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by Zhu, C and Zou, Z and Huang, CX and Zheng, J and Liu, N and Li, JS and Yang, RH
CHEMICAL COMMUNICATIONS, ISSN 1359-7345, 03/2019, Volume 55, Issue 22, pp. 3235 - 3238
In this work, we propose a pH-regulated and target-activated fluorescent nanoprobe for highly selective monitoring of lysosomal azoreductase under hypoxia in... 
PROBE | CHEMISTRY, MULTIDISCIPLINARY | BETA-LAPACHONE
Journal Article
02/2015, Volume 5, Issue 26, pp. 239 - 2338
The non-communicable disease, cancer, is one of the major causes of death across the world and is forecast to increase by 75% to reach close to 25 million... 
Journal Article
RSC Advances, ISSN 2046-2069, 2015, Volume 5, Issue 26, pp. 20309 - 20338
The non-communicable disease, cancer, is one of the major causes of death across the world and is forecast to increase by 75% to reach close to 25 million... 
BIOREDUCTIVE ALKYLATING-AGENTS | ANTITUMOR ANTIBIOTICS | OXIDOREDUCTASE DT-DIAPHORASE | 1,4-NAPHTHOQUINONE DERIVATIVES | MANSONONE-F | ABC TRANSPORTERS | DNA TOPOISOMERASE-I | MULTIDRUG-RESISTANCE MDR | CHEMISTRY, MULTIDISCIPLINARY | BETA-LAPACHONE | FREE-RADICALS
Journal Article
by Tam, YT and Gao, JM and Kwon, GS
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, ISSN 0002-7863, 07/2016, Volume 138, Issue 28, pp. 8674 - 8677
Poly(ethylene glycol)-block-poly(D,L-lactic acid) (PEG-b-PLA) micelles are nanocarriers for poorly water-soluble anticancer agents and have advanced paclitaxel... 
CREMOPHOR-FREE | STABILITY | HYDROLYTIC DEGRADATION | GENEXOL-PM | POLYMERIC MICELLES | FORMULATION | DERIVATIVES | CANCER | CHEMISTRY, MULTIDISCIPLINARY | BETA-LAPACHONE | PACLITAXEL
Journal Article
CLINICAL CANCER RESEARCH, ISSN 1078-0432, 04/2019, Volume 25, Issue 8, pp. 2601 - 2609
Purpose: Development of tumor-specific therapies for the treatment of recalcitrant non-small cell lung cancers (NSCLC) is urgently needed. Here, we... 
APOPTOSIS | ACTIVATION | THERAPY | ONCOLOGY | NANOTHERAPEUTICS | DRUGS | CALCIUM | MECHANISMS | MICELLES | RADIATION | BETA-LAPACHONE
Journal Article
Journal of Organic Chemistry, ISSN 0022-3263, 02/2015, Volume 80, Issue 4, pp. 2120 - 2127
Herein, we report a solvent- and metal-free methodology for the alkoxy-chalcogenylation of styrenes, using molecular iodine as a catalyst, DMSO as a... 
SELENENYLATING AGENT | DELTA-LACTONE | DIPHENYL DISELENIDE | GLUTATHIONE-PEROXIDASE | CHEMISTRY, ORGANIC | GAMMA-LACTONE | CYCLIC ETHER FORMATION | RING-CLOSURE | DIMETHYL(METHYLTHIO)SULFONIUM FLUOROBORATE | BETA-LAPACHONE | ASYMMETRIC METHOXYSELENENYLATIONS
Journal Article
MOLECULAR CANCER THERAPEUTICS, ISSN 1535-7163, 08/2019, Volume 18, Issue 8, pp. 1355 - 1365
Chemotherapy and radiation are more effective in wild-type (WT) p53 tumors due to p53 activation. This is one rationale for developing drugs that reactivate... 
CELLS | OXIDATIVE STRESS | INHIBITION | ONCOLOGY | DRUGS | SYNERGIZES | BETA-LAPACHONE | CHEMOTHERAPY
Journal Article
Organic Letters, ISSN 1523-7060, 06/2018, Volume 20, Issue 12, pp. 3635 - 3638
Tripartite prodrug 1, composed of an NAD­(P)­H:quinone oxidoreductase 1 (NQO1)-responsive trigger group, a self-immolative linker, and the active drug... 
CELL LUNG-CANCER | QUINONE | CHEMISTRY, ORGANIC | REDUCTASE | BETA-LAPACHONE | DISCOVERY | OVEREXPRESS NQO1
Journal Article
The Journal of Organic Chemistry, ISSN 0022-3263, 08/2018, Volume 83, Issue 15, pp. 8003 - 8010
An efficient reaction utilizing propargyl carbonates through Claisen rearrangement to synthesize furanonaphthoquinones is described. The remarkable... 
ANTITUMOR AGENTS | NAPHTHOQUINONES | TRYPTOPHAN | QUINONES | PATHWAY | NATURAL-PRODUCTS | DRUG DISCOVERY | CHEMISTRY, ORGANIC | 1,4-NAPHTHOQUINONES | DERIVATIVES | BETA-LAPACHONE
Journal Article
Quimica Nova, ISSN 0100-4042, 05/2003, Volume 26, Issue 3, pp. 407 - 416
Journal Article
Organic and Biomolecular Chemistry, ISSN 1477-0520, 2019, Volume 17, Issue 3, pp. 692 - 702
A new perspective on the reactivity of hydroxyquinones was revealed as an acetal derivative of lawsone was synthesized, isolated, and used in tandem... 
ALPHA-LAPACHONE | 2-HYDROXY-1,4-NAPHTHOQUINONE | PYRANONAPHTHOQUINONES | QUINONES | PHENYLIODONIUM YLIDE | TRYPANOSOMA-CRUZI | CYCLOADDITIONS | BETA-LAPACHONE DERIVATIVES | CHEMISTRY, ORGANIC
Journal Article
by Wu, LQ and Liu, YX and Li, YZ
MOLECULES, ISSN 1420-3049, 09/2018, Volume 23, Issue 9
A series of novel spirooxindole-O-naphthoquinone-tetrazolo[1,5-a] pyrimidine hybrids were designed, synthesized and evaluated as potent antitumor agents. These... 
spirooxindole | antitumor activity | BIOCHEMISTRY & MOLECULAR BIOLOGY | O-naphthoquinone | hybrids | ANTIFUNGAL | SCAFFOLDS | NAPHTHOQUINONE | CYTOTOXICITY | CHEMISTRY, MULTIDISCIPLINARY | BETA-LAPACHONE
Journal Article
RSC Advances, ISSN 2046-2069, 2016, Volume 6, Issue 34, pp. 28555 - 28562
A series of novel substituted 5H-benzo[i][1,3,4]thiadiazolo[3,2-a]quinazoline-6,7-diones, designed via a molecular hybridization approach, were synthesized in... 
Journal Article
CHEMICAL SCIENCE, ISSN 2041-6520, 09/2018, Volume 9, Issue 34
Using machine learning, targets were identified for -lapachone. Resorting to biochemical assays, -lapachone was validated as a potent, ligand efficient,... 
MACROMOLECULAR TARGETS | CANCER-CELLS | C2-LIKE DOMAIN | NATURAL-PRODUCTS | DRUG DISCOVERY | IN-VIVO | HL-60 CELLS | CLASSIFICATION | DERIVATIVES | CHEMISTRY, MULTIDISCIPLINARY | BETA-LAPACHONE
Journal Article
RSC Advances, ISSN 2046-2069, 11/2017, Volume 7, Issue 84, pp. 53355 - 53361
The objective of this paper was to investigate the plasma pharmacokinetics and brain distribution kinetics of lapachol in rats. A sensitive and specific... 
NAPHTHOQUINONES | GLYCOSIDES | IN-VITRO | RESISTANT STAPHYLOCOCCUS-AUREUS | MS/MS | DERIVATIVES | CHEMISTRY, MULTIDISCIPLINARY | BETA-LAPACHONE | EXTRACT
Journal Article
Chemical Science, ISSN 2041-6520, 2016, Volume 7, Issue 12, pp. 7079 - 7086
Recent studies have suggested that selective targeting of overexpressed enzymes in cancer cells by small molecules that induce the formation of reactive oxygen... 
CANCER-CELLS | OXYGEN | OXIDATIVE STRESS | REDUCTION | SMALL-MOLECULE | DEUBIQUITINASES | ELECTRODE | MECHANISMS | CHEMISTRY, MULTIDISCIPLINARY | BETA-LAPACHONE | DISCOVERY
Journal Article
New Journal of Chemistry, ISSN 1144-0546, 2014, Volume 38, Issue 6, pp. 2569 - 2580
Two new benzothiadiazole-triazole-linked lapachone derivatives were designed, synthesized and characterized by 1D and 2D NMR spectroscopy. Their photophysical... 
CELLS | OXIDATIVE STRESS | REACTIVE OXYGEN | DYES | SENSITIVE FLUOROPHORES | CLICK CHEMISTRY | IMAGING PROBES | PHOTOPHYSICAL PROPERTIES | CHEMISTRY, MULTIDISCIPLINARY | BETA-LAPACHONE | SOLVENT
Journal Article
Journal of Natural Products, ISSN 0163-3864, 07/2018, Volume 81, Issue 7, pp. 1636 - 1644
Napabucasin (6) and its angularly anellated isomer (7), for which the synthesis is described, together with related plant-derived naphthoquinones, were... 
APOPTOSIS | CHEMISTRY, MEDICINAL | MECHANISM | TARGETING STAT3 | REDOX ACTIVATION | SUPPRESSION | BETA-LAPACHONE | STRATEGIES | PLANT SCIENCES | ROS | PHARMACOLOGY & PHARMACY | NQO1 BIOACTIVATABLE DRUG | DERIVATIVES
Journal Article
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