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beta-lapachone (31) 31
science & technology (19) 19
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humans (12) 12
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naphthoquinones - pharmacology (7) 7
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1. Full Text Therapeutic strategies and biomarkers to modulate parp activity for targeted cancer therapy
by Singh, Naveen and Louise Pay, S and Bhandare, Snehal B and Arimpur, Udhaya and Motea, Edward A
Cancers, ISSN 2072-6694, 04/2020, Volume 12, Issue 4, p. 972
NQO1 | PARG | Cancer therapeutics | CMET | NAMPT | PARP Inhibitors | Beta‐lapachone | DNA repair | Life Sciences & Biomedicine | Oncology | Science & Technology | cancer therapeutics | beta-lapachone
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2. Full Text Beta-lapachone attenuates immobilization-induced skeletal muscle atrophy in mice
by Park, Soyoung and Shin, Min-Gyeong and Kim, Jae-Ryong and Park, So-Young
Experimental gerontology, ISSN 0531-5565, 10/2019, Volume 126, pp. 110711 - 110711
Skeletal muscle atrophy | Immobilization | Oxidative stress | Beta-lapachone | Life Sciences & Biomedicine | Geriatrics & Gerontology | Science & Technology | Index Medicus
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3. Full Text Assessment of various formulation approaches for the application of beta-lapachone in prostate cancer therapy
by Wu, Xiao and Kasselouri, Athena and Vergnaud-Gauduchon, Juliette and Rosilio, Véronique
International journal of pharmaceutics, ISSN 0378-5173, 04/2020, Volume 579, pp. 119168 - 119168
NQO1 | Cyclodextrin | PC-3 cell | Double loaded liposome | Poly-lactide | Beta-lapachone | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Cell Survival | Drug Compounding - methods | Humans | Cells, Cultured | Solubility | Phospholipids - chemistry | Male | Naphthoquinones - pharmacology | Antineoplastic Agents - therapeutic use | Drug Carriers - chemistry | Nanoparticles | Animals | Cyclodextrins - chemistry | Cell Line, Tumor | Naphthoquinones - chemistry | Mice | Liposomes | Prostatic Neoplasms - drug therapy | Index Medicus
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4. Full Text Light effect on the stability of β‐lapachone in solution: pathways and kinetics of degradation
by Cunha‐Filho, Marcílio S.S and Estévez‐Braun, Ana and Pérez‐Sacau, Elisa and Echezarreta‐López, Ma Magdalena and Martínez‐Pacheco, Ramón and Landín, Mariana
Journal of pharmacy and pharmacology, ISSN 0022-3573, 09/2011, Volume 63, Issue 9, pp. 1156 - 1160
chemical photostability | beta‐lapachone | degradation products | preformulation | cancer chemotherapy | beta-lapachone | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Hydrolysis | Naphthoquinones - pharmacokinetics | Darkness | Dextrans | Photolysis | Solutions | Drug Stability | Light | Naphthoquinones - chemistry | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - chemistry | Index Medicus
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5. Full Text NQO1-dependent, Tumor-selective Radiosensitization of Non-small Cell Lung Cancers
by Motea, Edward A and Huang, Xiumei and Singh, Naveen and Kilgore, Jessica A and Williams, Noelle S and Xie, Xian-Jin and Gerber, David E and Beg, Muhammad S and Bey, Erik A and Boothman, David A
Clinical cancer research, ISSN 1078-0432, 04/2019, Volume 25, Issue 8, pp. 2601 - 2609
Life Sciences & Biomedicine | Oncology | Science & Technology | Lung Neoplasms - genetics | Carcinoma, Non-Small-Cell Lung - radiotherapy | Carcinoma, Non-Small-Cell Lung - genetics | Humans | Lung Neoplasms - metabolism | Radiation-Sensitizing Agents - pharmacology | Carcinoma, Non-Small-Cell Lung - metabolism | Lung Neoplasms - radiotherapy | Radiation Tolerance - genetics | Naphthoquinones - pharmacology | Treatment Outcome | NAD(P)H Dehydrogenase (Quinone) - genetics | Xenograft Model Antitumor Assays | Poly(ADP-ribose) Polymerases - metabolism | Animals | Cell Line, Tumor | Mice | Dose-Response Relationship, Radiation | Disease Models, Animal | Radiation, Ionizing | Index Medicus | lung cancer | NQO1 | beta-lapachone | ionizing radiation | reactive oxygen species
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6. Full Text Heat shock increases expression of NAD(P)H:quinone oxidoreductase (NQO1), mediator of -lapachone cytotoxicity, by increasing NQO1 gene activity and via Hsp70-mediated stabilisation of NQO1 protein
by Dong, Guang-Zhi and Youn, Hyewon and Park, Moon-Taek and Oh, Eun-Taex and Park, Kyung Hee and Song, Chang Won and Kyung Choi, Eun and Park, Heon Joo
International journal of hyperthermia, ISSN 0265-6736, 2009, Volume 25, Issue 6, pp. 477 - 487
NQO1 | Hsp70 | Hyperthermia | Beta-lapachone
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7. Full Text Potent Cytotoxicity of Novel L-Shaped Ortho-Quinone Analogs through Inducing Apoptosis
by Li, Sheng-You and Sun, Ze-Kun and Zeng, Xue-Yi and Zhang, Yue and Wang, Meng-Ling and Hu, Sheng-Cao and Song, Jun-Rong and Luo, Jun and Chen, Chao and Luo, Heng and Pan, Wei-Dong
Molecules (Basel, Switzerland), ISSN 1420-3049, 11/2019, Volume 24, Issue 22, p. 4138
Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Neoplasms - metabolism | Cytotoxins - chemical synthesis | PC-3 Cells | Quinones - chemistry | Apoptosis - drug effects | Quinones - chemical synthesis | Antineoplastic Agents - chemical synthesis | Humans | Structure-Activity Relationship | Antineoplastic Agents - chemistry | Neoplasms - drug therapy | Cytotoxins - pharmacology | Cytotoxins - chemistry | K562 Cells | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Neoplasms - pathology | Quinones - pharmacology | Drug Screening Assays, Antitumor | Index Medicus | beta-lapachone | ortho-quinones | antitumor activity | tanshione iia
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8. Full Text Metabolic Profile, Enzyme Kinetics, and Reaction Phenotyping of β‑Lapachone Metabolism in Human Liver and Intestine in Vitro
by Cheng, Xuefang and Liu, Fang and Yan, Tingting and Zhou, Xueyan and Wu, Liang and Liao, Ke and Wang, Guangji and Hao, Haiping
Molecular pharmaceutics, ISSN 1543-8384, 12/2012, Volume 9, Issue 12, pp. 3476 - 3485
beta;-lapachone | reaction phenotyping | UGT | enzyme kinetics | glucuronidation | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Isoenzymes | Humans | Microsomes, Liver - metabolism | Metabolome | Intestines - metabolism | Phenotype | Glucuronides - metabolism | Spectrometry, Mass, Electrospray Ionization | Glucuronosyltransferase - metabolism | NAD(P)H Dehydrogenase (Quinone) - metabolism | Kinetics | In Vitro Techniques | Naphthoquinones - metabolism | Index Medicus
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9. Full Text Mechanistic studies of cancer cell mitochondria- and NQO1-mediated redox activation of beta-lapachone, a potentially novel anticancer agent
by Li, Jason Z and Ke, Yuebin and Misra, Hara P and Trush, Michael A and Li, Y. Robert and Zhu, Hong and Jia, Zhenquan
Toxicology and applied pharmacology, ISSN 0041-008X, 12/2014, Volume 281, Issue 3, pp. 285 - 293
NQO1 | Beta-lapachone | EPR | Mitochondrial electron transport chain | ROS | Cancer cells | Pharmacology & Pharmacy | Toxicology | Life Sciences & Biomedicine | Science & Technology | Biological and medical sciences | Chemotherapy | Medical sciences | Antineoplastic agents | Pharmacology. Drug treatments | Neoplasms - metabolism | Mitochondria - enzymology | Reactive Oxygen Species - metabolism | Humans | Reverse Transcriptase Inhibitors - pharmacology | Neoplasm Proteins - antagonists & inhibitors | Prodrugs - chemistry | Neoplasm Proteins - metabolism | Electron Transport Complex I - metabolism | Prodrugs - metabolism | Reverse Transcriptase Inhibitors - chemistry | Antineoplastic Agents, Phytogenic - antagonists & inhibitors | Oxidation-Reduction - drug effects | Rotenone - pharmacology | Activation, Metabolic - drug effects | Antineoplastic Agents, Phytogenic - metabolism | Electron Transport Complex I - antagonists & inhibitors | Naphthoquinones - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Indolequinones - pharmacology | Neoplasms - enzymology | Naphthoquinones - pharmacology | Mitochondria - metabolism | Mitochondria - drug effects | NAD(P)H Dehydrogenase (Quinone) - antagonists & inhibitors | Neoplasms - drug therapy | Animals | Cell Line, Tumor | NAD(P)H Dehydrogenase (Quinone) - metabolism | Mice | Reverse Transcriptase Inhibitors - metabolism | Antineoplastic Agents, Phytogenic - pharmacology | Naphthoquinones - metabolism | Prodrugs - pharmacology | Antimitotic agents | Oncology, Experimental | Melanoma | Mitochondrial DNA | Research | Cancer | Index Medicus | ELECTRON SPIN RESONANCE | SUPEROXIDE DISMUTASE | HEPATOMAS | CLINICAL TRIALS | CHEMILUMINESCENCE | MITOCHONDRIA | MELANOMAS | BENZOQUINONES | 60 APPLIED LIFE SCIENCES | OXYGEN | CELL KILLING | PHOSPHATES | RADICALS | OXIDES | PEROXIDASES
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10. Full Text Growth inhibitory effects of 3′-nitro-3-phenylamino nor-beta-lapachone against HL-60: A redox-dependent mechanism
by Araújo, A.J and de Souza, A.A and da Silva Júnior, E.N and Marinho-Filho, J.D.B and de Moura, M.A.B.F and Rocha, D.D and Vasconcellos, M.C and Costa, C.O and Pessoa, C and de Moraes, M.O and Ferreira, V.F and de Abreu, F.C and Pinto, A.V and Montenegro, R.C and Costa-Lotufo, L.V and Goulart, M.O.F
Toxicology in vitro, ISSN 0887-2333, 06/2012, Volume 26, Issue 4, pp. 585 - 594
Cytotoxicity | Nitroquinone | Bioelectrochemistry | Nor-beta-lapachone | Apoptosis | DNA sensors | Life Sciences & Biomedicine | Toxicology | Science & Technology | Cell Survival - drug effects | Reactive Oxygen Species - metabolism | Oxidation-Reduction | Apoptosis - drug effects | Humans | HL-60 Cells | Benzofurans - pharmacology | Naphthoquinones - pharmacology | Antineoplastic Agents - pharmacology | DNA Damage | Comet Assay | Index Medicus
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11. Full Text Corpus Cavernosal Smooth Muscle Relaxation Effect of a Novel AMPK Activator, Beta‐Lapachone
by Bae, Jae Hyun and Kim, Jin Wook and Kweon, Gi Ryang and Park, Myoung Gyu and Jeong, Kyeong‐Hoon and Kim, Je Jong and Moon, Du Geon
Journal of sexual medicine, ISSN 1743-6095, 08/2011, Volume 8, Issue 8, pp. 2205 - 2214
AMPK Activator | eNOS | Beta‐Lapachone | Smooth Muscle Relaxation | Corpus Cavernosum | Penile Erection | Beta-Lapachone | ENOS | Life Sciences & Biomedicine | Urology & Nephrology | Science & Technology | Rabbits | AMP-Activated Protein Kinases - metabolism | Phosphorylation | Human Umbilical Vein Endothelial Cells - drug effects | Human Umbilical Vein Endothelial Cells - metabolism | Humans | Nitric Oxide Synthase Type III - biosynthesis | Male | Naphthoquinones - pharmacology | Muscle, Smooth - drug effects | Penis - drug effects | Animals | Penis - metabolism | Neuromuscular Agents - pharmacology | Muscle Relaxation - drug effects | Nitric Oxide Synthase Type III - metabolism | Adenosine | Impotence | Nitric oxide | Sodium nitroferricyanide | Dosage and administration | Cyanides | Cyclic guanylic acid | Protein kinases | Endothelium | Index Medicus
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