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Biophysical Journal, ISSN 0006-3495, 07/2019, Volume 117, Issue 2, pp. 269 - 280
The -crystallins of the eye lens nucleus are among the longest-lived proteins in the human body. Synthesized in utero, they must remain folded and soluble... 
TRYPTOPHAN FLUORESCENCE | MYXOCOCCUS-XANTHUS | IN-VITRO | BIOPHYSICS | STRUCTURAL SIMILARITY | S-CRYSTALLIN | HUMAN CATARACT | PROTEIN-S | EYE LENS | BETA-CRYSTALLIN | AGGREGATION | Index Medicus
Journal Article
JOURNAL OF APPLIED PHYSIOLOGY, ISSN 8750-7587, 06/2019, Volume 126, Issue 6, pp. 1607 - 1618
alpha beta-crystallin (CRYAB) is an important actor in the immediate cell stabilizing response following mechanical stress in skeletal muscle. Yet, only little... 
fiber types | SPORT SCIENCES | PHYSIOLOGY | ACTIN | B-CRYSTALLIN | MEMBRANE | LENGTHENING CONTRACTIONS | CONTRACTION-INDUCED INJURY | alpha beta-crystallin | STRESS-PROTEIN | HEAT-SHOCK PROTEINS | small heat shock proteins | MUSCLE-FIBER RECRUITMENT | MOTOR UNITS | ECCENTRIC EXERCISE | resistance exercise | skeletal muscle
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 05/2019, Volume 294, Issue 19, pp. 7546 - 7555
Journal Article
JOURNAL OF PROTEOMICS, ISSN 1874-3919, 02/2017, Volume 154, pp. 128 - 133
Rett syndrome (RTT) is a severe genetic disorder resulting from mutations in the X-linked methyl-CpG-binding protein 2 (MECP2) gene. Recently, a zebrafish... 
Oxidative stress | Energy metabolism | BIOCHEMICAL RESEARCH METHODS | SENSITIVITY | Zebrafish | DISORDERS | NATURAL-HISTORY | MECP2 | Rett syndrome | MOUSE MODEL | MITOCHONDRIAL DYSFUNCTION | Muscle | MUTATIONS | BETA-CRYSTALLIN | EXPRESSION
Journal Article
Investigative Ophthalmology and Visual Science, ISSN 0146-0404, 2009, Volume 50, Issue 8, pp. 3869 - 3875
PURPOSE. Stress-induced crystallin expression is commonly viewed as activation of the cell survival mechanism. The authors analyzed the expression of alpha A-... 
IN-VIVO ELECTROPORATION | LENS EPITHELIAL-CELLS | INDUCED APOPTOSIS | RAT RETINA | GENE-EXPRESSION | OPHTHALMOLOGY | INTRAOCULAR-PRESSURE | BETA-CRYSTALLIN | MICROARRAY ANALYSIS | CATARACT | HEAT-SHOCK-PROTEIN
Journal Article
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, ISSN 1422-0067, 07/2018, Volume 19, Issue 7
The H1069Q substitution is the most frequent mutation of the Cu transporter ATP7B that causes Wilson disease in the Caucasian population. ATP7B localizes to... 
DIAGNOSIS | PROTEIN ATP7B | HOMEOSTASIS | Wilson disease | B-CRYSTALLIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | alpha beta-crystallin | CELL-LINES | CHAPERONE | pharmacological peptide | CHEMISTRY, MULTIDISCIPLINARY | ATPASES | ATP7B | MUTATION | COPPER ACCUMULATION | EXPRESSION
Journal Article
by Ren, ZK and Yang, M and Guan, ZZ and Yu, WF
CURRENT ALZHEIMER RESEARCH, ISSN 1567-2050, 2019, Volume 16, Issue 1, pp. 39 - 48
Background: beta-amyloid (A beta) aggregation plays an important role in the pathogenesis of Alzheimer's disease (AD), and astrocytes can significantly inhibit... 
PROTEIN | MECHANISM | ALZHEIMERS-DISEASE | B-CRYSTALLIN | PHOSPHATIDYLINOSITOL 3-KINASE | MEMORY DEFICITS | beta -amyloid aggregation | alpha beta-crystallin | NEUROSCIENCES | CLINICAL NEUROLOGY | alpha 7 neuronal nicotinic acetylcholine receptors | MOUSE MODEL | A-BETA | dementia | PI3K/Akt signaling pathway | Alzheimer's disease | EXPRESSION | BINDING
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2007, Volume 282, Issue 47, pp. 34276 - 34287
Three mutations (R120G, Q151X, and 464delCT) in the small heat shock protein alpha B-crystallin cause inherited myofibrillar myopathy. In an effort to... 
DESMIN-RELATED MYOPATHY | MARIE-TOOTH-DISEASE | POSTERIOR POLAR CATARACT | MYOGENIC DIFFERENTIATION | INDUCED APOPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MUTATION | CHAPERONE | BETA-CRYSTALLIN | HEREDITARY MOTOR NEUROPATHY | HSP22 HSPB8
Journal Article
International Journal of Ophthalmology, ISSN 2222-3959, 2018, Volume 11, Issue 10, pp. 1577 - 1582
AIM: To summarize the phenotypes and identify the underlying genetic cause of the CRYBB1 and CRYBB2 gene responsible for congenital cataract in two Chinese... 
CRYBB2 | Next-generation sequencing | CRYBB1 | Congenital cataract | HUMAN LENS | GENE | next-generation sequencing | MISSENSE MUTATION | OPHTHALMOLOGY | congenital cataract | BETA-CRYSTALLIN | EPHA2
Journal Article
Journal Article
Investigative Ophthalmology and Visual Science, ISSN 0146-0404, 2008, Volume 49, Issue 12, pp. 5476 - 5483
PURPOSE. The beta B2-crystallin gene (Crybb2) is expressed at an increasing level in the postnatal lens cortex. It has been assumed that the gene functions as... 
PROTEIN | PHILLY MOUSE | LENS EPITHELIAL-CELLS | MUTATION | 2-DIMENSIONAL ELECTROPHORESIS | OPHTHALMOLOGY | ALPHA-B-CRYSTALLIN | MICE | BETA-CRYSTALLIN | EYE LENS | ASSOCIATION
Journal Article
Journal Article
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 43, pp. 74767 - 74780
Protein quality control (PQC) plays a key role in maintaining cardiomyocyte function and homeostasis, and malfunction in PQC is implicated in various forms of... 
Coxsackievirus | AlphaB-crystallin | Dilated cardiomyopathy | Desmin | Viral myocarditis | APOPTOSIS | TRANSLOCATION | coxsackievirus | desmin | CARDIAC DYSFUNCTION | QUALITY CONTROL | ISCHEMIA | CELL BIOLOGY | HEAT-SHOCK PROTEINS | DESMIN-RELATED CARDIOMYOPATHY | MOUSE MODEL | viral myocarditis | STRESS | BETA-CRYSTALLIN | alphaB-crystallin | dilated cardiomyopathy
Journal Article
Journal Article
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, ISSN 0175-7571, 12/2016, Volume 45, Issue 8, pp. 853 - 859
Superoxide dismutase [Cu-Zn], or SOD1, is a homo-dimeric protein that functions as an antioxidant by scavenging for superoxides. A wide range of SOD1 variants... 
Electrostatic loop | ALZHEIMERS-DISEASE | DOCKING | Superoxide dismutase | Amyotrophic lateral sclerosis | ALPHA-B-CRYSTALLIN | NEURODEGENERATION | AMYOTROPHIC-LATERAL-SCLEROSIS | MODEL | alpha beta-crystallin | OLIGOMERS | HEAT-SHOCK PROTEINS | BIOPHYSICS | POLYGLUTAMINE AGGREGATION | SUPEROXIDE-DISMUTASE
Journal Article