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ubiquitin - metabolism (58) 58
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COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, ISSN 1943-0264, 10/2009, Volume 1, Issue 4, pp. 5 - 18
Nuclear factor-kappa B (NF-kappa B) consists of a family of transcription factors that play critical roles in inflammation, immunity, cell proliferation,... 
KINASE-ALPHA | DNA-BINDING | BETA-TRCP | UBIQUITIN LIGASE | CRYSTAL-STRUCTURE | INDUCIBLE NUCLEAR-PROTEIN | GENE-EXPRESSION | IKK-ALPHA | SIGNALING MODULE | DEPENDENT DEGRADATION | CELL BIOLOGY | 040
Journal Article
Nature Cell Biology, ISSN 1465-7392, 08/2005, Volume 7, Issue 8, pp. 758 - 765
The transcription factor NF-kappa B (nuclear factor kappa enhancer binding protein) controls many processes, including immunity, inflammation and apoptosis.... 
ACTIVATION | IMMUNE-SYSTEM | SITE-SPECIFIC PHOSPHORYLATION | BETA-TRCP | PROTEASOME PATHWAY | DEFECTIVE INTERLEUKIN-1 | POLYUBIQUITIN CHAINS | TUMOR-SUPPRESSOR CYLD | NF-KAPPA-B1 PRECURSOR PROTEIN | CELL-DEATH | CELL BIOLOGY
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 03/2011, Volume 31, Issue 6, pp. 1121 - 1133
Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
OXIDATIVE STRESS | PROTEIN | CUL3-BASED E3 LIGASE | BETA-TRCP | PROTEASOMAL DEGRADATION | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | THERAPEUTIC TARGET | UBIQUITIN-LIGASE COMPLEX | KEAP1 | CELL-PROLIFERATION | CELL BIOLOGY
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 07/2019, Volume 79, Issue 14, pp. 3725 - 3736
mTOR complex 1 (mTORC1) positively regulates cell invasion and metastasis by enhancing translation of Snail. A connection between mTOR complex 2 (mTORC2) and... 
MAMMALIAN TARGET | MIGRATION | ACTIVATION | ONCOLOGY | BETA-TRCP | PHOSPHORYLATION | COMPLEX 2 | MESENCHYMAL TRANSITION | INHIBITOR | UBIQUITIN LIGASES | EMT
Journal Article
MOLECULAR & CELLULAR PROTEOMICS, ISSN 1535-9476, 07/2015, Volume 14, Issue 7, pp. 1781 - 1795
The identification of ubiquitin E3 ligase substrates has been challenging, due in part to low-affinity, transient interactions, the rapid degradation of... 
NUCLEAR-ENVELOPE | HUMAN-DISEASE | PROTEIN | LINC COMPLEX | PARTIAL LIPODYSTROPHY | BIOCHEMICAL RESEARCH METHODS | MUSCULAR-DYSTROPHY | SCF-BETA-TRCP | KAPPA-B | UBIQUITIN LIGASES | MASS-SPECTROMETRY
Journal Article
CURRENT BIOLOGY, ISSN 0960-9822, 02/2007, Volume 17, Issue 4, pp. 304 - 315
Background: The mitotic kinases, Cdk1, Aurora A/B, and Polo-like kinase 1 (Plk1) have been characterized extensively to further understanding of mitotic... 
CELL-DIVISION | ANAPHASE-PROMOTING COMPLEX | SPINDLE-CHECKPOINT PROTEINS | BIOCHEMISTRY & MOLECULAR BIOLOGY | SCF-BETA-TRCP | CHROMOSOME ALIGNMENT | MOTOR PROTEINS | BOX DOMAIN | POLO-LIKE KINASE | KINETOCHORE-MICROTUBULE ATTACHMENT | AURORA-B
Journal Article
by Luo, YW and Liu, Y and Wu, LY and Ma, XC and Liu, Q and Huang, F and Zhang, X and Zhang, YW and Zhang, JS and Luo, HH and Yang, YY and Lu, G and Tang, XP and Li, LH and Zeng, YX and Pan, T and Zhang, H
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 07/2019, Volume 203, Issue 1, pp. 269 - 281
Activation-induced cytidine deaminase (AID) initiates class switch recombination and somatic hypermutation in Ig genes. The activity and protein levels of AID... 
CULLIN-RING LIGASES | PROTEIN | SOMATIC HYPERMUTATION | AID EXPRESSION | GENE | BETA-TRCP | SCF | REGIONS | C-MYC | IMMUNOLOGY | DNA-DAMAGE-RESPONSE
Journal Article
EXPERIMENTAL EYE RESEARCH, ISSN 0014-4835, 10/2018, Volume 175, pp. 173 - 180
Muller cells are the primary glia in the retina, playing a critical role in retinal homeostasis and retinal pathology. This study evaluated the canonical Wnt... 
ACTIVATION | ANGIOGENESIS | BETA-TRCP | PATHWAY | PHOSPHORYLATION | C-MYC | OPHTHALMOLOGY | DEGRADATION | TRANSGENIC MODEL | EXPRESSION | MULLER CELLS
Journal Article
Journal of Cell Science, ISSN 0021-9533, 07/2010, Volume 123, Issue 13, pp. 2163 - 2169
Centrioles are the main constituents of the mammalian centrosome and act as basal bodies for ciliogenesis. Centrosomes organize the cytoplasmic microtubule... 
Autophosphorylation | Centriole duplication | Plk4 | βTrCP | CELLS | PROTEIN | MECHANISMS | CENTROSOME DUPLICATION | CELL BIOLOGY | UBIQUITINATION | BIOGENESIS | ELEGANS | beta TrCP | CYTOSTATIC FACTOR | DEPENDENT DEGRADATION | KINASES
Journal Article
Nature Reviews Molecular Cell Biology, ISSN 1471-0072, 12/2011, Volume 12, Issue 12, pp. 769 - 769
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2014, Volume 9, Issue 10, pp. e109159 - e109159
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 04/2005, Volume 25, Issue 7, pp. 2795 - 2807
Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
DOUBLE-TIME | DROSOPHILA PERIOD PROTEIN | UBIQUITIN LIGASE | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CLOCK PROTEIN | LIGHT | GENE-EXPRESSION | SCF-BETA-TRCP | CASEIN-KINASE-I | POSTTRANSLATIONAL REGULATION | CELL BIOLOGY
Journal Article
MOLECULAR CELL, ISSN 1097-2765, 03/2013, Volume 49, Issue 6, pp. 1159 - 1166
F-box proteins and DCAF proteins are the substrate binding subunits of the Skp1-Cul1-F-box protein (SCF) and Cul4-RING protein ligase (CRL4) ubiquitin ligase... 
PCNA | PROTEIN | GENE | OTITIS-MEDIA | BETA-TRCP | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | UBIQUITYLATION | DEGRADATION | PROTEOLYSIS | IDENTIFICATION | CELL BIOLOGY
Journal Article
Nature Communications, ISSN 2041-1723, 01/2017, Volume 8, Issue 1, pp. 14002 - 14002
beta-TrCP and SKP2 are two well-studied F-box proteins, which often act as oncogenes. Whether and how they communicate with each other is unknown. Here we... 
CULLIN-RING LIGASES | COMPLEX | ANTICANCER | BETA-TRCP | MULTIDISCIPLINARY SCIENCES | F-BOX PROTEINS | MEDIATED DEGRADATION | KAPPA-B | SKP2 | E3 UBIQUITIN LIGASE | MTOR INHIBITOR | Index Medicus
Journal Article
Journal of Investigative Dermatology, ISSN 0022-202X, 01/2018, Volume 138, Issue 1, pp. 78 - 88
Systemic sclerosis (scleroderma, SSc) is a devastating fibrotic disease with few treatment options. Fumaric acid esters, including dimethyl fumarate (DMF,... 
RECEPTOR-TYPE-I | CELLS | GENE PROGRAM | MULTIPLE-SCLEROSIS | PATHWAY | REGULATES YAP | SCF-BETA-TRCP | GROWTH-FACTOR | FIBROBLASTS | WOUND REPAIR | DERMATOLOGY | Index Medicus
Journal Article
by Deng, YQ and Wu, LMN and Bai, SJ and Zhao, CT and Wang, HB and Wang, JC and Xu, LL and Sakabe, M and Zhou, WH and Xin, M and Lu, QR
NATURE COMMUNICATIONS, ISSN 2041-1723, 04/2017, Volume 8, Issue 1, pp. 15161 - 15161
Schwann cell (SC) myelination in the peripheral nervous system is essential for motor function, and uncontrolled SC proliferation occurs in cancer. Here, we... 
PERIPHERAL-NERVE | INACTIVATION | HIPPO SIGNALING PATHWAY | MULTIDISCIPLINARY SCIENCES | GROWTH | SCF-BETA-TRCP | TUMOR-SUPPRESSOR | DIFFERENTIATION | YAP PATHWAY | TUMORIGENESIS | MOLECULAR-MECHANISMS | Index Medicus
Journal Article