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beta-globins - genetics (420) 420
science & technology (412) 412
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transcription, genetic (45) 45
gamma-globins - genetics (43) 43
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alpha-globins - genetics (40) 40
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fetal hemoglobin - metabolism (31) 31
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beta-globins - biosynthesis (30) 30
dna (30) 30
gene regulation (30) 30
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polymorphism, single nucleotide (29) 29
transcription factors (29) 29
cell differentiation (28) 28
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gene frequency (28) 28
genetic vectors - genetics (28) 28
epigenetics (27) 27
globins - genetics (27) 27
heterozygote (27) 27
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1. Full Text Controlling Long-Range Genomic Interactions at a Native Locus by Targeted Tethering of a Looping Factor
by Deng, Wulan and Lee, Jongjoo and Wang, Hongxin and Miller, Jeff and Reik, Andreas and Gregory, Philip D and Dean, Ann and Blobel, Gerd A
Cell (Cambridge), ISSN 0092-8674, 06/2012, Volume 149, Issue 6, pp. 1233 - 1244
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Protein Structure, Tertiary | Cell Line | Chromatin - metabolism | Promoter Regions, Genetic | Zinc Fingers | Cell Separation | Erythroblasts - metabolism | Gene Expression Regulation | Male | LIM Domain Proteins - metabolism | DNA-Binding Proteins - chemistry | GATA1 Transcription Factor - metabolism | beta-Globins - genetics | DNA-Binding Proteins - metabolism | Animals | Embryo, Mammalian - cytology | Female | Transcription, Genetic | Mice | LIM Domain Proteins - chemistry | Proteins | Chromatin | Zinc finger proteins | RNA | Developmental biology | Genes | Index Medicus | zinc finger proteins | Ldb1 | transcription | chromatin | looping | hemoglobin
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2. Full Text Induction of fetal hemoglobin synthesis by CRISPR/Cas9-mediated editing of the human beta-globin locus
by Antoniani, Chiara and Meneghini, Vasco and Lattanzi, Annalisa and Felix, Tristan and Romano, Oriana and Magrin, Elisa and Weber, Leslie and Pavani, Giulia and El Hoss, Sara and Kurita, Ryo and Nakamura, Yukio and Cradick, Thomas J and Lundberg, Ante S and Porteus, Matthew and Amendola, Mario and El Nemer, Wassim and Cavazzana, Marina and Mavilio, Fulvio and Miccio, Annarita
Blood, ISSN 0006-4971, 04/2018, Volume 131, Issue 17, pp. 1960 - 1973
Life Sciences & Biomedicine | Hematology | Science & Technology | Anemia, Sickle Cell - pathology | Cell Line | Fetal Hemoglobin - biosynthesis | Humans | Hematopoietic Stem Cells - pathology | Hematopoietic Stem Cells - metabolism | Genetic Loci | beta-Globins - genetics | Gene Editing | Anemia, Sickle Cell - therapy | beta-Globins - metabolism | Anemia, Sickle Cell - metabolism | CRISPR-Cas Systems | Fetal Hemoglobin - genetics | Anemia, Sickle Cell - genetics | Index Medicus | Abridged Index Medicus
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3. Full Text Phase Separation and Transcription Regulation: Are Super‐Enhancers and Locus Control Regions Primary Sites of Transcription Complex Assembly?
by Gurumurthy, Aishwarya and Shen, Yong and Gunn, Eliot M and Bungert, Jörg
BioEssays, ISSN 0265-9247, 01/2019, Volume 41, Issue 1, pp. e1800164 - n/a
super‐enhancer | transcription regulation | phase separation | mediators | RNA polymerase II | super-enhancer | Biochemistry & Molecular Biology | Biology | Life Sciences & Biomedicine - Other Topics | Life Sciences & Biomedicine | Science & Technology | Enhancer Elements, Genetic | Humans | Gene Expression Regulation | Transcription, Genetic | Locus Control Region | RNA Polymerase II - metabolism | beta-Globins - genetics | Transcription elongation | Genes | Gene regulation | RNA polymerase | Ribonucleic acid--RNA | Loci | DNA-directed RNA polymerase | Proteins | Transcription termination | Enhancers | Phase separation | Elongation | Mediator
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4. Full Text CTCF-mediated transcriptional regulation through cell type-specific chromosome organization in the β-globin locus
by Junier, Ivan and Dale, Ryan K and Hou, Chunhui and Képès, François and Dean, Ann
Nucleic acids research, ISSN 0305-1048, 09/2012, Volume 40, Issue 16, pp. 7718 - 7727
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Cell Line | Chromosomes, Human, Pair 11 - chemistry | Humans | Gene Expression Regulation | Genetic Loci | Locus Control Region | beta-Globins - genetics | CCCTC-Binding Factor | K562 Cells | Chromosomes, Human, Pair 11 - metabolism | Transcription, Genetic | Genome, Human | beta-Globins - biosynthesis | Repressor Proteins - metabolism | Chromatin - chemistry | Index Medicus | Chromatin | Transcription | Protein folding | Gene regulation | Nucleosomes | chromosome 11 | Erythroid cells | Chromosomes | Life Sciences | Modeling and Simulation | Biological Physics | Biochemistry, Molecular Biology | Computer Science | Biophysics | Physics | Gene Regulation, Chromatin and Epigenetics
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5. Full Text Epigenetic interplay at the β-globin locus
by Lee, Wei Shern and McColl, Bradley and Maksimovic, Jovana and Vadolas, Jim
Biochimica et biophysica acta. Gene regulatory mechanisms, ISSN 1874-9399, 04/2017, Volume 1860, Issue 4, pp. 393 - 404
Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Chromatin - metabolism | Animals | Epigenesis, Genetic | Humans | Protein Processing, Post-Translational - genetics | Genetic Loci | Histones - metabolism | beta-Globins - genetics | Index Medicus
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6. Full Text Improved Titer and Gene Transfer by Lentiviral Vectors Using Novel, Small β-Globin Locus Control Region Elements
by Morgan, Richard A and Unti, Mildred J and Aleshe, Bamidele and Brown, Devin and Osborne, Kyle S and Koziol, Colin and Ayoub, Paul G and Smith, Oliver B and O’Brien, Rachel and Tam, Curtis and Miyahira, Eric and Ruiz, Marlene and Quintos, Jason P and Senadheera, Shantha and Hollis, Roger P and Kohn, Donald B
Molecular therapy, ISSN 1525-0016, 01/2020, Volume 28, Issue 1, pp. 328 - 340
hemoglobinopathies | transplantation | hematopoietic stem cell | locus control region | gene therapy | lentiviral vector | sickle cell disease | ENCODE | Genetics & Heredity | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Humans | Hematopoietic Stem Cells - metabolism | Healthy Volunteers | beta-Globins - genetics | Anemia, Sickle Cell - therapy | Phenotype | Animals | Transfection | HEK293 Cells | Locus Control Region - genetics | Lentivirus - genetics | Mice | Genetic Vectors | Transduction, Genetic - methods | Bone Marrow Cells - metabolism | Disease Models, Animal | Genetic Therapy - methods | Phenotypes | Copy number | Genomes | FDA approval | Patients | Vectors (Biology) | Progenitor cells | Hemopoiesis | Efficiency | Hemoglobin | Bone marrow | Gene therapy | Sickle cell disease | Drug dosages | Expression vectors | Index Medicus
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7. Full Text A multiprotein complex necessary for both transcription and DNA replication at the β-globin locus
by Mahajan, Milind C and Weissman, Sherman M and Karmakar, Subhradip and Schulz, Vincent and Boyapaty, Gokul
The EMBO journal, ISSN 0261-4189, 10/2010, Volume 29, Issue 19, pp. 3260 - 3271
replication | multiprotein complex | transcription | purification | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Oligonucleotides - genetics | DNA-Binding Proteins - physiology | Humans | Nuclear Factor 45 Protein - genetics | DNA Repair - physiology | Nuclear Factor 45 Protein - metabolism | Multiprotein Complexes - genetics | DNA Repair - genetics | DNA-Binding Proteins - genetics | beta-Globins - genetics | Multiprotein Complexes - physiology | DNA-Binding Proteins - metabolism | Nuclear Factor 90 Proteins - metabolism | Multiprotein Complexes - metabolism | p300-CBP Transcription Factors - metabolism | Transcription, Genetic - physiology | beta-Globins - metabolism | DNA Replication - physiology | RNA Interference | p300-CBP Transcription Factors - genetics | Cell Line, Tumor | DNA Replication - genetics | Transcription, Genetic - genetics | Nuclear Factor 90 Proteins - genetics | Index Medicus
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