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beta-lapachone (673) 673
index medicus (283) 283
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apoptosis (158) 158
β-lapachone (152) 152
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cells (53) 53
quinones (53) 53
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cell survival - drug effects (50) 50
lapachol (50) 50
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structure-activity relationship (49) 49
analysis (47) 47
alpha-lapachone (46) 46
chemotherapy (46) 46
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molecular structure (43) 43
reactive oxygen species - metabolism (43) 43
dose-response relationship, drug (42) 42
hydrogen-peroxide (42) 42
cell biology (41) 41
naphthoquinone (41) 41
nor-beta-lapachone (40) 40
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chemistry (37) 37
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one-pot synthesis (26) 26
neoplasms - drug therapy (25) 25
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lapachone (24) 24
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camptothecin (23) 23
naphthoquinones - therapeutic use (23) 23
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1. Full Text Highly selective imaging of lysosomal azoreductase under hypoxia using pH-regulated and target-activated fluorescent nanoprobes
by Zhu, C and Zou, Z and Huang, CX and Zheng, J and Liu, N and Li, JS and Yang, RH
CHEMICAL COMMUNICATIONS, ISSN 1359-7345, 03/2019, Volume 55, Issue 22, pp. 3235 - 3238
In this work, we propose a pH-regulated and target-activated fluorescent nanoprobe for highly selective monitoring of lysosomal azoreductase under hypoxia in... 
PROBE | CHEMISTRY, MULTIDISCIPLINARY | BETA-LAPACHONE
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2. Full Text Understanding cancer and the anticancer activities of naphthoquinones - a review
by Wellington, Kevin W
02/2015, Volume 5, Issue 26, pp. 239 - 2338
The non-communicable disease, cancer, is one of the major causes of death across the world and is forecast to increase by 75% to reach close to 25 million... 
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3. Full Text Understanding cancer and the anticancer activities of naphthoquinones-a review
by Wellington, Kevin W
RSC Advances, ISSN 2046-2069, 2015, Volume 5, Issue 26, pp. 20309 - 20338
The non-communicable disease, cancer, is one of the major causes of death across the world and is forecast to increase by 75% to reach close to 25 million... 
BIOREDUCTIVE ALKYLATING-AGENTS | ANTITUMOR ANTIBIOTICS | OXIDOREDUCTASE DT-DIAPHORASE | 1,4-NAPHTHOQUINONE DERIVATIVES | MANSONONE-F | ABC TRANSPORTERS | DNA TOPOISOMERASE-I | MULTIDRUG-RESISTANCE MDR | CHEMISTRY, MULTIDISCIPLINARY | BETA-LAPACHONE | FREE-RADICALS
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4. Full Text Oligo(lactic acid)(n)-Paclitaxel Prodrugs for Poly(ethylene glycol)-block-poly(lactic acid) Micelles: Loading, Release, and Backbiting Conversion for Anticancer Activity
by Tam, YT and Gao, JM and Kwon, GS
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, ISSN 0002-7863, 07/2016, Volume 138, Issue 28, pp. 8674 - 8677
Poly(ethylene glycol)-block-poly(D,L-lactic acid) (PEG-b-PLA) micelles are nanocarriers for poorly water-soluble anticancer agents and have advanced paclitaxel... 
CREMOPHOR-FREE | STABILITY | HYDROLYTIC DEGRADATION | GENEXOL-PM | POLYMERIC MICELLES | FORMULATION | DERIVATIVES | CANCER | CHEMISTRY, MULTIDISCIPLINARY | BETA-LAPACHONE | PACLITAXEL
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5. Full Text NQO1-dependent, Tumor-selective Radiosensitization of Non-small Cell Lung Cancers
by Motea, EA and Huang, XM and Singh, N and Kilgore, JA and Williams, NS and Xie, XJ and Gerber, DE and Beg, MS and Bey, EA and Boothman, DA
CLINICAL CANCER RESEARCH, ISSN 1078-0432, 04/2019, Volume 25, Issue 8, pp. 2601 - 2609
Purpose: Development of tumor-specific therapies for the treatment of recalcitrant non-small cell lung cancers (NSCLC) is urgently needed. Here, we... 
APOPTOSIS | ACTIVATION | THERAPY | ONCOLOGY | NANOTHERAPEUTICS | DRUGS | CALCIUM | MECHANISMS | MICELLES | RADIATION | BETA-LAPACHONE
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6. Full Text Catalytic chalcogenylation under greener conditions: A solvent-free sulfur- and seleno-functionalization of olefins via I 2 /DMSO oxidant system
by Vieira, André A and Azeredo, Juliano B and Godoi, Marcelo and Santi, Claudio and Da Silva Júnior, Eufrânio N and Braga, Antonio L
Journal of Organic Chemistry, ISSN 0022-3263, 02/2015, Volume 80, Issue 4, pp. 2120 - 2127
Herein, we report a solvent- and metal-free methodology for the alkoxy-chalcogenylation of styrenes, using molecular iodine as a catalyst, DMSO as a... 
SELENENYLATING AGENT | DELTA-LACTONE | DIPHENYL DISELENIDE | GLUTATHIONE-PEROXIDASE | CHEMISTRY, ORGANIC | GAMMA-LACTONE | CYCLIC ETHER FORMATION | RING-CLOSURE | DIMETHYL(METHYLTHIO)SULFONIUM FLUOROBORATE | BETA-LAPACHONE | ASYMMETRIC METHOXYSELENENYLATIONS
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7. Full Text Combinatorial Therapy of Zinc Metallochaperones with Mutant p53 Reactivation and Diminished Copper Binding
by Zaman, S and Yu, X and Bencivenga, AF and Blanden, AR and Liu, Y and Withers, T and Na, B and Blayney, AJ and Gilleran, J and Boothman, DA and Loh, SN and Kimball, SD and Carpizo, DR
MOLECULAR CANCER THERAPEUTICS, ISSN 1535-7163, 08/2019, Volume 18, Issue 8, pp. 1355 - 1365
Chemotherapy and radiation are more effective in wild-type (WT) p53 tumors due to p53 activation. This is one rationale for developing drugs that reactivate... 
CELLS | OXIDATIVE STRESS | INHIBITION | ONCOLOGY | DRUGS | SYNERGIZES | BETA-LAPACHONE | CHEMOTHERAPY
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8. Full Text An NAD(P)H:Quinone Oxidoreductase 1 Responsive and Self-Immolative Prodrug of 5‑Fluorouracil for Safe and Effective Cancer Therapy
by Zhang, Xian and Li, Xiang and Li, Zhihong and Wu, Xingsen and Wu, Yue and You, Qidong and Zhang, Xiaojin
Organic Letters, ISSN 1523-7060, 06/2018, Volume 20, Issue 12, pp. 3635 - 3638
Tripartite prodrug 1, composed of an NAD­(P)­H:quinone oxidoreductase 1 (NQO1)-responsive trigger group, a self-immolative linker, and the active drug... 
CELL LUNG-CANCER | QUINONE | CHEMISTRY, ORGANIC | REDUCTASE | BETA-LAPACHONE | DISCOVERY | OVEREXPRESS NQO1
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9. Full Text DBU: A highly efficient catalyst for one-pot synthesis of substituted 3, 4- dihydropyrano[3, 2-c]chromenes, dihydropyrano[4, 3-b]pyranes, 2-amino-4H- benzo[h]chromenes and 2-amino-4H benzo[g]chromenes in aqueous medium
by Khurana, Jitender M and Nand, Bhaskara and Saluja, Pooja
Tetrahedron, ISSN 0040-4020, 07/2010, Volume 66, Issue 30, pp. 5637 - 5641
We have reported DBU catalyzed one-pot synthesis of 3, 4-dihydropyrano[3, 2-c]chromenes, dihy- dropyrano[4, 3-b]pyranes, 2-amino-4H-benzo[h]chromenes and... 
Synthesis in water | Chromenes | 1, 8-Diazabicyclo[5.4.0]undec-7-ene (DBU) | Aldehydes | Multi-component reaction | 1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU) | ONE-STEP SYNTHESIS | CHEMISTRY, ORGANIC | IONIC LIQUID | 2-AMINO-2-CHROMENES | BETA-LAPACHONE | HETEROCYCLIC SYNTHESIS | MULTICOMPONENT REACTIONS | 3-COMPONENT CONDENSATION | DERIVATIVES | NICKEL BORIDE | WATER | Nitriles
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10. Full Text Palladium(II)-Catalyzed Reaction of Lawsones and Propargyl Carbonates: Construction of 2,3-Furanonaphthoquinones and Evaluation as Potential Indoleamine 2,3-Dioxygenase Inhibitors
by Feng, Xi and Qiu, Xiaqiu and Huang, Huidan and Wang, Jubo and Xu, Xi and Xu, Pengfei and Ge, Ruijia and Liu, Xiaojin and Li, Zhiyu and Bian, Jinlei
The Journal of Organic Chemistry, ISSN 0022-3263, 08/2018, Volume 83, Issue 15, pp. 8003 - 8010
An efficient reaction utilizing propargyl carbonates through Claisen rearrangement to synthesize furanonaphthoquinones is described. The remarkable... 
ANTITUMOR AGENTS | NAPHTHOQUINONES | TRYPTOPHAN | QUINONES | PATHWAY | NATURAL-PRODUCTS | DRUG DISCOVERY | CHEMISTRY, ORGANIC | 1,4-NAPHTHOQUINONES | DERIVATIVES | BETA-LAPACHONE
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11. Full Text Um panorama atual da química e da farmacologia de naftoquinonas, com ênfase na β-Lapachona e derivados
by Da Silva, Milton N and Ferreira, Vítor F and De Souza, Maria Cecília B. V
Quimica Nova, ISSN 0100-4042, 05/2003, Volume 26, Issue 3, pp. 407 - 416
Pyranaphthoquinone | Beta-Lapachone | Naphthoquinone | Apoptosis
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12. Full Text Site-selectivity control in hetero-Diels-Alder reactions of methylidene derivatives of lawsone through modification of the reactive carbonyl group: An experimental and theoretical study
by Tsanakopoulou, Maria and Tsovaltzi, Erifili and Tzani, Marina A and Selevos, Periklis and Malamidou-Xenikaki, Elizabeth and Bakalbassis, Evangelos G and Domingo, Luis R
Organic and Biomolecular Chemistry, ISSN 1477-0520, 2019, Volume 17, Issue 3, pp. 692 - 702
A new perspective on the reactivity of hydroxyquinones was revealed as an acetal derivative of lawsone was synthesized, isolated, and used in tandem... 
ALPHA-LAPACHONE | 2-HYDROXY-1,4-NAPHTHOQUINONE | PYRANONAPHTHOQUINONES | QUINONES | PHENYLIODONIUM YLIDE | TRYPANOSOMA-CRUZI | CYCLOADDITIONS | BETA-LAPACHONE DERIVATIVES | CHEMISTRY, ORGANIC
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13. Full Text Synthesis of Spirooxindole-O-NaphthoquinoneTetrazolo[1,5-a] Pyrimidine Hybrids as Potential Anticancer Agents
by Wu, LQ and Liu, YX and Li, YZ
MOLECULES, ISSN 1420-3049, 09/2018, Volume 23, Issue 9
A series of novel spirooxindole-O-naphthoquinone-tetrazolo[1,5-a] pyrimidine hybrids were designed, synthesized and evaluated as potent antitumor agents. These... 
spirooxindole | antitumor activity | BIOCHEMISTRY & MOLECULAR BIOLOGY | O-naphthoquinone | hybrids | ANTIFUNGAL | SCAFFOLDS | NAPHTHOQUINONE | CYTOTOXICITY | CHEMISTRY, MULTIDISCIPLINARY | BETA-LAPACHONE
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14. Full Text Synthesis and antitumor activity evaluation of novel substituted 5H-benzo[i][1,3,4]thiadiazolo[3,2-a]quinazoline-6,7-diones
by Wu, Liqiang and Zhang, Chong
RSC Advances, ISSN 2046-2069, 2016, Volume 6, Issue 34, pp. 28555 - 28562
A series of novel substituted 5H-benzo[i][1,3,4]thiadiazolo[3,2-a]quinazoline-6,7-diones, designed via a molecular hybridization approach, were synthesized in... 
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15. Full Text Machine intelligence decrypts -lapachone as an allosteric 5-lipoxygenase inhibitor
by Rodrigues, T and Werner, M and Roth, J and da Cruz, EHG and Marques, MC and Akkapeddi, P and Lobo, SA and Koeberle, A and Corzana, F and da Silva, EN and Werz, O and Bernardes, GJL
CHEMICAL SCIENCE, ISSN 2041-6520, 09/2018, Volume 9, Issue 34
Using machine learning, targets were identified for -lapachone. Resorting to biochemical assays, -lapachone was validated as a potent, ligand efficient,... 
MACROMOLECULAR TARGETS | CANCER-CELLS | C2-LIKE DOMAIN | NATURAL-PRODUCTS | DRUG DISCOVERY | IN-VIVO | HL-60 CELLS | CLASSIFICATION | DERIVATIVES | CHEMISTRY, MULTIDISCIPLINARY | BETA-LAPACHONE
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16. Full Text Plasma pharmacokinetics and brain distribution kinetics of lapachol in rats using LC-MS and microdialysis techniques
by Bai, Lu and Han, Ying and Xu, Pingxiang and Xia, Binbin and Zhao, Yuming and Li, Xiaorong and Xue, Ming
RSC Advances, ISSN 2046-2069, 11/2017, Volume 7, Issue 84, pp. 53355 - 53361
The objective of this paper was to investigate the plasma pharmacokinetics and brain distribution kinetics of lapachol in rats. A sensitive and specific... 
NAPHTHOQUINONES | GLYCOSIDES | IN-VITRO | RESISTANT STAPHYLOCOCCUS-AUREUS | MS/MS | DERIVATIVES | CHEMISTRY, MULTIDISCIPLINARY | BETA-LAPACHONE | EXTRACT
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17. Full Text Understanding and predicting the potency of ROS-based enzyme inhibitors, exemplified by naphthoquinones and ubiquitin specific protease-2
by Gopinath, Pushparathinam and Mahammed, Atif and Ohayon, Shimrit and Gross, Zeev and Brik, Ashraf
Chemical Science, ISSN 2041-6520, 2016, Volume 7, Issue 12, pp. 7079 - 7086
Recent studies have suggested that selective targeting of overexpressed enzymes in cancer cells by small molecules that induce the formation of reactive oxygen... 
CANCER-CELLS | OXYGEN | OXIDATIVE STRESS | REDUCTION | SMALL-MOLECULE | DEUBIQUITINASES | ELECTRODE | MECHANISMS | CHEMISTRY, MULTIDISCIPLINARY | BETA-LAPACHONE | DISCOVERY
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18. Full Text Design, synthesis and application of fluorescent 2,1,3-benzothiadiazole- triazole-linked biologically active lapachone derivatives
by Da Cruz, Eduardo H. G and Carvalho, Pedro H. P. R and Corrêa, José R and Silva, Diego A. C and Diogo, Emilay B. T and De Souza Filho, José D and Cavalcanti, Bruno C and Pessoa, Claudia and De Oliveira, Heibbe C. B and Guido, Bruna C and Da Silva Filho, Demétrio A and Neto, Brenno A. D and Da Silva Júnior, Eufrânio N
New Journal of Chemistry, ISSN 1144-0546, 2014, Volume 38, Issue 6, pp. 2569 - 2580
Two new benzothiadiazole-triazole-linked lapachone derivatives were designed, synthesized and characterized by 1D and 2D NMR spectroscopy. Their photophysical... 
CELLS | OXIDATIVE STRESS | REACTIVE OXYGEN | DYES | SENSITIVE FLUOROPHORES | CLICK CHEMISTRY | IMAGING PROBES | PHOTOPHYSICAL PROPERTIES | CHEMISTRY, MULTIDISCIPLINARY | BETA-LAPACHONE | SOLVENT
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19. Full Text Napabucasin and Related Heterocycle-Fused Naphthoquinones as STAT3 Inhibitors with Antiproliferative Activity against Cancer Cells
by Löcken, Hauke and Clamor, Cinzia and Müller, Klaus
Journal of Natural Products, ISSN 0163-3864, 07/2018, Volume 81, Issue 7, pp. 1636 - 1644
Napabucasin (6) and its angularly anellated isomer (7), for which the synthesis is described, together with related plant-derived naphthoquinones, were... 
APOPTOSIS | CHEMISTRY, MEDICINAL | MECHANISM | TARGETING STAT3 | REDOX ACTIVATION | SUPPRESSION | BETA-LAPACHONE | STRATEGIES | PLANT SCIENCES | ROS | PHARMACOLOGY & PHARMACY | NQO1 BIOACTIVATABLE DRUG | DERIVATIVES
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20. Full Text A Tumor‐Specific Cascade Amplification Drug Release Nanoparticle for Overcoming Multidrug Resistance in Cancers
by Ye, Mingzhou and Han, Yuxin and Tang, Jianbin and Piao, Ying and Liu, Xiangrui and Zhou, Zhuxian and Gao, Jianqing and Rao, Jianghong and Shen, Youqing
Advanced Materials, ISSN 0935-9648, 10/2017, Volume 29, Issue 38, pp. 1702342 - n/a
A cascade amplification release nanoparticle (CARN) is constructed by the coencapsulation of β‐lapachone and a reactive‐oxygen‐species (ROS)‐responsive... 
β‐lapachone | multidrug resistance | drug delivery | anticancer prodrug | cascade amplification drug release | β-lapachone | APOPTOSIS | PHYSICS, CONDENSED MATTER | OXIDATIVE STRESS | PHYSICS, APPLIED | GENE DELIVERY | SOLID TUMORS | MATERIALS SCIENCE, MULTIDISCIPLINARY | CHEMISTRY, PHYSICAL | NANOSCIENCE & NANOTECHNOLOGY | CHEMISTRY, MULTIDISCIPLINARY | BETA-LAPACHONE | lapachone | P-GLYCOPROTEIN | CELL LUNG-CANCER | THERAPY | IN-VIVO | HYDROGEN-PEROXIDE | Nanoparticles | Prodrugs | Drug Resistance, Multiple | Humans | Cell Line, Tumor | Drug Liberation | Drug Resistance, Neoplasm | Doxorubicin | Drugs | Drug resistance in microorganisms | Drug delivery systems | Drug therapy | Cancer | Vehicles | Amplification | Side effects | Catalysis | Tumors
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