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Cancer Discovery, ISSN 2159-8274, 03/2017, Volume 7, Issue 3, pp. 252 - 263
Journal Article
MOLECULAR CANCER THERAPEUTICS, ISSN 1535-7163, 07/2019, Volume 18, Issue 7, pp. 1323 - 1334
FCFR1 was recently shown to be activated as part of a compensatory response to prolonged treatment with the MEK inhibitor trametinib in several KRAS-mutant... 
CELL LUNG-CANCER | ACTIVATION | POTENT | ONCOLOGY | RAS | PHOSPHORYLATION | NEGATIVE FEEDBACK-REGULATION | SENSITIVITY | REGULATORS | NVP-BGJ398 | DISCOVERY
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 01/2017, Volume 35, Issue 2, pp. 157 - 157
Journal Article
The Journal of Infectious Diseases, ISSN 0022-1899, 09/2019, Volume 220, Issue 8, pp. 1377 - 1387
Abstract Zika virus (ZIKV) is an emerging pathogen that can cause microcephaly and other neurological defects in developing fetuses. The cellular response to... 
APOPTOSIS | INFECTIOUS DISEASES | BGJ398 | MAP kinase | MICROBIOLOGY | Zika virus | congenital | IMMUNOLOGY | interferon | explant | FAMILY | REPLICATION | fetal brain | ROLES | fibroblast growth factor 2 | astrocytes
Journal Article
Molecules, ISSN 1420-3049, 10/2018, Volume 23, Issue 10, p. 2643
Journal Article
Hepatology, ISSN 0270-9139, 04/2014, Volume 59, Issue 4, pp. 1427 - 1434
Journal Article
Cancer Discovery, ISSN 2159-8274, 04/2015, Volume 5, Issue 4, pp. 424 - 437
Journal Article
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi, ISSN 0253-2727, 02/2018, Volume 39, Issue 2, pp. 143 - 147
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 10/2015, Volume 21, Issue 19, pp. 4356 - 4364
Journal Article
The Lancet Oncology, ISSN 1470-2045, 10/2019, Volume 20, Issue 10, pp. 1454 - 1466
The clinical activity of fibroblast growth factor receptor (FGFR) inhibitors seems restricted to cancers harbouring rare genetic aberrations. In preclinical... 
SENSITIVITY | ONCOLOGY | INHIBITOR | PREDICT | BGJ398 | GENETIC ALTERATIONS
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2016, Volume 291, Issue 15, pp. 8031 - 8047
Journal Article
PATHOLOGE, ISSN 0172-8113, 12/2018, Volume 39, Issue Suppl 2, pp. 189 - 192
BackgroundFibroblast growth factor receptor (FGFR) signalling plays an important role in embryogenesis as well as in tumorigenesis. In current studies FGFR has... 
ADVANCED SOLID TUMORS | Colorectal cancer | BGJ398 | SENSITIVITY | PATHOLOGY | FGFR | Metastases | DOSE-ESCALATION | Biomarkers | RNA in situ hybridization | INHIBITOR | PHASE-I | EXPRESSION
Journal Article
Molecular Oncology, ISSN 1574-7891, 04/2019, Volume 13, Issue 4, pp. 738 - 756
Endometrial cancer is the most commonly diagnosed gynaecological malignancy. Unfortunately, 15–20% of women demonstrate persistent or recurrent tumours that... 
ABT263 | endometrial cancer | cell death | FGFR2 inhibitor | BGJ398 | BIM | DOVITINIB TKI258 | AUTOPHAGY | ANTITUMOR-ACTIVITY | IN-VITRO | AMPLIFICATION | PHARMACOKINETICS | ONCOLOGY | GROWTH | EXPRESSION | PROMOTES
Journal Article
Cancer Treatment Reviews, ISSN 0305-7372, 08/2019, Volume 78, pp. 1 - 7
Cholangiocarcinoma is the most common aggressive biliary tract malignancy with dismal prognosis. Though surgical resection of the primary tumors yields better... 
ARQ 087 | Targeted therapy | FGFR | Cholangiocarcinoma | BGJ398 | HSP90 | ADVANCED SOLID TUMORS | PHASE-II | BILIARY-TRACT | KINASE INHIBITOR | GENE FUSIONS | TARGETED INHIBITION | ONCOLOGY | RESISTANCE | FIBROBLAST GROWTH-FACTORS | Medical colleges | Chromatin | Cyclic adenylic acid | Fibroblast growth factors | Gene mutations | Protein kinases
Journal Article