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Journal Article
Journal Article
Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, 07/2017, Volume 171, pp. 157 - 177
Several members of the short-chain dehydrogenase/reductase (SDR) enzyme family play fundamental roles in adrenal and gonadal steroidogenesis as well as in the... 
Virtual screening | Hydroxysteroid dehydrogenase | Drug development | Short-chain dehydrogenase/reductase | Endocrine disrupting chemicals | CARBONYL REDUCTASE SNIFFER | SELECTIVE NONSTEROIDAL INHIBITORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CRYSTAL-STRUCTURES | BETA-HYDROXYSTEROID DEHYDROGENASE | 17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE-1 17-BETA-HSD1 | 11-BETA-HYDROXYSTEROID DEHYDROGENASE | ENDOCRINOLOGY & METABOLISM | BICYCLIC SUBSTITUTED HYDROXYPHENYLMETHANONES | 11-BETA-HSD1 INHIBITORS | (-)-GOSSYPOLS POTENTLY INHIBIT | STRUCTURE-BASED DESIGN | Chemistry, Pharmaceutical - methods | Hydroxysteroid Dehydrogenases - chemistry | Expert Systems | Humans | Substrate Specificity | Isoenzymes - chemistry | Machine Learning | Endocrine Disruptors - pharmacology | Isoenzymes - metabolism | Enzyme Inhibitors - chemistry | Enzyme Inhibitors - toxicity | Drug Design | Hydroxysteroid Dehydrogenases - metabolism | Toxicology - methods | Computer-Aided Design - trends | Binding Sites | Chemistry, Pharmaceutical - trends | Endocrine Disruptors - metabolism | Enzyme Inhibitors - metabolism | Endocrine Disruptors - chemistry | Computational Biology | Enzyme Inhibitors - pharmacology | Toxicology - trends | Molecular Docking Simulation - trends | High-Throughput Screening Assays - trends | Endocrine Disruptors - toxicity | Animals | Validation Studies as Topic | Databases, Chemical | Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Protein Conformation | Isoenzymes - antagonists & inhibitors | Enzymes | Dehydroepiandrosterone | Corticosteroids | Bile acids | Estrogen | Cytochrome P-450 | Physiological aspects | Alcoholic beverages | Drug discovery | Retinoids | Progesterone | Index Medicus | Short-chain dehydrogenase | reductase | virtual screening | hydroxysteroid dehydrogenase | endocrine disrupting chemicals | drug development | in silico
Journal Article
Journal Article
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