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induced apoptosis (173) 173
rats (173) 173
antineoplastic agents - pharmacology (171) 171
blotting, western (167) 167
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hematology (166) 166
bcl-x l (161) 161
nf-kappa-b (160) 160
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article (149) 149
autophagy (149) 149
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neurosciences (146) 146
inhibition (141) 141
pharmacology & pharmacy (141) 141
protein binding (140) 140
biophysics (139) 139
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genetics & heredity (138) 138
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bcl-x protein - genetics (131) 131
immunology (131) 131
gene expression (127) 127
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molecular sequence data (122) 122
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induction (117) 117
amino acid sequence (116) 116
analysis (115) 115
proto-oncogene proteins c-bcl-2 - biosynthesis (115) 115
bh3 domain (113) 113
p53 (113) 113
abridged index medicus (112) 112
flow cytometry (109) 109
caspase 3 (108) 108
up-regulation (108) 108
apoptosis regulatory proteins - metabolism (107) 107
cell survival - drug effects (107) 107
chemotherapy (107) 107
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mcl-1 (106) 106
resistance (105) 105
mitochondria - drug effects (104) 104
oxidative stress (103) 103
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Optics Express, ISSN 1094-4087, 2019, Volume 27, Issue 13, pp. 18282 - 18295
Simultaneous linear unmixing of excitation-emission spectra (ExEm-unmixing)-based fluorescence resonance energy transfer (FRET) two-hybrid assay method, named... 
BCL-2 | BAX | OPTICS | PROTEINS | BCL-X(L) | BH3 DOMAIN
Journal Article
NATURE REVIEWS CANCER, ISSN 1474-175X, 12/2008, Volume 8, Issue 12, pp. 976 - 990
Just over 25 years ago, MYC, the human homologue of a retroviral oncogene, was identified. Since that time, MYC research has been intense and the advances... 
PLURIPOTENT STEM-CELLS | BCL-X-L | RNA-POLYMERASE-I | AVIAN MYELOCYTOMATOSIS VIRUS | ONCOLOGY | INDUCED APOPTOSIS | TRANSCRIPTION FACTOR NETWORK | DNA-DAMAGE RESPONSE | HUMAN C-MYC | MOUSE ERYTHROLEUKEMIA-CELLS | TRANSGENIC MICE
Journal Article
BLOOD, ISSN 0006-4971, 12/2016, Volume 128, Issue 23, pp. 2655 - 2665
The intercellular crosstalk between hematological malignancies and the tumor microenvironment is mediated by cell-to-cell interactions and soluble factors. One... 
PROTEIN | CASPASE-3 | BAX | DEATH | SORAFENIB | HEMATOLOGY | BCL-X(L) | MODULATION
Journal Article
AUTOPHAGY, ISSN 1554-8627, 07/2009, Volume 5, Issue 5, pp. 720 - 722
Beclin 1, an essential autophagic protein, is a BH3-only protein that binds Bcl-2 anti-apoptotic family members. The dissociation of Beclin I from the Bcl-2... 
Bcl-2 | COMPLEX | autophagy | PROTEIN | Bcl-X-L | DAP-kinase | beclin 1 | BH3 DOMAIN | CELL BIOLOGY
Journal Article
NATURE CELL BIOLOGY, ISSN 1465-7392, 07/2013, Volume 15, Issue 7, pp. 773 - 773
Following exocytosis, the rate of recovery of neurotransmitter release is determined by vesicle retrieval from the plasma membrane and by recruitment of... 
CENTRAL SYNAPSES | CYTOCHROME-C | BCL-X-L | APOPTOSIS | TRANSMISSION | TERMINALS | POOL | PROTEINS | HIPPOCAMPAL-NEURONS | MITOCHONDRIAL FISSION | CELL BIOLOGY
Journal Article
CELL DEATH & DISEASE, ISSN 2041-4889, 10/2014, Volume 5
We sought to identify miRNAs that can efficiently induce apoptosis in ovarian cancer cells by overcoming BCL-X-L and MCL1 anti-apoptotic activity, using... 
CELLS | INVASION | THERAPY | MCL-1 | TARGETS | MICRORNA EXPRESSION | CANCER | BCL-X(L) | STRATEGIES | CELL BIOLOGY
Journal Article
Nature Immunology, ISSN 1529-2908, 03/2002, Volume 3, Issue 3, pp. 221 - 227
The choice between life and death is one of the major events in regulation of the immune system. T cells that specifically recognize viral or bacterial... 
INDUCED CELL-DEATH | ALPHA-INDUCED APOPTOSIS | NECROSIS-FACTOR ALPHA | CYTOKINE PRODUCTION | IKK-BETA SUBUNIT | NEGATIVE REGULATION | LIVER DEGENERATION | EMBRYONIC LETHALITY | IMMUNOLOGY | MICE LACKING | BCL-X(L) EXPRESSION
Journal Article
GENES & DEVELOPMENT, ISSN 0890-9369, 06/2005, Volume 19, Issue 11, pp. 1294 - 1305
Commitment of cells to apoptosis is governed largely by the interaction between members of the Bcl-2 protein family. its three subfamilies have distinct roles:... 
Bcl-2 | MITOCHONDRIAL APOPTOSIS | MEMBRANE | apoptosis | DEVELOPMENTAL BIOLOGY | Bak | INITIATE APOPTOSIS | BH3-only | CELL-DEATH | BH3 DOMAIN | FAMILY | CYTOCHROME-C | Mcl-1 | IN-VIVO | GENETICS & HEREDITY | X-DEFICIENT MICE | ADENOVIRUS E1B 19K | Bcl-x(L) | Genetic research | DNA binding proteins | Research | Apoptosis
Journal Article
Current Opinion in Cell Biology, ISSN 0955-0674, 2010, Volume 22, Issue 2, pp. 140 - 149
Journal Article
MOLECULAR BIOLOGY OF THE CELL, ISSN 1059-1524, 05/2019, Volume 30, Issue 10, pp. 1138 - 1146
The anti-apoptotic Bcl-2 family protein Bcl-xL plays a critical role in cell survival by protecting the integrity of the mitochondrial outer membrane (MOM).... 
CYTOCHROME-C | APOPTOSIS | INSERTION | FAMILY-MEMBERS | IN-VIVO | PREVENTION | BAX | OLIGOMERIZATION | BCL-X(L) | CELL-DEATH | CELL BIOLOGY
Journal Article
MOLECULAR THERAPY, ISSN 1525-0016, 02/2010, Volume 18, Issue 2, pp. 413 - 420
To enhance the strength of activation afforded by tumor antigen-specific receptors, we investigated the effect of adding combined CD28 and 4-1BB costimulatory... 
MEDICINE, RESEARCH & EXPERIMENTAL | BCL-X-L | IMMUNITY | EFFECTOR FUNCTION | PROTEIN-KINASE B | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | IN-VIVO | GENETICS & HEREDITY | COSTIMULATION | LIGAND | ADOPTIVE IMMUNOTHERAPY | ANTITUMOR EFFICACY | LYMPHOCYTES
Journal Article
ONCOGENE, ISSN 0950-9232, 06/2007, Volume 26, Issue 27, pp. 3972 - 3979
ABT-737 is a subnanomolar inhibitor of the antiapoptotic proteins Bcl-2, Bcl-XL and Bcl-w. Although ABT-737 triggers extensive cell death in many small-cell... 
CELLS | off-target | seed | RNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | Bcl-X-L | ABT-737 | siRNA | CELL BIOLOGY | Mcl-1 | ONCOLOGY | GENETICS & HEREDITY | PROTEINS | EXPRESSION
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 06/2016, Volume 6
ABT-199, a potent and selective small-molecule antagonist of BCL-2, is being clinically vetted as pharmacotherapy for the treatment of acute myeloid leukemia... 
BCL-X-L | CELLS | POTENT | ACTIVATION | MCL-1 | MULTIDISCIPLINARY SCIENCES | ABT-737 | CHRONIC LYMPHOCYTIC-LEUKEMIA | MEK INHIBITORS | NAVITOCLAX | COMBINED BRAF
Journal Article
Journal Article
Molecular Cell, ISSN 1097-2765, 03/2009, Volume 33, Issue 6, pp. 679 - 691
Adaptation to endoplasmic reticulum (ER) stress depends on the activation of an integrated signal transduction pathway known as the unfolded protein response... 
PROTEINS | CELLCYCLE | MOLIMMUNO | BCL-X-L | APOPTOSIS | UNFOLDED PROTEIN RESPONSE | MESSENGER-RNA | GENE | DNA-DAMAGE RESPONSE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION FACTOR XBP-1 | ENDOPLASMIC-RETICULUM STRESS | PLASMA-CELL DIFFERENTIATION | FAMILY | CELL BIOLOGY
Journal Article
Molecular Cell, ISSN 1097-2765, 2001, Volume 8, Issue 3, pp. 705 - 711
Critical issues in apoptosis include the importance of caspases versus organelle dysfunction, dominance of anti- versus proapoptotic BCL-2 members, and whether... 
PROGRAMMED CELL-DEATH | CYTOCHROME-C | ACTIVATION | PROTEIN | MEMBRANE | ELEGANS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DIMERIZATION | RELEASE | BCL-X(L) | FAMILY | CELL BIOLOGY
Journal Article
Autophagy, ISSN 1554-8627, 2012, Volume 8, Issue 1, pp. 6 - 17
Beclin 1 (Atg6) is a well-known key regulator of autophagy. Although Beclin 1 is enzymatically inert, it governs the autophagic process by regulating... 
Bcl-2 | Membrane trafficking | Atg6 | Autophagy | Beclin 1 | BCL-X-L | autophagy | EMBRYONIC-DEVELOPMENT | AUTOPHAGY-RELATED PROTEIN | 1-DEPENDENT AUTOPHAGY | PHOSPHATIDYLINOSITOL 3-KINASE COMPLEXES | REGULATES AUTOPHAGY | SACCHAROMYCES-CEREVISIAE | CELL-DEATH | CELL BIOLOGY | CASPASE-MEDIATED CLEAVAGE | TUMOR-SUPPRESSOR | membrane trafficking
Journal Article
Autophagy, ISSN 1554-8627, 05/2019, Volume 15, Issue 5, pp. 785 - 795
BECN1/Beclin 1 is a critical protein in the initiation of autophagosome formation. Recent studies have shown that phosphorylation of BECN1 by STK4/MST1 at... 
BCL2L1/Bcl-x | BH3 domain | STK4/MST1 | BCL2/Bcl-2 | BECN1/Beclin1 | L | Autophagy | BCL2L1/Bcl-x(L) | CELL BIOLOGY
Journal Article