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Journal Article
Biotechnology letters, ISSN 0141-5492, 03/2020, Volume 42, Issue 3, pp. 461 - 469
To characterize methyltransferases involved in the biosynthesis of benzylisoquinoline alkaloids in Stephania intermedia. Three N-methyltransferases, SiCNMT1,... 
MOLECULAR CHARACTERIZATION | Benzylisoquinoline alkaloids | Biosynthetic pathway | N-methyltransferase | METABOLISM | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENES | O-methyltransferase | Stephania intermedia | Alkaloids | E coli | Methyltransferase | Biosynthesis | Methylation | Recombinant | Expression vectors
Journal Article
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, ISSN 0002-7863, 01/2020, Volume 142, Issue 2, pp. 792 - 800
The Pictet-Spengler reaction is a valuable route to 1,2,3,4-tetrahydro-beta-carboline (THBC) and isoquinoline scaffolds found in many important... 
TETRAHYDRO-BETA-CARBOLINES | BENZYLISOQUINOLINE ALKALOID BIOSYNTHESIS | CAMPTOTHECIN | RAUVOLFIA | PURIFICATION | KEY ENZYME | INTERMEDIATE | NORCOCLAURINE SYNTHASE | AUXILIARY | CHEMISTRY, MULTIDISCIPLINARY | CYCLIZATION
Journal Article
by Yang, L and Zhu, JM and Sun, CH and Deng, ZX and Qu, XD
CHEMICAL SCIENCE, ISSN 2041-6520, 01/2020, Volume 11, Issue 2, pp. 364 - 371
Herein, we report a biocatalytic approach to synthesize plant tetrahydroisoquinoline alkaloids (THIQAs) from dihydroisoquinoline (DHIQ) precursors using imine... 
ASYMMETRIC-SYNTHESIS | 1-PHENYL-1,2,3,4-TETRAHYDROISOQUINOLINES | ENANTIOSELECTIVE SYNTHESIS | COCLAURINE N-METHYLTRANSFERASE | PURIFICATION | MOLECULAR-CLONING | ENABLES | BENZYLISOQUINOLINE | NORCOCLAURINE SYNTHASE | CHEMISTRY, MULTIDISCIPLINARY | STRATEGIES
Journal Article
Chemical science, ISSN 2041-6520, 01/2020, Volume 11, Issue 2, pp. 364 - 371
Herein, we report a biocatalytic approach to synthesize plant tetrahydroisoquinoline alkaloids (THIQAs) from dihydroisoquinoline (DHIQ) precursors using imine... 
Journal Article
by Zhao, YC and Zhang, ZP and Li, MZ and Luo, J and Chen, F and Gong, YF and Li, YR and Wei, YJ and Su, YJ and Kong, LY
SCIENTIFIC DATA, ISSN 2052-4463, 05/2019, Volume 6, Issue 1, pp. 66 - 10
Opium poppy is one of the most important medicinal plants and remains the only commercial resource of morphinan-based painkillers. However, little is known... 
BENZYLISOQUINOLINE ALKALOID BIOSYNTHESIS | MULTIDISCIPLINARY SCIENCES | Medicinal plants | Alkaloids | Alternative splicing | Transcription | Genomes | Biosynthesis | Ribonucleic acid--RNA | Gene expression | Cultivars
Journal Article
by Li, J and Xiong, YC and Li, Y and Ye, SQ and Yin, Q and Gao, SQ and Yang, D and Yang, M and Palva, ET and Deng, XB
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, ISSN 1422-0067, 10/2019, Volume 20, Issue 20, p. 5006
The WRKY family is one of the largest transcription factor (TF) families in plants and plays central roles in modulating plant stress responses and... 
WRKY | transcription factor | benzylisoquinoline alkaloids | FACTOR FAMILY | DNA-BINDING | BIOCHEMISTRY & MOLECULAR BIOLOGY | evolution | Lotus | IDENTIFICATION | CHEMISTRY, MULTIDISCIPLINARY | LEAF SENESCENCE | ALKALOID BIOSYNTHESIS | SALICYLIC-ACID | SUPERFAMILY | ARABIDOPSIS | FACTOR GENES | JASMONATE | lotus | wrky
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 10/2019, Volume 294, Issue 40, pp. 14482 - 14498
Journal Article
ACS CATALYSIS, ISSN 2155-5435, 10/2019, Volume 9, Issue 10, pp. 9640 - 9649
Norcoclaurine synthase (NCS) catalyzes a stereoselective Pictet-Spengler reaction to give the key intermediate, (S)-norcoclaurine in benzylisoquinoline... 
norcoclaurine synthase | ENZYME | TETRAHYDROISOQUINOLINES | BENZYLISOQUINOLINE ALKALOID BIOSYNTHESIS | ALKYLATION | tetrahydroisoquinoline | kinetic resolution | DOPAMINE-1ST MECHANISM | CHEMISTRY, PHYSICAL | Pictet-Spengler | biocatalysis
Journal Article
FRONTIERS IN PLANT SCIENCE, ISSN 1664-462X, 08/2019, Volume 10, p. 1058
Journal Article
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, ISSN 0002-7863, 07/2019, Volume 141, Issue 28, pp. 11230 - 11238
The Pictet-Spengler (PS) reaction, i.e., the acidcatalyzed condensation between beta-arylethylamine and an aldehyde or a ketone and the subsequent ring... 
ASYMMETRIC-SYNTHESIS | BENZYLISOQUINOLINE ALKALOID BIOSYNTHESIS | STEREOSELECTIVITY | PURIFICATION | DOPAMINE-1ST MECHANISM | INTERMEDIATE | CASCADES | ENABLES | CHEMISTRY, MULTIDISCIPLINARY | CYCLIZATION | SCAFFOLD | Index Medicus | Naturvetenskap | Natural Sciences | Kemi | Chemical Sciences
Journal Article
FRONTIERS IN MICROBIOLOGY, ISSN 1664-302X, 04/2019, Volume 10, p. 925
Secondary metabolite biosynthesis in medicinal plants is multi-step cascade known to be modulated by associated endophytes. While a single endophyte is not... 
benzylisoquinoline alkaloids | BACTERIA | FUNGUS | ROOT | consortium | Papaver somniferum | MICROBIOLOGY | endophytes | morphine | OPIUM POPPY | opium | STRESS TOLERANCE | PLANT-GROWTH | PCR | Consortia | Metabolites | Medicine, Botanic | Genes | Physiological aspects | Morphine | Biosynthesis | Medicine, Herbal
Journal Article