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NATURE CHEMICAL BIOLOGY, ISSN 1552-4450, 06/2013, Volume 9, Issue 6, pp. 390 - 390
The prosurvival BCL-2 family protein BCL-X-L is often overexpressed in solid tumors and renders malignant tumor cells resistant to anticancer therapeutics.... 
IN-VITRO | CRYSTAL-STRUCTURE | MCL-1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | PEPTIDE COMPLEX | FAMILY PROTEINS | APOPTOSIS PATHWAY | BCL-X(L) | CANCER | SMALL-MOLECULE INHIBITOR | CELL-DEATH
Journal Article
GENES & DEVELOPMENT, ISSN 0890-9369, 06/2005, Volume 19, Issue 11, pp. 1294 - 1305
Commitment of cells to apoptosis is governed largely by the interaction between members of the Bcl-2 protein family. its three subfamilies have distinct roles:... 
Bcl-2 | MITOCHONDRIAL APOPTOSIS | MEMBRANE | apoptosis | DEVELOPMENTAL BIOLOGY | Bak | INITIATE APOPTOSIS | BH3-only | CELL-DEATH | BH3 DOMAIN | FAMILY | CYTOCHROME-C | Mcl-1 | IN-VIVO | GENETICS & HEREDITY | X-DEFICIENT MICE | ADENOVIRUS E1B 19K | Bcl-x(L) | Genetic research | DNA binding proteins | Research | Apoptosis
Journal Article
JOURNAL OF MOLECULAR BIOLOGY, ISSN 0022-2836, 05/2010, Volume 398, Issue 5, pp. 747 - 762
Interactions among Bcl-2 family proteins are important for regulating apoptosis. Prosurvival members of the family interact with proapoptotic BH3... 
APOPTOSIS | yeast surface display screening | COMPLEX | FLUORESCENCE POLARIZATION | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | Bcl-2 proteins | BH3 peptides | BCL-X(L) | LIGANDS | SPOT array | interaction specificity | YEAST SURFACE DISPLAY | BCL-2 FAMILY | DOMAINS | BH3-ONLY PROTEINS
Journal Article
Journal Article
by Kim, JJ and Lee, SB and Park, JK and Yoo, YD
CELL DEATH AND DIFFERENTIATION, ISSN 1350-9047, 09/2010, Volume 17, Issue 9, pp. 1420 - 1434
Reactive oxygen species (ROS) produced by tumor necrosis factor-a (TNF-alpha) have an important function in cell death by activating c-Jun N-terminal kinase.... 
PATHWAYS | OXYGEN SPECIES PRODUCTION | ACTIVATION | PROTEIN | TNF-alpha | Romo1 | mitochondria | BIOCHEMISTRY & MOLECULAR BIOLOGY | Bcl-X-L | apoptosis | RECEPTOR | NECROSIS-FACTOR-ALPHA | INDUCTION | CELL BIOLOGY | SIGNAL-TRANSDUCTION | ROS | NECROTIC CELL-DEATH | NF-KAPPA-B
Journal Article
NATURE CELL BIOLOGY, ISSN 1465-7392, 10/2011, Volume 13, Issue 10, pp. 1224 - U130
Anti-apoptotic Bcl2 family proteins such as Bcl-x(L) protect cells from death by sequestering apoptotic molecules, but also contribute to normal neuronal... 
OXIDATIVE-PHOSPHORYLATION | MANGANESE-SUPEROXIDE-DISMUTASE | ESCHERICHIA-COLI | BCL-X | SYNAPTIC-TRANSMISSION | UNCOUPLING PROTEIN-2 | INNER MITOCHONDRIAL | MAMMALIAN-CELLS | HIPPOCAMPAL-NEURONS | CELL-DEATH | CELL BIOLOGY
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 11/2010, Volume 120, Issue 11, pp. 3923 - 3939
Journal Article
Molecular Cell, ISSN 1097-2765, 2001, Volume 8, Issue 3, pp. 705 - 711
Critical issues in apoptosis include the importance of caspases versus organelle dysfunction, dominance of anti- versus proapoptotic BCL-2 members, and whether... 
PROGRAMMED CELL-DEATH | CYTOCHROME-C | ACTIVATION | PROTEIN | MEMBRANE | ELEGANS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DIMERIZATION | RELEASE | BCL-X(L) | FAMILY | CELL BIOLOGY
Journal Article
NATURE CELL BIOLOGY, ISSN 1465-7392, 07/2013, Volume 15, Issue 7, pp. 773 - 773
Following exocytosis, the rate of recovery of neurotransmitter release is determined by vesicle retrieval from the plasma membrane and by recruitment of... 
CENTRAL SYNAPSES | CYTOCHROME-C | BCL-X-L | APOPTOSIS | TRANSMISSION | TERMINALS | POOL | PROTEINS | HIPPOCAMPAL-NEURONS | MITOCHONDRIAL FISSION | CELL BIOLOGY
Journal Article
Journal Article
CELL DEATH & DISEASE, ISSN 2041-4889, 08/2016, Volume 7
Colorectal cancer (CRC) is the second most common malignant neoplasia in women and men worldwide. The B-cell lymphoma 2 (Bcl-2) protein family is mainly known... 
OVEREXPRESSION | PROTEIN | BCL-X | INDUCTION | INHIBITOR | EXPRESSION | CHEMOTHERAPY | APOPTOSIS RESISTANCE | CELL-DEATH | FAMILY | CELL BIOLOGY
Journal Article
Scientific Reports, ISSN 2045-2322, 04/2015, Volume 5
Anti-apoptotic B-cell lymphoma 2 (Bcl-2) family members target several intracellular Ca2+-transport systems. Bcl-2, via its N-terminal Bcl-2 homology (BH) 4... 
HEART | DEPENDENT ANION CHANNEL | MALIGNANT HYPERTHERMIA | CA2 | MULTIDISCIPLINARY SCIENCES | BAX | ENDOPLASMIC-RETICULUM | MUTATIONS | BCL-X(L) | PEPTIDES PROTECT | MODULATION
Journal Article
Journal of Cell Biology, ISSN 0021-9525, 03/2009, Volume 184, Issue 5, pp. 707 - 719
Journal Article
MOLECULAR THERAPY, ISSN 1525-0016, 02/2010, Volume 18, Issue 2, pp. 413 - 420
To enhance the strength of activation afforded by tumor antigen-specific receptors, we investigated the effect of adding combined CD28 and 4-1BB costimulatory... 
MEDICINE, RESEARCH & EXPERIMENTAL | BCL-X-L | IMMUNITY | EFFECTOR FUNCTION | PROTEIN-KINASE B | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | IN-VIVO | GENETICS & HEREDITY | COSTIMULATION | LIGAND | ADOPTIVE IMMUNOTHERAPY | ANTITUMOR EFFICACY | LYMPHOCYTES
Journal Article
AUTOPHAGY, ISSN 1554-8627, 07/2009, Volume 5, Issue 5, pp. 720 - 722
Beclin 1, an essential autophagic protein, is a BH3-only protein that binds Bcl-2 anti-apoptotic family members. The dissociation of Beclin I from the Bcl-2... 
Bcl-2 | COMPLEX | autophagy | PROTEIN | Bcl-X-L | DAP-kinase | beclin 1 | BH3 DOMAIN | CELL BIOLOGY
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2014, Volume 57, Issue 4, pp. 1323 - 1343
The prosurvival BCL-2 proteins are attractive yet challenging targets for medicinal chemists. Their involvement in the initiation and progression of many, if... 
APOPTOSIS | POTENT | COMPLEX | CHEMISTRY, MEDICINAL | NONPEPTIDE MIMETICS | MCL-1 | BIOLOGICAL EVALUATION | DUAL INHIBITORS | FAMILY PROTEINS | BCL-X(L) | DISCOVERY
Journal Article
Proteins: Structure, Function and Bioinformatics, ISSN 0887-3585, 07/2015, Volume 83, Issue 7, pp. 1262 - 1272
Apoptosis or programmed cell death is a regulatory process in cells in response to stimuli perturbing physiological conditions. The Bcl-2 family of proteins... 
Bcl-X L | BH3 binding | Mitochondria | BIM | BID | Structure comparison | Apoptosis | PROSURVIVAL BCL-2 | DOMAIN | PROTEIN | mitochondria | BIOCHEMISTRY & MOLECULAR BIOLOGY | Bcl-X-L | apoptosis | MECHANISMS | FAMILY | BIOPHYSICS | structure comparison | BIOLOGY | PEPTIDE COMPLEX | INHIBITOR | BINDING
Journal Article
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