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1. Full Text The locus control region is required for association of the murine β-globin locus with engaged transcription factories during erythroid maturation
by Ragoczy, Tobias and Bender, M.A and Telling, Agnes and Byron, Rachel and Groudine, Mark
Genes and Development, ISSN 0890-9369, 06/2006, Volume 20, Issue 11, pp. 1447 - 1457
We have examined the relationship between nuclear localization and transcriptional activity of the endogenous murine beta-globin locus during erythroid... 
β-globin locus | Erythroid differentiation | Nuclear periphery | Nuclear organization | RNA polymerase II | Fluorescence in situ hybridization | RNA-POLYMERASE-II | nuclear periphery | NUCLEAR-ORGANIZATION | CELLS | beta-globin locus | CHROMATIN | DEVELOPMENTAL BIOLOGY | SPATIAL-ORGANIZATION | ACTIVE GENES | erythroid differentiation | CELL BIOLOGY | fluorescence in situ hybridization | GENETICS & HEREDITY | GENE-EXPRESSION | nuclear organization | DIFFERENTIATION | CENTROMERIC HETEROCHROMATIN | INTERPHASE NUCLEI | Transcription Factors - metabolism | Globins - genetics | Animals | Cell Nucleus - genetics | Erythroid Cells - metabolism | In Situ Hybridization, Fluorescence | Cell Differentiation | Liver - cytology | Mice | Locus Control Region | RNA Polymerase II - metabolism | Liver - embryology | Beta globulins | Research | Genetic transcription | Globin genes | Hybridization | Research Paper
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2. Full Text Locus control regions
by Li, Qiliang and Peterson, Kenneth R and Fang, Xiangdong and Stamatoyannopoulos, George
Blood, ISSN 0006-4971, 11/2002, Volume 100, Issue 9, pp. 3077 - 3086
Locus control regions (LCRs) are operationally defined by their ability to enhance the expression of linked genes to physiological levels in a tissue-specific... 
HIGH-LEVEL EXPRESSION | TISSUE-SPECIFIC EXPRESSION | HEAVY-CHAIN LOCUS | TRANSCRIPTION FACTOR NF-E2 | T-CELL RECEPTOR | POSITION-INDEPENDENT EXPRESSION | HEMATOLOGY | ERYTHROID-SPECIFIC EXPRESSION | BETA-GLOBIN LOCUS | OPEN CHROMATIN STRUCTURE | TRANSGENIC MICE | Chromatin - ultrastructure | Vertebrates - genetics | Gene Expression Regulation - genetics | Humans | Rats | DNA Replication | Heterochromatin - ultrastructure | Locus Control Region | Cell Lineage | Globins - genetics | Animals | Heterochromatin - genetics | Enhancer Elements, Genetic | Histones - physiology | Chickens - genetics | Transcription, Genetic | Mice | Acetylation | Chromatin - genetics
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3. Full Text Controlling Long-Range Genomic Interactions at a Native Locus by Targeted Tethering of a Looping Factor
by Deng, Wulan and Lee, Jongjoo and Wang, Hongxin and Miller, Jeff and Reik, Andreas and Gregory, Philip D and Dean, Ann and Blobel, Gerd A
Cell, ISSN 0092-8674, 06/2012, Volume 149, Issue 6, pp. 1233 - 1244
Chromatin loops juxtapose distal enhancers with active promoters, but their molecular architecture and relationship with transcription remain unclear. In... 
CONTROL REGION | TRANSCRIPTION FACTOR GATA-1 | CHROMOSOMAL INTERACTIONS | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | GENE-EXPRESSION | FUNCTIONAL-ANALYSIS | POSITIVE ROLE | BINDING PROTEIN | BETA-GLOBIN LOCUS | ERYTHROID-DIFFERENTIATION | CELL BIOLOGY | Protein Structure, Tertiary | Cell Line | Chromatin - metabolism | Promoter Regions, Genetic | Zinc Fingers | Cell Separation | Erythroblasts - metabolism | Gene Expression Regulation | Male | LIM Domain Proteins - metabolism | DNA-Binding Proteins - chemistry | GATA1 Transcription Factor - metabolism | beta-Globins - genetics | DNA-Binding Proteins - metabolism | Animals | Embryo, Mammalian - cytology | Female | Transcription, Genetic | Mice | LIM Domain Proteins - chemistry | Proteins | Chromatin | Zinc finger proteins | RNA | Developmental biology | Genes | zinc finger proteins | Ldb1 | transcription | chromatin | looping | hemoglobin
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4. Full Text Regulation of Th2 differentiation and Il4 locus accessibility
by Ansel, K. Mark and Djuretic, Ivana and Tanasa, Bogdan and Rao, Anjana
Annual Review of Immunology, ISSN 0732-0582, 2006, Volume 24, pp. 607 - 656
Helper T cells coordinate immune responses through the production of cytokines. Th2 cells express the closely linked 114, 1113, and 115 cytokine genes, whereas... 
Chromatin | Transcription factors | Epigenetic regulation | RNA interference/RNAi | Cytokine | cytokine | T-CELL DIFFERENTIATION | transcription factors | ALLERGIC AIRWAY INFLAMMATION | IMMUNOLOGY | chromatin | TRANSCRIPTION FACTOR GATA-3 | epigenetic regulation | CYTOKINE GENE-EXPRESSION | DROSOPHILA BITHORAX COMPLEX | BETA-GLOBIN LOCUS | ANTIGEN-PRESENTING CELLS | CHROMATIN-REMODELING COMPLEXES | RANGE INTRACHROMOSOMAL INTERACTIONS | HISTONE H2B UBIQUITYLATION | Signal Transduction | Epigenesis, Genetic | Humans | Chromatin Assembly and Disassembly | Th2 Cells - cytology | Th2 Cells - immunology | Th1 Cells - immunology | DNA Methylation | Models, Immunological | Animals | Histones - genetics | Feedback | Gene Expression Regulation, Developmental | Immunologic Memory | Cell Differentiation | Mice | Models, Genetic | Th1 Cells - cytology | Histones - metabolism | Interleukin-4 - genetics | Cytokines - genetics | Receptors, Notch - immunology
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5. Full Text The IgH locus 3' regulatory region: Pulling the strings from behind
by Pinaud, Eric and Marquet, Marie and Fiancette, Rémi and Péron, Sophie and Vincent-Fabert, Christelle and Denizot, Yves and Cogné, Michel
Advances in Immunology, ISSN 0065-2776, 2011, Volume 110, pp. 27 - 70
Antigen receptor gene loci are among the most complex in mammals. The IgH locus, encoding the immunoglobulin heavy chain (IgH) in B-lineage cells, undergoes... 
Enhancers | B cells | Immunoglobulin heavy chain | Gene regulation | Knock out | IMMUNOGLOBULIN CLASS-SWITCH | B-CELL-DEVELOPMENT | HEAVY-CHAIN GENE | TRANSCRIPTION FACTOR BSAP | CLASS-SWITCH RECOMBINATION | HELIX-LOOP-HELIX | IMMUNOLOGY | DNA-BINDING PROTEIN | NF-KAPPA-B | BETA-GLOBIN LOCUS | ALPHA-CONSTANT-REGION | B-Lymphocytes - cytology | Humans | Gene Expression Regulation | Mice, Transgenic | Regulatory Sequences, Nucleic Acid - genetics | Genes, Immunoglobulin Heavy Chain - physiology | Mice, Knockout | Animals | B-Lymphocytes - immunology | Genes, Immunoglobulin Heavy Chain - genetics | Mice | B-Lymphocytes - pathology | B-Lymphocytes - metabolism | Immunoglobulin Heavy Chains - genetics | Antigens | Chromatin | Immunoglobulins | Transcription | V(D)J recombination | Regulatory sequences | Boundaries | Promoters | Class switching | Chromosome translocations | somatic hypermutation | Lymphocytes B | DNA | Heavy chains | Oncogenes | Genes, Immunoglobulin Heavy Chain | Life Sciences | Immunology | Immunoglobulin Heavy Chains | Regulatory Sequences, Nucleic Acid | B-Lymphocytes
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6. Full Text Intergenic transcription and transinduction of the human β-globin locus
by Ashe, Hilary L and Monks, Joan and Wijgerde, Mark and Fraser, Peter and Proudfoot, Nick J
Genes and Development, ISSN 0890-9369, 10/1997, Volume 11, Issue 19, pp. 2494 - 2509
We have identified novel nuclear transcripts in the human beta-globin locus using nuclear run-on analysis in erythroid cell lines and in situ hybridization... 
Transinduction | Transcription | Human β-globin locus | Locus control region | HIV-1 | human beta-globin locus | SITE | transcription | transinduction | DOMINANT CONTROL REGION | ERYTHROID-CELLS | K HY DEVELOPMENTAL BIOLOGY | DEVELOPMENTAL BIOLOGY | K KM GENETICS & HEREDITY | RNA POLYMERASE-II | CHROMOSOME | HIGH-LEVEL EXPRESSION | GENE | GENETICS & HEREDITY | locus control region | TERMINATION | TRANSGENIC MICE
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7. Full Text Complete TCR-α gene locus control region activity in T cells derived in vitro from embryonic stem cells
by Lahiji, Armin and Kučerová-Levisohn, Martina and Lovett, Jordana and Holmes, Roxanne and Zúñiga-Pflücker, Juan Carlos and Ortiz, Benjamin D
Journal of Immunology, ISSN 0022-1767, 07/2013, Volume 191, Issue 1, pp. 472 - 479
Locus control regions (LCRs) are cis-acting gene regulatory elements with the unique, integration site-independent ability to transfer the characteristics of... 
HIGH-LEVEL | THALASSEMIC MICE | HEMATOPOIETIC PROGENITOR CELLS | CHROMATIN-STRUCTURE | RECEPTOR ALPHA/DELTA LOCUS | HUMAN CD2 GENE | IMMUNOLOGY | HUMAN BETA-GLOBIN | ACTIVATION REGION | EXPRESSION | TRANSGENIC MICE | T-Lymphocyte Subsets - immunology | Cell Line | Embryonic Stem Cells - metabolism | Embryonic Stem Cells - cytology | T-Lymphocyte Subsets - cytology | Coculture Techniques | Cells, Cultured | Mice, Transgenic | Locus Control Region - immunology | Random Allocation | Receptors, Antigen, T-Cell, alpha-beta - genetics | Cell Differentiation - genetics | Cell Differentiation - immunology | Animals | T-Lymphocyte Subsets - metabolism | Mice | Embryonic Stem Cells - immunology | Cell Lineage - genetics | Genes, Reporter - immunology | Cell Lineage - immunology
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8. Full Text Three‐dimensional architecture of the IgH locus facilitates class switch recombination
by Kenter, Amy L and Feldman, Scott and Wuerffel, Robert and Achour, Ikbel and Wang, Lili and Kumar, Satyendra
Annals of the New York Academy of Sciences, ISSN 0077-8923, 09/2012, Volume 1267, Issue 1, pp. 86 - 94
Immunoglobulin (Ig) class switch recombination (CSR) is responsible for diversification of antibody effector function during an immune response. This... 
transcription | chromatin | class switch recombination | long‐range interactions | Chromatin | Class switch recombination | Transcription | Long-range interactions | RNA-POLYMERASE-II | SOMATIC HYPERMUTATION | INDUCED CYTIDINE DEAMINASE | MULTIDISCIPLINARY SCIENCES | S-REGIONS | TRANSCRIPTION ELONGATION | R-LOOPS | BETA-GLOBIN LOCUS | B-CELLS | IN-VIVO | GENETICS & HEREDITY | HISTONE MODIFICATIONS | long-range interactions | Humans | Genetic Loci | Cytidine Deaminase - physiology | GC Rich Sequence | Animals | Mutagenesis | Recombination, Genetic | Base Sequence | Cytidine Deaminase - metabolism | Immunoglobulin Heavy Chains | Transcription, Genetic | Mutation | Nucleic Acid Conformation | Immunoglobulin Class Switching | long range interactions
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9. Full Text Chromatin looping and eRNA transcription precede the transcriptional activation of gene in the β-globin locus
by Kim, Yea Woon and Lee, Sungkung and Yun, Jangmi and Kim, AeRi
Bioscience Reports, ISSN 0144-8463, 01/2015, Volume 35, Issue 2, pp. 1 - 8
Enhancers are closely positioned with actively transcribed target genes by chromatin looping. Non-coding RNAs are often transcribed on active enhancers,... 
Chromatin looping | Transcriptional activation | Mouse β-globin locus | Enhancer RNAs (eRNAs) | RNA-POLYMERASE-II | RECRUITMENT | BIOCHEMISTRY & MOLECULAR BIOLOGY | INTERGENIC TRANSCRIPTION | GATA-1 | transcriptional activation | CELL BIOLOGY | CONTROL REGION | HS2 ENHANCER | chromatin looping | mouse beta-globin locus | LCR | PROMOTER | PROXIMITY | enhancer RNAs (eRNAs) | ERYTHROID-DIFFERENTIATION | Cell Line | Chromatin - metabolism | RNA - biosynthesis | Animals | Genetic Loci - physiology | Mice | Transcriptional Activation - physiology | Chromatin - genetics | beta-Globins - biosynthesis | beta-Globins - genetics | Chromatin Assembly and Disassembly - physiology | RNA - genetics | mouse β-globin locus
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10. Full Text Chromatin decondensation and nuclear reorganization of the HoxB locus upon induction of transcription
by Chambeyron, Séverine and Bickmore, Wendy A
Genes and Development, ISSN 0890-9369, 05/2004, Volume 18, Issue 10, pp. 1119 - 1130
The colinearity of genes in Hox clusters suggests a role for chromosome structure in gene regulation. We reveal programmed changes in chromatin structure and... 
Chromosome territory | Histone modification | Nuclear structure | Chromatin decondensation | Differentiation | Gene expression | COMPLEX | differentiation | histone modification | CHROMOSOME TERRITORIES | chromatin decondensation | DEVELOPMENTAL BIOLOGY | nuclear structure | BETA-GLOBIN LOCUS | HOMEOBOX GENES | HISTONE LYSINE METHYLATION | RETINOIC ACID | EMBRYONAL CARCINOMA-CELLS | GENETICS & HEREDITY | INACTIVE GENES | EXPRESSION | gene expression | INTERPHASE NUCLEI | chromosome territory | Chromosome Painting | Cell Line | Chromatin - metabolism | Multigene Family | Stem Cells - cytology | Stem Cells - metabolism | Homeodomain Proteins - genetics | DNA - genetics | Gene Expression Regulation - drug effects | Animals | Cell Nucleus - metabolism | Cell Nucleus - genetics | Cell Differentiation - drug effects | Models, Biological | Base Sequence | Stem Cells - drug effects | Transcription, Genetic | Mice | Histones - metabolism | Chromatin - genetics | Genes, Homeobox | Tretinoin - pharmacology | Genetic research | Chromatin | Research | Genetic transcription | Research Papers
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11. Full Text Erythroid specific activator GATA-1-dependent interactions between CTCF sites around the β-globin locus
by Kang, Yujin and Kang, Jin and Kim, AeRi and Kim, Yea Woon and Yun, Won Ju
BBA - Gene Regulatory Mechanisms, ISSN 1874-9399, 04/2017, Volume 1860, Issue 4, pp. 416 - 426
CTCF sites (binding motifs for CCCTC-binding factor, an insulator protein) are located considerable distances apart on genomes but are closely positioned in... 
GATA-1 | CTCF sites | β-globin locus | Chromatin interaction | beta-globin locus | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | COHESIN | GENOME TOPOLOGY | CCCTC-BINDING FACTOR | CONTROL REGION | BIOPHYSICS | GENES | CELL DIFFERENTIATION | CHROMATIN INTERACTIONS | EXPRESSION | Chromatin - metabolism | Protein Binding - genetics | Nucleotide Motifs - genetics | Humans | Erythroid Cells - metabolism | Binding Sites - genetics | Genetic Loci | GATA1 Transcription Factor - metabolism | beta-Globins - genetics | Deoxyribonuclease I - metabolism | Organ Specificity - genetics | Kruppel-Like Transcription Factors - metabolism | Base Sequence | CCCTC-Binding Factor | K562 Cells | Locus Control Region - genetics | Repressor Proteins - metabolism | Sequence Deletion - genetics
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12. Full Text Nuclease-mediated gene editing by homologous recombination of the human globin locus
by Voit, Richard A and Hendel, Ayal and Pruett-Miller, Shondra M and Porteus, Matthew H
Nucleic Acids Research, ISSN 0305-1048, 2014, Volume 42, Issue 2, pp. 1365 - 1378
Tal-effector nucleases (TALENs) are engineered proteins that can stimulate precise genome editing through specific DNA double-strand breaks. Sickle cell... 
LEUKEMIC K562 CELLS | STEM-CELLS | MESSENGER-RNA | DNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | INDUCTION | BETA-GLOBIN | ZINC-FINGER NUCLEASES | HEMOGLOBIN PRODUCTION | EXPRESSION | ERYTHROID-DIFFERENTIATION | Gene Targeting | Humans | Homologous Recombination | Green Fluorescent Proteins - genetics | Genetic Loci | beta-Globins - genetics | Deoxyribonucleases - metabolism | K562 Cells | Protein Engineering | gamma-Globins - genetics | Fluorescent Dyes | Genes, Reporter | Deoxyribonucleases - chemistry | Synthetic Biology and Chemistry
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13. Full Text Phase Separation and Transcription Regulation: Are Super‐Enhancers and Locus Control Regions Primary Sites of Transcription Complex Assembly?
by Gurumurthy, Aishwarya and Shen, Yong and Gunn, Eliot M and Bungert, Jörg
BioEssays, ISSN 0265-9247, 01/2019, Volume 41, Issue 1, pp. e1800164 - n/a
Super ‐ enhancers and locus control regions recruit Mediator and RNA Polymerase II transcription complexes, which form phase separated domains. It is proposed... 
super‐enhancer | transcription regulation | phase separation | mediators | RNA polymerase II | super-enhancer | RNA-POLYMERASE-II | RECRUITMENT | PHOSPHORYLATION | MEDIATOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL IDENTITY | HYPERSENSITIVE SITES | PREINITIATION COMPLEX | BETA-GLOBIN GENE | IN-VIVO | BIOLOGY | PROMOTER | Transcription elongation | Genes | Gene regulation | RNA polymerase | Loci | DNA-directed RNA polymerase | Proteins | Transcription termination | Polymerase | Enhancers | Ribonucleic acids | Phase separation | Elongation
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14. Full Text Long-range intrachromosomal interactions in the T helper type 2 cytokine locus
by Flavell, Richard A and Spilianakis, Charalampos G
Nature Immunology, ISSN 1529-2908, 10/2004, Volume 5, Issue 10, pp. 1017 - 1027
The T helper type 2 (T(H)2) locus control region is important in the regulation of the genes encoding the cytokines interleukins 4, 5 and 13. Using the... 
TH2 CELLS | BETA-GLOBIN GENE | CHROMATIN-STRUCTURE | IN-VIVO | HYPERSENSITIVE SITES | PROMOTER REGION