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The EMBO Journal, ISSN 0261-4189, 10/2000, Volume 19, Issue 20, pp. 5418 - 5428
When T cells are activated, the expression of the CD95 ligand is elevated, with the purpose of inducing apoptosis in target cells and to later eliminate the... 
apoptosis | MAP kinase | T cell receptor | T cell activation | death receptor | Death receptor | Apoptosis | DEATH DOMAIN | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | RECEPTOR | FAS-MEDIATED APOPTOSIS | CELL BIOLOGY | MOLECULAR-CLONING | COMPLEX DISC | LIGAND | FLICE | SURFACE ANTIGEN | Caspase 9 | Muromonab-CD3 - immunology | Protein Biosynthesis | Caspase 8 | Tetradecanoylphorbol Acetate - pharmacology | Membrane Glycoproteins - metabolism | T-Lymphocytes - enzymology | Apoptosis - drug effects | Humans | BH3 Interacting Domain Death Agonist Protein | fas Receptor - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | fas Receptor - immunology | Caspases - metabolism | Membrane Glycoproteins - antagonists & inhibitors | Protein Processing, Post-Translational - drug effects | T-Lymphocytes - metabolism | T-Lymphocytes - drug effects | Muromonab-CD3 - pharmacology | Membrane Glycoproteins - immunology | Phosphorylation - drug effects | Jurkat Cells | Cells, Cultured | Intracellular Signaling Peptides and Proteins | Enzyme Activation - drug effects | Fas Ligand Protein | Carrier Proteins - metabolism | MAP Kinase Signaling System - drug effects | Lymphocyte Activation - drug effects | CD3 Complex - immunology | Fluorescent Antibody Technique | T-Lymphocytes - immunology | CASP8 and FADD-Like Apoptosis Regulating Protein | Kinetics | bcl-Associated Death Protein | Mitogen-Activated Protein Kinases - metabolism | T cell activation | T cell receptor
Journal Article
Oncogene, ISSN 0950-9232, 09/2000, Volume 19, Issue 40, pp. 4563 - 4573
Caspase-8 plays an essential role in apoptosis triggered by death receptors, Through the cleavage of Bid, a proapoptotic Bcl-2 member, it further activates the... 
Caspase-8 | Anticancer drugs | CD95 | Caspase-9 | Apoptosis | DEATH RECEPTORS | WILD-TYPE | caspase-8 | ACTIVATION | caspase-9 | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOCHONDRIA | apoptosis | MEDIATED APOPTOSIS | anticancer drugs | NEUROBLASTOMA-CELLS | APO-1/FAS RECEPTOR/LIGAND SYSTEM | CELL BIOLOGY | BCL-2 | ONCOLOGY | GENETICS & HEREDITY | LEUKEMIA-CELLS | CYTOCHROME-C RELEASE | Caspases - physiology | Caspase 9 | Adenocarcinoma - pathology | Caspase 8 | Proto-Oncogene Proteins c-bcl-2 - physiology | Humans | Neoplasm Proteins - physiology | BH3 Interacting Domain Death Agonist Protein | Breast Neoplasms - enzymology | Tumor Cells, Cultured - enzymology | Amino Acid Chloromethyl Ketones - pharmacology | Caspases - biosynthesis | Caspase 3 | Antineoplastic Agents - pharmacology | Caspases - deficiency | fas Receptor - physiology | Neoplasm Proteins - genetics | Carrier Proteins - physiology | bcl-X Protein | Caspases - genetics | Neoplasm Proteins - biosynthesis | Tumor Cells, Cultured - drug effects | Adenocarcinoma - enzymology | Etoposide - pharmacology | Intracellular Signaling Peptides and Proteins | Mitomycin - pharmacology | Carrier Proteins - genetics | Enzyme Precursors - metabolism | Poly(ADP-ribose) Polymerases - metabolism | Carrier Proteins - metabolism | Breast Neoplasms - pathology | Cysteine Proteinase Inhibitors - pharmacology | CASP8 and FADD-Like Apoptosis Regulating Protein | Jurkat Cells - enzymology | Neoplasm Proteins - deficiency | Apoptosis - physiology | Enzyme Activation | Mitochondria - physiology | Proto-Oncogene Proteins c-bcl-2 - genetics | Jurkat Cells - drug effects
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 11/2000, Volume 192, Issue 10, pp. 1391 - 1401
Cytotoxic T lymphocytcs (CTLs) destroy target cells through a mechanism involving the exocytosis of cytolytic granule components including granzyme B (grB) and... 
Bcl-2 | Bax | Granzyme B | Bid | Cytotoxic T lymphocyte | MEDICINE, RESEARCH & EXPERIMENTAL | granzyme B | APOPTOSIS | ACTIVATION | COMPLEX | MITOCHONDRIA | CASPASE-3 | IMMUNOLOGY | CELL-DEATH | PERMEABILITY TRANSITION | SUBSTRATE-SPECIFICITY | cytotoxic T lymphocyte | DNA FRAGMENTATION | PROTEASE
Journal Article
Journal Article
Cancer Research, ISSN 0008-5472, 12/2000, Volume 60, Issue 24, pp. 6811 - 6817
Journal Article
Journal Article