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CNS and Neurological Disorders - Drug Targets, ISSN 1871-5273, 12/2016, Volume 15, Issue 10, pp. 1279 - 1289
Journal Article
EMBO MOLECULAR MEDICINE, ISSN 1757-4676, 06/2016, Volume 8, Issue 6, pp. 595 - 608
Despite continuing debate about the amyloid -protein (or A hypothesis, new lines of evidence from laboratories and clinics worldwide support the concept that... 
MEDICINE, RESEARCH & EXPERIMENTAL | treatment | NEURITIC DEGENERATION | TAU PATHOLOGY | Alzheimer | APOLIPOPROTEIN-E | genetics | cell biology | IN-VIVO | BETA-SECRETASE BACE1 | A-BETA | PRECURSOR PROTEIN | TRANSGENIC MOUSE MODEL | GAMMA-SECRETASE | GENOME-WIDE ASSOCIATION
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 7/2011, Volume 39, Issue suppl_2, pp. W270 - W277
Most life science processes involve, at the atomic scale, recognition between two molecules. The prediction of such interactions at the molecular level, by... 
BETA-SECRETASE | GEOMETRIES | DESIGN | BIOCHEMISTRY & MOLECULAR BIOLOGY | FORCE FIELD | MMFF94 | VALIDATION | INHIBITORS | SIMULATION | SOLVATION | DISCOVERY | Drug Design | Protein Engineering | Models, Molecular | Ligands | Protein Conformation | Software | Internet | Index Medicus
Journal Article
TRENDS IN NEUROSCIENCES, ISSN 0166-2236, 03/2016, Volume 39, Issue 3, pp. 158 - 169
The protease beta-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1) is required for the production of the amyloid-beta (A beta) peptide, which is... 
CLOSE HOMOLOG | MICE DEFICIENT | ALZHEIMERS-DISEASE | GATED SODIUM-CHANNELS | SYNAPTIC-TRANSMISSION | BETA-SECRETASE BACE1 | AMYLOID PRECURSOR PROTEIN | CEREBROSPINAL-FLUID | CLEAVING ENZYME BACE1 | NEUROSCIENCES | REGULATES HIPPOCAMPAL
Journal Article
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 08/2019, Volume 203, Issue 3, pp. 665 - 675
beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1) is best known for its role in Alzheimer's disease amyloid plaque formation but also contributes... 
BETA-SECRETASE | AUTOIMMUNE | INHIBITION | PATHWAY | KINASE | GENE-EXPRESSION | DOWN-REGULATION | PTEN | IMMUNOLOGY | DIFFERENTIAL REGULATION | CAMP-PKA
Journal Article
Aging, ISSN 1945-4589, 12/2018, Volume 11, Issue 1, pp. 13 - 14
Journal Article
JOURNAL OF CELL BIOLOGY, ISSN 0021-9525, 12/2004, Volume 167, Issue 5, pp. 953 - 960
Recent experimental and clinical retrospective studies support the view that reduction of brain cholesterol protects against Alzheimer's disease (AD). However,... 
BETA-SECRETASE | ALZHEIMERS-DISEASE | LIPID RAFTS | RISK | MICE | PRECURSOR PROTEIN | HIPPOCAMPAL-NEURONS | STATINS | CELL BIOLOGY
Journal Article
Nature, ISSN 0028-0836, 08/2012, Volume 488, Issue 7409, pp. 96 - 99
Journal Article
Alzheimer's Research and Therapy, ISSN 1758-9193, 12/2014, Volume 6, Issue 9, pp. 89 - 89
beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) is the beta-secretase enzyme required for the production of the neurotoxic beta-amyloid (A beta)... 
CLOSE HOMOLOG | CLEAVING ENZYME-1 | BETA-SECRETASE ACTIVITY | OLFACTORY SENSORY NEURONS | INCREASED EXPRESSION | ASPARTYL PROTEASE | MEMORY DEFICITS | A-BETA | AMYLOID PRECURSOR PROTEIN | KNOCKOUT MICE | NEUROSCIENCES | CLINICAL NEUROLOGY | Advertising executives | Enzymes | Hydrolases | Drug targeting | Pharmaceutical industry | Alzheimer's disease | Amino acids
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 01/2012, Volume 55, Issue 2, pp. 678 - 687
Fragment based drug discovery (FBDD) is a widely used tool for discovering novel therapeutics. NMR is a powerful means for implementing FBDD, and several... 
BETA-SECRETASE | CHEMISTRY, MEDICINAL | MACROMOLECULES | LIGANDS | FLUORINE | OPTIMIZATION | COMPUTATION | BINDING-SITES | ANALYTICAL SHAPE | DRUGGABILITY | PROTEINS
Journal Article
HUMAN MOLECULAR GENETICS, ISSN 0964-6906, 07/2012, Volume 21, Issue 13, pp. 2973 - 2990
The purpose of this study was to investigate the protective effects of the mitochondria-targeted antioxidant catalase (MCAT) and lifespan extension in mice... 
BETA-SECRETASE ACTIVITY | INCREASED OXIDATIVE DAMAGE | DNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | A-BETA | HYDROGEN-PEROXIDE | PRECURSOR PROTEIN | DYSFUNCTION | GAMMA-SECRETASE | NEURONAL DAMAGE | TRANSGENIC MICE
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 05/2019, Volume 10
The beta-site APP cleaving enzyme 1 (BACE1) is known primarily for its initial cleavage of the amyloid precursor protein (APP), which ultimately leads to the... 
BACE1 | BIOMARKERS | APP | PROTEIN | BETA-SECRETASE CLEAVAGE | INCREASED EXPRESSION | MULTIDISCIPLINARY SCIENCES | MUTATION | VALIDATION | CEREBROSPINAL-FLUID | PEPTIDE
Journal Article
Neuroscience, ISSN 0306-4522, 01/2019, Volume 397, pp. 138 - 146
Beta secretase 1 (BACE1) is an enzyme involved in the pathogenesis of Alzheimer’s disease (AD). PLB4 mice are a neuron-specific human BACE1 knock-in mouse... 
beta secretase 1 (BACE1) | PLB4 | brain | Alzheimer's disease | metabolites | INVOLVEMENT | DEPENDS | MICE | MODEL | CERAMIDE | NEUROSCIENCES | Index Medicus
Journal Article
ACS Chemical Biology, ISSN 1554-8929, 12/2018, Volume 13, Issue 12, pp. 3236 - 3242
Heparanase is a mammalian endoglycosidase that cleaves heparan sulfate (HS) polysaccharides and contributes to remodelling of the extracellular matrix and... 
BETA-SECRETASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PG545 | MECHANISMS | TUMOR-GROWTH | CANCER | PROGRESSION | DISCOVERY
Journal Article
Neurologia, ISSN 0213-4853, 01/2018, Volume 33, Issue 1, pp. 35 - 46
Introduction Alzheimer disease (AD) is a major neurodegenerative disorder which eventually results in total intellectual disability. The high global prevalence... 
Gamma-secretase | Amyloid hypotheses | Beta-secretase | Alzheimer disease | Beta-amyloid
Journal Article
JOURNAL OF NEUROCHEMISTRY, ISSN 0022-3042, 01/2012, Volume 120, pp. 71 - 83
beta-Secretase (memapsin 2; BACE-1) is the first protease in the processing of amyloid precursor protein leading to the production of amyloid-beta (A beta) in... 
memapsin 2 | BACE 1 | inhibitors | drugs | BIOCHEMISTRY & MOLECULAR BIOLOGY | HUMAN BETA-SECRETASE | X-RAY-STRUCTURE | AMYLOID PRECURSOR PROTEIN | POTENT INHIBITORS | NEUROSCIENCES | HYDROXY ETHYLAMINES HEAS | beta-secretase | WILD-TYPE MICE | IN-VIVO | A-BETA | Alzheimer's disease | CARBINAMINE BACE-1 INHIBITORS | STRUCTURE-BASED DESIGN
Journal Article
INORGANIC CHEMISTRY, ISSN 0020-1669, 11/2016, Volume 55, Issue 22, pp. 12001 - 12010
Two high-spin Fe(II) and Co(II) complexes of 1,4,7,10-tetraazacyclododecane (CYCLEN) appended with four 2-amino-6-picolyl groups, denoted as [Fe(TAPC)](2+) and... 
SATURATION-TRANSFER CEST | BETA-SECRETASE | EXCHANGE-RATES | IN-VIVO | COBALT(II) | LANTHANIDE(III) COMPLEXES | INHIBITORS | PROVIDES | SENSORS | MRI CONTRAST AGENTS | CHEMISTRY, INORGANIC & NUCLEAR
Journal Article
Scientific Reports, ISSN 2045-2322, 01/2017, Volume 7, Issue 1, pp. 40256 - 40256
Endothelial dysfunction and monocyte adhesion to vascular endothelial cells are two critical steps in atherosclerosis development, and emerging evidence... 
BETA-SECRETASE | ARREST | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | IN-VIVO | SIALYLATION | ATHEROSCLEROSIS | VE-CADHERIN | GLYCOSYLATION | GLYCOSYLTRANSFERASES | VASCULAR ENDOTHELIUM | Index Medicus
Journal Article