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Cell Adhesion & Migration, ISSN 1933-6918, 01/2019, Volume 13, Issue 1, pp. 249 - 259
BECN1/Beclin1 is one of the key proteins in autophagy regulation. However, the biological functions of BECN1 in non-small cell lung cancer (NSCLC) were... 
Vimentin | migration | BECN1 | NSCLC | ubiquitination
Journal Article
Toxicological Sciences, ISSN 1096-6080, 11/2016, Volume 154, Issue 1, pp. 101 - 114
Journal Article
Autophagy, ISSN 1554-8627, 03/2015, Volume 11, Issue 3, pp. 452 - 459
Disruption of the complex of BECN1 with BCL2 or BCL2L1/BCL-X L is an essential switch that turns on cellular autophagy in response to environmental stress or... 
STS, staurosporine | apoptosis | MAP1LC3/LC3, microtubule-associated protein 1 light chain 3 | HRP, horseradish peroxidase | PBS, phosphate-buffered saline | BAK1 | HBSS, Hanks' balanced salt solution | BCL2, B-cell CLL/lymphoma 2 | GAPDH, glyceraldehyde-3-phosphate dehydrogenase | Baf A1, bafilomycin A | MTOR, mechanistic target of rapamycin | autophagy | ACTB, actin, β | FBS, fetal bovine serum | WT, wild type | ABT-737 | BECN1 (Beclin 1) | BECN1, Beclin 1, autophagy-related | DKO, double-knockout | SQSTM1, sequestosome 1 | BAX, BCL2-associated X protein | BCL2 | BAX | MEFs, mouse embryonic fibroblasts | MCL1, myeloid cell leukemia 1 | BAK1, BCL2-antagonist/killer 1 | Autophagy | Apoptosis | bafilomycin A | sequestosome 1 | HRP | BCL2-associated X protein | mechanistic target of rapamycin | phosphate-buffered saline | ACTB | PEPTIDE | CELL BIOLOGY | 1 PHOSPHORYLATION | STS | FBS | X-L | autophagy-related | horseradish peroxidase | Hanks' balanced salt solution | mouse embryonic fibroblasts | LC3 | MOLECULAR-BASIS | PBS | MEFs | BECLIN 1-DEPENDENT AUTOPHAGY | killer 1 | lymphoma 2 | BH3-ONLY PROTEIN | DKO | double-knockout | MAP1LC3 | fetal bovine serum | actin | BCL2-antagonist | wild type | GAPDH | SQSTM1 | BECN1 | staurosporine | myeloid cell leukemia 1 | Baf A1 | BH3 DOMAIN | microtubule-associated protein 1 light chain 3 | glyceraldehyde-3-phosphate dehydrogenase | B-cell CLL | BCL-2 FAMILY-MEMBERS | MCL1 | SUPPRESSION | MTOR | Beclin 1 | HBSS | Beclin-1 | Peptide Fragments | Sulfonamides - chemistry | HCT116 Cells | Humans | bcl-2-Associated X Protein - metabolism | Piperazines - chemistry | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Nitrophenols - chemistry | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Proto-Oncogene Proteins c-bcl-2 - metabolism | Animals | Flow Cytometry | Cell Line, Tumor | Protein Binding | Membrane Proteins - metabolism | Mice | Proto-Oncogene Proteins | Biphenyl Compounds - chemistry | Microscopy, Fluorescence | Fibroblasts - metabolism | Index Medicus
Journal Article
Autophagy, ISSN 1554-8627, 11/2014, Volume 10, Issue 11, pp. 2053 - 2074
Restoration of BECN1/Beclin 1-dependent autophagy and depletion of SQSTM1/p62 by genetic manipulation or autophagy-stimulatory proteostasis regulators, such as... 
PM, plasma membrane | autophagy | epigallocatechin gallate | TNF, tumor necrosis factor | CHX, cycloheximide | CXCL2, chemokine (C-X-C motif) ligand 2 | TGM2, transglutaminase 2 | CF, cystic fibrosis | CSNK2, casein kinase 2 | CFTR, cystic fibrosis transmembrane conductance regulator | EGCG, epigallocatechin gallate | SQSTM1, sequestosome 1 | CXCL8, chemokine (C-X-C motif) ligand 8 | cystic fibrosis | cysteamine | sweat chloride | FEV, forced expiratory volume | RPD, rectal potential difference | CFTR | BECN1/Beclin 1, autophagy-related | Sweat chloride | Cysteamine | Cystic fibrosis | Epigallocatechin gallate | Autophagy | GREEN TEA POLYPHENOLS | CELL BIOLOGY | TRANSMEMBRANE CONDUCTANCE REGULATOR | IN-VITRO | GENE | DISEASE | AIRWAY EPITHELIUM | KINASE CK2 | TISSUE TRANSGLUTAMINASE | CHLORIDE | Tumor Necrosis Factor-alpha - metabolism | Sequestosome-1 Protein | Humans | Male | Chlorides - chemistry | Young Adult | Adult | Cystamine - pharmacology | Female | Cell Membrane - metabolism | Membrane Proteins - metabolism | Interleukin-8 - metabolism | Catechin - pharmacology | Child | Cysteamine - administration & dosage | Beclin-1 | Mice, Inbred CFTR | Administration, Oral | Cystic Fibrosis - metabolism | Mice, Transgenic | Apoptosis Regulatory Proteins - metabolism | Homozygote | Phenotype | Pilot Projects | Animals | Adolescent | Cystic Fibrosis Transmembrane Conductance Regulator - genetics | Catechin - analogs & derivatives | Mice | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Index Medicus
Journal Article
Autophagy, ISSN 1554-8627, 12/2018, Volume 14, Issue 12, pp. 2173 - 2175
Ferroptosis is a form of regulated cell death caused by iron accumulation and oxidative injury. BECN1 is a key regulator of macroautophagy/autophagy, a... 
BECN1 | autophagy | ferroptosis | AMPK | cancer | SLC7A11 | chemotherapy | phosphorylation | redox | CELL BIOLOGY | Index Medicus
Journal Article
Current Biology, ISSN 0960-9822, 08/2018, Volume 28, Issue 15, pp. 2388 - 2399.e5
Ferroptosis is a form of regulated cell death triggered by lipid peroxidation after inhibition of the cystine/glutamate antiporter system X . However, key... 
BECN1 | cancer therapy | autophagy | ferroptosis | autosis | AMPK | SLC7A11 | lipid peroxidation | phosphorylation | necroptosis
Journal Article
Asian Pacific Journal of Cancer Prevention, ISSN 1513-7368, 2016, Volume 17, Issue 12, pp. 6073 - 6077
Journal Article
Autophagy, ISSN 1554-8627, 06/2019, Volume 15, Issue 6, pp. 1122 - 1123
Macroautophagy/autophagy is an evolutionarily conserved degradation system with fundamental biological functions. The activation of the class III... 
hydrogen-deuterium exchange | HIV | Rubicon | Cryoelectron microscopy | human immunodeficiency virus | Nef | Tat-BECN1 peptide | CELL BIOLOGY
Journal Article
Autophagy, ISSN 1554-8627, 08/2016, Volume 12, Issue 8, pp. 1340 - 1354
Reactive oxygen species (ROS) have been commonly accepted as inducers of autophagy, and autophagy in turn is activated to relieve oxidative stress. Yet,... 
BECN1 | TRPM2 | acetaminophen | autophagy | reactive oxygen species | CAMK2 | oxidative stress
Journal Article
Journal Article
Autophagy, ISSN 1554-8627, 07/2017, Volume 13, Issue 7, pp. 1091 - 1092
When it comes to cancer initiation and progression, macroautophagy/autophagy seemingly acts in a contradictory fashion, serving either as a suppressive factor... 
PGK1 | BECN1 | stress | cancer | autophagy | glutamine | CELL BIOLOGY | Index Medicus
Journal Article
The Korean Journal of Internal Medicine, ISSN 1226-3303, 2019, Volume 34, Issue 2, p. 401
Background/Aims: The outcome of local treatment for advanced non-small cell lung cancer (NSCLC) remains poor, with therapies such as induction chemother apy... 
Induction chemotherapy | Carcinoma | non-small-cell lung | human | BECN1 protein
Journal Article
Autophagy, ISSN 1554-8627, 05/2019, Volume 15, Issue 5, pp. 785 - 795
BECN1/Beclin 1 is a critical protein in the initiation of autophagosome formation. Recent studies have shown that phosphorylation of BECN1 by STK4/MST1 at... 
BCL2L1/Bcl-x | BH3 domain | STK4/MST1 | BCL2/Bcl-2 | BECN1/Beclin1 | L | Autophagy | BCL2L1/Bcl-x(L) | CELL BIOLOGY
Journal Article
Current Biology, ISSN 0960-9822, 08/2018, Volume 28, Issue 15, pp. 2388 - 2399.e5
Ferroptosis is a form of regulated cell death triggered by lipid peroxidation after inhibition of the cystine/glutamate antiporter system X . However, key... 
BECN1 | cancer therapy | autophagy | ferroptosis | autosis | AMPK | SLC7A11 | lipid peroxidation | phosphorylation | necroptosis | BECLIN 1 | INHIBITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | REGULATES AUTOPHAGY | KINASE | AUTOPHAGIC CELL-DEATH | DEGRADATION | INDUCTION | PROTEINS | PROTECTS | CELL BIOLOGY
Journal Article
Autophagy, ISSN 1554-8627, 01/2018, Volume 14, Issue 1, pp. 80 - 97
HSPB6/Hsp20 (heat shock protein family B [small] member 6) has emerged as a novel cardioprotector against stress-induced injury. We identified a human mutant... 
human mutation | BECN1 | heart failure | autophagy | HSPB6 | Index Medicus
Journal Article
Korean Journal of Internal Medicine, ISSN 1226-3303, 03/2019, Volume 34, Issue 2, pp. 401 - 408
Background/Aims: The outcome of local treatment for advanced non-small cell lung cancer (NSCLC) remains poor, with therapies such as induction chemotherapy... 
Human | Induction chemotherapy | Carcinoma | Non-small-cell lung | BECN1 protein | SURGERY | SURVIVAL | CHEMOSENSITIVITY | PHASE-III | AUTOPHAGY | PACLITAXEL | MEDICINE, GENERAL & INTERNAL | BECN1 protein, human | CISPLATIN | ERCC1 | PROTEIN EXPRESSION | DNA-REPAIR | Carcinoma, non-small-cell lung | Original
Journal Article
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