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IMMUNITY, ISSN 1074-7613, 06/2012, Volume 36, Issue 6, pp. 947 - 958
The adaptor protein BcI10 is a critically important mediator of T cell receptor (TCR)-to-NF-kappa B signaling. BcI10 degradation is a poorly understood... 
LYSOSOMES | GENE | RECOGNITION | PHOSPHORYLATION | UBIQUITIN | INFLAMMATION | DEGRADATION | PROLIFERATION | BCL10 | IMMUNOLOGY | P62
Journal Article
Journal of Immunology, ISSN 0022-1767, 06/2009, Volume 182, Issue 12, pp. 7718 - 7728
The Carmal-Bcl10-Malt1 signaling module bridges TCR signaling to the canonical I kappa B kinase (IKK)/NF-kappa B pathway. Covalent attachment of regulatory... 
PARACASPASE MALT1 | INHIBITOR A20 | ACTIVATION | ENZYME | ANTIGEN-RECEPTOR | CASPASE-8 | BCL10 | IMMUNOLOGY | LYMPHOCYTE-PROLIFERATION | REQUIREMENT | LIGASE
Journal Article
Nature Immunology, ISSN 1529-2908, 03/2008, Volume 9, Issue 3, pp. 263 - 271
The paracaspase MALT1 mediates T cell antigen receptor-induced signaling to the transcription factor NF-kappa B and is indispensable for T cell activation and... 
ACTIVATION | CYTOKINE PRODUCTION | SIGNALING PATHWAY | UBIQUITIN LIGASE | CARMA1 | LIPID RAFTS | LYMPHOMA | BCL10 | IMMUNOLOGY | DEPENDENT GENE-EXPRESSION | CHROMOSOMAL TRANSLOCATION
Journal Article
Journal of Immunology, ISSN 0022-1767, 10/2010, Volume 185, Issue 8, pp. 4520 - 4524
TCR-mediated activation of the transcription factor NFkB is required for T cell proliferation, survival, and effector differentiation. Although this pathway is... 
GAMMA | PROTEIN | DISCRIMINATION | MICE | BCL10 | IMMUNOLOGY | T-CELLS | MALT1
Journal Article
FEBS Open Bio, ISSN 2211-5463, 01/2015, Volume 5, Issue 1, pp. 175 - 181
The complexes formed by BCL10, MALT1 and members of the family of CARMA proteins have recently been the focus of much attention because they represent a key... 
CARMA | NF-kB | BCL10
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2014, Volume 134, Issue 2, pp. 276 - 284
Next-generation DNA sequencing has accelerated the genetic characterization of many human primary immunodeficiency diseases (PIDs). These discoveries can be... 
Allergy and Immunology | nuclear factor κB | next-generation sequencing | CARMA1 | primary immunodeficiency diseases | CARD11-BCL10-MALT1 signalosome complex | paracaspase | congenital B-cell lymphocytosis | combined immunodeficiency | nuclear factor kappa B | IMMUNE-DEFICIENCY | T-CELL | BCL10 | IMMUNOLOGY | CLEAVAGE | MALT LYMPHOMA | JNK ACTIVATION | ALLERGY | ECTODERMAL DYSPLASIA | CARD11 MUTATIONS | NF-KAPPA-B | Immunologic Deficiency Syndromes - pathology | Caspases - immunology | Humans | NF-kappa B - immunology | Neoplasm Proteins - immunology | CARD Signaling Adaptor Proteins - genetics | Adaptor Proteins, Signal Transducing - immunology | Germ-Line Mutation | B-Lymphocytes - pathology | Immunologic Deficiency Syndromes - diagnosis | Immunologic Deficiency Syndromes - immunology | Neoplasm Proteins - genetics | CARD Signaling Adaptor Proteins - immunology | Guanylate Cyclase - immunology | Signal Transduction | Caspases - genetics | Gene Expression Regulation | Receptors, Antigen, B-Cell - immunology | B-Lymphocytes - immunology | NF-kappa B - genetics | B-Cell CLL-Lymphoma 10 Protein | Adaptor Proteins, Signal Transducing - genetics | Immunologic Deficiency Syndromes - genetics | Guanylate Cyclase - genetics | Receptors, Antigen, B-Cell - genetics | High-Throughput Nucleotide Sequencing | Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein | Lymphomas | Immunodeficiency | Primary immunodeficiency diseases | Congenital B cell lymphocytosis | NF-κB | Combined immunodeficiency | CARD11–BCL10–MALT1 (CBM) signalosome complex | Paracaspase | Next generation sequencing
Journal Article
The Journal of allergy and clinical immunology, ISSN 0091-6749, 11/2015, Volume 136, Issue 5, pp. 1139 - 1149
Three members of the caspase recruitment domain (CARD) family of adaptors (CARD9, CARD10, and CARD11) are known to form heterotrimers with B-cell lymphoma 10... 
BCL10 | CARMA1 | MALT1 | CARD9 | Primary immunodeficiency | combined immunodeficiency
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 08/2019, Volume 515, Issue 4, pp. 572 - 578
Transcriptional factors (TFs) are key regulators in orchestrating gene transcription during cancer development. However, their roles in glioma remain elusive.... 
Cell proliferation | ZNF436 | CREB1 | BCL10 | Glioma | KAPPA-B ACTIVATION | BIOPHYSICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CYCLE PROGRESSION
Journal Article
Nature Cell Biology, ISSN 1465-7392, 2008, Volume 10, Issue 11, pp. 1309 - 1317
The covalent attachment of ubiquitin to target proteins influences various cellular processes, including DNA repair, NF-kappa B signalling and cell... 
UBA DOMAIN | ACTIVATION | SIGNALING PATHWAY | STRUCTURAL BASIS | ALPHA-DEPENDENT APOPTOSIS | LINKED INHIBITOR | XIAP | PROTEIN LIGASE | BCL10 | MALT LYMPHOMA | CELL BIOLOGY
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 02/2018, Volume 115, Issue 7, pp. 1499 - 1504
The CARMA1-BCL10-MALT1 (CBM) signalosome is a central mediator of T cell receptor and B cell receptor-induced NF-kappa B signaling that regulates multiple... 
Innate immunity | CARMA1–BCL10–MALT1 | Cryo-EM | TRAF6 | Assembly | COMPLEX | PHOSPHORYLATION | CRYSTAL-STRUCTURE | CARMA1 | MULTIDISCIPLINARY SCIENCES | KINASE C-THETA | MALT1 | innate immunity | T-CELL-ACTIVATION | assembly | CARD11 MUTATIONS | cryo-EM | NF-KAPPA-B | CRYO-EM STRUCTURE | CARMA1-BCL10-MALT1 | Biological Sciences
Journal Article
Frontiers in immunology, ISSN 1664-3224, 2019, Volume 10, p. 1217
Journal Article
Immunity, ISSN 1074-7613, 2005, Volume 23, Issue 6, pp. 561 - 574
PKC isoforms and CARMA1 play crucial roles in immunoreceptor-dependent NF-κB activation. We tested whether PKC-dependent phosphorylation of CARMA1 directly... 
LIPID RAFT RECRUITMENT | COMPLEX | TCR | KINASE-C-THETA | T-CELL-RECEPTOR | MAGUK FAMILY | COSTIMULATION | BCL10 | IMMUNOLOGY | LYMPHOCYTE-ACTIVATION | BETA
Journal Article
by Chou and Ho and Lai and Chen and Wu and Shun and Wen
International Journal of Molecular Sciences, ISSN 1422-0067, 10/2019, Volume 20, Issue 20, p. 5022
B-cell activating factor (BAFF) is found to be associated with the histological severity of nonalcoholic steatohepatitis (NASH). BAFF was also found to have a... 
B-cell activating factor (BAFF) | B-cell CLL/lymphoma 10 (BCL10) | liver regeneration | angiogenesis | 70% partial hepatectomy
Journal Article
Immunity, ISSN 1074-7613, 2005, Volume 23, Issue 6, pp. 575 - 585
CARMA1 mediates T cell receptor (TCR)-induced NF-κB activation. However, how TCR links to CARMA1 in the signaling pathway is not clear. Here, we show that... 
RECRUITMENT | KINASE-C-THETA | IMMUNE-RESPONSES | FAMILY MEMBER | COSTIMULATION | BCL10 | IMMUNOLOGY | IMMUNOLOGICAL SYNAPSE | LYMPHOCYTE-ACTIVATION | PKC-THETA | ANTIGEN
Journal Article