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FEBS JOURNAL, ISSN 1742-464X, 07/2016, Volume 283, Issue 14, pp. 2661 - 2675
Malignant cells routinely violate cellular checkpoints that should initiate cell death in normal cells by triggering pro-apoptotic members of the BCL2 family... 
BH3-mimetic | BCL-2 family | STRUCTURE-GUIDED DESIGN | MCL-1 | therapy | BIOCHEMISTRY & MOLECULAR BIOLOGY | apoptosis | ACUTE MYELOID-LEUKEMIA | ENDOPLASMIC-RETICULUM STRESS | BH3 MIMETIC ABT-737 | CELL LUNG-CANCER | ANTI-APOPTOTIC MCL-1 | SELECTIVE SMALL-MOLECULE | ACUTE LYMPHOBLASTIC-LEUKEMIA | BH3-ONLY PROTEIN NOXA | CHRONIC LYMPHOCYTIC-LEUKEMIA | cancer
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2014, Volume 111, Issue 23, pp. 8512 - 8517
Antiapoptotic B-cell lymphoma 2 (Bcl-2) family members such as Bcl-2, myeloid cell leukemia 1 (Mcl-1), and B-cell lymphoma-X large (Bcl-xL) are proposed to... 
Myeloid cells | Starvation | Cell death | Cell lines | Fibroblasts | Cultured cells | Gene expression regulation | Viability | Family members | Apoptosis | ABT-737 | LC3B | LC3 | BH3 mimetic | Bim | SURVIVAL | APOPTOSIS | MCL-1 | MULTIDISCIPLINARY SCIENCES | KINASE | CELL-DEATH | CONNECTION | BECLIN-1 | ROLES | BH3-ONLY PROTEINS | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | bcl-2 Homologous Antagonist-Killer Protein - genetics | Cell Survival - genetics | Apoptosis - genetics | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Autophagy | Proto-Oncogene Proteins c-bcl-2 - metabolism | Flow Cytometry | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | RNA Interference | bcl-2-Associated X Protein - genetics | Fibroblasts - metabolism | Phagosomes - metabolism | Cells, Cultured | bcl-2-Associated X Protein - metabolism | Sulfonamides - pharmacology | Piperazines - pharmacology | Blotting, Western | Myeloid Cell Leukemia Sequence 1 Protein - genetics | Mice, Knockout | Animals | Autophagy-Related Protein 5 | Embryo, Mammalian - cytology | Fibroblasts - drug effects | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Fibroblasts - cytology | Mice | Proto-Oncogene Proteins c-bcl-2 - genetics | Cell Line, Transformed | Autophagy (Cytology) | Cell research | Oncology, Experimental | Physiological aspects | Lymphomas | Research | B cells | Health aspects | Cancer | Proteins | Experiments | Cells | Index Medicus | Biological Sciences
Journal Article
Journal Article
Journal Article
Journal of Cell Science, ISSN 0021-9533, 05/2002, Volume 115, Issue 8, pp. 1567 - 1574
Journal Article
Autophagy, ISSN 1554-8627, 11/2007, Volume 3, Issue 6, pp. 561 - 568
Journal Article
Cancer Research, ISSN 0008-5472, 02/2007, Volume 67, Issue 3, pp. 1176 - 1183
ABT-737 is a novel and potent Bcl-2 antagonist with single-agent activity against small-cell lung cancer (SCLC) cell lines. Here, we evaluated the contribution... 
SURVIVAL | APOPTOSIS | ETOPOSIDE | ONCOLOGY | MITOCHONDRIA | RESISTANCE | DEATH | INHIBITORS | EXPRESSION | CARCINOMA | BH3-ONLY PROTEINS | Piperazines - administration & dosage | Lung Neoplasms - drug therapy | RNA, Small Interfering - genetics | Up-Regulation | Apoptosis - drug effects | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | Neoplasm Proteins - antagonists & inhibitors | Proto-Oncogene Proteins - biosynthesis | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Transfection | Bcl-2-Like Protein 11 | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | Apoptosis Regulatory Proteins - genetics | Neoplasm Proteins - genetics | Apoptosis Regulatory Proteins - biosynthesis | Carcinoma, Small Cell - metabolism | Cell Growth Processes - drug effects | Membrane Proteins - genetics | Neoplasm Proteins - biosynthesis | Carcinoma, Small Cell - drug therapy | Down-Regulation | Carboplatin - administration & dosage | Etoposide - administration & dosage | Nitrophenols - administration & dosage | Proto-Oncogene Proteins - genetics | Sulfonamides - pharmacology | Piperazines - pharmacology | Proto-Oncogene Proteins c-bcl-2 - biosynthesis | Drug Synergism | Membrane Proteins - biosynthesis | Myeloid Cell Leukemia Sequence 1 Protein | Biphenyl Compounds - administration & dosage | Cell Line, Tumor | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Carcinoma, Small Cell - pathology | Proto-Oncogene Proteins c-bcl-2 - genetics | Sulfonamides - administration & dosage | Index Medicus
Journal Article
Journal Article
Immunology, ISSN 0019-2805, 12/2008, Volume 125, Issue 4, pp. 549 - 557
Fas‐associated protein with death domain/mediator of receptor induced toxicity (FADD/MORT1) was first described as a transducer of death receptor signalling... 
apoptosis | Bcl‐3 | FADD | proliferation | T cell | Bcl-3 | Proliferation | Apoptosis | ACTIVATION | DEATH | IMMUNOLOGY | DOMINANT INTERFERING MUTANT | MEDIATED-IMMUNITY | C-FLIP | CASPASE-8 | FADD/MORT1 | BH3-ONLY PROTEINS | LYMPHOCYTES | Original
Journal Article