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bi-d1870 (11) 11
ribosomal protein s6 kinases, 90-kda - antagonists & inhibitors (7) 7
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pteridines - pharmacology (6) 6
ribosomal s6 kinase (6) 6
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proto-oncogene proteins c-akt - metabolism (2) 2
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rsk (2) 2
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Molecular Cancer Therapeutics, ISSN 1535-7163, 08/2017, Volume 16, Issue 8, pp. 1658 - 1668
A subset of non–small cell lung cancers (NSCLC) are dependent upon oncogenic driver mutations, including the most frequently observed driver mutant KRAS, which... 
Hsp90 protein | Cross-resistance | Extracellular signal-regulated kinase | Non-small cell lung carcinoma | Activation | Lethality | K-Ras protein | Signaling | Inhibitors | Lungs | Mutation | Bypasses | Cancer | Ganetespib | SCH772984 | NSC-663284 | KRAS | p90RSK | drug resistance | CDC25C | BI-D1870 | Hsp90 Inhibitor
Journal Article
Biotechnology and Bioengineering, ISSN 0006-3592, 03/2019, Volume 116, Issue 3, pp. 569 - 580
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2007, Volume 401, Issue 1, pp. 29 - 38
Hormones and growth factors induce the activation of a number of protein kinases that belong to the AGC subfamily, including isoforms of PKA, protein kinase B... 
Kinase-specific inhibitor | Phosphorylation | p90 ribosomal S6 kinase (RSK) | BI-D1870 | Mitogen-activated protein kinase (MAPK) | ACTIVATED PROTEIN-KINASE | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | mitogen-activated protein kinase (MAPK) | MSK1 | INDUCTION | IDENTIFICATION | INACTIVATION | CREB | GROWTH | BI-DI870 | SUPPRESSES | phosphorylation | kinase-specific inhibitor | Cell Line | Pteridines - pharmacology | Humans | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Rats | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Animals | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Kinetics | Chromones - pharmacology | Isoenzymes - antagonists & inhibitors | MES, mouse embryonic stem | PI3K, phosphoinositide 3-kinase | EGF, epidermal growth factor | PKA, cAMP-dependent protein kinase A | FKHR, forkhead in rhabdosarcoma transcription factor | RSK, p90 ribosomal S6 kinase | JNK, c-Jun N-terminal kinase | CREB, cAMP-response-element-binding protein | SGK1, serum- and glucocorticoid-induced kinase-1 | PDK1, phosphoinositide-dependent kinase 1 | PKB, protein kinase B | Lck, lymphocyte kinase | ROCK, Rho-dependent protein kinase | MKK1, MAPK kinase-1 | protein kinase G | AGC, cAMP-dependent protein kinase | protein kinase C | HEK-293, human embryonic kidney 293 | ERK1, extracellular-signal-regulated kinase 1 | GST, glutathione S-transferase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | PH, pleckstrin homology | PLK1, polo-like kinase 1 | CK1, casein kinase-1 | FBS, foetal bovine serum | MSK, mitogen- and stress-activated protein kinase | CDK2–A, cyclin-dependent kinase 2 complexed with cyclin A | DYRK1a, dual-specificity tyrosine-phosphorylated and -regulated kinase 1a | GSK3α, glycogen synthase kinase 3α | MAPK, mitogen-activated protein kinase
Journal Article
CELL DEATH & DISEASE, ISSN 2041-4889, 10/2013, Volume 4
The p90 ribosomal S6 kinase (RSK) family is a group of highly conserved Ser/Thr kinases that promote cell proliferation, growth, motility and survival. As they... 
ACTIVATION | cell cycle | PROTEIN-KINASE | CYTOPLASMIC LOCALIZATION | apoptosis | BI-D1870 | MAPK PATHWAYS | P21 | P27(KIP1) | CELL BIOLOGY | senescence | off-target effect | AKT-DEPENDENT PHOSPHORYLATION | CANCER-CELL-PROLIFERATION | SL0101 | BINDING | PROMOTES
Journal Article
Cellular Signalling, ISSN 0898-6568, 08/2015, Volume 27, Issue 8, pp. 1630 - 1642
The 90 kDa ribosomal S6 kinases (RSK) are effectors of the Ras-ERK1/2 signaling pathway. RSK signaling controls proliferation and protein synthesis, and is... 
p70 ribosomal S6 kinase (p70S6K) | Tuberin (TSC2) | SL0101 | BI-D1870 | Ribosomal protein S6 (rpS6) | p90 kDa ribosomal S6 kinase (RSK) | P70 ribosomal S6 kinase (p70S6K) | P90 kDa ribosomal S6 kinase (RSK) | ACTIVATION | RAS-ERK | PHOSPHORYLATION | PROTEIN-KINASE | CANCER | FAMILY | CELL BIOLOGY | IN-VITRO | OVERCOMING RESISTANCE | GROWTH | RIBOSOMAL S6 KINASE | Glioblastoma - enzymology | Phosphorylation | TOR Serine-Threonine Kinases - metabolism | Humans | Substrate Specificity | Data Mining | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - antagonists & inhibitors | Dose-Response Relationship, Drug | TOR Serine-Threonine Kinases - antagonists & inhibitors | Multiprotein Complexes - metabolism | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Transfection | Glioblastoma - genetics | RNA Interference | Time Factors | HEK293 Cells | Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors | Benzopyrans - pharmacology | Pteridines - pharmacology | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Signal Transduction - drug effects | Glioblastoma - pathology | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Cell Line, Tumor | Monosaccharides - pharmacology | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Tumor Suppressor Proteins | Phosphotransferases | Protein biosynthesis | Epidermal growth factor | Genetic translation | Mitogens | Protein kinases | Protein binding
Journal Article
Cell Death and Disease, ISSN 2041-4889, 10/2013, Volume 4, Issue 10, pp. e859 - e859
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 2/2014, Volume 73, Issue 2, pp. 237 - 247
Journal Article
Journal Article
Mitogen-Activated protein kinase (MAPK) 活化後,進行一連串複雜的細胞反應,如細胞增生、分化及細胞凋亡等。 Ribosomal S6 kinase (RSK),在MAPK... 
口腔癌 | apoptosis | 設定性凋亡 | Ribosomal S6 kinase | BI-D1870 | oral cancer
Dissertation
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