X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
beta-gamma-subunits (2219) 2219
index medicus (1585) 1585
animals (1249) 1249
biochemistry & molecular biology (1041) 1041
humans (753) 753
signal transduction (497) 497
cell biology (454) 454
neurosciences (427) 427
activation (367) 367
rats (360) 360
gtp-binding proteins - metabolism (349) 349
phosphorylation (326) 326
pharmacology & pharmacy (302) 302
mice (271) 271
molecular sequence data (227) 227
g proteins (225) 225
physiology (224) 224
phospholipase-c (223) 223
amino acid sequence (213) 213
expression (212) 212
pertussis toxin (208) 208
heterotrimeric g-proteins (204) 204
cells (201) 201
proteins (192) 192
male (187) 187
protein-kinase-c (183) 183
signal transduction - physiology (180) 180
signal-transduction (178) 178
cell line (172) 172
biophysics (169) 169
calcium - metabolism (169) 169
cells, cultured (166) 166
enzyme activation (163) 163
binding (160) 160
inhibition (159) 159
gtp-binding proteins - physiology (154) 154
female (150) 150
alpha-subunit (149) 149
receptors (149) 149
adenylate-cyclase (144) 144
map kinase (143) 143
adenylyl cyclase (142) 142
ca2+ channels (142) 142
protein binding (142) 142
receptor (141) 141
g-protein (140) 140
stimulation (140) 140
alpha-subunits (139) 139
g-proteins (135) 135
multidisciplinary sciences (134) 134
coupled receptors (133) 133
transfection (133) 133
research (132) 132
molecular-cloning (126) 126
adenylyl cyclases - metabolism (125) 125
gtp-binding proteins (123) 123
kinetics (121) 121
g protein (118) 118
protein-coupled receptors (117) 117
adenylyl-cyclase (116) 116
patch-clamp techniques (115) 115
virulence factors, bordetella - pharmacology (115) 115
identification (111) 111
cyclic amp - metabolism (109) 109
physiological aspects (108) 108
endocrinology & metabolism (107) 107
calcium channels (105) 105
calcium (102) 102
binding sites (100) 100
cell membrane - metabolism (97) 97
crystal-structure (97) 97
phosphatidylinositol 3-kinase (97) 97
enzyme inhibitors - pharmacology (96) 96
modulation (96) 96
neurons (95) 95
rats, sprague-dawley (94) 94
protein structure, tertiary (92) 92
dose-response relationship, drug (91) 91
in vitro techniques (91) 91
signal transduction - drug effects (90) 90
pleckstrin homology domain (87) 87
protein kinase c - metabolism (87) 87
functional expression (86) 86
models, biological (86) 86
activated protein-kinase (83) 83
cos cells (83) 83
mutation (83) 83
rat-brain (83) 83
type c phospholipases - metabolism (83) 83
brain (82) 82
potassium channels (81) 81
cloning (78) 78
article (77) 77
cattle (77) 77
recombinant proteins - metabolism (77) 77
cricetinae (76) 76
electrophysiology (76) 76
gtp-binding protein (76) 76
heterotrimeric gtp-binding proteins - metabolism (76) 76
phosphoinositide 3-kinase (76) 76
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (2412) 2412
Japanese (15) 15
Chinese (6) 6
French (4) 4
Turkish (2) 2
Russian (1) 1
Spanish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


NATURE, ISSN 0028-0836, 06/2013, Volume 498, Issue 7453, pp. 190 - 190
G-protein-gated inward rectifier K+ (GIRK) channels allow neurotransmitters, through G-protein-coupled receptor stimulation, to control cellular electrical... 
NMR SYSTEM | SODIUM-DEPENDENT ACTIVATION | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | MUSCARINIC POTASSIUM CHANNEL | CRYSTALLOGRAPHY | BETA-GAMMA-SUBUNITS | RECEPTORS | BINDING | PIP2 | RECTIFIER K+ CHANNEL
Journal Article
NATURE CELL BIOLOGY, ISSN 1465-7392, 05/2012, Volume 14, Issue 5, pp. 477 - U80
Stem-cell functions require activation of stem-cell-intrinsic transcriptional programs and extracellular interaction with a niche microenvironment. How the... 
ADHESION | IN-VIVO | SELF-RENEWAL | VASCULAR NICHE | NEUROGENESIS | PROLIFERATION | BETA-GAMMA-SUBUNITS | UBIQUITIN LIGASE HUWE1 | CEREBRAL-CORTEX | BRAIN | CELL BIOLOGY
Journal Article
MOLECULAR PHARMACOLOGY, ISSN 0026-895X, 04/2019, Volume 95, Issue 4, pp. 376 - 385
The neurohypophyseal hormone oxytocin (OT) regulates biologic functions in both peripheral tissues and the central nervous system. In the central nervous... 
SOCIAL-BEHAVIOR | BKCA CHANNELS | ACTIVATION | INHIBITION | POTASSIUM CHANNELS | VASOPRESSIN | HIGH-CONDUCTANCE | PHARMACOLOGY & PHARMACY | BETA-GAMMA-SUBUNITS | PROTEINS | MODULATION
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 03/2015, Volume 352, Issue 3, pp. 480 - 493
G protein-coupled receptors (GPCRs) often activate multiple signaling pathways, and ligands may evoke functional responses through individual pathways. These... 
ACTIVATION | AFFINITY | PHARMACOLOGY | ARRESTIN | PROTEIN-COUPLED-RECEPTORS | FUNCTIONAL SELECTIVITY | PHARMACOLOGY & PHARMACY | BETA-GAMMA-SUBUNITS | ADENYLATE-CYCLASE | ARIPIPRAZOLE
Journal Article
DEVELOPMENTAL CELL, ISSN 1534-5807, 08/2013, Volume 26, Issue 4, pp. 358 - 368
Primary cilia undergo cell-cycle-dependent assembly and disassembly. Emerging data suggest that ciliary resorption is a checkpoint for S phase reentry and that... 
BREAST-CANCER | I RECEPTORS | G(BETA-GAMMA) SUBUNITS | INSULIN-RECEPTOR | NEURITE OUTGROWTH | PROTEIN-KINASE | AGS3 | NEUROGENESIS | DEVELOPMENTAL BIOLOGY | EXPRESSION | CEREBRAL-CORTEX | CELL BIOLOGY
Journal Article
SCIENCE, ISSN 0036-8075, 12/2005, Volume 310, Issue 5754, pp. 1686 - 1690
G protein-coupled receptor kinase 2 (GRK2) plays a key role in the desensitization of G protein-coupled receptor signaling by phosphorylating activated... 
G-ALPHA-SUBUNITS | 2.0 ANGSTROM | SELECTIVE REGULATION | CRYSTAL-STRUCTURE | ADENYLYL-CYCLASE | MULTIDISCIPLINARY SCIENCES | BINDING-SITE | BETA-GAMMA-SUBUNITS | COUPLED RECEPTOR KINASE-2 | MUSCARINIC ACETYLCHOLINE-RECEPTORS | STRUCTURAL DETERMINANTS
Journal Article
ELIFE, ISSN 2050-084X, 04/2016, Volume 5
G protein gated inward rectifier K+ (GIRK) channels open and thereby silence cellular electrical activity when inhibitory G protein coupled receptors (GPCRs)... 
INWARD RECTIFIER | ACTIVATION | SODIUM | MECHANISM | POTASSIUM CHANNELS | BIOLOGY | MEMBRANES | BETA-GAMMA-SUBUNITS | BILAYERS | BINDING | IMMOBILIZATION
Journal Article
Neuron, ISSN 0896-6273, 06/2007, Volume 54, Issue 5, pp. 801 - 812
Endocannabinoids (eCBs) have emerged as key activity-dependent signals that, by activating presynaptic cannabinoid receptors (i.e., CB1) coupled to G protein,... 
SYSNEURO | MOLNEURO | SIGNALING | PROTEIN-KINASE-A | CYCLASE MUTANT MICE | CANNABINOID RECEPTORS | DEPOLARIZATION-INDUCED SUPPRESSION | CEREBELLAR STELLATE CELLS | HIPPOCAMPAL CA1 CELLS | INHIBITORY SYNAPTIC-TRANSMISSION | METABOTROPIC GLUTAMATE RECEPTORS | BETA-GAMMA-SUBUNITS | NEUROSCIENCES | PARALLEL FIBER SYNAPSES
Journal Article
BRITISH JOURNAL OF PHARMACOLOGY, ISSN 0007-1188, 03/2016, Volume 173, Issue 5, pp. 888 - 898
Background and PurposeGalanin is a widely expressed neuropeptide, which in the gut is thought to modulate gastrointestinal motility and secretion. We aimed to... 
ACTIVATION | CONCISE GUIDE | PHARMACOLOGY | RAT ILEUM | GIRK CHANNELS | PHARMACOLOGY & PHARMACY | MOLECULAR-CLONING | BETA-GAMMA-SUBUNITS | G-PROTEIN | PEPTIDE-1 SECRETION | POTASSIUM CHANNEL
Journal Article
SCIENCE, ISSN 0036-8075, 05/2003, Volume 300, Issue 5623, pp. 1256 - 1262
The phosphorylation of heptahelical receptors by heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptor kinases (GRKs) is a universal... 
ALPHA-SUBUNITS | CATALYTIC SUBUNIT | G(BETA-GAMMA) SUBUNITS | HETEROTRIMERIC G-PROTEINS | STRUCTURAL BASIS | GTPASE-ACTIVATING PROTEINS | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | PLECKSTRIN HOMOLOGY DOMAIN | PHOSPHOLIPASE-C-BETA | BINDING
Journal Article
MOLECULAR PHARMACOLOGY, ISSN 0026-895X, 02/2015, Volume 87, Issue 2, pp. 240 - 250
Neuronal voltage-gated N-type (Ca(v)2.2) calcium channels are expressed throughout the nervous system and regulate neurotransmitter release and hence synaptic... 
NEUROPATHIC PAIN | BACLOFEN | C-TERMINUS | CA2+ CHANNELS | PROTEIN-COUPLED RECEPTORS | GIRK CHANNELS | PHARMACOLOGY & PHARMACY | BETA-GAMMA-SUBUNITS | NICOTINIC ACETYLCHOLINE-RECEPTORS | SENSORY NEURONS | MODULATION
Journal Article
MOLECULAR PHARMACOLOGY, ISSN 0026-895X, 07/2015, Volume 88, Issue 1, pp. 151 - 160
UDP-sugars, which are indispensable for protein glycosylation reactions in cellular secretory pathways, also act as important extracellular signaling... 
CELLS | HUMAN NEUTROPHILS | PROTEIN-COUPLED RECEPTOR | FUNCTIONAL EXPRESSION | GPR105 KIAA0001 | PHARMACOLOGY & PHARMACY | ENDOPLASMIC-RETICULUM | BETA-GAMMA-SUBUNITS | FIND-ME SIGNAL | P2Y14 RECEPTOR | MAMMARY-GLAND
Journal Article
JOURNAL OF PHYSIOLOGY-LONDON, ISSN 0022-3751, 04/2013, Volume 591, Issue 7, pp. 1599 - 1612
Key points center dot Voltage-dependent Ca2+ channels mediate a large repertoire of physiological actions, including the generation of dendritic spikes in... 
SYNAPTIC ACTIVATION | PHYSIOLOGY | DISTAL APICAL DENDRITES | SELECTIVE MODULATION | G-PROTEIN REGULATION | SENSITIVE CALCIUM-CHANNELS | BETA-GAMMA-SUBUNITS | PHYSIOLOGICAL FUNCTIONS | HIPPOCAMPAL-NEURONS | NEUROSCIENCES | PROPAGATING ACTION-POTENTIALS | K+ CHANNELS
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 08/2014, Volume 5
The role of G alpha(s) in G protein-coupled receptor (GPCR) signalling at the cell surface is well established. Recent evidence has revealed the presence of G... 
ENDOSOME FUSION | GOLGI MEMBRANES | DELTA-OPIOID RECEPTORS | ALPHA-SUBUNIT | MULTIDISCIPLINARY SCIENCES | DOWN-REGULATION | ADRENERGIC-RECEPTOR | BETA-GAMMA-SUBUNITS | HETEROTRIMERIC-G-PROTEINS | PLASMA-MEMBRANE | BETA-ADRENERGIC RECEPTOR
Journal Article
BIOCHEMISTRY, ISSN 0006-2960, 10/2017, Volume 56, Issue 41, pp. 5604 - 5614
Phospholipase C beta (PLC beta) enzymes hydrolyze phosphatidylinositol 4,5-bisphosphate to produce second messengers that regulate intracellular Ca2+, cell... 
SIGNAL-TRANSDUCTION | MIXED VESICLES | TRANSFER PROTEIN | G-ALPHA-Q | BIOCHEMISTRY & MOLECULAR BIOLOGY | CARDIAC-HYPERTROPHY | HEART-FAILURE | BETA-GAMMA-SUBUNITS | DEPENDENT ACTIVATION | MUTATIONAL ANALYSIS | SURFACE PRESSURE
Journal Article
BIOCHEMISTRY, ISSN 0006-2960, 05/2016, Volume 55, Issue 20, pp. 2841 - 2848
Interactions between proteins and cell membranes are critical for biological processes such as transmembrane signaling, and specific components of the membrane... 
MOLECULAR-INTERACTIONS | GRK2 | INTERFACIAL WATER | BIOCHEMISTRY & MOLECULAR BIOLOGY | SECONDARY STRUCTURES | PHASE-TRANSITION | SUM-FREQUENCY GENERATION | SURFACE | VIBRATIONAL SPECTROSCOPY | BETA-GAMMA-SUBUNITS | ADSORPTION
Journal Article
CELLULAR SIGNALLING, ISSN 0898-6568, 01/2017, Volume 30, pp. 50 - 58
GPCRs form signalling complexes with other receptors as part of dimers, G proteins and effector partners. A proteomic screen to identify proteins that... 
SYSTEM | BETA-GAMMA SUBUNITS | PATHWAY | ADENYLYL-CYCLASE | PROTEASOME | AAA-ATPASE | PROTEIN-COUPLED RECEPTORS | DEGRADATION | ENDOPLASMIC-RETICULUM | SIGNALING COMPLEXES | CELL BIOLOGY
Journal Article