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Leukemia, ISSN 0887-6924, 03/2016, Volume 30, Issue 3, pp. 761 - 764
INHIBITION | ONCOLOGY | MCL-1 | DEATH | LEUKEMIA | HEMATOLOGY | ABT-199 | ADDICTION | Recurrence | Antineoplastic Agents - chemical synthesis | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | bcl-X Protein - genetics | Male | Plasma Cells - pathology | Plasma Cells - drug effects | Proto-Oncogene Proteins c-bcl-2 - metabolism | Peptides - chemical synthesis | bcl-X Protein - antagonists & inhibitors | Aged, 80 and over | Biological Assay | Female | Plasma Cells - metabolism | Antineoplastic Agents - pharmacology | Bridged Bicyclo Compounds, Heterocyclic - chemical synthesis | Myeloid Cell Leukemia Sequence 1 Protein - antagonists & inhibitors | Aniline Compounds - pharmacology | Cytochromes c - secretion | Multiple Myeloma - diagnosis | Mitochondria - metabolism | Mitochondria - drug effects | Mitochondria - pathology | Multiple Myeloma - metabolism | Organ Specificity | Sulfonamides - pharmacology | Myeloid Cell Leukemia Sequence 1 Protein - genetics | Peptides - pharmacology | Sulfonamides - chemical synthesis | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Multiple Myeloma - pathology | Cell Line, Tumor | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Aged | bcl-X Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Aniline Compounds - chemical synthesis | Multiple Myeloma - genetics | Drug metabolism | Development and progression | Genetic aspects | Tumor proteins | Health aspects | Multiple myeloma | Life Sciences | Cancer | BCL-2 | BH3 profiling | BH3 mimetics | Multiple Myeloma | Apoptosis
Journal Article
Pharmacological Research, ISSN 1043-6618, 04/2019, Volume 142, pp. 87 - 100
ABT-737, ABT-263 (Navitoclax) and ABT-199 (Venetoclax) are under intensive preclinical and clinical investigation as treatments for hematologic and other... 
ABT-737 | Allosteric modulator | ABT-263 | BH3 mimetic | ABT-199 | Sigma receptor | RAT-LIVER | LIGAND-BINDING | CRYSTAL-STRUCTURE | PROTEIN-COUPLED RECEPTORS | IN-VITRO | TARGETING BCL2 | BINDING-AFFINITY | RECOGNITION SITES | LIPID RAFTS | CHRONIC LYMPHOCYTIC-LEUKEMIA | PHARMACOLOGY & PHARMACY | Proteins | Cell death | Analysis | Lung cancer | Lymphomas | Progesterone | Protein binding
Journal Article
F1000Research, ISSN 2046-1402, 2016, Volume 5, p. 2804
The BCL2-selective BH3 mimetic venetoclax was recently approved for the treatment of relapsed, chromosome 17p-deleted chronic lymphocytic leukemia (CLL) and is... 
Pediatric Oncology | Membranes & Sorting | Immunopharmacology & Hematologic Pharmacology | Pediatric Hematology | Cell Signaling | Cancer Therapeutics | Leukemia & Proliferative Disorders of Hematic Cells | Cellular Death & Stress Responses
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 09/2019, Volume 517, Issue 1, pp. 15 - 22
Bcl-2 family proteins play an important role in regulation of the cell survival and death. The inhibition of the anti-apoptotic proteins of Bcl-2 family leads... 
Bcl-2 | Virtual screening | NSCLC | Autophagy | BH3 mimetics | Apoptosis | BIOPHYSICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BAX | NAVITOCLAX ABT-263 | Proteins | Clathrate compounds | Lung cancer, Non-small cell | Leukemia
Journal Article
Journal Article
Journal Article
Drug Resistance Updates, ISSN 1368-7646, 2007, Volume 10, Issue 6, pp. 207 - 217
Abstract Tumor cell survival is highly dependent on the expression of certain pro-survival Bcl-2 family proteins. An attractive therapeutic approach is to... 
Infectious Disease | Hematology, Oncology and Palliative Medicine | ABT-737 | Drug resistance | BH3 mimetic | Apoptosis | Cancer | CARCINOMA-CELLS | BCL-X-L | ANTIAPOPTOTIC BCL-2-FAMILY PROTEINS | FAMILY-MEMBERS | apoptosis | MULTIPLE-MYELOMA CELLS | SMALL-MOLECULE INHIBITOR | APOPTOSIS-INDUCING LIGAND | PHARMACOLOGY & PHARMACY | cancer | drug resistance | CYTOCHROME-C RELEASE | KINASE-DEPENDENT MECHANISM | BH3-ONLY PROTEINS | Neoplasms - metabolism | Drugs, Investigational - pharmacology | Apoptosis - drug effects | Humans | Drugs, Investigational - therapeutic use | Molecular Sequence Data | Drug Resistance, Neoplasm | Antineoplastic Agents - therapeutic use | Neoplasm Proteins - metabolism | Biphenyl Compounds - therapeutic use | Proto-Oncogene Proteins c-bcl-2 - metabolism | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | bcl-X Protein - antagonists & inhibitors | Nitrophenols - therapeutic use | Proto-Oncogene Proteins c-bcl-2 - chemistry | Antineoplastic Agents - pharmacology | Protein Structure, Tertiary | Amino Acid Sequence | Treatment Outcome | Piperazines - therapeutic use | Sulfonamides - pharmacology | Piperazines - pharmacology | Neoplasms - drug therapy | Sequence Alignment | Animals | Sulfonamides - therapeutic use | Myeloid Cell Leukemia Sequence 1 Protein | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Neoplasms - pathology | bcl-X Protein - metabolism | Antimitotic agents | Care and treatment | Antineoplastic agents | Health aspects
Journal Article