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Biochemical journal, ISSN 1470-8728, 2011, Volume 435, Issue 2, pp. 297 - 312
Assessing mitochondrial dysfunction requires definition of the dysfunction to be investigated... 
Mitochondrion | Membrane potential | Respiration | Respiratory control | Mitochondrial function | respiratory control | CEREBELLAR GRANULE NEURONS | SPARE RESPIRATORY CAPACITY | BROWN-ADIPOSE-TISSUE | mitochondrial function | ELECTROCHEMICAL POTENTIAL GRADIENT | BIOCHEMISTRY & MOLECULAR BIOLOGY | respiration | DOWN ELASTICITY ANALYSIS | RAT-LIVER MITOCHONDRIA | mitochondrion | SKELETAL-MUSCLE MITOCHONDRIA | INS-1E INSULINOMA CELLS | membrane potential | PANCREATIC BETA-CELLS | METABOLIC CONTROL-THEORY | Mitochondrial Diseases - pathology | Protons | Clinical Laboratory Techniques | Humans | Mitochondrial Diseases - metabolism | Cells - ultrastructure | Mitochondria - metabolism | Mitochondria - pathology | Cells - pathology | Animals | Energy Metabolism | Models, Biological | Cells - metabolism | Electron Transport - physiology | Mitochondria - physiology | Mitochondrial Diseases - physiopathology | Mitochondrial Diseases - diagnosis | FCCP, carbonyl cyanide p-trifluoromethoxyphenylhydrazone | state 4o, state 4oligomycin | TPMP, triphenylmethylphosphonium | TMRM, tetramethylrhodamine methyl ester | PMPI, plasma membrane potential indicator | UQ, ubiquinone | Review | pmf, protonmotive force | state 4 | Δψm, mitochondrial membrane potential | state 3u, uncoupled state | Δψp, plasma membrane potential | TPP, tetraphenylphosphonium | ΔpH, pH gradient | RCR, respiratory control ratio (state 3 | R123, rhodamine 123
Journal Article
Journal Article
Frontiers in endocrinology (Lausanne), ISSN 1664-2392, 2013, Volume 4, p. 37
Beta cell dysfunction and insulin resistance are inherently complex with their interrelation for triggering the pathogenesis of diabetes also somewhat undefined... 
Obesity | Oxidative stress | Diabetes | Proliferation | Beta cell compensation | beta cell compensation | Oxidative Stress | proliferation | diabetes
Journal Article
Circulation Research, ISSN 0009-7330, 02/2012, Volume 110, Issue 4, pp. 598 - 608
RATIONALE:Hyperamylinemia is common in patients with obesity and insulin resistance, coincides with hyperinsulinemia, and results in amyloid deposition. Amylin... 
hyperamylinemia | UCD-T2DM rat | calcium | diabetic cardiomyopathy | hyperinsulinemia | HIP rat | CARDIAC & CARDIOVASCULAR SYSTEMS | IMPAIRED GLUCOSE-TOLERANCE | ISLET-AMYLOID POLYPEPTIDE | INSULIN-RESISTANCE | VENTRICULAR EXPRESSION | DISEASE | PANCREATIC BETA-CELLS | PERIPHERAL VASCULAR DISEASE | NONISCHEMIC HEART-FAILURE | HEMATOLOGY | UCD-T2DM RATS | LIGHT-CHAINS | Immunohistochemistry | Prediabetic State - metabolism | Diabetic Cardiomyopathies - metabolism | Diabetic Cardiomyopathies - etiology | Ventricular Function, Left | Humans | Middle Aged | Heart Failure - physiopathology | Cardiomegaly - etiology | Male | Islet Amyloid Polypeptide - genetics | Diabetes Mellitus, Type 2 - metabolism | Diabetic Cardiomyopathies - physiopathology | Young Adult | Ventricular Remodeling | Myocardium - metabolism | Ultrasonography | Adult | Female | Heart Failure - diagnostic imaging | Heart Failure - etiology | Calcium Signaling | Diabetes Mellitus, Type 2 - complications | Disease Models, Animal | Diabetic Cardiomyopathies - diagnostic imaging | Rats, Transgenic | Obesity - complications | NFATC Transcription Factors - metabolism | Cardiomegaly - physiopathology | Islet Amyloid Polypeptide - metabolism | Rats | Ventricular Dysfunction, Left - etiology | Histone Deacetylases - metabolism | Myocardium - pathology | Heart Failure - metabolism | Prediabetic State - complications | Rats, Sprague-Dawley | Blotting, Western | Ventricular Dysfunction, Left - physiopathology | Obesity - metabolism | Ventricular Dysfunction, Left - metabolism | Animals | Aged | Ventricular Pressure | Cardiomegaly - metabolism
Journal Article
Antioxidants & redox signaling, ISSN 1557-7716, 2017, Volume 26, Issue 10, pp. 501 - 518
...), a disease that currently affects ∼8% of the adult population worldwide. Pancreatic beta-cell dysfunction and loss are central to the disease process, although... 
Forum Review Articles | beta cell | hypoxia | diabetes | zinc | Insulin secretion | CHELATING-AGENT TPEN | OBSTRUCTIVE SLEEP-APNEA | OXYGEN SPECIES PRODUCTION | TRANSCRIPTION FACTOR PDX-1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | FATTY-ACID-METABOLISM | insulin secretion | GLYCEROL-PHOSPHATE DEHYDROGENASE | GLUTATHIONE REDOX STATE | IMPAIRED INSULIN-SECRETION | FREE CYTOSOLIC ZN2 | ENDOCRINOLOGY & METABOLISM | GENOME-WIDE ASSOCIATION | Reactive Oxygen Species - metabolism | Oxidative Stress | Zinc - metabolism | Antioxidants - metabolism | Humans | Diabetes Mellitus - metabolism | Lipid Metabolism | Mitochondria - metabolism | Antioxidants - pharmacology | Diabetes Mellitus, Type 2 - metabolism | Hypoxia - metabolism | Antioxidants - therapeutic use | Insulin - metabolism | Insulin-Secreting Cells - metabolism | Animals | Insulin-Secreting Cells - drug effects | Islets of Langerhans - metabolism | Diabetes Mellitus - therapy | Diabetes Mellitus, Type 2 - therapy | Glucose - metabolism | Islets of Langerhans Transplantation | Diabetes Mellitus - etiology | Diabetes Mellitus, Type 2 - etiology | Hypoxia (Aquatic ecology) | Oxidative stress | Pancreatic beta cells | Research | Diabetes | Health aspects | Reactive oxygen species | Genes | Risk | Glucose | Metabolic syndrome | Antioxidants | Mitochondria | Hyperglycemia | Nutrients | Damage accumulation | Pancreas | Diabetes mellitus (non-insulin dependent) | Secretion | Diabetes mellitus | Health risks | Gene expression | Insulin | Fatty acids | Zinc | Zinc transporter | Beta cells | Molecular modelling | Hypoxia | Electron transport | Transporter | Metabolic disorders | Forum Review
Journal Article
American journal of physiology: endocrinology and metabolism, ISSN 1522-1555, 2011, Volume 300, Issue 2, pp. E255 - E262