X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
autophagy (1207) 1207
beclin 1 (1165) 1165
index medicus (1123) 1123
humans (816) 816
apoptosis (621) 621
animals (620) 620
cell biology (572) 572
proteins (442) 442
beclin-1 (406) 406
cancer (350) 350
mice (282) 282
biochemistry & molecular biology (278) 278
apoptosis regulatory proteins - metabolism (274) 274
autophagy - drug effects (270) 270
autophagy - physiology (257) 257
oncology (216) 216
cell-death (214) 214
membrane proteins - metabolism (212) 212
protein (195) 195
cell line, tumor (189) 189
biology (179) 179
phagocytosis (178) 178
male (172) 172
signal transduction (160) 160
female (159) 159
expression (155) 155
autophagy - genetics (146) 146
inhibition (145) 145
phosphorylation (141) 141
calcium (136) 136
cell death (136) 136
death (136) 136
binding (135) 135
microtubule-associated proteins - metabolism (130) 130
activation (128) 128
article (126) 126
apoptosis - drug effects (123) 123
apoptosis regulatory proteins - genetics (122) 122
cell (122) 122
cycle (119) 119
lc3 (119) 119
bioscience (118) 118
kinases (118) 118
regulates autophagy (118) 118
landes (117) 117
organogenesis (117) 117
analysis (115) 115
tumorigenesis (113) 113
research (112) 112
bcl-2 (111) 111
cells (110) 110
health aspects (109) 109
models, biological (108) 108
oxidative stress (108) 108
neurosciences (101) 101
membrane proteins - genetics (100) 100
gene expression (93) 93
disease (92) 92
mtor (91) 91
medicine, research & experimental (90) 90
rats (86) 86
pharmacology & pharmacy (84) 84
physiological aspects (83) 83
immunohistochemistry (82) 82
pathway (82) 82
cell survival (81) 81
middle aged (81) 81
tumor-suppressor (81) 81
endoplasmic-reticulum (80) 80
cell line (77) 77
gene (77) 77
prognosis (77) 77
review (77) 77
bcl-x-l (76) 76
pathology (76) 76
phosphatidylinositol 3-kinase (75) 75
survival (75) 75
protein binding (74) 74
beclin (70) 70
macroautophagy (70) 70
mechanisms (70) 70
up-regulation (70) 70
development and progression (69) 69
beclin-1 - metabolism (68) 68
cancer-cells (68) 68
chemotherapy (68) 68
proto-oncogene proteins c-bcl-2 - metabolism (68) 68
tumors (68) 68
adult (66) 66
aged (66) 66
degradation (66) 66
homeostasis (66) 66
induction (66) 66
inflammation (65) 65
apoptosis - physiology (64) 64
beclin 1-dependent autophagy (64) 64
endoplasmic-reticulum stress (63) 63
signal transduction - drug effects (62) 62
tor serine-threonine kinases - metabolism (62) 62
blotting, western (61) 61
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Autophagy, ISSN 1554-8627, 05/2015, Volume 11, Issue 5, pp. 740 - 747
BECN1/Beclin 1 is regarded as a critical component in the class III phosphatidylinositol 3-kinase (PtdIns3K) complex to trigger autophagy in mammalian cells.... 
BECN1 | MAP1LC3B/LC3B, microtubule-associated protein 1 light chain 3 β | MAP1LC3/LC3, microtubule-associated protein 1 light chain 3 | BCL2L1/Bcl | PtdIns3K | BECN1, Beclin 1, autophagy related | BafA1, bafilomycin A | BECN1P1/BECN2, Beclin 1, autophagy related, pseudogene 1 | EM, electron microscopy | UVRAG, UV radiation resistance associated | MAP1LC3-II/LC3-II, proteolytically processed and lipid-modified microtubule-associated protein 1 light chain 3 | LC3 | ZFYVE1/DFCP1, zinc finger, FYVE domain containing 1 | GAPDH, glyceraldehyde-3-phosphate dehydrogenase | TALEN, transcription activator-like effector nuclease | GFP, green fluorescent protein | autophagy | SQSTM1/p62, sequestosome 1 | xL, BCL2-like 1 | PtdIns3K, phosphatidylinositol 3-kinase | - | PIK3R4/VPS15, phosphoinositide-3-kinase, regulatory subunit 4 | TUBB, tubulin, β class I | 1 | KO, knockout | MAP1LC3-I/LC3-I, soluble, proteolytically processed microtubule-associated protein 1 light chain 3 | ATG, autophagy related | autophagosome | PIK3C3/VPS34, phosphatidylinositol 3-kinase, catalytic subunit type 3 | Autophagosome | Autophagy | CANCER-CELLS | ATG PROTEINS | COMPLEX | PHOSPHATIDYLINOSITOL 3-KINASE | BECLIN 1-INDEPENDENT AUTOPHAGY | MACROAUTOPHAGY | ARSENIC TRIOXIDE | CELL BIOLOGY | 1 PHOSPHORYLATION | PATHWAY | RUBICON | Beclin-1 | Microtubule-Associated Proteins - metabolism | Humans | Phagosomes - metabolism | Class III Phosphatidylinositol 3-Kinases - metabolism | Molecular Sequence Data | Apoptosis Regulatory Proteins - metabolism | Membrane Proteins - deficiency | Lipids - chemistry | Apoptosis Regulatory Proteins - deficiency | Base Sequence | Phagosomes - ultrastructure | Membrane Proteins - metabolism | HeLa Cells | Index Medicus
Journal Article
EMBO reports, ISSN 1469-221X, 03/2009, Volume 10, Issue 3, pp. 285 - 292
Autophagy, an evolutionarily conserved process, has functions both in cytoprotective and programmed cell death mechanisms. Beclin 1, an essential autophagic... 
Bcl-2 | SURVIVAL | UVRAG | COMPLEX | autophagy | PROTEIN | BAD | BIOCHEMISTRY & MOLECULAR BIOLOGY | DAPK | REGULATES AUTOPHAGY | CELL-DEATH | CELL BIOLOGY | beclin 1 | STARVATION
Journal Article
Autophagy, ISSN 1554-8627, 03/2015, Volume 11, Issue 3, pp. 452 - 459
Disruption of the complex of BECN1 with BCL2 or BCL2L1/BCL-X L is an essential switch that turns on cellular autophagy in response to environmental stress or... 
STS, staurosporine | apoptosis | MAP1LC3/LC3, microtubule-associated protein 1 light chain 3 | HRP, horseradish peroxidase | PBS, phosphate-buffered saline | BAK1 | HBSS, Hanks' balanced salt solution | BCL2, B-cell CLL/lymphoma 2 | GAPDH, glyceraldehyde-3-phosphate dehydrogenase | Baf A1, bafilomycin A | MTOR, mechanistic target of rapamycin | autophagy | ACTB, actin, β | FBS, fetal bovine serum | WT, wild type | ABT-737 | BECN1 (Beclin 1) | BECN1, Beclin 1, autophagy-related | DKO, double-knockout | SQSTM1, sequestosome 1 | BAX, BCL2-associated X protein | BCL2 | BAX | MEFs, mouse embryonic fibroblasts | MCL1, myeloid cell leukemia 1 | BAK1, BCL2-antagonist/killer 1 | Autophagy | Apoptosis | bafilomycin A | sequestosome 1 | HRP | BCL2-associated X protein | mechanistic target of rapamycin | phosphate-buffered saline | ACTB | PEPTIDE | CELL BIOLOGY | 1 PHOSPHORYLATION | STS | FBS | X-L | autophagy-related | horseradish peroxidase | Hanks' balanced salt solution | mouse embryonic fibroblasts | LC3 | MOLECULAR-BASIS | PBS | MEFs | BECLIN 1-DEPENDENT AUTOPHAGY | killer 1 | lymphoma 2 | BH3-ONLY PROTEIN | DKO | double-knockout | MAP1LC3 | fetal bovine serum | actin | BCL2-antagonist | wild type | GAPDH | SQSTM1 | BECN1 | staurosporine | myeloid cell leukemia 1 | Baf A1 | BH3 DOMAIN | microtubule-associated protein 1 light chain 3 | glyceraldehyde-3-phosphate dehydrogenase | B-cell CLL | BCL-2 FAMILY-MEMBERS | MCL1 | SUPPRESSION | MTOR | Beclin 1 | HBSS | Beclin-1 | Peptide Fragments | Sulfonamides - chemistry | HCT116 Cells | Humans | bcl-2-Associated X Protein - metabolism | Piperazines - chemistry | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Nitrophenols - chemistry | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Proto-Oncogene Proteins c-bcl-2 - metabolism | Animals | Flow Cytometry | Cell Line, Tumor | Protein Binding | Membrane Proteins - metabolism | Mice | Proto-Oncogene Proteins | Biphenyl Compounds - chemistry | Microscopy, Fluorescence | Fibroblasts - metabolism | Index Medicus
Journal Article
Autophagy, ISSN 1554-8627, 11/2014, Volume 10, Issue 11, pp. 1937 - 1952
Lipopolysaccharide (LPS)-induced activation of TLR4 (toll-like receptor 4) is followed by a subsequent overwhelming inflammatory response, a hallmark of the... 
ACTB, actin, beta | MYD88, myeloid differentiation primary response 88 | PELI3 | CHX, cycloheximide | BECN1, Beclin 1, autophagy related | TICAM1, toll-like receptor adaptor molecule 1 | LPS | RIPK1, receptor (TNFRSF)-interacting serine-threonine kinase 1 | TUBB, tubulin, beta class I | PRRs, pattern recognition receptors | UBB, ubiquitin B | IRAKs, interleukin-1 receptor-associated kinases | HBSS, Hank's balanced salt solution | ATG7, autophagy-related 7 | MAP1LC3B, microtubule-associated protein 1 light chain 3 beta | TLRs, toll-like receptors | Baf A1, bafilomycin A | WT, wildtype | autophagy | TNF, tumor necrosis factor | MAPK14, mitogen-activated protein kinase 14 | NFKB, nuclear factor of kappa light polypeptide gene enhancer in B-cells | MAPK1/3, mitogen-activated protein kinase 1/3 | Epoxo, epoxomycin | TRAF6, TNF receptor-associated factor 6, E3 ubiquitin protein ligase | IL1B, interleukin 1, beta | MTOR, mechanistic target of rapamycin (serine/threonine kinase) | TABs, TGF-beta activated kinase 1/MAP3K7 binding protein 1/2/3 | Wortm, wortmannin | PELI3, pellino E3 ubiquitin protein ligase family member 3 | MAPK8/9, mitogen-activated protein kinase 8/9 | SQSTM1, sequestosome 1 | NFE2L2, nuclear factor, erythroid 2-like 2 | NLRP3, NLR family, pyrin domain containing 3 | LAMP2, lysosomal-associated membrane protein 2 | LPS, lipopolysaccharide | MAP3K14, mitogen-activated protein kinase kinase kinase 14 | MΦ, macrophages | Rapa, rapamycin | SQSTM1 | TBK1, TANK-binding kinase 1 | Torin2 | MAP3K7, mitogen-activated protein kinase kinase kinase 7 | Autophagy | TOLL-LIKE-RECEPTORS | ACTIVATION | BECLIN 1 | RECOGNITION | SELECTIVE AUTOPHAGY | CELL BIOLOGY | UBIQUITINATION | IL-1-BETA PRODUCTION | INFLAMMASOME | SCAFFOLD PROTEINS | INNATE IMMUNITY | Cell Line | Cytokines - metabolism | Signal Transduction | Ubiquitin - metabolism | Ubiquitin-Protein Ligases - metabolism | Adenosine Triphosphatases - metabolism | Lipopolysaccharides - metabolism | Inflammation | Immunity, Innate | RNA, Messenger - metabolism | Toll-Like Receptor 4 - metabolism | Point Mutation | Macrophages - metabolism | Animals | Interleukin-1beta - metabolism | Sepsis - metabolism | Mice | Naphthyridines - metabolism | RNA, Small Interfering - metabolism | Index Medicus
Journal Article
Autophagy, ISSN 1554-8627, 2012, Volume 8, Issue 1, pp. 6 - 17
Beclin 1 (Atg6) is a well-known key regulator of autophagy. Although Beclin 1 is enzymatically inert, it governs the autophagic process by regulating... 
Bcl-2 | Membrane trafficking | Atg6 | Autophagy | Beclin 1 | BCL-X-L | autophagy | EMBRYONIC-DEVELOPMENT | AUTOPHAGY-RELATED PROTEIN | 1-DEPENDENT AUTOPHAGY | PHOSPHATIDYLINOSITOL 3-KINASE COMPLEXES | REGULATES AUTOPHAGY | SACCHAROMYCES-CEREVISIAE | CELL-DEATH | CELL BIOLOGY | CASPASE-MEDIATED CLEAVAGE | TUMOR-SUPPRESSOR | membrane trafficking
Journal Article
Autophagy, ISSN 1554-8627, 03/2015, Volume 11, Issue 3, pp. 503 - 515
Autophagy is an essential component of host innate and adaptive immunity. Viruses have developed diverse strategies for evading or utilizing autophagy for... 
RNAi, RNA interference | dsRNA, double-stranded RNA | mAb, monoclonal antibody | TSC, tuberous sclerosis complex | Gg, Gallus gallus (chicken) | HE-IBDV, heat-inactivated IBDV | DMEM, Dulbecco's modified Eagle's medium | HSP90AA1, heat shock protein 90 kDa alpha (cytosolic), class A member 1 | ANOVA, analysis of variance | EIF2AK2, eukaryotic translation initiation factor 2-alpha kinase 2 | HSP90AA1 | autophagy | GST, glutathione S-transferase | IBDV, infectious bursal disease virus | EBSS, Earle's balanced salt solution | EIF2S1, eukaryotic translation initiation factor 2, subunit 1 alpha | BECN1, Beclin 1, autophagy-related | MTOR, mechanistic target of rapamycin (serine/threonine kinase) | IgG, immunoglobulin G | Ni-NTA, nickel-nitrilotriacetic acid | SQSTM1, sequestosome 1 | LPS, lipopolysaccharide | shRNA, short hairpin RNA | PAMP, pathogen-associated molecular patterns | 50% tissue culture infectious doses | PI3K, phosphoinositide 3-kinase | cDNA, complementary DNA | eGFP, enhanced green fluorescent protein | HSV-1, herpes simplex virus 1 | hpi, hours post-infection | MAP1LC3/LC3, microtubule-associated protein 1 light chain 3 | SDS, sodium dodecyl sulfate | PBS, phosphate-buffered saline | SVP, subviral particle | ATG5, autophagy-related 5 | PRR, pattern recognition receptors | GAPDH, glyceraldehyde-3-phosphate dehydrogenase | CoIP, coimmunoprecipitation | VP, viral protein | BCA, bicinchoninic acid | Hs, Homo sapiens (human) | TCID | TLR, toll-like receptors | siRNA, small interfering RNA | AKT-MTOR pathway | viral protein VP2 | MOI, multiplicity of infection | GOPC, golgi-associated PDZ and coiled-coil motif containing | ER, endoplasmic reticulum | avibirnavirus | Viral protein VP2 | Autophagy | Avibirnavirus | PROTEIN | toll-like receptors | sequestosome 1 | nickel-nitrilotriacetic acid | phosphate-buffered saline | CELL BIOLOGY | class A member 1 | PI3K | autophagy-related | infectious bursal disease virus | dsRNA | HE-IBDV | BCA | SDS | Dulbecco's modified Eagle's medium | HERPES-SIMPLEX-VIRUS | heat-inactivated IBDV | mechanistic target of rapamycin (serine | BIOSYNTHESIS | PURIFICATION | lipopolysaccharide | SQSTM1 | phosphoinositide 3-kinase | RNA interference | PARTICLES | IBDV | SVP | LPS | complementary DNA | heat shock protein 90kDa alpha (cytosolic) | ANOVA | subunit 1 alpha | ATG5 | hpi | EIF2AK2 | viral protein | EIF2S1 | mAb | PAMP | eukaryotic translation initiation factor 2 | enhanced green fluorescent protein | glutathione S-transferase | coimmunoprecipitation | SYSTEM | subviral particle | autophagy-related 5 | small interfering RNA | double-stranded RNA | PRR | HSV-1 | CoIP | shRNA | short hairpin RNA | INFECTIOUS BURSAL DISEASE | herpes simplex virus 1 | cDNA | threonine kinase | EBSS | LC3 | Homo sapiens (human) | PBS | RNAi | golgi-associated PDZ and coiled-coil motif containing | TSC | MAP1LC3 | hours post-infection | pathogen-associated molecular patterns | GAPDH | Ni-NTA | INNATE IMMUNITY | BECN1 | tuberous sclerosis complex | Earle's balanced salt solution | IgG | TCID50 | microtubule-associated protein 1 light chain 3 | bicinchoninic acid | DMEM | multiplicity of infection | analysis of variance | Gallus gallus (chicken) | sodium dodecyl sulfate | glyceraldehyde-3-phosphate dehydrogenase | TLR | CELLS | eGFP | immunoglobulin G | MOI | eukaryotic translation initiation factor 2-alpha kinase 2 | GST | siRNA | MTOR | pattern recognition receptors | Beclin 1 | GOPC | monoclonal antibody | endoplasmic reticulum | Microscopy, Electron, Transmission | Phosphorylation | TOR Serine-Threonine Kinases - metabolism | Capsid Proteins - metabolism | Microtubule-Associated Proteins - metabolism | Humans | Phagosomes - metabolism | Avibirnavirus - metabolism | Microscopy, Confocal | Animals | Lysosomes - metabolism | RNA Interference | Chickens | HEK293 Cells | HSP90 Heat-Shock Proteins - metabolism | Protein Binding | Cytosol - metabolism | Cell Membrane - metabolism | Proto-Oncogene Proteins c-akt - metabolism | RNA, Small Interfering - metabolism | Index Medicus
Journal Article
Autophagy, ISSN 1554-8627, 12/2014, Volume 10, Issue 12, pp. 2362 - 2378
We investigated the role of autophagy, a controlled cellular self-digestion process, in regulating survival of neurons exposed to atypical antipsychotic... 
DHR, dihydrorhodamine 123 | RPS6KB1/S6K1, ribosomal protein S6 kinase, 70kDa, polypeptide 1 | AKT1, v-akt murine thymoma viral oncogene homolog 1 | BCL2L1, BCL2-like 1 | MAP1LC3B, microtubule-associated protein 1 light chain 3 β | BBC3, BCL2 binding component 3 | apoptosis | AMPK, AMP-activated protein kinase | ATG, autophagy-related | PAPA-NONOate, propylamine propylamine NONOate | PMAIP1, phorbol-12-myristate-13-acetate-induced protein 1 | olanzapine | neurotoxicity | XIAP, X-linked inhibitor of apoptosis | APAF1, apoptotic protease activating factor 1 | antipsychotic | BCL2L11, BCL2-like 11 (apoptosis facilitator) | GABARAP, GABA(A) receptor-associated protein | ROS, reactive oxygen species | BCL2, B-cell CLL/lymphoma 2 | TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling | FOXO, forkhead box O | BIRC5, baculoviral IAP repeat containing 5 | MTOR, mechanistic target of rapamycin | autophagy | SQSTM1/p62, sequestosome 1 | CDKN1B, cyclin-dependent kinase inhibitor 1B (p27, Kip1) | LDH, lactate dehydrogenase | BECN1, Beclin 1, autophagy-related | CDKN1A, cyclin-dependent kinase inhibitor 1A (p21, Cip1) | COX4I1/COX IV, cytochrome c oxidase IV isoform 1 | CFLAR/FLIP, CASP8 and FADD-like apoptosis regulator | mitophagy | DEA-NONOate, diethylamine NONOate | BAX, BCL2-associated X protein | TRP53, transformation related protein 53 (mouse ortholog of human TP53, tumor protein p53) | nitric oxide, NO | BAD, BCL2-associated agonist of cell death | SQSTM1 | PTEN, phosphatase and tensin homolog | oxidative stress | BAK1, BCL2-antagonist/killer 1 | Oxidative stress | Neurotoxicity | Olanzapine | Antipsychotic | Mitophagy | Autophagy | Apoptosis | NEURODEGENERATIVE DISEASE | MAMMALIAN TARGET | AKT/MTOR PATHWAY | ALZHEIMERS-DISEASE | MACAQUE MONKEYS | SH-SY5Y NEUROBLASTOMA-CELLS | CELL BIOLOGY | MITOCHONDRIAL PERMEABILITY TRANSITION | IN-VITRO | NITRIC-OXIDE | Lysosomes - drug effects | Cell Line | AMP-Activated Protein Kinases - metabolism | Benzodiazepines - pharmacology | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Humans | Neurons - cytology | Mitochondria - drug effects | Autophagy - drug effects | Animals | Mice | Antipsychotic Agents - pharmacology | Neurons - drug effects | Index Medicus
Journal Article
Autophagy, ISSN 1554-8627, 12/2014, Volume 10, Issue 12, pp. 2223 - 2238
Impaired autophagy function and enhanced ARG2 (arginase 2)-MTOR (mechanistic target of rapamycin) crosstalk are implicated in vascular aging and... 
AKT/PKB, v-akt murine thymoma viral oncogene homolog 1 | SMC, smooth muscle cells | arginase type II deficient | SA-ß-gal, senescence-associated-β-gal | VWF, von Willebrand factor | HAEC, human aortic endothelial cells | senescence | nor-NOHA, N | | LC3, microtubule-associated protein 1 light chain 3 | ANOVA, analysis of variance | ULK1, unc-51 like autophagy activating kinase 1 | EC | atherosclerosis | MTOR, mechanistic target of rapamycin | autophagy | ARGINASE | PE, phosphatidylethanolamine | PtdIns3K, phosphatidylinositol 3-kinase | BECN1, Beclin 1, autophagy-related | Apolipoprotein E-deficient | arg2 | 1 | Three-MA, 3-methyladenine | shRNA, short hairpin RNA | RPS6KB1/S6K1, ribosomal protein S6 kinase, 70kDa, polypeptide 1 | endothelial cells | ARG1, arginase 1 | ω | AR, aortic roots | LDL, low-density lipoprotein | Baf A1, bafilomycin A | Atg, autophagy-related | HUVEC, human umbilical vein endothelial cells | PRKAA | SQSTM1/p62, sequestosome 1 | endothelial cell | WT, wild type | apoe | H160F, inactive mutant of mouse ARG2 | MTOR | BEC, S-12 bromoethyl-L-cystine-HCl | TP53/p53, tumor protein 53 | hydroxy-nor-Arginine | CMV, cytomegalovirus | RPS6, ribosomal protein S6 | ARG2, arginase 2 | NOS3/eNOS, nitric oxide synthase 3 (endothelial cell) | PRKAA/AMPK, protein kinase, AMP-activated, α catalytic subunit | Senescence | Atherosclerosis | Autophagy | Endothelial cells | ACTIVATED PROTEIN-KINASE | PHOSPHORYLATION | MECHANISMS | CELL BIOLOGY | LYSOSOMES | INHIBITION | NITRIC-OXIDE | DEGRADATION | S6 KINASE | STRESS | AMP-Activated Protein Kinases - metabolism | Atherosclerosis - pathology | TOR Serine-Threonine Kinases - metabolism | Humans | Arginase - metabolism | Cellular Senescence - physiology | Mice, Transgenic | Autophagy - physiology | Mechanistic Target of Rapamycin Complex 2 | Atherosclerosis - metabolism | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - metabolism | Animals | Diet, High-Fat | Signal Transduction - physiology | Index Medicus
Journal Article
Journal Article
Circulation Research, ISSN 0009-7330, 03/2007, Volume 100, Issue 6, pp. 914 - 922
Journal Article
Autophagy, ISSN 1554-8627, 11/2014, Volume 10, Issue 11, pp. 2036 - 2052
Earlier studies reported allelic deletion of the essential autophagy regulator BECN1 in breast cancers implicating BECN1 loss, and likely defective autophagy,... 
TNBCs, triple-negative breast cancers | EGF, epidermal growth factor | DAPI, 4′, 6-diamidino-2-phenylindole | MEGM, mammary epithelial growth medium | ATG, autophagy-related | 8-O-dG, 8-oxo-7, 8-dihydroguanine | ITGB1/CD29, Integrin, beta 1 (fibronectin receptor beta polypeptide, antigen CD29 includes MDF2, MSK12) | LY76 | E, 17b-estradiol | EM, electron microscopy | DMEM, Dulbecco's modified Eagle's medium | CD24, cluster of differentiation 24 | KRT, keratin | TNFSF11 | TNBC | TNFRSF11A/TNR11/RANK, tumor necrosis factor receptor superfamily, member 11a, NFKB activator | MAP1LC3B/LC3B, microtubule-associated protein 1 light chain 3 beta | LY76/TER119, lymphocyte antigen 76 | EGFP, enhanced green fluorescent protein | MaPC, mammary progenitor cell | PI, propidium iodide | TNF, tumor necrosis factor | TP53 (TRP53 in mice), tumor protein p53 (transformation related protein 53 in mice) | NFKB | BECN1, Beclin 1, autophagy-related | PECAM1/CD31, platelet/endothelial cell adhesion molecule 1 | RELA/P65, v-rel avian reticuloendotheliosis viral oncogene homolog a | IL, interleukin | lineage negative (CD31 | IF, immunofluorescence | CD45 | SQSTM1/p62, sequestosome1 | GSEA, gene set enrichment analysis | H&E, hematoxylin &, eosin | DFS, disease-free survival | basal-like breast cancer | parity | iMMECs, immortalized mouse mammary epithelial cells | TNFRSF11A | HR, hormone receptor | PGR, progesterone receptor | FACS, fluorescence activated cell sorting | PBS, phosphate-buffered saline | TEBs, terminal end buds | IHC, immunohistochemistry | SD, standard deviation | MGs, mammary glands | ROS, reactive oxygen species | WNT1 | MEC, mammary epithelial cell | ITGB3/CD61, integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | MKI67, marker of proliferation Ki-67 | CASP3, caspase 3 | BSA, bovine serum albumin | MaSC, mammary stem cell | EMT, epithelial-to-mesenchymal transition | Keratin 6 | WNT1, wingless-Type MMTV integration site family, member 1 | TNF11 | NFKB/NFkB, nuclear factor of kappa light polypeptide gene enhancer in B-cells | MMTV, mouse mammary tumor virus | FGF2/bFGF, fibroblast growth factor 2 (basic) | LIN | p-KRT8/p-K8, phosphorylated Keratin 8 | SNPs, single nucleotide polymorphisms | PTPRC/CD45, protein tyrosine phosphatase, receptor type, C | EGFR/ERBB1, epidermal growth factor receptor | Beclin 1 | TNFSF11/TNF11/RANKL, tumor necrosis factor (ligand) superfamily, member 11 | ESR1, estrogen receptor 1 | TNR11 | ERBB2, v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 | Parity | Basal-like breast cancer | PROGENITOR CELLS | STEM-CELLS | MOUSE | DEFICIENT MICE | CELL BIOLOGY | BREAST-CANCER | EPITHELIAL-CELLS | BECLIN-1 | TUMOR-SUPPRESSOR | LUNG-TUMORS | TRANSGENIC MICE | Beclin-1 | Cell Proliferation | Oligonucleotide Array Sequence Analysis | Signal Transduction | Humans | Gene Expression Regulation, Neoplastic | Stem Cells - cytology | Wnt1 Protein - metabolism | Mammary Neoplasms, Experimental - metabolism | Autophagy | Apoptosis Regulatory Proteins - metabolism | Breast Neoplasms - metabolism | Animals | Mice, Nude | Triple Negative Breast Neoplasms - metabolism | Mammary Neoplasms, Animal - metabolism | Alleles | Female | Heterozygote | Membrane Proteins - metabolism | Mice | Epithelial Cells - cytology | Apoptosis | Index Medicus
Journal Article
Oncogene, ISSN 0950-9232, 05/2013, Volume 32, Issue 18, pp. 2261 - 2272
Journal Article