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Angewandte Chemie International Edition, ISSN 1433-7851, 03/2016, Volume 55, Issue 11, pp. 3552 - 3565
The recent uptake of molecular metathesis catalysts in specialty‐chemicals and pharmaceutical manufacturing is reviewed. The metathesis industry: Olefin... 
olefin metathesis | large-scale synthesis | renewable feedstocks | industrial chemistry | pharmaceutical chemistry | BILN-2061 | SB-462795 | OILS | CONVERGENT | CHEMISTRY, MULTIDISCIPLINARY | DISCOVERY | RING-CLOSING METATHESIS | ETHENOLYSIS | HCV PROTEASE INHIBITOR | Olefins | Reviews | Catalysts | Metathesis | Decomposition reactions | Manufacturing | Chemicals | Pharmaceuticals
Journal Article
Organic Process Research & Development, ISSN 1083-6160, 01/2016, Volume 20, Issue 1, pp. 76 - 80
A practical through-process to prepare iso-Boc (S)-2-amino-8-nonenoic acid has been developed. The short synthesis utilizes a highly enantioselective,... 
CHEMISTRY, ORGANIC | BILN-2061 | THERAPY | CHEMISTRY, APPLIED | INHIBITOR | PROTEASE
Journal Article
Organic Process Research & Development, ISSN 1083-6160, 03/2009, Volume 13, Issue 2, pp. 250 - 254
The ring-closing metathesis (RCM) step, a key reaction in our process to BILN 2061, was dramatically improved from the first-generation process by the... 
BILN-2061 | RUTHENIUM CARBENES | CHEMISTRY, ORGANIC | OLEFIN METATHESIS | SCALE | CHEMISTRY, APPLIED | RCM | MACROCYCLIZATION
Journal Article
Organic Process Research & Development, ISSN 1083-6160, 11/2012, Volume 16, Issue 11, pp. 1697 - 1706
As pharmaceutical API projects advance from Development to Chemical Production, the primary objective of the Process Research and Development (R&D) chemists is... 
ORGANIC-SYNTHESIS | BILN-2061 | DESIGN | RING-CLOSING METATHESIS | HEPATITIS-C VIRUS | NS3 PROTEASE | AZAINDOLES | EFFICIENT SYNTHESIS | CHEMISTRY, ORGANIC | HCV PROTEASE INHIBITOR | CHEMISTRY, APPLIED | ECONOMY
Journal Article
Journal Article
Journal Article
Organic Process Research & Development, ISSN 1083-6160, 07/2005, Volume 9, Issue 4, pp. 513 - 515
BILN 2061 ZW (4) is a new chemical entity which shows promising results against the Hepatitis C virus. The major issue in the synthetic route represents the... 
PROTEASE INHIBITOR | BILN-2061 | HEPATITIS-C VIRUS | HUMANS | CHEMISTRY, ORGANIC | CATALYST | CHEMISTRY, APPLIED
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 03/2006, Volume 50, Issue 3, pp. 899 - 909
Journal Article
Journal Article
Sensors and Actuators: B. Chemical, ISSN 0925-4005, 10/2019, Volume 296, p. 126595
•A liquid crystal-based protease inhibition assay is developed.•This assay is used to assess inhibition efficiency of a protease inhibitor pefabloc.•IC50 value... 
Cartridge | Segmental flow | Reversibility | Protease inhibition | IC50 | SYSTEM | ELECTROCHEMISTRY | CHEMISTRY, ANALYTICAL | BILN-2061 | SERINE-PROTEASES | BLOOD-COAGULATION | ENZYMATIC-ACTIVITIES | ANTIBODY | SENSOR | TIME | INSTRUMENTS & INSTRUMENTATION | EVOLUTION | SURFACES
Journal Article
Journal Article
Journal Article
The Journal of Organic Chemistry, ISSN 0022-3263, 10/2011, Volume 76, Issue 19, pp. 7804 - 7815
Development of a practical synthesis of MK-7009, a 22-membered macrocycle, is described. A variety of ring-closing strategies were evaluated, including... 
SUZUKI | BILN-2061 | RING-CLOSING METATHESIS | EFFICIENT SYNTHESIS | CHEMISTRY, ORGANIC | HCV PROTEASE INHIBITOR | CATALYST | HECK REACTION | HEPATITIS-C | BROMIDES | ARYL CHLORIDES | Palladium catalysts | Ring formation (Chemistry) | Chemical properties | Macrocycles | Structure | Analysis
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2010, Volume 53, Issue 17, pp. 6466 - 6476
Journal Article