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11/2012
3BP2 was originally identified through its interaction with the ABL kinase. Fusion of ABL with the BCR gene forms the BCR-ABL onco-protein, which is causative... 
leukemia | signal transduction | BCR-ABL | 3BP2 | 0307
Dissertation
The American Journal of the Medical Sciences, ISSN 0002-9629, 11/2019
Journal Article
Pharmacological Research, ISSN 1043-6618, 2015, Volume 94, pp. 9 - 25
The physiological Src proto-oncogene is a protein-tyrosine kinase that plays key roles in cell growth, division, migration, and survival signaling pathways.... 
SH3 domain | SH2 domain | BCR-Abl | Catalytic spine | Regulatory spine | Targeted cancer therapy
Journal Article
Autophagy, ISSN 1554-8627, 2015, Volume 11, Issue 2, pp. 355 - 372
Journal Article
NATURE METHODS, ISSN 1548-7091, 12/2016, Volume 13, Issue 12, pp. 1029 - 1029
A large number of genetic variants have been associated with human diseases. However, the lack of a genetic diversification approach has impeded our ability to... 
CRISPR | SOMATIC HYPERMUTATION | ABL TYROSINE KINASE | STRUCTURAL BASIS | BCR-ABL | BIOCHEMICAL RESEARCH METHODS | URACIL-DNA GLYCOSYLASE | RESISTANCE | R-LOOPS | CLASS-SWITCH RECOMBINATION | MOLECULAR-MECHANISMS
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 12/2019, Volume 29, Issue 24, p. 126758
To reveal insights into the inhibition of BCR-ABL and its mutants, structure-based computing methods, such as docking, molecular dynamics (MD) simulation, the... 
Nilotinib | Flumatinib | Pharmacophore zones | Imatinib derivatives | BCR-ABL
Journal Article
2016, Methods in molecular biology, ISBN 1493940090, Volume 1465
This volume highlights the molecular and cellular methods used in studying Chronic Myeloid Leukimia (CML) pathogenesis and stem cell biology. Written in the... 
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Web Resource
LEUKEMIA, ISSN 0887-6924, 07/2014, Volume 28, Issue 7, pp. 1407 - 1413
Disease-specific mutations facilitate diagnostic precision and drug target discovery. In myeloproliferative neoplasms (MPN), this is best exemplified by the... 
POLYCYTHEMIA-VERA | CSF3R | PROGNOSIS | CHRONIC NEUTROPHILIC LEUKEMIA | CALRETICULIN | SEVERE CONGENITAL NEUTROPENIA | BCR-ABL | RECEPTOR | ESSENTIAL THROMBOCYTHEMIA | neutrophilic | JAK2 EXON-12 MUTATIONS | ACTIVATING MUTATION | ONCOLOGY | myeloproliferative | CALR | HEMATOLOGY | WHO
Journal Article
HAEMATOLOGICA, ISSN 0390-6078, 10/2018, Volume 103, Issue 11, pp. E549 - E552
Journal Article
BLOOD, ISSN 0006-4971, 04/2012, Volume 119, Issue 15, pp. 3374 - 3376
Journal Article
by Experts in Chronic Myeloid Leukemia, in Chronic Myeloid Leukemia and Abboud, Camille and Berman, Ellin and Cohen, Adam and Cortes, Jorge and DeAngelo, Daniel and Deininger, Michael and Devine, Steven and Druker, Brian and Fathi, Amir and Jabbour, Elias and Jagasia, Madan and Kantarjian, Hagop and Khoury, Jean and Laneuville, Pierre and Larson, Richard and Lipton, Jeffrey and Moore, Joseph O and Mughal, Tariq and O'Brien, Susan and Pinilla-Ibarz, Javier and Quintas-Cardama, Alfonso and Radich, Jerald and Reddy, Vishnu and Schiffer, Charles and Shah, Neil and Shami, Paul and Silver, Richard T and Snyder, David and Stone, Richard and Talpaz, Moshe and Tefferi, Ayalew and Van Etten, Richard A and Wetzler, Meir and Abruzzese, Elisabetta and Apperley, Jane and Breccia, Massimo and Byrne, Jenny and Cervantes, Francisco and Chelysheva, Ekaterina and Clark, R.E and De Lavallade, Hugues and Dyagil, Iryna and Gambacorti-Passerini, Carlo and Goldman, John and Haznedaroglu, Ibrahim and Hjorth-Hansen, Henrik and Holyoake, Tessa and Huntly, Brian and Le Coutre, Philipp and Lomaia, Elza and Mahon, Francois-Xavier and Marin-Costa, David and Martinelli, Giovanni and Mayer, Jiri and Milojkovic, Dragana and Olavarria, Eduardo and Porkka, Kimmo and Richter, Johan and Rousselot, Philippe and Saglio, Giuseppe and Saydam, Guray and Stentoft, Jesper and Turkina, Anna and Vigneri, Paolo and Zaritskey, Andrey and Aguayo, Alvaro and Ayala, Manuel and Bendit, Israel and Bengio, Raquel Maria and Best, Carlos and Bullorsky, Eduardo and Cervera, Eduardo and Desouza, Carmino and Fanilla, Ernesto and Gomez-Almaguer, David and Hamerschlak, Nelson and Lopez, Jose and Magarinos, Alicia and Meillon, Luis and Milone, Jorge and Moiraghi, Beatriz and Pasquini, Ricardo and Pavlovsky, Carolina and Ruiz-Arguelles, Guillermo J and Spector, Nelson and Arthur, Christopher and Browett, Peter and Grigg, Andrew and Hu, Jianda and Huang, Xiao-jun and Hughes, Tim and Jiang, Qian and Jootar, Saengsuree and Kim, Dong-Wook and Malhotra, Hemant and Malhotra, Pankaj and Matsumura, Itaru and Melo, Junia and Ohnishi, Kazunori and ... and Experts Chronic Myeloid Leukemia and Experts in Chronic Myeloid Leukemia
Blood, ISSN 0006-4971, 05/2013, Volume 121, Issue 22, pp. 4439 - 4442
Journal Article
Cancer Letters, ISSN 0304-3835, 03/2016, Volume 372, Issue 1, pp. 82 - 88
In this study, a synthetic steroidal glycoside SBF-had strong and preferential antitumor effects on the human chronic myeloid leukemia (CML) cell line K562 and... 
Imatinib | PTP1B | Bcr-Abl | Chronic myeloid leukemia | SBF-1
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 09/2019, Volume 79, Issue 18, pp. 4744 - 4753
Although the use of ATP-competitive tyrosine kinase inhibitors of oncoprotein BCR-ABL1 has enabled durable responses in patients with chronic myeloid leukemia... 
TRANSFORMATION | SITE | AUTOINHIBITION | STEM-CELLS | INHIBITION | ONCOLOGY | BCR-ABL | KINASE | IMATINIB | MECHANISMS | MOLECULES
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2018, Volume 61, Issue 18, pp. 8120 - 8135
Chronic myelogenous leukemia (CML) arises from the constitutive activity of the BCR-ABL1 oncoprotein. Tyrosine kinase inhibitors (TKIs) that target the... 
CHEMISTRY, MEDICINAL | MANAGEMENT | C-ABL | BCR-ABL | DRUG DISCOVERY | IMATINIB | RESISTANCE | BINDING-SITE | PATCH-CLAMP | CHRONIC MYELOID-LEUKEMIA
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 02/2019, Volume 62, Issue 4, pp. 2154 - 2171
Abelson kinase (c-Abl) is a ubiquitously expressed, nonreceptor tyrosine kinase which plays a key role in cell differentiation and survival. It was... 
DESIGN | CHEMISTRY, MEDICINAL | TYROSINE KINASE | BCR-ABL | INHIBITORS | BINDING | CANCER | DISCOVERY
Journal Article
Blood, ISSN 0006-4971, 08/2013, Volume 122, Issue 6, pp. 872 - 884
Journal Article
Cell, ISSN 0092-8674, 04/2013, Volume 153, Issue 2, pp. 293 - 305
Journal Article