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JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, ISSN 0022-3565, 03/2013, Volume 344, Issue 3, pp. 708 - 717
The concept of ligand bias at G protein-coupled receptors broadens the possibilities for agonist activities and provides the opportunity to develop safer, more... 
BETA-ARRESTIN 2 | SIGNAL-TRANSDUCTION | 7-TRANSMEMBRANE RECEPTORS | ACTIVATION | PAIN | BETA-ARRESTIN-2 | TOLERANCE | FUNCTIONAL SELECTIVITY | PHARMACOLOGY & PHARMACY | KNOCKOUT MICE | AGONIST
Journal Article
Biological Psychiatry, ISSN 0006-3223, 04/2012, Volume 71, Issue 8, pp. 714 - 724
Background: Cannabinoid CB receptors (CB Rs) mediate the effects of -tetrahydrocannabinol (THC), the psychoactive component in marijuana. Repeated THC... 
GPCR | cannabinoid receptors | tolerance | Beta-arrestin | statistical parametric mapping
Journal Article
PHARMACOLOGICAL REVIEWS, ISSN 0031-6997, 01/2013, Volume 65, Issue 1, pp. 223 - 254
Morphine and related m-opioid receptor (MOR) agonists remain among the most effective drugs known for acute relief of severe pain. A major problem in treating... 
BETA-ARRESTIN 2 | PERIAQUEDUCTAL GRAY NEURONS | TERMINAL SPLICE VARIANTS | AGONIST-SELECTIVE MECHANISMS | MORPHINE ANTINOCICEPTIVE TOLERANCE | BASAL SIGNALING ACTIVITY | PHARMACOLOGY & PHARMACY | RAT LOCUS-COERULEUS | SINGLE-NUCLEOTIDE POLYMORPHISM | PROTEIN-COUPLED-RECEPTOR | PHOSPHOLIPASE-D ACTIVATION
Journal Article
by Fan, XF and Gu, XJ and Zhao, R and Zheng, QQ and Li, L and Yang, WB and Ding, L and Xue, F and Fan, JM and Gong, YS and Wang, YY
PLOS ONE, ISSN 1932-6203, 08/2016, Volume 11, Issue 8
Previous studies have demonstrated that beta(2)-adrenergic receptors (beta(2)ARs) can be phosphorylated by G protein-coupled receptor kinases (GRKs) and... 
PROTEIN-KINASE-A | MYOCYTES | MULTIDISCIPLINARY SCIENCES | BETA-ARRESTIN | MICE | BINDING
Journal Article
MOLECULAR PHARMACOLOGY, ISSN 0026-895X, 08/2015, Volume 88, Issue 2, pp. 335 - 346
Biased agonism is having a major impact on modern drug discovery, and describes the ability of distinct G protein-coupled receptor (GPCR) ligands to activate... 
INTERNALIZATION | LIGAND BIAS | MORPHINE | ENDOMORPHIN-2 | FUNCTIONAL SELECTIVITY | PHARMACOLOGY & PHARMACY | BETA-ARRESTIN | KNOCKOUT MICE | G-PROTEIN ACTIVATION | PHOSPHORYLATION SITES | ANALGESIA
Journal Article
NATURE CHEMICAL BIOLOGY, ISSN 1552-4450, 07/2012, Volume 8, Issue 7, pp. 622 - 630
Functional selectivity of G protein-coupled receptor (GPCR) ligands toward different downstream signals has recently emerged as a general hallmark of this... 
PATHWAYS | ACTIVATION | CONFORMATIONAL-CHANGES | BETA-ARRESTIN-2 | ADENYLYL-CYCLASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | INCREASES | PROTEIN-COUPLED RECEPTORS | FUNCTIONAL SELECTIVITY | BETA-ARRESTIN | SIGNALING COMPLEXES
Journal Article
JOURNAL OF CLINICAL INVESTIGATION, ISSN 0021-9738, 09/2007, Volume 117, Issue 9, pp. 2445 - 2458
Deleterious effects on the heart from chronic stimulation of beta-adrenergic receptors (beta ARs), members of the 7 transmembrane receptor family, have... 
MEDICINE, RESEARCH & EXPERIMENTAL | GROWTH-FACTOR RECEPTOR | CARDIOMYOCYTE HYPERTROPHY | SIGNAL-REGULATED KINASES | PROTEIN-COUPLED RECEPTOR | HEART-FAILURE | CARDIAC DYSFUNCTION | BETA-ARRESTIN | ERK ACTIVATION | BETA-ADRENERGIC RECEPTOR | ANGIOTENSIN RECEPTOR
Journal Article
by Yang, F and Yu, X and Liu, C and Qu, CX and Gong, Z and Liu, HD and Li, FH and Wang, HM and He, DF and Yi, F and Song, C and Tian, CL and Xiao, KH and Wang, JY and Sun, JP
NATURE COMMUNICATIONS, ISSN 2041-1723, 09/2015, Volume 6
Specific arrestin conformations are coupled to distinct downstream effectors, which underlie the functions of many G-protein-coupled receptors (GPCRs). Here,... 
RECRUITMENT | STRESS-RESPONSE PATHWAY | BIASED AGONISM | PROTEIN-COUPLED RECEPTOR | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | BETA-ARRESTIN | VISUAL ARRESTIN | PHOSPHORYLATION SITES | C-SRC | KINASES
Journal Article
Nature, ISSN 0028-0836, 08/2014, Volume 512, Issue 7513, pp. 218 - 222
Journal Article
TRENDS IN PHARMACOLOGICAL SCIENCES, ISSN 0165-6147, 04/2007, Volume 28, Issue 4, pp. 166 - 172
Drugs that act on dopamine neurotransmission are important tools for the management of multiple neuropsychiatric disorders. Classically, dopamine receptors... 
GLYCOGEN-SYNTHASE KINASE-3-BETA | PROTEIN | REWARDING PROPERTIES | IN-VIVO | PHARMACOLOGY & PHARMACY | BETA-ARRESTIN | MICE | DOPAMINE-RECEPTORS | LITHIUM | COUPLED RECEPTOR INTERNALIZATION | PREFRONTAL CORTEX
Journal Article
Nature, ISSN 0028-0836, 08/2016, Volume 537, Issue 7619, pp. 185 - 190
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 06/2019, Volume 294, Issue 24, pp. 9416 - 9429
The human complement component, C5a, binds two different seven-transmembrane receptors termed C5aR1 and C5aR2. C5aR1 is a prototypical G-protein-coupled... 
signal transduction | BIOCHEMISTRY & MOLECULAR BIOLOGY | cell signaling | BETA-ARRESTIN | G-protein-coupled receptor (GPCR) | ANAPHYLATOXIN | arrestin | complement | DISCOVERY
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 04/2019, Volume 62, Issue 7, pp. 3753 - 3772
G protein-coupled receptors (GPCRs) are capable of downstream signaling through distinct noncanonical pathways such as beta-arrestins in addition to the... 
ACTIVATION | DESIGN | CHEMISTRY, MEDICINAL | BIASED AGONISM | LIGANDS | OPIOID RECEPTOR | BETA-ARRESTIN-2 | TRANSDUCTION | BETA-ARRESTIN | DISCOVERY | MOLECULAR-MECHANISMS
Journal Article
PHARMACOLOGICAL REVIEWS, ISSN 0031-6997, 12/2011, Volume 63, Issue 4, pp. 1001 - 1019
Opioids are the most effective analgesic drugs for the management of moderate or severe pain, yet their clinical use is often limited because of the onset of... 
BETA-ARRESTIN 2 | CLATHRIN-MEDIATED ENDOCYTOSIS | PROTEIN-KINASE-C | TERMINAL SPLICE VARIANTS | MORPHINE ANTINOCICEPTIVE TOLERANCE | IN-VIVO | COUPLED RECEPTORS | PHARMACOLOGY & PHARMACY | RAT LOCUS-COERULEUS | AGONIST-SPECIFIC REGULATION | SEROTONIN 2A RECEPTOR
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 10/2018, Volume 61, Issue 19, pp. 8895 - 8907
While mu opioid receptor (MOR) agonists are especially effective as broad-spectrum pain relievers, it has been exceptionally difficult to achieve a clear... 
BETA-ARRESTIN 2 | LACKING | POTENT | CHEMISTRY, MEDICINAL | TRV130 | TOLERANCE | FUNCTIONAL SELECTIVITY | MORPHINE ANALGESIA | KNOCKOUT MICE | DISCOVERY | DEPENDENCE
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 03/2000, Volume 97, Issue 7, pp. 3684 - 3689
Heptahelical receptors that interact with heterotrimeric G proteins represent the largest family of proteins involved in signal transduction across biological... 
INTERNALIZATION | COEXPRESSION | PROTEIN | GENE | MULTIDISCIPLINARY SCIENCES | BETA-ARRESTIN | ENDOCYTOSIS | BINDING
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 01/2019, Volume 148, Issue 1, pp. 46 - 62
βarrestin (βarr)-1 and -2 are ubiquitously (outside the retina) expressed G-protein-coupled receptor adapter proteins. They uncouple G-protein-coupled... 
spontaneously hypertensive rat | renin–angiotensin–aldosterone system | astrocytes | Angiotensin type 1 receptor | beta-arrestin | G-protein-coupled receptor
Journal Article
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