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Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 5/2016, Volume 77, Issue 5, pp. 997 - 1003
VS-6063 (also known as defactinib or PF-04554878) is a second-generation inhibitor of focal adhesion kinase and proline-rich tyrosine kinase-2. This phase 1... 
Defactinib | Medicine & Public Health | Oncology | Cancer Research | Proline-rich tyrosine kinase-2 | VS-6063 | Focal adhesion kinase | Pharmacology/Toxicology | First-in-Asian phase 1 study | NF2/MERLIN | ONCOLOGY | PHARMACOLOGY & PHARMACY | Area Under Curve | Benzamides - pharmacokinetics | Humans | Middle Aged | Pyrazines - administration & dosage | Half-Life | Male | Response Evaluation Criteria in Solid Tumors | Antineoplastic Agents - therapeutic use | Pyrazines - therapeutic use | Antineoplastic Agents - administration & dosage | Focal Adhesion Kinase 2 - antagonists & inhibitors | Dose-Response Relationship, Drug | Benzamides - administration & dosage | Benzamides - therapeutic use | Neoplasms - blood | Antineoplastic Agents - adverse effects | Adult | Female | Antineoplastic Agents - pharmacokinetics | Benzamides - adverse effects | Drug Administration Schedule | Administration, Oral | Neoplasms - enzymology | Sulfonamides - pharmacokinetics | Neoplasms - drug therapy | Asian Continental Ancestry Group | Neoplasms - urine | Sulfonamides - therapeutic use | Pyrazines - pharmacokinetics | Pyrazines - adverse effects | Sulfonamides - adverse effects | Aged | Focal Adhesion Kinase 1 - antagonists & inhibitors | Sulfonamides - administration & dosage | Tyrosine | Safety and security measures | Colorectal cancer | Clinical trials | Proline | Development and progression | Tumors | Index Medicus | Original
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2016, Volume 59, Issue 18, pp. 8473 - 8494
Journal Article
Journal Article
Clinical Toxicology, ISSN 1556-3650, 01/2017, Volume 55, Issue 1, pp. 55 - 59
Journal Article
Organic Letters, ISSN 1523-7060, 03/2019, Volume 21, Issue 6, pp. 1908 - 1911
N-Chloroformyl imidazolidinone derivatives of enantiopure amino acids may be deprotonated to give remarkably well-behaved enolates with both nucleophilic and... 
CHEMISTRY, ORGANIC | DESIGN | BENZAMIDES | ACID | DERIVATIVES
Journal Article
The Journal of Clinical Pharmacology, ISSN 0091-2700, 09/2014, Volume 54, Issue 9, pp. 968 - 978
Accumulating evidence indicates that selective antagonism of kappa opioid receptors may provide therapeutic benefit in the treatment of major depressive... 
kappa opioid receptor | LY2456302 | dynorphin | DEPRESSION | DYNORPHINS | SUBSTANCE USE DISORDERS | STIMULATION | ALCOHOL | NALTREXONE | PHARMACOLOGY & PHARMACY | STRESS | WITHDRAWAL | Narcotic Antagonists - administration & dosage | Benzamides - pharmacokinetics | Humans | Middle Aged | Ethanol - administration & dosage | Pyrrolidines - administration & dosage | Pyrrolidines - adverse effects | Male | Postural Balance - drug effects | Alcohol Drinking | Healthy Volunteers | Pyrrolidines - blood | Benzamides - administration & dosage | Drug Interactions | Ethanol - blood | Reaction Time - drug effects | Adult | Female | Hydrocortisone - blood | Narcotic Antagonists - pharmacokinetics | Benzamides - adverse effects | Adrenocorticotropic Hormone - blood | Receptors, Opioid, kappa - antagonists & inhibitors | Double-Blind Method | Luteinizing Hormone - blood | Narcotic Antagonists - blood | Administration, Oral | Pyrrolidines - pharmacokinetics | Benzamides - blood | Narcotic Antagonists - adverse effects | Ethanol - pharmacokinetics | Cognition - drug effects | Cross-Over Studies | Prolactin - blood | Care and treatment | Safety and security measures | Drug interactions | Alcohol | Research | Major depressive disorder | Receptors | Alcohol, Denatured | Analysis | Opioids | Anxiety | Dosage and administration | Pharmacokinetics | Narcotics | Mass spectrometry | Chromatography
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2015, Volume 89, pp. 252 - 265
Journal Article