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Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2018, Volume 115, Issue 21, pp. 5474 - 5479
Mammalian sex determination is controlled by the antagonistic interactions of two genetic pathways: The SRY-SOX9-FGF9 network promotes testis determination... 
SOX9 Transcription Factor/genetics | Wnt Proteins/antagonists & inhibitors | Humans | Cells, Cultured | Testis/metabolism | Male | Zebrafish | Sex Differentiation | Mutation, Missense | Disorders of Sex Development/genetics | Young Adult | Animals | Gene Expression Regulation, Developmental | Adolescent | Gonads/metabolism | Embryo, Nonmammalian/cytology | Thrombospondins/genetics | Adult | Female | beta Catenin/antagonists & inhibitors | Mice | Ubiquitin-Protein Ligases/genetics | ZNRF3 | DSD | Sex determination | WNT signaling | Organogenesis | OVARIAN DEVELOPMENT | MULTIDISCIPLINARY SCIENCES | organogenesis | BETA-CATENIN | REVERSAL | R-SPONDIN | TUMOR-SUPPRESSOR | MICE | TESTIS DEVELOPMENT | SOX9 | DIFFERENTIATION | sex determination | CRITICAL TIME WINDOW | Embryo, Nonmammalian - cytology | Testis - metabolism | Thrombospondins - genetics | Embryo, Nonmammalian - metabolism | Gonads - pathology | Ubiquitin-Protein Ligases - physiology | Wnt Proteins - metabolism | Wnt Proteins - genetics | Disorders of Sex Development - pathology | SOX9 Transcription Factor - metabolism | Disorders of Sex Development - genetics | beta Catenin - metabolism | beta Catenin - genetics | Gonads - metabolism | Testis - pathology | beta Catenin - antagonists & inhibitors | Ubiquitin-Protein Ligases - genetics | Wnt Proteins - antagonists & inhibitors | SOX9 Transcription Factor - genetics | Thrombospondins - metabolism | Biological research | Physiological aspects | Genetic aspects | Cellular signal transduction | Research | Wnt proteins | Sex determination, Genetic | Biology, Experimental | Wnt Proteins / genetics | SOX9 Transcription Factor / metabolism | SOX9 Transcription Factor / genetics | beta Catenin / metabolism | Testis / pathology | Life Sciences | Gonads / metabolism | Thrombospondins / metabolism | Genetics | Testis / metabolism | beta Catenin / genetics | Disorders of Sex Development / pathology | beta Catenin / antagonists & inhibitors | Wnt Proteins / antagonists & inhibitors | Embryo, Nonmammalian / cytology | Wnt Proteins / metabolism | Ubiquitin-Protein Ligases / genetics | Gonads / pathology | Thrombospondins / genetics | Ubiquitin-Protein Ligases / physiology | Disorders of Sex Development / genetics | Embryo, Nonmammalian / metabolism | Human genetics | Biological Sciences
Journal Article
PLoS biology, ISSN 1545-7885, 2009, Volume 7, Issue 6, p. e1000121
Journal Article
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2011, Volume 108, Issue 15, pp. 5954 - 5963
Misregulated β-catenin responsive transcription (CRT) has been implicated in the genesis of various malignancies, including colorectal carcinomas, and it is a... 
Molecules | HT29 cells | HEK293 cells | HCT116 cells | Epithelial cells | Drosophila | Medical treatment | Cell lines | Cells | Tumors | High-throughput s.creen | T.hiazole | T.hiazolidinedione | Beta-catenin | O.xazole | beta-catenin | CELLS | thiazolidinedione | ACTIVATION | AXIN | MULTIDISCIPLINARY SCIENCES | COMPONENTS | E-CADHERIN | PHOSPHORYLATED BETA-CATENIN | oxazole | high-throughput screen | WNT PROTEINS | WNT/BETA-CATENIN | COLORECTAL-CANCER | thiazole | HOT-SPOTS | Transcription, Genetic - drug effects | Wnt1 Protein - antagonists & inhibitors | Wnt1 Protein - genetics | Colonic Neoplasms - drug therapy | Humans | Drug Discovery - methods | Antineoplastic Agents - therapeutic use | Oxazoles - chemistry | Wnt Proteins - genetics | RNA Interference | Antineoplastic Agents - isolation & purification | Oxazoles - isolation & purification | Drosophila Proteins - antagonists & inhibitors | Oxazoles - therapeutic use | Genes, Reporter | Antineoplastic Agents - chemistry | beta Catenin - genetics | Xenograft Model Antitumor Assays | Animals | High-Throughput Screening Assays | Small Molecule Libraries | beta Catenin - antagonists & inhibitors | Cell Line, Tumor | Mice | Drosophila Proteins - genetics | Wnt Proteins - antagonists & inhibitors | Drosophila melanogaster | Drug Screening Assays, Antitumor | Cellular signal transduction | Genetic aspects | Genetic screening | Methods | Biological Sciences
Journal Article
Development, ISSN 0950-1991, 05/2011, Volume 138, Issue 10, pp. 1967 - 1975
During male sexual differentiation, the transforming growth factor-beta (TGF-beta) signaling molecule anti-Mullerian hormone (AMH; also known as Mullerian... 
β-Catenin | Mouse | AMH | MIS | Wnt4 | Müllerian duct regression | MESENCHYMAL CELLS | INHIBITING SUBSTANCE | RECEPTOR | KIDNEY DEVELOPMENT | DEVELOPMENTAL BIOLOGY | Mullerian duct regression | SIGNAL-TRANSDUCTION | HORMONE | WNT/BETA-CATENIN | beta-Catenin | FEMALE REPRODUCTIVE-TRACT | EXPRESSION | Receptors, Peptide - physiology | Receptors, Transforming Growth Factor beta - genetics | Testis - metabolism | Wnt Proteins - deficiency | Male | DNA Primers - genetics | Mice, 129 Strain | Receptors, Transforming Growth Factor beta - physiology | Receptors, Peptide - genetics | Wnt Proteins - genetics | Testis - embryology | Gene Expression Regulation, Developmental | Base Sequence | Female | beta Catenin - physiology | Genitalia, Female - metabolism | Mullerian Ducts - metabolism | Mesoderm - embryology | Signal Transduction | Receptors, Peptide - deficiency | Mice, Inbred C57BL | Sex Differentiation - genetics | beta Catenin - deficiency | Genitalia, Female - embryology | Mice, Transgenic | Anti-Mullerian Hormone - physiology | beta Catenin - genetics | Mice, Knockout | Pregnancy | Sex Differentiation - physiology | Animals | Models, Biological | Mesoderm - metabolism | Mice | Mullerian Ducts - embryology | Wnt Proteins - physiology | Wnt4 Protein | Receptors, Transforming Growth Factor beta - deficiency | Testis | Mesoderm | Sex Differentiation | Wnt Proteins | Life Sciences | Mullerian Ducts | Anti-Mullerian Hormone | Receptors, Peptide | beta Catenin | DNA Primers | Genitalia, Female | Receptors, Transforming Growth Factor beta | Reproductive Biology
Journal Article