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INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ISSN 0146-0404, 07/2018, Volume 59, Issue 9
Conference Proceeding
Experimental Eye Research, ISSN 0014-4835, 07/2013, Volume 112, pp. 10 - 20
An Arg-Gly-Asp (RGD) motif in the fourth FAS1 domain of the human BIGH3 (transforming growth factor-β1-inducible gene-h3) protein has been reported to play an... 
Anti-angiogenesis | Corneal neovascularization | RGDRGD | BIGH3
Journal Article
Human Mutation, ISSN 1059-7794, 06/2019, Volume 40, Issue 6, pp. 675 - 693
Journal Article
by Yoo, SY and Kim, TI and Lee, SY and Kim, EK and Keum, KC and Yoo, NC and Yoo, WM
BRITISH JOURNAL OF OPHTHALMOLOGY, ISSN 0007-1161, 06/2007, Volume 91, Issue 6, pp. 722 - 727
Aim: To develop a diagnostic DNA chip to detect mutations in the beta igh3 gene causing the most common corneal dystrophies (CDs). Methods: Samples from 98... 
BIGH3 GENE | OPHTHALMOLOGY | LATTICE
Journal Article
Human Mutation, ISSN 1059-7794, 07/2006, Volume 27, Issue 7, pp. 615 - 625
Journal Article
International Journal of Clinical Medicine, ISSN 2158-284X, 2016, Volume 7, Issue 7, pp. 496 - 510
Metabolically stressed kidney is in part characterized by infiltrating macrophages and macrophage-derived TGF-β1 that promote the synthesis of various ECM... 
TGF | Diabetes | Extracellular Matrix | Macrophages | BIGH3
Journal Article
CORNEA, ISSN 0277-3740, 12/2008, Volume 27, Issue 10, pp. S1 - S42
Background: The recent availability of genetic analyses has demonstrated the shortcomings of the current phenotypic method of corneal dystrophy classification.... 
Grayson-Wilbrandt corneal dystrophy | Meesmann corneal dystrophy | TGFBI BIGH3 GENE | pre-Descemet corneal dystrophy | GROENOUW TYPE-I | corneal histopathology | GELSOLIN-RELATED AMYLOIDOSIS | Thiel-Behnke corneal dystrophy | posterior polymorphous corneal dystrophy | epithelial basement membrane dystrophy | POSTERIOR POLYMORPHOUS DYSTROPHY | granular corneal dystrophy 2 | COMPOUND HETEROZYGOUS MUTATIONS | granular corneal dystrophy 1 | genetic corneal disease | Schnyder corneal dystrophy | inherited corneal disease | WHORLED MICROCYSTIC DYSTROPHY | congenital hereditary endothelial dystrophy 1 | congenital hereditary endothelial dystrophy 2 | posterior amorphous corneal dystrophy | central cloudy dystrophy of Francois | macular corneal dystrophy | Schnyder crystalline corneal dystrophy | congenital stromal corneal dystrophy | gene | subepithelial mucinous corneal dystrophy | VIVO CONFOCAL MICROSCOPY | CENTRAL CLOUDY DYSTROPHY | Lisch epithelial corneal dystrophy | corneal dystrophy | eponym | X-linked endothelial corneal dystrophy | mutation | key reference | CARBOHYDRATE SULFOTRANSFERASE GENE | fleck corneal dystrophy | HEREDITARY ENDOTHELIAL DYSTROPHY | epithelial recurrent erosion dystrophy | gelatinous drop-like corneal dystrophy | OPHTHALMOLOGY | Avellino corneal dystrophy | lattice gelsolin type dystrophy | Fuchs endothelial corneal dystrophy | lattice corneal dystrophy | Reis-Bucklers corneal dystrophy
Journal Article
HUMAN MUTATION, ISSN 1059-7794, 06/2006, Volume 27, Issue 6, pp. 553 - 557
Epithelial basement membrane corneal dystrophy (EBMD), also known as Cogan microcystic epithelial dystrophy or map-dot-fingerprint dystrophy, is a common... 
MATRIX | Cogan dystrophy | PROTEIN | epithelial basement membrane corneal dystrophy | corneal dystrophy | CELL-ADHESION | FIBROBLASTS | BIGH3 | GROWTH-FACTOR-BETA | IN-VITRO | EBMD | BETA-IG-H3 | CLONING | GENETICS & HEREDITY | BIGH3 GENE | TGFBI | TISSUES
Journal Article
International Eye Science, ISSN 1672-5123, 03/2017, Volume 17, Issue 3, pp. 449 - 450
BIGH3 gene plays an important role in ocular diseases. On the one hand, it is closely related to the occurrence of corneal diseases. BIGH3 gene can inhibit... 
Diabetic retinopathy | Corneal dystrophy | Keratoconus | Corneal neovascularization | BIGH3 | corneal dystrophy | keratoconus | diabetic retinopathy | corneal neovascularization
Journal Article
Investigative ophthalmology & visual science, ISSN 0146-0404, 8/2009, Volume 50, Issue 8, pp. 3542 - 3552
Journal Article
Journal Article
国际眼科杂志, ISSN 1672-5123, 2017, Volume 17, Issue 3, pp. 449 - 450
BIGH3基因在眼部疾病中起重要作用。一方面,与角膜疾病的发生息息相关,BIGH3基因可以抑制角膜新生血管形成,导致角膜营养不良,参与圆锥角膜形成;另一方面,可以导致糖尿病视网膜病变中新生血管的生成,有最新实验证明,巨噬细胞分泌的TGFβ可以促进BIGH3... 
角膜营养不良 | 圆锥角膜 | 角膜新生血管 | 糖尿病视网膜病变 | BIGH3
Journal Article
Structure, ISSN 0969-2126, 11/2017, Volume 25, Issue 11, pp. 1740 - 1750.e2
A major cause of visual impairment, corneal dystrophies result from accumulation of protein deposits in the cornea. One of the proteins involved is... 
extracellular matrix protein | cysteine-rich CROPT domain | multi-domain protein | pathological mutants | crystal structure | corneal dystrophy | fasciclin FAS1 domain | GENOTYPE-PHENOTYPE CORRELATIONS | KERATO-EPITHELIN MUTATIONS | BIOCHEMISTRY & MOLECULAR BIOLOGY | AMYLOID DEPOSITS | STRUCTURE ALIGNMENT | CELL BIOLOGY | BIOPHYSICS | STRUCTURE VALIDATION | MACROMOLECULAR CRYSTALLOGRAPHY | CHINESE PATIENTS | BIGH3 GENE-MUTATIONS | STRUCTURE PREDICTION | GRANULAR DYSTROPHY | Protein Aggregates | Humans | Integrins - chemistry | Corneal Dystrophies, Hereditary - genetics | Integrins - genetics | Crystallography, X-Ray | Transforming Growth Factor beta - chemistry | Integrins - metabolism | Corneal Dystrophies, Hereditary - pathology | Cloning, Molecular | HEK293 Cells | Protein Interaction Domains and Motifs | Binding Sites | Protein Aggregation, Pathological - genetics | Extracellular Matrix Proteins - metabolism | Recombinant Proteins - metabolism | Amino Acid Sequence | Protein Conformation, alpha-Helical | Extracellular Matrix Proteins - chemistry | Gene Expression | Genetic Vectors - chemistry | Extracellular Matrix Proteins - genetics | Genetic Vectors - metabolism | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Corneal Dystrophies, Hereditary - metabolism | Sequence Homology, Amino Acid | Sequence Alignment | Transforming Growth Factor beta - genetics | Protein Conformation, beta-Strand | Protein Binding | Mutation | Transforming Growth Factor beta - metabolism | Protein Aggregation, Pathological - metabolism | Index Medicus
Journal Article
Biochemical Journal, ISSN 0264-6021, 05/2017, Volume 474, Issue 10, pp. 1705 - 1725
Corneal stromal dystrophies are a group of genetic disorders that may be caused by mutations in the transforming growth factor beta-induced (TGFBI) gene which... 
GENE-MUTATIONS | INDUCED PROTEIN TGFBIP | GROWTH-FACTOR-BETA | IN-VITRO | FIBRILS | NMR CHEMICAL-SHIFTS | KERATOEPITHELIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIGH3 GENE | CELL-ADHESION | AGGREGATION | Cornea - ultrastructure | Up-Regulation | Humans | Transforming Growth Factor beta1 - metabolism | Corneal Dystrophies, Hereditary - genetics | Eye Proteins - chemistry | Amyloidogenic Proteins - chemistry | Amyloid - chemistry | Chromatography, High Pressure Liquid | Transforming Growth Factor beta - chemistry | Amyloid - ultrastructure | Tandem Mass Spectrometry | Transforming Growth Factor beta1 - chemistry | Spectrometry, Mass, Electrospray Ionization | Amyloid - metabolism | Corneal Dystrophies, Hereditary - pathology | Nuclear Magnetic Resonance, Biomolecular | Cornea - cytology | Cornea - pathology | Protein Interaction Domains and Motifs | Eye Proteins - genetics | Protein Stability | Circular Dichroism | Peptide Fragments - genetics | Protein Aggregation, Pathological - genetics | Amyloidogenic Proteins - genetics | Amyloid - genetics | Microscopy, Electron, Transmission | Peptide Fragments - metabolism | Cells, Cultured | Transforming Growth Factor beta1 - genetics | Corneal Dystrophies, Hereditary - metabolism | Cornea - metabolism | Point Mutation | Amyloidogenic Proteins - metabolism | Peptide Fragments - chemistry | Transforming Growth Factor beta - genetics | Eye Proteins - metabolism | Kinetics | Transforming Growth Factor beta - metabolism | Protein Aggregation, Pathological - metabolism | Amino Acid Substitution | Index Medicus | corneal dystrophy | amyloid | amino acid substitution | β-sheet propensity | protein aggregation | TGFBIp
Journal Article
Zhonghua Shiyan Yanke Zazhi/Chinese Journal of Experimental Ophthalmology, ISSN 2095-0160, 11/2013, Volume 31, Issue 11, pp. 1006 - 1010
Journal Article
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