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11/2012
γ-Secretase plays a pivotal role in the production of neurotoxic amyloid β-peptide (Aβ), the principal component of amyloid plaques present in Alzheimer’s... 
Gamma-secretase | Alzheimer's Disease | Proteomics | Amyloid beta peptide | 0317
Dissertation
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 07/2014, Volume 111, Issue 26, pp. 9384 - 9389
The two major forms of the amyloid-beta (A beta) peptide found in plaques in patients suffering from Alzheimer's disease, A beta 40 and A beta 42, only differ... 
aggregation mechanism | MECHANISM | protein aggregation | rate law | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | AMYLOID-BETA-PEPTIDE | neurodegeneration | OCCURS
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 06/2013, Volume 110, Issue 24, pp. 9758 - 9763
The generation of toxic oligomers during the aggregation of the amyloid-beta (A beta) peptide A beta 42 into amyloid fibrils and plaques has emerged as a... 
PROTEIN AGGREGATION | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | neurodegeneration | COMMON MECHANISM | POLYMERIZATION | OLIGOMERS | molecular mechanisms | chemical kinetics | FIBRILS | PATHWAY | protein misfolding | CONFORMATIONAL CONVERSION | KINETICS | AMYLOID-BETA-PEPTIDE | Naturvetenskap | Kemi | Physical Chemistry | Fysikalisk kemi | Natural Sciences | Chemical Sciences
Journal Article
Neuroscience, ISSN 0306-4522, 2016, Volume 344, pp. 39 - 47
Highlights • Resveratrol pretreatment significantly inhibited the spatial learning memory impairment induced by Aβ1–42 in a rat model. • Resveratrol... 
Neurology | amyloid beta peptide | LTP | CREB | learning and memory | resveratrol | SIRT1 | Index Medicus
Journal Article
NEUROLOGY, ISSN 0028-3878, 07/2003, Volume 61, Issue 1, pp. 46 - 54
Background: AD is characterized by cerebral deposition of beta-amyloid plaques with amyloid beta-peptide (Abeta) 42 as the major peptide constituent, along... 
ANTIBODIES | MRI FINDINGS | MEMORY | ACUTE DISSEMINATED ENCEPHALOMYELITIS | ALZHEIMERS-DISEASE | AMYLOID-BETA-PEPTIDE | VACCINATION | MODEL | PATHOLOGY | CLINICAL NEUROLOGY | TRANSGENIC MICE
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 01/2017, Volume 114, Issue 2, pp. E200 - E208
The aggregation of the 42-residue form of the amyloid-beta peptide (A beta 42) is a pivotal event in Alzheimer's disease (AD). The use of chemical kinetics has... 
THERAPEUTICS | DESIGN | MULTIDISCIPLINARY SCIENCES | NEURODEGENERATION | AMYLOID HYPOTHESIS | BETA-PEPTIDE | MECHANISMS | amyloid-beta peptide | CAENORHABDITIS-ELEGANS | drug discovery | protein misfolding | protein aggregation | Alzheimer's disease | MODULATION
Journal Article
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, ISSN 0002-7863, 04/2012, Volume 134, Issue 15, pp. 6625 - 6636
Abnormal interactions of Cu and Zn ions with the amyloid beta (A beta) peptide are proposed to play an important role in the pathogenesis of Alzheimer's... 
NADPH OXIDASE | ALZHEIMER A-BETA | OXIDATIVE STRESS | IN-VITRO | AMYLOID-BETA-PEPTIDE | HIGH-AFFINITY | BINDING-SITE | PARKINSONS-DISEASES | ZINC-BINDING | CHEMISTRY, MULTIDISCIPLINARY | TRANSGENIC MICE
Journal Article
Journal of Physical Chemistry B, ISSN 1520-6106, 2019, Volume 123, Issue 25, pp. 5206 - 5215
Aggregation of amyloid beta peptide (Aβ) and inflammatory processes associated with the generation of superoxide, hydrogen peroxide, and hydroxyl radicals are... 
AMYLOID-BETA PEPTIDE | MOLECULAR-DYNAMICS | BINDS | EXPERIMENTAL CONSTRAINTS | RELEVANCE | COMPLEXES | CHEMISTRY, PHYSICAL | TOXICITY | MODEL | AGGREGATION
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 07/2019, Volume 431, Issue 15, pp. 2687 - 2699
Within the amyloid hypothesis in Alzheimer's disease, current focus has shifted to earlier stages of amyloid beta (Aβ) peptide assembly, involving soluble... 
amyloid beta peptide | high-speed atomic force microscopy | oligomerization | Alzheimer's disease | single molecule kinetics
Journal Article
Chemistry – A European Journal, ISSN 0947-6539, 08/2016, Volume 22, Issue 34, pp. 11874 - 11874
Learning by looking into a mirror , using a variant of the Alzheimer′s amyloid beta 42 peptide (E22e variant) with a d ‐amino acid introduced at the glutamate... 
amyloid beta peptide | Alzheimer′s disease | aggregation | neurotoxicity | chirality
Journal Article
by Yi, Y and Han, J and Park, MH and Park, N and Nam, E and Jin, HK and Bae, JS and Lim, MH
CHEMICAL COMMUNICATIONS, ISSN 1359-7345, 05/2019, Volume 55, Issue 42, pp. 5847 - 5850
We report a new series of small molecules able to achieve the tunability of modulatory activities against acid sphingomyelinase (ASM) and Zn(II)bound... 
SYSTEM | SPECTROSCOPY | AMYLOID-BETA-PEPTIDE | DISEASE | A-BETA | MECHANISMS | CHEMISTRY, MULTIDISCIPLINARY | ALZHEIMERS | ZINC
Journal Article
CHEMICAL COMMUNICATIONS, ISSN 1359-7345, 05/2019, Volume 55, Issue 34, pp. 4933 - 4936
Inspired by the unique mechanism of proteolytic maturation of host cell factor-1, we designed small peptide-based constructs that selectively recognized... 
ALPHA-SECRETASE | PROTEIN | DISRUPTION | ALZHEIMERS-DISEASE | A-BETA | CLEAVAGE | CHEMISTRY, MULTIDISCIPLINARY | BETA PEPTIDE
Journal Article
NEUROLOGY, ISSN 0028-3878, 01/2005, Volume 64, Issue 1, pp. 94 - 101
Background: Abeta42-immunization reduces plaque burden and improves cognition in transgenic mouse models of Alzheimer disease (AD). This phase 1 study... 
IMMUNIZATION | PROTEIN | ALZHEIMERS-DISEASE | AMYLOID-BETA-PEPTIDE | MOUSE | TAU | PATHOLOGY | MODEL | CLINICAL NEUROLOGY | TRANSGENIC MICE
Journal Article
by Yin, ZZ and Wang, SH and Shen, BC and Deng, CY and Tu, QY and Jin, Y and Shen, L and Jiao, B and Xiang, J
ANALYTICAL CHEMISTRY, ISSN 0003-2700, 03/2019, Volume 91, Issue 5, pp. 3539 - 3545
Phosphorylated proteins play important roles in the pathogenesis of Alzheimer's disease (AD). The most abundant constituent in AD's brain deposit is the... 
CHEMISTRY, ANALYTICAL | DEMENTIA | ALZHEIMERS-DISEASE | AMYLOID-BETA-PEPTIDE | LIGHT | MASS | ASSOCIATION | BINDING | AGGREGATION
Journal Article
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, ISSN 1943-0264, 07/2011, Volume 3, Issue 7
Over the last three decades, advances in biochemical pathology and human genetics have illuminated one of the most enigmatic subjects in... 
BETA-PEPTIDE DEPOSITION | PAIRED HELICAL FILAMENTS | A-BETA | AMYLOID-PRECURSOR-PROTEIN | CENTRAL-NERVOUS-SYSTEM | LONG-TERM POTENTIATION | GAMMA-SECRETASE | APOLIPOPROTEIN-E | TRANSGENIC MICE | SENILE PLAQUES | CELL BIOLOGY
Journal Article
Food Chemistry, ISSN 0308-8146, 05/2016, Volume 199, pp. 185 - 194
Various food constituents have been proposed as disease-modifying agents for Alzheimer’s disease (AD), due to epidemiological evidence of their beneficial... 
Antioxidants | Polyphenols | Vitamins | Metal chelators | Amyloid-beta peptide
Journal Article
Cell Calcium, ISSN 0143-4160, 2011, Volume 50, Issue 3, pp. 222 - 233
Abstract A variety of stimuli utilize an increase of cytosolic free Ca2+ concentration as a second messenger to transmit signals, through Ca2+ release from the... 
Advanced Basic Science | Mitochondria | Permeability transition pore | Apoptosis | Necrosis | AMYOTROPHIC-LATERAL-SCLEROSIS | WOLF-HIRSCHHORN-SYNDROME | CELL-DEATH | CELL BIOLOGY | HEXOKINASE-II | CYCLOPHILIN-D | AMYLOID BETA-PEPTIDE | CYCLOSPORINE-A | Ca2 | BCL-2 PROTEIN FAMILY | ENDOPLASMIC-RETICULUM | PARKINSONS-DISEASE
Journal Article
Chemical Communications, ISSN 1359-7345, 06/2011, Volume 47, Issue 21, pp. 5933 - 5941
Journal Article
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