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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2014, Volume 111, Issue 23, pp. 8512 - 8517
Antiapoptotic B-cell lymphoma 2 (Bcl-2) family members such as Bcl-2, myeloid cell leukemia 1 (Mcl-1), and B-cell lymphoma-X large (Bcl-xL) are proposed to... 
Myeloid cells | Starvation | Cell death | Cell lines | Fibroblasts | Cultured cells | Gene expression regulation | Viability | Family members | Apoptosis | ABT-737 | LC3B | LC3 | BH3 mimetic | Bim | SURVIVAL | APOPTOSIS | MCL-1 | MULTIDISCIPLINARY SCIENCES | KINASE | CELL-DEATH | CONNECTION | BECLIN-1 | ROLES | BH3-ONLY PROTEINS | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | bcl-2 Homologous Antagonist-Killer Protein - genetics | Cell Survival - genetics | Apoptosis - genetics | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Autophagy | Proto-Oncogene Proteins c-bcl-2 - metabolism | Flow Cytometry | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | RNA Interference | bcl-2-Associated X Protein - genetics | Fibroblasts - metabolism | Phagosomes - metabolism | Cells, Cultured | bcl-2-Associated X Protein - metabolism | Sulfonamides - pharmacology | Piperazines - pharmacology | Blotting, Western | Myeloid Cell Leukemia Sequence 1 Protein - genetics | Mice, Knockout | Animals | Autophagy-Related Protein 5 | Embryo, Mammalian - cytology | Fibroblasts - drug effects | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Fibroblasts - cytology | Mice | Proto-Oncogene Proteins c-bcl-2 - genetics | Cell Line, Transformed | Autophagy (Cytology) | Cell research | Oncology, Experimental | Physiological aspects | Lymphomas | Research | B cells | Health aspects | Cancer | Proteins | Experiments | Cells | Index Medicus | Biological Sciences
Journal Article
FEBS JOURNAL, ISSN 1742-464X, 07/2016, Volume 283, Issue 14, pp. 2661 - 2675
Malignant cells routinely violate cellular checkpoints that should initiate cell death in normal cells by triggering pro-apoptotic members of the BCL2 family... 
BH3-mimetic | BCL-2 family | STRUCTURE-GUIDED DESIGN | MCL-1 | therapy | BIOCHEMISTRY & MOLECULAR BIOLOGY | apoptosis | ACUTE MYELOID-LEUKEMIA | ENDOPLASMIC-RETICULUM STRESS | BH3 MIMETIC ABT-737 | CELL LUNG-CANCER | ANTI-APOPTOTIC MCL-1 | SELECTIVE SMALL-MOLECULE | ACUTE LYMPHOBLASTIC-LEUKEMIA | BH3-ONLY PROTEIN NOXA | CHRONIC LYMPHOCYTIC-LEUKEMIA | cancer
Journal Article
Journal Article
Autophagy, ISSN 1554-8627, 11/2007, Volume 3, Issue 6, pp. 561 - 568
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2019, Volume 1877, pp. 163 - 172
Flow cytometry is a powerful technique for the detection and quantification of cell surface and intracellular proteins. It enables the ability to measure the... 
Molecules of equivalent soluble fluorochrome | BCL-2 | Quantitative flow cytometry method | MCL-1 | BCL-X | Cell Line | Proto-Oncogene Proteins c-bcl-2 - metabolism | Flow Cytometry - methods | Humans | Proto-Oncogene Proteins c-bcl-2 - analysis | bcl-X Protein - analysis | bcl-X Protein - metabolism | Index Medicus
Journal Article
Annals of Oncology, ISSN 0923-7534, 2012, Volume 23, Issue 6, pp. 1617 - 1626
Background: Chondrosarcomas are malignant cartilage-forming tumors notorious for their resistance to conventional chemo-and radiotherapy. Postulated... 
ABT-737 | BCL-2 | Chondrosarcoma | BCL-X | Chemoresistance | Apoptosis | CANCER-CELLS | BCL-X-L | SOLID TUMORS | apoptosis | PERIPHERAL CHONDROSARCOMA | CELL-LINES | P-GLYCOPROTEIN | chemoresistance | ONCOLOGY | DRUGS | chondrosarcoma | RESISTANCE | BONE | EXPRESSION | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Apoptosis - drug effects | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | bcl-X Protein - genetics | Drug Resistance, Neoplasm | Neoplasm Proteins - metabolism | Antineoplastic Agents - metabolism | Dose-Response Relationship, Drug | Proto-Oncogene Proteins c-bcl-2 - metabolism | Cell Nucleus - metabolism | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | ATP-Binding Cassette Transporters - metabolism | Inhibitory Concentration 50 | Antineoplastic Agents - pharmacology | Doxorubicin - metabolism | Cell Culture Techniques | Cell Survival - drug effects | Gene Expression | Cisplatin - pharmacology | Sulfonamides - pharmacology | Piperazines - pharmacology | Cell Shape - drug effects | Drug Synergism | Myeloid Cell Leukemia Sequence 1 Protein | HL-60 Cells | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | ATP Binding Cassette Transporter, Sub-Family B | Cell Proliferation - drug effects | bcl-X Protein - metabolism | Multidrug Resistance-Associated Proteins - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Doxorubicin - pharmacology | Index Medicus
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2019, Volume 1877, pp. 173 - 183
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 4/2009, Volume 185, Issue 2, pp. 279 - 290
It is still unclear whether the BH3-only protein Puma (p53 up-regulated modulator of apoptosis) can prime cells to death and render antiapoptotic BH3-binding... 
Proteins | Yeasts | Microinjections | Cell death | HCT116 cells | Cell lines | Antibodies | Cytochromes | Down regulation | Apoptosis | YEAST MITOCHONDRIA | ALPHA-HELIX | INTRACELLULAR-LOCALIZATION | X-L | DEATH | COLORECTAL-CANCER CELLS | MITOCHONDRIAL-MEMBRANE | BH3 DOMAINS | MEMBRANE PERMEABILIZATION | APOPTOTIC ACTIVITY | CELL BIOLOGY | Humans | Nitrophenols - metabolism | Piperazines - metabolism | Biphenyl Compounds - metabolism | Gene Knockdown Techniques | Proto-Oncogene Proteins c-bcl-2 - metabolism | Yeasts - physiology | Cyclin-Dependent Kinase Inhibitor p21 - genetics | RNA Interference | Apoptosis Regulatory Proteins - genetics | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Colorectal Neoplasms - metabolism | bcl-2-Associated X Protein - genetics | Proto-Oncogene Proteins - metabolism | bcl-2-Associated X Protein - metabolism | Proto-Oncogene Proteins - genetics | bcl-2-Associated X Protein - antagonists & inhibitors | Apoptosis Regulatory Proteins - metabolism | Myeloid Cell Leukemia Sequence 1 Protein | Sulfonamides - metabolism | Cell Line, Tumor | Protein Binding | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Apoptosis - physiology | Proto-Oncogene Proteins c-bcl-2 - genetics | Physiological aspects | Cellular proteins | Genetic aspects | Research | Studies | Biochemistry | Cells | Colorectal cancer | Index Medicus | Life Sciences | Cellular Biology
Journal Article
Cancer Research, ISSN 0008-5472, 02/2007, Volume 67, Issue 3, pp. 1176 - 1183
ABT-737 is a novel and potent Bcl-2 antagonist with single-agent activity against small-cell lung cancer (SCLC) cell lines. Here, we evaluated the contribution... 
SURVIVAL | APOPTOSIS | ETOPOSIDE | ONCOLOGY | MITOCHONDRIA | RESISTANCE | DEATH | INHIBITORS | EXPRESSION | CARCINOMA | BH3-ONLY PROTEINS | Piperazines - administration & dosage | Lung Neoplasms - drug therapy | RNA, Small Interfering - genetics | Up-Regulation | Apoptosis - drug effects | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | Neoplasm Proteins - antagonists & inhibitors | Proto-Oncogene Proteins - biosynthesis | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Transfection | Bcl-2-Like Protein 11 | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | Apoptosis Regulatory Proteins - genetics | Neoplasm Proteins - genetics | Apoptosis Regulatory Proteins - biosynthesis | Carcinoma, Small Cell - metabolism | Cell Growth Processes - drug effects | Membrane Proteins - genetics | Neoplasm Proteins - biosynthesis | Carcinoma, Small Cell - drug therapy | Down-Regulation | Carboplatin - administration & dosage | Etoposide - administration & dosage | Nitrophenols - administration & dosage | Proto-Oncogene Proteins - genetics | Sulfonamides - pharmacology | Piperazines - pharmacology | Proto-Oncogene Proteins c-bcl-2 - biosynthesis | Drug Synergism | Membrane Proteins - biosynthesis | Myeloid Cell Leukemia Sequence 1 Protein | Biphenyl Compounds - administration & dosage | Cell Line, Tumor | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Carcinoma, Small Cell - pathology | Proto-Oncogene Proteins c-bcl-2 - genetics | Sulfonamides - administration & dosage | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2013, Volume 8, Issue 12, pp. e80625 - e80625
The miR-99 family is one of the evolutionarily most ancient microRNA families, and it plays a critical role in developmental timing and the maintenance of... 
MIR-100 | AXIAL SKELETON | HUMAN GROWTH-HORMONE | METASTASIS | MAMMARY-CARCINOMA CELLS | MULTIDISCIPLINARY SCIENCES | DOWN-REGULATION | ONCOGENIC TRANSFORMATION | HOX GENES | UP-REGULATION | CANCER | Cell Line | Genome-Wide Association Study | Homeodomain Proteins - biosynthesis | Humans | Gene Expression Regulation - physiology | MicroRNAs - biosynthesis | Proto-Oncogene Proteins - genetics | Transcription Factors - biosynthesis | Gene Expression Profiling | Transcription Factors - genetics | Proto-Oncogene Proteins - biosynthesis | Homeodomain Proteins - genetics | MicroRNAs - genetics | MicroRNA | Homeobox genes | Epithelial cells | Luciferase | Physiological aspects | Research | Homeotic genes | Membrane proteins | TOR protein | Cell proliferation | Chromatin | Immunoprecipitation | Bcl-2 protein | Downstream effects | Genes | Genomes | Kinases | Tissues | Cell adhesion & migration | Gene sequencing | Maxillofacial surgery | Homeobox | Embryogenesis | N-Myristoyltransferase | Cell growth | Reporter gene | Transfection | Actin | Rodents | Surgery | Penicillin | Physiology | Tumorigenesis | Bioinformatics | Wound healing | HOXA1 protein | MiRNA | Rapamycin | Dentistry | Gene expression | Embryonic growth stage | Studies | Oral diseases | Hospitals | Ribonucleic acids | MicroRNAs | Pancreatic cancer | Healing | Skin | Molecular biology | Cell migration | Apoptosis | Cancer | Index Medicus
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 09/2016, Volume 15, Issue 9, pp. 2030 - 2041
Journal Article