spanish (115) 115
German (106) 106
Polish (86) 86
Czech (25) 25
Turkish (25) 25
Italian (19) 19
Persian (15) 15
Dutch (9) 9
Croatian (8) 8
Hungarian (8) 8
Ukrainian (8) 8
Romanian (7) 7
Serbian (6) 6
Norwegian (4) 4
Slovak (4) 4
Swedish (4) 4
Bulgarian (2) 2
Arabic (1) 1
Bosnian (1) 1
Catalan (1) 1
Danish (1) 1
Finnish (1) 1
Indonesian (1) 1
Slovenian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Journal Article
Cancer cell, ISSN 1535-6108, 2006, Volume 10, Issue 5, pp. 375 - 388
BCL-2 proteins are critical for cell survival and are overexpressed in many tumors. ABT-737 is a small-molecule BH3 mimetic that exhibits single-agent activity... 
CELLCYCLE | PROGRAMMED CELL-DEATH | CANCER-CELLS | STEM-CELLS | PROAPOPTOTIC ACTIVITY | ONCOLOGY | X-L | ACUTE MYELOGENOUS LEUKEMIA | IN-VIVO | MITOCHONDRIAL-MEMBRANE | BCL-2 FAMILY-MEMBERS | BH3-ONLY PROTEINS | RNA, Small Interfering - genetics | bcl-2-Associated X Protein - chemistry | Humans | Leukemia, Myeloid, Acute - metabolism | Nitrophenols - metabolism | bcl-2 Homologous Antagonist-Killer Protein - genetics | Piperazines - metabolism | Neoplasm Proteins - metabolism | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Biphenyl Compounds - metabolism | Biphenyl Compounds - therapeutic use | Recombinant Fusion Proteins - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Nitrophenols - therapeutic use | Hematopoietic Stem Cells - physiology | Leukemia, Myeloid, Acute - drug therapy | Proto-Oncogene Proteins c-bcl-2 - chemistry | Dimerization | bcl-2-Associated X Protein - genetics | Protein Structure, Tertiary | Cell Line | bcl-2-Associated X Protein - metabolism | Piperazines - therapeutic use | Animals | Sulfonamides - therapeutic use | Myeloid Cell Leukemia Sequence 1 Protein | Sulfonamides - metabolism | Recombinant Fusion Proteins - genetics | Protein Conformation | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Mice | Apoptosis - physiology | Drug Resistance, Neoplasm - physiology | Proto-Oncogene Proteins c-bcl-2 - genetics | RNA, Small Interfering - metabolism | Proteins | Oncology, Experimental | Lung cancer | Bone marrow | Transplantation | Lymphomas | Research | Hematopoietic stem cells | Cancer | Apoptosis
Journal Article
The FEBS journal, ISSN 1742-4658, 2017, Volume 285, Issue 3, pp. 416 - 431
Bax and Bak are members of the Bcl‐2 family and core regulators of the intrinsic pathway of apoptosis. Upon apoptotic stimuli, they are activated and... 
BCL‐2 family | mitochondria | apoptosis | BAX | mitochondrial outer membrane permeabilization | BAK | DRP1 | BCL-2 family | OUTER-MEMBRANE | PROAPOPTOTIC BAX | BIOCHEMISTRY & MOLECULAR BIOLOGY | PORE FORMATION | BH3 DOMAINS | CELL-DEATH | PROSURVIVAL BCL-2 PROTEINS | CYTOCHROME-C | CONFORMATIONAL-CHANGES | BH3-ONLY PROTEINS | MEMBRANE PERMEABILIZATION | Mitochondrial Dynamics | Mitochondria - enzymology | bcl-2-Associated X Protein - chemistry | Proto-Oncogene Proteins c-bcl-2 - agonists | Humans | Protein Multimerization | bcl-2-Associated X Protein - agonists | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Mitochondrial Membranes - chemistry | Proto-Oncogene Proteins c-bcl-2 - chemistry | Mitochondrial Membranes - enzymology | Protein Interaction Domains and Motifs | Mitochondria - chemistry | Dimerization | Apoptosis Regulatory Proteins - chemistry | bcl-2-Associated X Protein - metabolism | Mitochondria - metabolism | Lipid Mobilization | Apoptosis Regulatory Proteins - metabolism | Mitochondrial Membranes - metabolism | Animals | Models, Biological | Apoptosis Regulatory Proteins - agonists | Protein Conformation | Lipid Bilayers - chemistry | Lipid Bilayers - metabolism | Porosity | bcl-2 Homologous Antagonist-Killer Protein - chemistry | Apoptosis | bcl-2 Homologous Antagonist-Killer Protein - agonists | Mitochondria | Regulators | Oligomerization | Bax protein | Bcl-2 protein | Organelles
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2007, Volume 104, Issue 49, pp. 19512 - 19517
Journal Article
FEBS letters, ISSN 0014-5793, 2010, Volume 584, Issue 14, pp. 2981 - 2989
Apoptosis, an essential and basic biological phenomenon, is regulated in a complex manner by a multitude of factors. Myeloid cell leukemia 1 (Mcl-1), an... 
Post-translational modification | Phosphorylation | Myeloid cell leukemia 1 | Apoptosis | granzyme B | Bcl-2 homologous antagonist killer | MULE | JNK | HIF-1α | BFL-1/A1 | NF-κB | p53 upregulated modulator of apoptosis | CHX | GM-CSF | GrB | checkpoint 1 protein | cAMP response element binding protein | cyclin dependent kinase 1 | BCL-XL | Mir-29b | β-TrCP | Bcl-2 homology | proliferating cell nuclear antigen | extracellular regulated protein kinase | PEST | STAT response element | Bcl-2-associated protein X | CRE | micro inhibiting RNA 29b | BH3 interacting domain death agonist | proline/glutamic acid/serine/threonine | ERK | beta transducin-containing protein | Pin-1 | PCNA | MCL-1 | SRE | nuclear factor kappa B | C-Jun N-terminal kinase | peptidyl-prolyl cis-trans isomerase NIMA interacting protein 1 | BCL-2 | signal transducers and activators of transcription | CREB | BID | interleukin | B-cell lymphoma 2 | MCL-1 ubiquitin ligase | cAMP response element | hypoxia-inducible factor 1α | Bcl-2 like protein X | VEGF | BAK | Bcl-2 related protein A1 | cycloheximide | STAT | vascular endothelial growth factor | CHK-1 | granulocyte–macrophage colony-stimulating factor | BAX | PUMA | CDK-1 | MULTIPLE-MYELOMA | ANTIAPOPTOTIC MCL-1 | KINASE PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | BH3-ONLY LIGANDS | CELL-SURVIVAL | NEUTROPHIL APOPTOSIS | CELL BIOLOGY | BIOPHYSICS | SIGNALING PATHWAY | BCL-2 PROTEINS | ANTISENSE OLIGONUCLEOTIDES | TRANSCRIPTION FACTOR | Myeloid Progenitor Cells - metabolism | Humans | Leukemia, Myeloid - genetics | Apoptosis - genetics | Leukemia - metabolism | Protein Structure, Tertiary - genetics | Lymphoma, B-Cell - genetics | Proteins - genetics | Proteins - metabolism | Myeloid Cells - metabolism | Protein Processing, Post-Translational | Dimerization | B-Lymphocytes - metabolism | Leukemia - genetics | Ubiquitin | Ligases | Cyclohexane | Proline | Lymphomas | Macrophage colony stimulating factor | Tumor proteins | Glutamate | Vascular endothelial growth factor | Protein binding
Journal Article
Autophagy, ISSN 1554-8635, 2014, Volume 4, Issue 8, pp. 989 - 997
γ-Herpesviruses (γHVs), including important human pathogens such as Epstein Barr virus, Kaposi's sarcoma-associated HV, and the murine γHV68, encode homologs... 
Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | Bcl-2 | Viral Bcl-2 | Autophagy | Beclin 1 | γ-herpesvirus | Apoptosis | autophagy | apoptosis | BHRF1 PROTEIN | CELL BIOLOGY | PROGRAMMED CELL-DEATH | gamma-herpesvirus | TUMOR-SUPPRESSOR FUNCTION | IN-VIVO | PEPTIDE COMPLEX | viral Bcl-2 | VIRAL EVASION | TUMORIGENESIS | EPSTEIN-BARR-VIRUS | SELF-DIGESTION
Journal Article
Oncogene, ISSN 1476-5594, 2009, Volume 27, Issue S1, pp. S149 - S157
Cancer cells show deviant behavior that induces apoptotic signaling. To survive, cancer cells typically acquire changes enabling evasion of death signals. One... 
Bcl-2 | Drug resistance and ABT-737 | BH3 mimetic | Apoptosis | Cancer | PROAPOPTOTIC ACTIVITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | MIMETIC ABT-737 | BCL-2 FAMILY PROTEINS | apoptosis | OUTER MITOCHONDRIAL-MEMBRANE | ANTIAPOPTOTIC BCL-2 | SMALL-MOLECULE INHIBITOR | CELL BIOLOGY | CYTOCHROME-C | SURVIVAL-PROMOTING PROTEINS | ONCOLOGY | X-L | GENETICS & HEREDITY | CHRONIC LYMPHOCYTIC-LEUKEMIA | cancer | drug resistance and ABT-737 | Neoplasms - metabolism | Sulfones - therapeutic use | Multigene Family | Proto-Oncogene Proteins c-bcl-2 - physiology | Apoptosis - drug effects | Humans | Drug Resistance, Neoplasm | Neoplasm Proteins - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Piperazines - chemistry | Structure-Activity Relationship | Nitrophenols - chemistry | Drug Delivery Systems | Benzamides - therapeutic use | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | Thionucleotides - chemistry | Sulfones - chemistry | Drug Design | Proto-Oncogene Proteins c-bcl-2 - chemistry | Antineoplastic Agents - pharmacology | Biphenyl Compounds - chemistry | Antineoplastic Agents - classification | Pyrroles - therapeutic use | Dimerization | Benzamides - chemistry | Binding, Competitive | Protein Structure, Tertiary | Sulfonamides - chemistry | Thionucleotides - therapeutic use | Clinical Trials as Topic | Mitochondria - drug effects | Antineoplastic Agents - chemistry | Sulfonamides - pharmacology | Piperazines - pharmacology | Neoplasms - drug therapy | Animals | Sulfonamides - therapeutic use | Pyrroles - chemistry | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Mice | Aniline Compounds - chemistry | Aniline Compounds - therapeutic use | Mitochondria - physiology | Drug Screening Assays, Antitumor | Proteins | Signal transduction | Oncology | Molecular biology
Journal Article