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Molecular Cell, ISSN 1097-2765, 11/2016, Volume 64, Issue 3, pp. 493 - 506
amplification in human cancers predicts poor prognosis and resistance to therapy. However, pharmacological strategies that directly target N-Myc, the protein... 
BI6727 | targeted therapy | ubiquitination | Myc | PLK1 | neuroblastoma | Fbw7 | small cell lung carcinoma | ABT199 | TARGETED THERAPY | INHIBITOR VOLASERTIB | BIOCHEMISTRY & MOLECULAR BIOLOGY | N-MYC | C-MYC | F-BOX PROTEINS | AMPLIFIED NEUROBLASTOMA | AURORA KINASE | FBW7 UBIQUITIN LIGASE | CANCER-THERAPY | HUMAN NEUROBLASTOMA | CELL BIOLOGY | RNA, Small Interfering - genetics | Humans | Neuroblastoma - mortality | N-Myc Proto-Oncogene Protein - antagonists & inhibitors | Transcription, Genetic | Neurons - metabolism | Brain Neoplasms - mortality | Protein-Serine-Threonine Kinases - metabolism | Signal Transduction | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Brain Neoplasms - genetics | Brain Neoplasms - drug therapy | Sulfonamides - pharmacology | Drug Synergism | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Feedback, Physiological | Mice, Nude | Survival Analysis | Cell Line, Tumor | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | RNA, Small Interfering - metabolism | F-Box-WD Repeat-Containing Protein 7 | Neurons - pathology | Brain Neoplasms - pathology | Gene Expression Regulation, Neoplastic | N-Myc Proto-Oncogene Protein - genetics | Cell Cycle Proteins - antagonists & inhibitors | Proto-Oncogene Proteins c-bcl-2 - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Antineoplastic Agents - pharmacology | Neurons - drug effects | Neuroblastoma - pathology | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Pteridines - pharmacology | F-Box Proteins - metabolism | Neuroblastoma - genetics | Protein-Serine-Threonine Kinases - genetics | Proto-Oncogene Proteins - genetics | Xenograft Model Antitumor Assays | Animals | Tumor Burden - drug effects | N-Myc Proto-Oncogene Protein - metabolism | Neuroblastoma - drug therapy | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Proto-Oncogene Proteins c-bcl-2 - genetics | Ubiquitin | Polo | Ligases | Lung cancer | Therapeutics | Homeopathy | Materia medica and therapeutics | Cancer
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 09/2017, Volume 261, pp. 199 - 206
Journal Article
Clinical & Experimental Ophthalmology, ISSN 1442-6404, 04/2017, Volume 45, Issue 3, pp. 288 - 296
Background Retinoblastoma is the most common malignant cancer of the eye in children. Although metastatic retinoblastoma is rare, cure rates for this advanced... 
BI6727 | polo like kinase 1 | targeted therapy | GSK461364 | metastasized retinoblastoma | CANCER-CELLS | APOPTOSIS | P53 | THERAPY | OPHTHALMOLOGY | OSTEOSARCOMA | VOLASERTIB BI 6727 | CHECKPOINT | ADVANCED SOLID MALIGNANCIES | PHASE-I | CDC2 Protein Kinase | Phosphorylation | Cyclin-Dependent Kinases - metabolism | Retinoblastoma - genetics | Apoptosis - drug effects | Humans | Retinal Neoplasms - pathology | Cyclin B1 - metabolism | Gene Expression Regulation, Enzymologic - physiology | Retinoblastoma - pathology | Cell Cycle Proteins - antagonists & inhibitors | Polymerase Chain Reaction | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Antineoplastic Agents - pharmacology | Retinal Neoplasms - metabolism | Tumor Cells, Cultured | Real-Time Polymerase Chain Reaction | Cell Survival - drug effects | Proto-Oncogene Proteins - antagonists & inhibitors | Pteridines - pharmacology | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Thiophenes - pharmacology | Proto-Oncogene Proteins - genetics | Retinoblastoma - metabolism | Blotting, Western | Benzimidazoles - pharmacology | Cell Proliferation - drug effects | Cell Cycle - drug effects | Retinal Neoplasms - genetics | Enzymes | Polo | Cell death | Analysis | Metastasis | Retinoblastoma | Tumor proteins | Enzyme-linked immunosorbent assay | Cyclin-dependent kinases | Cell cycle | Apoptosis
Journal Article
Leukemia Research, ISSN 0145-2126, 2015, Volume 39, Issue 4, pp. 462 - 470
Highlights • We demonstrate the effects of PLK1 inhibition on AML blasts in vivo and in vitro. • AML cells treated with PLK1 inhibition arrest in mitosis with... 
Hematology, Oncology and Palliative Medicine | AML | BI6727 | Bone marrow biopsy | BI2536 | PLK1 inhibition | Hematopoietic cells | Live cell imaging | Volasertib | OPEN-LABEL | BREAST-CANCER | TRIAL | OVEREXPRESSION | ONCOLOGY | BI 2536 | POLO-LIKE-KINASE-1 PLK1 | LEUKEMIA | HEMATOLOGY | PHASE-I | EXPRESSION | Blast Crisis - drug therapy | Apoptosis - drug effects | Humans | Male | Bone Marrow - enzymology | Immunoenzyme Techniques | Blast Crisis - enzymology | Cell Cycle Proteins - antagonists & inhibitors | Leukemia, Myeloid, Acute - enzymology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Aged, 80 and over | Leukemia, Myeloid, Acute - drug therapy | Female | Tumor Cells, Cultured | Real-Time Polymerase Chain Reaction | Protein-Serine-Threonine Kinases - metabolism | Bone Marrow - drug effects | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Pteridines - pharmacology | Blast Crisis - pathology | Leukemia, Myeloid, Acute - pathology | RNA, Messenger - genetics | Cell Cycle Proteins - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Mitosis - drug effects | Bone Marrow - pathology | Antimitotic Agents - pharmacology | Aged | Cell Proliferation - drug effects | Biochemistry | Cell death | Health aspects | Stem cells | Medical informatics
Journal Article
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