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Neurobiology of Disease, ISSN 0969-9961, 2014, Volume 68, Issue 100, pp. 66 - 77
Abstract Rett syndrome (RTT) is a rare neurodevelopmental disorder affecting almost exclusively females, caused in the overwhelming majority of the cases by... 
Neurology | Lipid peroxidation | Oxidative stress | Brain damage | Neurodevelopmental disorder | Murine models | Rett syndrome | F-4-NEUROPROSTANES | IRON | F-2-DIHOMO-ISOPROSTANES | NEUROSCIENCES | DEFICIENCY | CHOLESTEROL-METABOLISM | MECP2 | MOUSE MODEL | DISEASE | DYSFUNCTION | STRESS | Arachidonic Acid - metabolism | Rett Syndrome - complications | Gas Chromatography-Mass Spectrometry | Mice, Inbred C57BL | Neuroprostanes - metabolism | Oxidative Stress - physiology | Male | Mice, Transgenic | Aldehydes - metabolism | Mutation - genetics | Methyl-CpG-Binding Protein 2 - genetics | Animals | Isoprostanes - metabolism | Analysis of Variance | Nestin - genetics | Brain Injuries - blood | Female | Mice | Brain Injuries - etiology | Rett Syndrome - blood | Rett Syndrome - genetics | Brain Injuries - pathology | Disease Models, Animal | Docosahexaenoic Acids - metabolism | Models | Analysis | Protein binding | Organic chemistry | Chemical Sciences | OS, oxidative stress | Mecp2 | y, hemizygous null mice | NPBI, non-protein-bound iron | Mecp2, methyl-CpG-binding protein 2 — mouse protein | CRE, Cre-Recombinase | AdA, adrenic acid | AUs, arbitrary units | ARA, arachidonic acid | 4-HNE PAs, 4-HNE protein adducts | PSV, Preserved Speech Variant | Mecp2, methyl-CpG-binding protein 2 — mouse gene | wt, wild type | wt-Cre, wild type expressing Cre recombinase | MECP2, methyl-CpG-binding protein 2 — human gene | y, symptomatic Mecp2 308-mutated hemizygous males | ROS, reactive oxygen species | F2-IsoPs, F2-isoprostanes | MeCP2, methyl-CpG-binding protein 2 — human protein | y, Lox | F2-dihomo-IsoPs, F2-dihomo-isoprostanes | 4-HNE PAs, 4-hydroxy-2-nonenal protein adducts | Mecp2 stop | y NestinCre, rescued Lox | ASDs, autism spectrum disorders | F4-NeuroPs, F4-neuroprostanes | Mecp2 308 | stop pre-symptomatic hemizygous mice | x, symptomatic Mecp2 308-mutated females | DHA, docosahexaenoic acid | PUFAs, polyunsaturated fatty acids | BDNF, brain-derived neurotrophic factor | IsoPs, isoprostanes | RTT, Rett syndrome | stop mice (Mecp2 reactivated in the nervous tissue) | 4-HNE, 4-hydroxy-2-nonenal
Journal Article
Science, ISSN 0036-8075, 5/2008, Volume 320, Issue 5880, pp. 1224 - 1229
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2014, Volume 9, Issue 3, p. e90645
MeCP2 is a critical epigenetic regulator in brain and its abnormal expression or compromised function leads to a spectrum of neurological disorders including... 
AUTISM | RETT-SYNDROME PHENOTYPES | BASOLATERAL AMYGDALA | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | TRANSCRIPTION | LEUKEMIA-CELL LINE | GENE-EXPRESSION | NEURONS | CPG-BINDING PROTEIN-2 | PROMOTER | Immunohistochemistry | Brain - cytology | Methyl-CpG-Binding Protein 2 - metabolism | Gene Expression Regulation, Developmental - genetics | Molecular Sequence Data | Male | DNA Methylation - genetics | Sequence Analysis, DNA | Blotting, Western | Methyl-CpG-Binding Protein 2 - genetics | Brain - metabolism | Animals | Protein Isoforms - metabolism | Base Sequence | Female | Mice | Real-Time Polymerase Chain Reaction | Regulatory Elements, Transcriptional - genetics | Gene Expression Regulation, Developmental - physiology | Epigenetic inheritance | Brain | Nervous system diseases | Neurons | Analysis | DNA | Stem cells | Methylation | Neurophysiology | Cerebellum | Cortex (olfactory) | Brain stem | Leukemia | Regional development | Regulatory sequences | Biochemistry | Proteins | Methyl-CpG binding protein | Rodents | Oligodendrocytes | Neostriatum | DNA methylation | Thalamus | Cortex (temporal) | Deoxyribonucleic acid--DNA | CpG islands | Complications | Astrocytes | Regional analysis | RNA polymerase | Gene expression | Embryos | Neurological diseases | Medicine | Studies | Autism | Brain research | MeCP2 protein | Neurological complications | Isoforms | Rett syndrome | Neural stem cells | Olfactory bulb | Mutation | Comparative analysis | Hippocampus | Binding sites | Apoptosis | Deoxyribonucleic acid
Journal Article
Journal Article
NeuroMolecular Medicine, ISSN 1535-1084, 6/2014, Volume 16, Issue 2, pp. 231 - 264
Rett syndrome (RTT) is a severe and progressive neurological disorder, which mainly affects young females. Mutations of the methyl-CpG binding protein 2... 
MeCP2 | Neurosciences | Internal Medicine | Autism spectrum disorders | Neurology | Fetal alcohol spectrum disorders | Biomedicine | MeCP2E2 | MeCP2E1 | Rett syndrome | Epigenetics | DNA methylation | MeCP2 isoforms |