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Clinical Cancer Research, ISSN 1078-0432, 2014, Volume 20, Issue 4, pp. 912 - 925
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 02/2017, Volume 114, Issue 7, pp. E1072 - E1080
MYC is a major cancer driver but is documented to be a difficult therapeutic target itself. Here, we report on the biological activity, the structural basis,... 
Inhibitor | Bromodomain | PI3K | MYC | BRD4 | DESIGN | MULTIDISCIPLINARY SCIENCES | KINASE | BET BROMODOMAIN INHIBITION | DISCOVERY | FAMILY | BREAST-CANCER | bromodomain | THERAPY | inhibitor | GENERATION | LEUKEMIA | Biological Sciences | PNAS Plus
Journal Article
Cancer Discovery, ISSN 2159-8274, 03/2013, Volume 3, Issue 3, pp. 309 - 323
Bromodomain inhibition comprises a promising therapeutic strategy in cancer, particularly for hematologic malignancies. To date, however, genomic biomarkers to... 
ANAPLASTIC LYMPHOMA KINASE | CELL LUNG-CANCER | DRUG-SENSITIVITY | ONCOLOGY | ACUTE LYMPHOBLASTIC-LEUKEMIA | THERAPEUTIC TARGET | N-MYC | C-MYC | ALK KINASE | ACUTE MYELOID-LEUKEMIA | ACTIVATING MUTATIONS | Oncogene Proteins - genetics | RNA, Small Interfering - genetics | Apoptosis - drug effects | Humans | Transcription Factors - deficiency | Apoptosis - genetics | Molecular Targeted Therapy | Transfection | Nuclear Proteins - deficiency | Cell Cycle Checkpoints - genetics | Female | N-Myc Proto-Oncogene Protein | Cell Growth Processes - genetics | Nuclear Proteins - genetics | Child | Neuroblastoma - pathology | Protein Structure, Tertiary | Promoter Regions, Genetic | Neuroblastoma - genetics | Oncogene Proteins - metabolism | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Transcription Factors - genetics | Down-Regulation - drug effects | Azepines - pharmacology | Transcription Factors - metabolism | Triazoles - pharmacology | Xenograft Model Antitumor Assays | Animals | Gene Amplification | Cell Cycle Checkpoints - drug effects | Neuroblastoma - drug therapy | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Mice | Neuroblastoma - metabolism | Proto-Oncogene Proteins c-myc - genetics | RNA, Small Interfering - administration & dosage | neuroblastoma | BET bromodomain inhibitor | MYCN | JQ1 | BRD4
Journal Article
Journal Article
Nature Medicine, ISSN 1078-8956, 2014, Volume 20, Issue 7, pp. 732 - 740
Journal Article
Journal Article
Journal Article
Science Translational Medicine, ISSN 1946-6234, 11/2015, Volume 7, Issue 312, pp. 312ra176 - 312ra176
Journal Article
Journal Article
Cell Reports, ISSN 2211-1247, 09/2015, Volume 12, Issue 12, pp. 1986 - 1996
The underlying molecular mechanisms for many autoimmune diseases are poorly understood. Juvenile idiopathic arthritis (JIA) is an exceptionally well-suited... 
SELECTIVE-INHIBITION | IDENTITY | TARGET | VARIANTS | AUTOIMMUNITY | TRANSCRIPTION | C-MYC | BET BROMODOMAIN INHIBITION | ARTHRITIS | CELL BIOLOGY | Autoimmunity | Leukocytes, Mononuclear - metabolism | Proto-Oncogene Protein c-ets-1 - metabolism | Epigenesis, Genetic | Humans | Synovial Fluid - metabolism | Molecular Sequence Data | Synovial Fluid - drug effects | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Arthritis, Juvenile - drug therapy | Chemokine CXCL12 - genetics | T-Lymphocytes - metabolism | T-Lymphocytes - drug effects | Base Sequence | Receptors, Cytokine - metabolism | Synovial Fluid - cytology | T-Lymphocytes - pathology | Cytokines - genetics | Receptors, Cytokine - genetics | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Leukocytes, Mononuclear - drug effects | Core Binding Factor Alpha 2 Subunit - metabolism | Cytokines - metabolism | Signal Transduction | Proto-Oncogene Proteins - genetics | Arthritis, Juvenile - genetics | Enhancer Elements, Genetic - drug effects | Arthritis, Juvenile - metabolism | Azepines - pharmacology | Triazoles - pharmacology | Leukocytes, Mononuclear - pathology | Chemokine CXCL12 - metabolism | Proto-Oncogene Protein c-ets-1 - genetics | Immunologic Memory | High-Throughput Nucleotide Sequencing | Primary Cell Culture | Core Binding Factor Alpha 2 Subunit - genetics | Arthritis, Juvenile - pathology
Journal Article
International journal of oncology, ISSN 1019-6439, 12/2018, Volume 53, Issue 6, pp. 2503 - 2517
Prostate cancer (PCa) is a malignant tumor with a high incidence in males. Localized tumors can be treated via surgery or radiation; however, it remains... 
Bromodomain containing protein 4 | Bromodomain inhibitor | c-Myc | Forkhead box protein O1 | Prostate cancer | p21 | APOPTOSIS | CELL-PROLIFERATION | bromodomain inhibitor | bromodomain containing protein 4 | forkhead box protein O1 | LYMPHOMAGENESIS | prostate cancer | THERAPY | ONCOLOGY | CLIP-SEQ | STARBASE | BET BROMODOMAIN PROTEINS | CARCINOMA | Neoplasm Transplantation | Prostatic Neoplasms - metabolism | Humans | Middle Aged | Male | Neoplasm Metastasis | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Prostatic Neoplasms - genetics | Aged, 80 and over | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Nuclear Proteins - genetics | Cell Survival - drug effects | Forkhead Box Protein O1 - metabolism | Prostatic Neoplasms - pathology | RNA, Small Interfering - pharmacology | Nuclear Proteins - metabolism | Transcription Factors - genetics | Proto-Oncogene Proteins c-myc - metabolism | Azepines - pharmacology | Transcription Factors - metabolism | Triazoles - pharmacology | Up-Regulation - drug effects | Cell Movement - drug effects | Animals | Cell Line, Tumor | Aged | Cell Proliferation - drug effects | Mice | Proto-Oncogene Proteins c-myc - genetics | Cell Cycle - drug effects | Neoplasm Staging | Forkhead Box Protein O1 - genetics | Antigens | Pathogenesis | RNA polymerase | Metastasis | Gene expression | Kinases | Cancer therapies | Studies | Proteins | Androgens | Cell cycle | Tumors | Apoptosis | Index Medicus
Journal Article