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bi-d1870 (9) 9
life sciences & biomedicine (6) 6
pteridines - pharmacology (6) 6
ribosomal protein s6 kinases, 90-kda - antagonists & inhibitors (6) 6
science & technology (6) 6
ribosomal protein s6 kinases, 90-kda - metabolism (5) 5
humans (4) 4
animals (3) 3
benzopyrans - pharmacology (3) 3
cell biology (3) 3
monosaccharides - pharmacology (3) 3
p90 ribosomal s6 kinase (3) 3
phosphorylation (3) 3
protein kinase inhibitors - pharmacology (3) 3
sl0101 (3) 3
analysis (2) 2
apoptosis (2) 2
autophagy (2) 2
biochemistry & molecular biology (2) 2
cell cycle (2) 2
cell line, tumor (2) 2
egf, epidermal growth factor (2) 2
enzyme inhibitors - pharmacology (2) 2
extracellular signal-regulated kinase (2) 2
jnk, c-jun n-terminal kinase (2) 2
mapk, mitogen-activated protein kinase (2) 2
mice (2) 2
mitogens (2) 2
p90rsk (2) 2
pharmacology & pharmacy (2) 2
phosphotransferases (2) 2
pkb, protein kinase b (2) 2
protein kinases (2) 2
protein-serine-threonine kinases - metabolism (2) 2
proto-oncogene proteins c-akt - metabolism (2) 2
ribosomal protein s6 kinases, 90-kda - genetics (2) 2
rsk (2) 2
rsk, p90 ribosomal s6 kinase (2) 2
transfection (2) 2
14-3-3 proteins - metabolism (1) 1
3t3-l1 cells (1) 1
activation (1) 1
acute myeloid leukemia (1) 1
adenocarcinoma (1) 1
adipocytes - cytology (1) 1
adipocytes - metabolism (1) 1
agc, camp-dependent protein kinase (1) 1
apoptosis - drug effects (1) 1
apoptosis - radiation effects (1) 1
aurora kinases - metabolism (1) 1
autophagy - drug effects (1) 1
azepines - pharmacology (1) 1
benzimidazoles - pharmacology (1) 1
biological transport - drug effects (1) 1
bix 02565 (1) 1
bi‐d1870 (1) 1
bmdc, bone marrow-derived dendritic cells (1) 1
bypasses (1) 1
cancer (1) 1
cancer research (1) 1
carcinoma, squamous cell - drug therapy (1) 1
carcinoma, squamous cell - enzymology (1) 1
carcinoma, squamous cell - pathology (1) 1
cation transport proteins - metabolism (1) 1
cdc25c (1) 1
cdk2–a, cyclin-dependent kinase 2 complexed with cyclin a (1) 1
cell adhesion & migration (1) 1
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chromones - pharmacology (1) 1
cisplatin (1) 1
ck1, casein kinase-1 (1) 1
creb, camp-response-element-binding protein (1) 1
cross-resistance (1) 1
cyclin-dependent kinase inhibitor p21 - metabolism (1) 1
cyclin-dependent kinase inhibitor p21 - pharmacology (1) 1
data mining (1) 1
dc, dendritic cell (1) 1
dendritic cells (1) 1
dextrose (1) 1
dmem, dulbecco’s modified eagle’s medium (1) 1
dose-response relationship, drug (1) 1
drug resistance (1) 1
drug screening assays, antitumor (1) 1
dstt, division of signal transduction therapy (1) 1
dyrk1a, dual-specificity tyrosine-phosphorylated and -regulated kinase 1a (1) 1
endoplasmic reticulum stress - drug effects (1) 1
enzyme activation (1) 1
epidermal growth factor (1) 1
erk, extracellular-signal-regulated kinase (1) 1
erk1, extracellular-signal-regulated kinase 1 (1) 1
erm, ezrin, radixin and moesin (1) 1
fbs, foetal bovine serum (1) 1
fcs, foetal calf serum (1) 1
fkhr, forkhead in rhabdosarcoma transcription factor (1) 1
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Biochemical journal, ISSN 1470-8728, 01/2007, Volume 401, Issue 1, pp. 29 - 38
Hormones and growth factors induce the activation of a number of protein kinases that belong to the AGC subfamily, including isoforms of PKA, protein kinase B... 
Kinase-specific inhibitor | Phosphorylation | p90 ribosomal S6 kinase (RSK) | BI-D1870 | Mitogen-activated protein kinase (MAPK) | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Cell Line | Pteridines - pharmacology | Humans | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Rats | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Animals | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Kinetics | Chromones - pharmacology | Isoenzymes - antagonists & inhibitors | Index Medicus | MES, mouse embryonic stem | PI3K, phosphoinositide 3-kinase | EGF, epidermal growth factor | PKA, cAMP-dependent protein kinase A | FKHR, forkhead in rhabdosarcoma transcription factor | RSK, p90 ribosomal S6 kinase | JNK, c-Jun N-terminal kinase | CREB, cAMP-response-element-binding protein | SGK1, serum- and glucocorticoid-induced kinase-1 | PDK1, phosphoinositide-dependent kinase 1 | PKB, protein kinase B | Lck, lymphocyte kinase | ROCK, Rho-dependent protein kinase | MKK1, MAPK kinase-1 | protein kinase G | AGC, cAMP-dependent protein kinase | phosphorylation | protein kinase C | kinase-specific inhibitor | HEK-293, human embryonic kidney 293 | ERK1, extracellular-signal-regulated kinase 1 | GST, glutathione S-transferase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | mitogen-activated protein kinase (MAPK) | PH, pleckstrin homology | PLK1, polo-like kinase 1 | CK1, casein kinase-1 | FBS, foetal bovine serum | MSK, mitogen- and stress-activated protein kinase | CDK2–A, cyclin-dependent kinase 2 complexed with cyclin A | DYRK1a, dual-specificity tyrosine-phosphorylated and -regulated kinase 1a | GSK3α, glycogen synthase kinase 3α | MAPK, mitogen-activated protein kinase
Journal Article
Journal of pharmacy and pharmacology, ISSN 0022-3573, 11/2020, Volume 72, Issue 11, pp. 1536 - 1545
Journal Article
Cancer chemotherapy and pharmacology, ISSN 0344-5704, 2/2014, Volume 73, Issue 2, pp. 237 - 247
Journal Article
Molecular cancer therapeutics, ISSN 1535-7163, 08/2017, Volume 16, Issue 8, pp. 1658 - 1668
A subset of non–small cell lung cancers (NSCLC) are dependent upon oncogenic driver mutations, including the most frequently observed driver mutant KRAS, which... 
Hsp90 protein | Cross-resistance | Extracellular signal-regulated kinase | Non-small cell lung carcinoma | Activation | Lethality | K-Ras protein | Signaling | Inhibitors | Lungs | Mutation | Bypasses | Cancer | Index Medicus | Ganetespib | SCH772984 | NSC-663284 | KRAS | p90RSK | drug resistance | CDC25C | BI-D1870 | Hsp90 Inhibitor
Journal Article
Cellular signalling, ISSN 0898-6568, 08/2015, Volume 27, Issue 8, pp. 1630 - 1642
The 90kDa ribosomal S6 kinases (RSK) are effectors of the Ras-ERK1/2 signaling pathway. RSK signaling controls proliferation and protein synthesis, and is... 
p70 ribosomal S6 kinase (p70S6K) | Tuberin (TSC2) | SL0101 | BI-D1870 | Ribosomal protein S6 (rpS6) | p90 kDa ribosomal S6 kinase (RSK) | P70 ribosomal S6 kinase (p70S6K) | P90 kDa ribosomal S6 kinase (RSK) | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Glioblastoma - enzymology | Phosphorylation | TOR Serine-Threonine Kinases - metabolism | Humans | Substrate Specificity | Data Mining | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - antagonists & inhibitors | Dose-Response Relationship, Drug | TOR Serine-Threonine Kinases - antagonists & inhibitors | Multiprotein Complexes - metabolism | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Transfection | Glioblastoma - genetics | RNA Interference | Time Factors | HEK293 Cells | Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors | Benzopyrans - pharmacology | Pteridines - pharmacology | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Signal Transduction - drug effects | Glioblastoma - pathology | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Cell Line, Tumor | Monosaccharides - pharmacology | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Tumor Suppressor Proteins | Phosphotransferases | Protein biosynthesis | Epidermal growth factor | Genetic translation | Mitogens | Protein kinases | Protein binding | Index Medicus
Journal Article
Cell death & disease, ISSN 2041-4889, 10/2013, Volume 4, Issue 10, pp. e859 - e859
Journal Article
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