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apoptosis (1101) 1101
bh3 interacting domain death agonist protein - metabolism (787) 787
animals (763) 763
biochemistry & molecular biology (535) 535
apoptosis - drug effects (529) 529
bh3 interacting domain death agonist protein (487) 487
cell biology (487) 487
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caspases - metabolism (443) 443
carrier proteins - metabolism (402) 402
mitochondria (388) 388
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proto-oncogene proteins c-bcl-2 - metabolism (371) 371
activation (326) 326
apoptosis - physiology (326) 326
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death (280) 280
bax (272) 272
bh3 interacting domain death agonist protein - genetics (259) 259
bcl-2-associated x protein - metabolism (257) 257
cytochromes c - metabolism (255) 255
bid (221) 221
signal transduction (213) 213
proto-oncogene proteins - metabolism (202) 202
bcl-2 (193) 193
cytochrome-c (191) 191
cancer (189) 189
caspase 8 (182) 182
caspase 8 - metabolism (182) 182
mitochondria - drug effects (168) 168
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enzyme activation (163) 163
protein (163) 163
female (157) 157
bcl-2-associated x protein (154) 154
cytochrome c (150) 150
membrane proteins - metabolism (150) 150
expression (147) 147
caspase 9 (141) 141
cell death (141) 141
phosphorylation (141) 141
caspase 3 - metabolism (139) 139
rats (133) 133
article (132) 132
bcl-2 family (132) 132
blotting, western (132) 132
apoptosis regulatory proteins - metabolism (128) 128
cytochrome c group - metabolism (128) 128
antineoplastic agents - pharmacology (127) 127
hela cells (127) 127
proto-oncogene proteins c-bcl-2 - genetics (124) 124
caspase 3 (122) 122
research (121) 121
time factors (121) 121
models, biological (119) 119
mice, knockout (115) 115
reactive oxygen species - metabolism (114) 114
tumor cells, cultured (114) 114
amino acid sequence (112) 112
biological phenomena, cell phenomena, and immunity (111) 111
fas receptor - metabolism (111) 111
molecular sequence data (110) 110
bcl-x protein - metabolism (108) 108
dose-response relationship, drug (107) 107
induced apoptosis (107) 107
caspase (104) 104
cell survival - drug effects (104) 104
cells (104) 104
protein binding (104) 104
bcl-2-like protein 11 (101) 101
signal transduction - drug effects (100) 100
bcl-2 homologous antagonist-killer protein - metabolism (99) 99
mice, inbred c57bl (99) 99
enzyme activation - drug effects (96) 96
caspase inhibitors (95) 95
apoptosis - genetics (93) 93
bh3-only proteins (93) 93
carrier proteins - genetics (92) 92
oxidative stress (91) 91
mediated apoptosis (90) 90
mitochondria - physiology (90) 90
mitochondrial dna (90) 90
flow cytometry (89) 89
inhibition (89) 89
jurkat cells (89) 89
protein structure, tertiary (89) 89
tumor suppressor protein p53 - metabolism (88) 88
caspase activation (87) 87
in-vivo (87) 87
nf-kappa-b (86) 86
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Journal Article
Science, ISSN 0036-8075, 12/2010, Volume 330, Issue 6009, pp. 1390 - 1393
Although the proteins BAX and BAK are required for initiation of apoptosis at the mitochondria, how BAX and BAK are activated remains unsettled. We provide in... 
T lymphocytes | Mitochondria | Cytokines | Thymocytes | Neurons | Cell death | REPORTS | Cytochromes | Mice | Potassium | Apoptosis | NEURONAL APOPTOSIS | CYTOCHROME-C | MITOCHONDRIAL APOPTOSIS | MECHANISM | MULTIDISCIPLINARY SCIENCES | BH3 DOMAINS | RELEASE | JNK PATHWAY | PROTEINS | BCL-2 FAMILY-MEMBERS | MEMBRANE PERMEABILIZATION | BH3 Interacting Domain Death Agonist Protein - deficiency | T-Lymphocytes - physiology | bcl-2-Associated X Protein - chemistry | Protein Multimerization | Stress, Physiological | bcl-2 Homologous Antagonist-Killer Protein - genetics | BH3 Interacting Domain Death Agonist Protein - genetics | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Membrane Proteins - deficiency | Caspases - metabolism | Bcl-2-Like Protein 11 | Apoptosis Regulatory Proteins - deficiency | Tumor Suppressor Proteins - deficiency | Tumor Suppressor Proteins - genetics | Neurons - physiology | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | BH3 Interacting Domain Death Agonist Protein - metabolism | bcl-2-Associated X Protein - genetics | Proto-Oncogene Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Membrane Proteins - genetics | Cytochromes c - metabolism | Cells, Cultured | bcl-2-Associated X Protein - metabolism | Proto-Oncogene Proteins - genetics | Mitochondria - metabolism | Permeability | Proto-Oncogene Proteins - deficiency | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Animals | Models, Biological | Cerebellum - cytology | Intracellular Membranes - metabolism | bcl-2 Homologous Antagonist-Killer Protein - chemistry | Protein research | Genetic aspects | Mitochondrial DNA | Biochemical genetics | Research | Properties | Methods | Index Medicus
Journal Article
Immunity, ISSN 1074-7613, 09/2015, Volume 43, Issue 3, pp. 451 - 462
Endoplasmic reticulum (ER) stress is observed in many human diseases, often associated with inflammation. ER stress can trigger inflammation through... 
LISTERIA-MONOCYTOGENES | CYTOCHROME-C | MESSENGER-RNA | BRUCELLA-ABORTUS | INDUCED APOPTOSIS | ER STRESS | THIOREDOXIN-INTERACTING PROTEIN | SECRETION | IMMUNOLOGY | TRANSCRIPTION FACTOR | CELL-DEATH | Caspase 2 - genetics | Inflammasomes - metabolism | Reactive Oxygen Species - metabolism | Brucella abortus - physiology | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | BH3 Interacting Domain Death Agonist Protein - genetics | Caspase 2 - metabolism | Mitochondria - immunology | Endoplasmic Reticulum Stress - genetics | Endoplasmic Reticulum Stress - immunology | Caspase 2 - immunology | Host-Pathogen Interactions - immunology | DNA-Binding Proteins - metabolism | Mitochondria - genetics | Brucella abortus - immunology | Interleukin-1beta - metabolism | Reactive Oxygen Species - immunology | HEK293 Cells | Transcription Factors - immunology | BH3 Interacting Domain Death Agonist Protein - metabolism | Carrier Proteins - immunology | Macrophages - immunology | Macrophages - microbiology | Protein-Serine-Threonine Kinases - metabolism | RNA Interference - immunology | DNA-Binding Proteins - immunology | Endoribonucleases - metabolism | Mice, Inbred C57BL | Cells, Cultured | Interleukin-1beta - immunology | Mitochondria - metabolism | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Regulatory Factor X Transcription Factors | Blotting, Western | Mice, Knockout | Transcription Factors - metabolism | Carrier Proteins - genetics | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Inflammasomes - immunology | BH3 Interacting Domain Death Agonist Protein - immunology | Protein-Serine-Threonine Kinases - immunology | Endoribonucleases - immunology | Medical colleges | Stress (Physiology) | Mitochondrial DNA | Analysis | Cytochrome | Bacterial infections | Dehydrogenases | Infections | Inflammation | Proteins | Studies | Mitochondria | Rodents | Ligands | Endoplasmic reticulum | Deoxyribonucleic acid--DNA | Apoptosis | Index Medicus
Journal Article
Science, ISSN 0036-8075, 2/2007, Volume 315, Issue 5813, pp. 856 - 859
A central issue in the regulation of apoptosis by the Bcl-2 family is whether its BH3-only members initiate apoptosis by directly binding to the essential... 
Research fellowships | Protein isoforms | Medical research | Myeloid cells | Antibodies | Cytochromes | Ligands | Reports | Grants | Viability | Apoptosis | RESPONSES | FAMILY-MEMBERS | X-L | MULTIDISCIPLINARY SCIENCES | BIM | HELIX | MITOCHONDRIAL-MEMBRANE | PUMA | DOMAINS | BH3-ONLY PROTEINS | CELL-DEATH | bcl-2-Associated X Protein - chemistry | Humans | BH3 Interacting Domain Death Agonist Protein - genetics | Proto-Oncogene Proteins - chemistry | Neoplasm Proteins - metabolism | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Bcl-2-Like Protein 11 | Tumor Suppressor Proteins - genetics | BH3 Interacting Domain Death Agonist Protein - chemistry | Apoptosis Regulatory Proteins - genetics | bcl-Associated Death Protein - metabolism | Membrane Proteins - metabolism | BH3 Interacting Domain Death Agonist Protein - metabolism | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Cell Line | Tumor Suppressor Proteins - metabolism | Membrane Proteins - genetics | Apoptosis Regulatory Proteins - chemistry | Cells, Cultured | bcl-2-Associated X Protein - metabolism | Proto-Oncogene Proteins - genetics | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Animals | Proteins - metabolism | Membrane Proteins - chemistry | Models, Biological | Myeloid Cell Leukemia Sequence 1 Protein | Mice | Mutation | bcl-X Protein - metabolism | Research | Peptides | Analysis | Biochemistry | Cellular biology | Molecular biology | Binding sites | Index Medicus
Journal Article
Molecular Cell, ISSN 1097-2765, 11/2011, Volume 44, Issue 4, pp. 517 - 531
Journal Article
Nature Cell Biology, ISSN 1465-7392, 10/2015, Volume 17, Issue 10, pp. 1270 - 1281
Multidomain pro-apoptotic BAX and BAK, once activated, permeabilize mitochondria to trigger apoptosis, whereas anti-apoptotic BCL-2 members preserve... 
CYTOCHROME-C | MITOCHONDRIAL APOPTOSIS | ACTIVATION | CONFORMATIONAL-CHANGE | MEMBERS | PROAPOPTOTIC BAX | BH3 DOMAINS | PUMA | BH3-ONLY PROTEINS | MEMBRANE PERMEABILIZATION | CELL BIOLOGY | bcl-2 Homologous Antagonist-Killer Protein - genetics | Immunoblotting | BH3 Interacting Domain Death Agonist Protein - genetics | Cytochromes c - genetics | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Embryo, Mammalian - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Bcl-2-Like Protein 11 | Mitochondria - genetics | RNA Interference | Tumor Suppressor Proteins - genetics | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | BH3 Interacting Domain Death Agonist Protein - metabolism | bcl-2-Associated X Protein - genetics | Fibroblasts - metabolism | Proto-Oncogene Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Membrane Proteins - genetics | Cytochromes c - metabolism | Mice, Inbred C57BL | Cells, Cultured | bcl-2-Associated X Protein - metabolism | Proto-Oncogene Proteins - genetics | Mitochondria - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Animals | Intestine, Small - cytology | Embryo, Mammalian - cytology | Models, Biological | Fibroblasts - cytology | Intestine, Small - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Apoptosis | Genotype | Genetic aspects | Properties | Cell death | Cellular control mechanisms | Index Medicus
Journal Article
Molecular Cell, ISSN 1097-2765, 11/2009, Volume 36, Issue 3, pp. 487 - 499
While activation of BAX/BAK by BH3-only molecules (BH3s) is essential for mitochondrial apoptosis, the underlying mechanisms remain unsettled. Here we... 
CELLCYCLE | CYTOCHROME-C | PROAPOPTOTIC BAX | OLIGOMERIZES BAK | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOPLASMIC-RETICULUM | SUBCELLULAR LOCATION | PROTEINS | BCL-2 FAMILY-MEMBERS | BH3 DOMAIN | CELL-DEATH | MEMBRANE PERMEABILIZATION | CELL BIOLOGY | bcl-2-Associated X Protein - chemistry | Immunoprecipitation | Apoptosis - drug effects | Protein Multimerization | bcl-2 Homologous Antagonist-Killer Protein - genetics | Immunoblotting | BH3 Interacting Domain Death Agonist Protein - genetics | Green Fluorescent Proteins - genetics | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Bcl-2-Like Protein 11 | Protein Binding - drug effects | Tumor Suppressor Proteins - genetics | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | BH3 Interacting Domain Death Agonist Protein - metabolism | bcl-2-Associated X Protein - genetics | Fibroblasts - metabolism | Proto-Oncogene Proteins - metabolism | Green Fluorescent Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Membrane Proteins - genetics | Cells, Cultured | bcl-2-Associated X Protein - metabolism | Etoposide - pharmacology | Proto-Oncogene Proteins - genetics | Mitochondria - metabolism | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Animals | Models, Biological | Tunicamycin - pharmacology | Fibroblasts - drug effects | Thapsigargin - pharmacology | Fibroblasts - cytology | Mice | Mutation | Microscopy, Fluorescence | Staurosporine - pharmacology | bcl-2 Homologous Antagonist-Killer Protein - chemistry | Monomers | Apoptosis | Oligomers | Index Medicus
Journal Article
Journal Article
Journal Article
Molecular Cell, ISSN 1097-2765, 2008, Volume 30, Issue 3, pp. 369 - 380
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 07/2012, Volume 109, Issue 27, pp. E1839 - E1847
In the course of apoptosis, activated caspases cleave ∼500 to ∼1,000 different proteins in a mammalian cell. The dynamics of apoptosis involve a number of... 
ATE1 | Arginylation | UBR1 | Proteolysis | APOPTOSIS | ACTIVATION | UBIQUITIN LIGASE | MULTIDISCIPLINARY SCIENCES | KAPPA-B | DEGRADATION SIGNALS | CANCER | arginylation | CASPASES | RIP | proteolysis | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Humans | Aminoacyltransferases - genetics | Caspase 3 - metabolism | bcl-X Protein - genetics | BH3 Interacting Domain Death Agonist Protein - genetics | Phosphoproteins - metabolism | Lim Kinases - metabolism | Mice, Mutant Strains | BRCA1 Protein - metabolism | HEK293 Cells | Antibodies - immunology | Apoptosis Regulatory Proteins - genetics | Peptide Fragments - genetics | BH3 Interacting Domain Death Agonist Protein - metabolism | Rabbits | Peptide Fragments - metabolism | TNF Receptor-Associated Factor 1 - metabolism | Ubiquitin-Protein Ligases - metabolism | TNF Receptor-Associated Factor 1 - genetics | Phosphoproteins - genetics | Apoptosis Regulatory Proteins - metabolism | BRCA1 Protein - genetics | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Animals | Adaptor Proteins, Signal Transducing - genetics | Lim Kinases - genetics | Aminoacyltransferases - metabolism | Mice | Apoptosis - physiology | Adaptor Proteins, Signal Transducing - metabolism | Ubiquitin-Protein Ligases - genetics | bcl-X Protein - metabolism | Arginine - metabolism | Proteins | Mutation | Metabolism | Proteases | Apoptosis | Index Medicus | Biological Sciences | PNAS Plus
Journal Article
Molecular Cell, ISSN 1097-2765, 09/2013, Volume 51, Issue 6, pp. 751 - 765
Journal Article