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NATURE, ISSN 0028-0836, 01/2011, Volume 469, Issue 7329, pp. 241 - 244
beta-adrenergic receptors (beta ARs) are G-protein-coupled receptors (GPCRs) that activate intracellular G proteins upon binding catecholamine agonist ligands... 
CRYSTALLIZATION | AMINO-ACID | ACTIVATION | LIGAND-BINDING | BETA-ADRENERGIC-RECEPTORS | PROTEIN-COUPLED RECEPTOR | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | CRYSTALLOGRAPHY | HIGH-AFFINITY BINDING | BETA-ADRENERGIC RECEPTOR | Dobutamine - metabolism | Hydroxyquinolines - chemistry | Catecholamines - metabolism | Albuterol - pharmacology | Amphetamines - pharmacology | Adrenergic beta-1 Receptor Antagonists - pharmacology | Crystallography, X-Ray | Adrenergic beta-1 Receptor Agonists - chemistry | Structure-Activity Relationship | Receptors, Adrenergic, beta-1 - chemistry | Adrenergic beta-1 Receptor Agonists - pharmacology | Turkeys | Adrenergic beta-1 Receptor Antagonists - chemistry | Drug Design | Adrenergic beta-1 Receptor Antagonists - metabolism | Dobutamine - chemistry | Isoproterenol - chemistry | Binding Sites | Hydroxyquinolines - pharmacology | Amphetamines - chemistry | Drug Partial Agonism | Albuterol - metabolism | Hydroxyquinolines - metabolism | Isoproterenol - metabolism | Models, Molecular | Receptors, Adrenergic, beta-1 - metabolism | Serine - chemistry | Serine - metabolism | Dobutamine - pharmacology | Animals | Hydrogen Bonding | Amphetamines - metabolism | Isoproterenol - pharmacology | Protein Stability - drug effects | Albuterol - chemistry | Ligands | Protein Conformation | Adrenergic beta-1 Receptor Agonists - metabolism | Index Medicus
Journal Article
Journal of Chemical Information and Modeling, ISSN 1549-9596, 05/2015, Volume 55, Issue 5, pp. 1045 - 61
Journal Article
Nature Communications, ISSN 2041-1723, 04/2017, Volume 8, Issue 1, pp. 14780 - 14780
Journal Article
Europace, ISSN 1099-5129, 07/2017, Volume 19, Issue 7, pp. 1211 - 1219
Postural tachycardia syndrome (POTS), a common and debilitating cardiovascular disorder, is characterized by an exaggerated heart rate increase during... 
Autoimmunity | Adrenergic receptors | Postural tachycardia syndrome | Allosteric activation | Vasovagal syncope | DIAGNOSIS | CARDIAC & CARDIOVASCULAR SYSTEMS | MANAGEMENT | INAPPROPRIATE SINUS TACHYCARDIA | ORTHOSTATIC INTOLERANCE | NITROGLYCERIN | HYPOTENSION | DISORDER | CONSENSUS STATEMENT | Receptors, Adrenergic, alpha-1 - metabolism | Cricetulus | Immunoglobulin G - blood | Autoantibodies - blood | Humans | Male | Receptors, Adrenergic, beta-2 - immunology | Receptors, Adrenergic, beta-2 - drug effects | Adrenergic beta-1 Receptor Agonists - pharmacology | Case-Control Studies | Adrenergic alpha-1 Receptor Agonists - pharmacology | Adrenergic beta-2 Receptor Agonists - pharmacology | Receptors, Adrenergic, alpha-1 - immunology | Dose-Response Relationship, Drug | Young Adult | Transfection | Receptors, Adrenergic, beta-1 - immunology | Adult | Female | Receptors, Adrenergic, beta-1 - drug effects | CHO Cells | Postural Orthostatic Tachycardia Syndrome - immunology | Receptors, Adrenergic, alpha-1 - drug effects | Receptors, Adrenergic, beta-2 - genetics | Rats | Receptors, Adrenergic, beta-1 - metabolism | Abdominal Muscles - blood supply | Arterioles - drug effects | Vasoconstriction - drug effects | Postural Orthostatic Tachycardia Syndrome - blood | Receptors, Adrenergic, beta-2 - metabolism | Animals | Arterioles - metabolism | Postural Orthostatic Tachycardia Syndrome - diagnosis | Receptors, Adrenergic, alpha-1 - genetics | Adolescent | Receptors, Adrenergic, beta-1 - genetics | In Vitro Techniques | Index Medicus | Clinical Research | Editor's Choice | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Immunologi inom det medicinska området | Immunology in the medical area
Journal Article
Clinical and Experimental Pharmacology and Physiology, ISSN 0305-1870, 09/2012, Volume 39, Issue 9, pp. 779 - 785
Journal Article
Journal of Pharmaceutical and Biomedical Analysis, ISSN 0731-7085, 11/2015, Volume 115, pp. 339 - 344
Chromatograms of extract with the β AR/CMC-Offline-UPLC/MS method. (A) β -AR/CMC chromatogram of extract. The fraction was collected. (B) UPLC/MS chromatograms... 
UPLC/MS | Coptis chinensis | Coptisine | Cell membrane chromatography | β1-Adrenergic receptors | Cricetulus | Rats, Wistar | Apoptosis - drug effects | Plant Extracts - pharmacology | Adrenergic beta-1 Receptor Antagonists - pharmacology | Male | Chromatography, High Pressure Liquid | Coptis - chemistry | Berberine - metabolism | Plant Extracts - metabolism | Transfection | Berberine - analogs & derivatives | Mass Spectrometry | Myocardial Infarction - pathology | Myocardium - metabolism | Adrenergic beta-1 Receptor Antagonists - metabolism | Metoprolol - metabolism | Cell Membrane - metabolism | Receptors, Adrenergic, beta-1 - drug effects | Phytotherapy | Cell Membrane - drug effects | Superoxide Dismutase - metabolism | CHO Cells | Disease Models, Animal | Binding, Competitive | Malondialdehyde - metabolism | Myocardium - pathology | Plant Extracts - isolation & purification | Receptors, Adrenergic, beta-1 - metabolism | Myocardial Infarction - metabolism | Berberine - isolation & purification | Berberine - pharmacology | Myocytes, Cardiac - pathology | Animals | Myocytes, Cardiac - drug effects | Myocytes, Cardiac - metabolism | Receptors, Adrenergic, beta-1 - genetics | Myocardial Infarction - prevention & control | Adrenergic beta-1 Receptor Antagonists - isolation & purification | Plants, Medicinal | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2017, Volume 12, Issue 7, pp. e0180319 - e0180319
The beta-1 adrenergic receptor (ADRB1) is a promising therapeutic target intrinsically involved in the cognitive deficits and pathological features associated... 
7-TRANSMEMBRANE RECEPTORS | ACTIVATION | INHIBITION | INTERFERON-GAMMA | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | FUNCTIONAL SELECTIVITY | NECROSIS-FACTOR-ALPHA | MICE | B-MEDIATED TRANSCRIPTION | Phenyl Ethers - pharmacokinetics | Cricetulus | Models, Chemical | Humans | Crystallography, X-Ray | Male | Adrenergic beta-1 Receptor Agonists - chemistry | Structure-Activity Relationship | Receptors, Adrenergic, beta-1 - chemistry | Propanolamines - pharmacokinetics | Brain - metabolism | Neurocognitive Disorders - drug therapy | Phenyl Ethers - chemistry | Propanolamines - therapeutic use | Adrenergic beta-1 Receptor Agonists - pharmacokinetics | Molecular Structure | Neurocognitive Disorders - metabolism | CHO Cells | Adrenergic beta-1 Receptor Agonists - therapeutic use | Cricetinae | Magnetic Resonance Spectroscopy | Mice, Inbred C57BL | Cells, Cultured | Alzheimer Disease - drug therapy | Models, Molecular | Receptors, Adrenergic, beta-1 - metabolism | Permeability | Drug Discovery | Rats, Sprague-Dawley | Animals | Phenyl Ethers - therapeutic use | Propanolamines - chemistry | Alzheimer Disease - metabolism | Cell Line, Tumor | Protein Binding | GTP-Binding Proteins - metabolism | Epinephrine | Care and treatment | Receptors | Usage | Cellular signal transduction | Research | Alzheimer's disease | Health aspects | Neuroprotection | Brain | Disorders | Cognitive ability | Cognition | Arrestin | Isoproterenol | Kinases | Neuromodulation | Modulators | Recruitment | Lipopolysaccharides | Signal transduction | Rodents | Tumor necrosis factor-TNF | Neurodegenerative diseases | Pharmacology | Inflammation | b-Arrestin | Pathology | Tumor necrosis factor | Adrenergic receptors | Transduction | In vitro methods and tests | Index Medicus
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 06/2013, Volume 169, Issue 3, pp. 528 - 538
PDE3 and/or PDE4 control ventricular effects of catecholamines in several species but their relative effects in failing human ventricle are unknown. We... 
inotropism and lusitropism | human heart failure | and β | metoprolol | adrenoceptors | phosphodiesterases 3 and 4 | noradrenaline and adrenaline | β | Adrenergic beta-1 Receptor Antagonists - adverse effects | Heart Failure - surgery | Cyclic Nucleotide Phosphodiesterases, Type 3 - chemistry | Norepinephrine - pharmacology | Adrenergic alpha-Agonists - chemistry | Phosphodiesterase 3 Inhibitors - pharmacology | Humans | Middle Aged | Adrenergic beta-1 Receptor Antagonists - pharmacology | Heart Failure - physiopathology | Myocardial Contraction - drug effects | Receptors, Adrenergic, beta-1 - chemistry | Adrenergic beta-1 Receptor Antagonists - therapeutic use | Adrenergic beta-Agonists - chemistry | Epinephrine - agonists | Receptors, Adrenergic, beta-2 - chemistry | Cardiotonic Agents - therapeutic use | Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - chemistry | Adrenergic beta-2 Receptor Antagonists - pharmacology | Adrenergic beta-Agonists - pharmacology | Heart Transplantation | Metoprolol - therapeutic use | Receptors, Adrenergic, beta-1 - metabolism | Drug Resistance - drug effects | Heart Failure - metabolism | Anti-Arrhythmia Agents - therapeutic use | Cardiotonic Agents - pharmacology | Metoprolol - adverse effects | Norepinephrine - agonists | Phosphodiesterase 4 Inhibitors - pharmacology | Receptors, Adrenergic, beta-2 - metabolism | Heart Failure - drug therapy | Heart Ventricles - physiopathology | Anti-Arrhythmia Agents - adverse effects | Adrenergic alpha-Agonists - pharmacology | Heart Ventricles - metabolism | In Vitro Techniques | Epinephrine - pharmacology | Heart Ventricles - drug effects | Index Medicus | Research Paper with | β1 and β2 adrenoceptors
Journal Article
FASEB Journal, ISSN 0892-6638, 01/2015, Volume 29, Issue 1, pp. 286 - 299
Journal Article
Journal of Investigative Dermatology, ISSN 0022-202X, 04/2019, Volume 139, Issue 4, pp. 940 - 950
We assessed the roles of Smad7 in skin inflammation and wound healing using genetic and pharmacological approaches. In K5.TGFβ1/K5.Smad7 bigenic (double... 
OVEREXPRESSION | PLASMA | TRANSFORMING-GROWTH-FACTOR-BETA-1 | TRANSFORMING GROWTH-FACTOR-BETA-1 | KERATINOCYTES | INDUCTION | DERMATOLOGY
Journal Article
Cell Research, ISSN 1001-0602, 01/2009, Volume 19, Issue 1, pp. 89 - 102
The TGF beta signaling pathway is conserved from flies to humans and has been shown to regulate such diverse processes as cell proliferation, differentiation,... 
Tumor-suppression | Breast cancer | Metastasis | Cytostasis | EMT | Prognostics | SIGNALING PATHWAYS | HUMAN-BREAST-CANCER | TUMOR PROGRESSION | ENHANCES TUMORIGENESIS | cytostasis | MAMMARY-CARCINOMA | breast cancer | CELL-CYCLE ARREST | tumor-suppression | CELL BIOLOGY | SUPPRESSES METASTASIS | metastasis | prognostics | TRANSFORMING GROWTH-FACTOR-BETA-1 | BONE METASTASIS | GROWTH-FACTOR BETA-1
Journal Article