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The EMBO Journal, ISSN 0261-4189, 05/2007, Volume 26, Issue 10, pp. 2527 - 2539
The anti-apoptotic proteins Bcl-2 and Bcl-X-L bind and inhibit Beclin-1, an essential mediator of autophagy. Here, we demonstrate that this interaction... 
Bcl-2 | autophagy | PROTEIN | PHOSPHORYLATION | mitochondria | BIOCHEMISTRY & MOLECULAR BIOLOGY | apoptosis | AUTOPHAGIC CELL-DEATH | MACROAUTOPHAGY | BH3 MIMETIC ABT-737 | CELL BIOLOGY | GENE | Bax | TUMOR-SUPPRESSOR | C-ELEGANS | TUMORIGENESIS
Journal Article
Journal Article
Molecular Cell, ISSN 1097-2765, 2008, Volume 30, Issue 3, pp. 369 - 380
Journal Article
Scientific Reports, ISSN 2045-2322, 09/2016, Volume 6, Issue 1, pp. 32979 - 32979
Journal Article
Journal Article
Scientific Reports, ISSN 2045-2322, 01/2016, Volume 6, Issue 1, pp. 19725 - 19725
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 2006, Volume 356, Issue 2, pp. 367 - 381
Dimeric interactions among anti- and pro-apoptotic members of the BCL-2 protein family are dynamically regulated and intimately involved in survival and death... 
X-ray crystallography | apoptosis | 3D-domain swapping | BCL-X L | dimer | BCL-X-L | ANTIMYCIN-A | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOCHONDRIAL-MEMBRANE | LIPID-MEMBRANES | BCL-X(L) | BH3 DOMAIN | PROGRAMMED CELL-DEATH | CYTOCHROME-C | ION-CHANNEL | BAX
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2014, Volume 289, Issue 38, pp. 26481 - 26491
The B cell lymphoma-2 (BCL-2) family is the key mediator of cellular sensitivity to apoptosis during pharmacological interventions for numerous human... 
POTENT | OLIGOMERIZES BAK | CANCERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEATH | MITOCHONDRIAL-MEMBRANE | INHIBITORS | CYTOCHROME-C RELEASE | DISCOVERY | ADDICTION | MEMBRANE PERMEABILIZATION | bcl-2-Associated X Protein - chemistry | Nitriles - pharmacology | Apoptosis - drug effects | Mitochondria, Liver - metabolism | Humans | Unilamellar Liposomes - chemistry | bcl-2-Associated X Protein - physiology | Piperazines - chemistry | Proto-Oncogene Proteins - chemistry | Sulfones - pharmacology | Nitrophenols - chemistry | Benzopyrans - chemistry | bcl-X Protein - chemistry | Molecular Mimicry | Bcl-2-Like Protein 11 | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | Membrane Proteins - physiology | Sulfones - chemistry | BH3 Interacting Domain Death Agonist Protein - chemistry | Myeloid Cell Leukemia Sequence 1 Protein - chemistry | Benzamides - pharmacology | Protein Interaction Domains and Motifs | Biphenyl Compounds - chemistry | Benzopyrans - pharmacology | Benzamides - chemistry | Aniline Compounds - pharmacology | BH3 Interacting Domain Death Agonist Protein - physiology | Sulfonamides - chemistry | Apoptosis Regulatory Proteins - chemistry | Permeability | Sulfonamides - pharmacology | Piperazines - pharmacology | Mitochondrial Membranes - metabolism | Mitochondria, Liver - drug effects | Myeloid Cell Leukemia Sequence 1 Protein - physiology | Pyrroles - pharmacology | Animals | Membrane Proteins - chemistry | bcl-X Protein - physiology | Nitriles - chemistry | Proto-Oncogene Proteins - physiology | Pyrroles - chemistry | Apoptosis Regulatory Proteins - physiology | Mice | Aniline Compounds - chemistry | HeLa Cells | Index Medicus | BH3 Mimetics | MOMP | Mitochondria | Bcl-2 Proteins | Bax | Anticancer Drug | Cell Biology | Apoptosis
Journal Article