X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (735) 735
animals (582) 582
humans (389) 389
mice (331) 331
liver (295) 295
element-binding protein (289) 289
male (262) 262
glucose (258) 258
liver - metabolism (250) 250
metabolism (245) 245
gene expression (233) 233
biochemistry & molecular biology (208) 208
physiological aspects (200) 200
fatty acids (197) 197
insulin-resistance (183) 183
lipogenesis (172) 172
cell biology (169) 169
insulin resistance (166) 166
gene-expression (164) 164
endocrinology & metabolism (163) 163
proteins (154) 154
lipids (150) 150
lipid metabolism (149) 149
transcription factors - metabolism (149) 149
rats (147) 147
glucose - metabolism (146) 146
insulin (146) 146
protein binding (145) 145
obesity (144) 144
rodents (142) 142
sterol regulatory element binding protein 1 - metabolism (133) 133
mice, inbred c57bl (130) 130
transcription factor (129) 129
fatty liver (124) 124
research (123) 123
transcription factors (121) 121
expression (118) 118
dextrose (114) 114
article (112) 112
sterol regulatory element binding protein 1 - genetics (112) 112
gene expression regulation (111) 111
chrebp (108) 108
diabetes (106) 106
genes (105) 105
female (102) 102
transcription factors - genetics (102) 102
liver diseases (101) 101
research article (99) 99
triglycerides (99) 99
signal transduction (98) 98
enzymes (97) 97
glucose metabolism (97) 97
adipose-tissue (95) 95
basic helix-loop-helix leucine zipper transcription factors - metabolism (92) 92
hepatic steatosis (92) 92
lipid-metabolism (90) 90
transcription (89) 89
multidisciplinary sciences (88) 88
genetic aspects (85) 85
homeostasis (84) 84
phosphorylation (82) 82
diet (81) 81
physiology (81) 81
hepatocytes - metabolism (80) 80
liver - drug effects (77) 77
analysis (76) 76
steatosis (76) 76
synthesis (76) 76
dna binding proteins (74) 74
medicine (74) 74
nuclear proteins - metabolism (74) 74
metabolic syndrome (73) 73
type 2 diabetes (72) 72
fatty acids - metabolism (71) 71
fatty liver - metabolism (71) 71
basic helix-loop-helix leucine zipper transcription factors - genetics (68) 68
carbohydrates (68) 68
kinases (68) 68
oxidative stress (68) 68
mice, knockout (67) 67
biophysics (66) 66
inflammation (65) 65
nutrition & dietetics (65) 65
cholesterol (64) 64
liver - pathology (64) 64
sterol regulatory element-binding protein (64) 64
triglycerides - metabolism (64) 64
liver x receptors (63) 63
cells, cultured (62) 62
science (62) 62
cell line (59) 59
glucose - pharmacology (59) 59
nuclear proteins - genetics (59) 59
rna, messenger - metabolism (59) 59
rats, sprague-dawley (58) 58
activation (55) 55
genetic transcription (55) 55
health aspects (55) 55
ppar-alpha (55) 55
fatty liver-disease (54) 54
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Nature, ISSN 0028-0836, 04/2012, Volume 484, Issue 7394, pp. 333 - 338
The prevalence of obesity and type 2 diabetes is increasing worldwide and threatens to shorten lifespan. Impaired insulin action in peripheral tissues is a... 
DIABETES-MELLITUS | FATTY-ACID SYNTHESIS | GENE | INSULIN-RESISTANCE | LIPOGENESIS | MULTIDISCIPLINARY SCIENCES | CARBOHYDRATE-RESPONSE ELEMENT | LIVER | BINDING-PROTEIN CHREBP | UCSC GENOME BROWSER | TRANSGENIC MICE | Transcription Factors - chemistry | Diabetes Mellitus - genetics | Humans | Male | RNA, Messenger - metabolism | Adipose Tissue - metabolism | Protein Isoforms - chemistry | Nuclear Proteins - deficiency | Lipogenesis | Body Mass Index | Glucose Transporter Type 4 - genetics | Adipose Tissue - pathology | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - chemistry | Genotype | Glucose - pharmacology | Nuclear Proteins - chemistry | Mice, Knockout | Insulin - metabolism | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics | Insulin Resistance - genetics | Glucose - metabolism | Mice | Blood Glucose - metabolism | Homeostasis - genetics | Cohort Studies | Diabetes Mellitus - blood | Body Weight | Glucose Transporter Type 4 - metabolism | Transcription Factors - deficiency | Adipose Tissue - cytology | Molecular Sequence Data | Obesity - genetics | Promoter Regions, Genetic - genetics | Protein Isoforms - metabolism | Adiposity | Female | Nuclear Proteins - genetics | Insulin - pharmacology | Glucose Intolerance - genetics | Cross-Sectional Studies | Gene Expression Regulation - genetics | RNA, Messenger - genetics | Cells, Cultured | Diabetes Mellitus - metabolism | Nuclear Proteins - metabolism | Transcription Factors - genetics | Obesity - metabolism | Transcription Factors - metabolism | Animals | Glucose Transporter Type 4 - biosynthesis | Adipocytes - metabolism | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Protein Isoforms - genetics | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 11/2016, Volume 126, Issue 11, pp. 4372 - 4386
Obese, insulin-resistant states are characterized by a paradoxical pathogenic condition in which the liver appears to be selectively insulin resistant.... 
RAT-LIVER | MEDICINE, RESEARCH & EXPERIMENTAL | METABOLIC SYNDROME | DE-NOVO LIPOGENESIS | TRANSCRIPTION FACTOR FOXO1 | FATTY LIVER-DISEASE | OB/OB MICE | ELEMENT-BINDING PROTEIN | HEPATIC STEATOSIS | ADIPOSE-TISSUE | PLASMA TRIGLYCERIDES | Glucose Intolerance - metabolism | Glucose-6-Phosphatase - genetics | Fatty Liver - pathology | Humans | Male | Glucose - biosynthesis | Glucose Intolerance - pathology | Fatty Liver - chemically induced | Glycolysis - drug effects | Glycolysis - genetics | Lipogenesis - genetics | Female | Glucose Intolerance - chemically induced | Insulin - genetics | Nuclear Proteins - genetics | Fatty Liver - genetics | Forkhead Box Protein O1 - metabolism | Glucose Intolerance - genetics | Fatty Liver - metabolism | Fructose - toxicity | Insulin Resistance | Glucose - genetics | Nuclear Proteins - metabolism | Signal Transduction - genetics | Transcription Factors - genetics | Glucose-6-Phosphatase - metabolism | Mice, Knockout | Transcription Factors - metabolism | Insulin - metabolism | Animals | Signal Transduction - drug effects | Lipogenesis - drug effects | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Mice | Forkhead Box Protein O1 - genetics | Obesity | Analysis | Insulin resistance | Genetic aspects | Genetic transcription | Research | Risk factors | Protein binding | Glucose | Metabolites | Rodents | Liver | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 06/2017, Volume 127, Issue 7, pp. 2855 - 2867
Epidemiologic and animal studies implicate overconsumption of fructose in the development of nonalcoholic fatty liver disease, but the molecular mechanisms... 
CHOLESTEROL-METABOLISM | MEDICINE, RESEARCH & EXPERIMENTAL | DIABETIC MICE | ENDOPLASMIC-RETICULUM-STRESS | FATTY LIVER-DISEASE | ER STRESS | INSULIN-RESISTANCE | SODIUM 4-PHENYLBUTYRATE PROTECTS | NONALCOHOLIC STEATOHEPATITIS | HEPATIC STEATOSIS | GROWTH-FACTOR 21 | Liver - pathology | Protein Binding - genetics | Cholesterol - genetics | Liver - injuries | Fructose - pharmacology | Protein Binding - drug effects | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | Chemical and Drug Induced Liver Injury - pathology | Nuclear Proteins - genetics | Unfolded Protein Response - drug effects | Fructose - adverse effects | Unfolded Protein Response - genetics | Dietary Carbohydrates - pharmacology | Liver - metabolism | Nuclear Proteins - metabolism | Chemical and Drug Induced Liver Injury - genetics | Transcription Factors - genetics | Cholesterol - metabolism | Mice, Knockout | Transcription Factors - metabolism | Animals | Chemical and Drug Induced Liver Injury - metabolism | Mice | Dietary Carbohydrates - adverse effects | Prevention | Physiological aspects | Liver diseases | Fructose | Protein binding | Adaptations | Transcription factors | Pathogenesis | Lipids | Biosynthesis | CCAAT/enhancer-binding protein | Chaperones | Kinases | Proteins | Signal transduction | Ubiquitination | Fatty liver | Sterols | Protein folding | Rodents | Cell cycle | Sterol regulatory element-binding protein | Lipid metabolism | Lipogenesis | Hepatotoxicity | Adaptation | Metabolism | Fatty acids | Cholesterol | Studies | Molecular modelling | Diet | Atorvastatin | Diabetes | Endoplasmic reticulum | Apoptosis | Index Medicus | Abridged Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 7, pp. e22544 - e22544
The carbohydrate response element binding protein (ChREBP), a basic helix-loop-helix/leucine zipper transcription factor, plays a critical role in the control... 
CHIP-SEQ DATA | CENTER-DOT-MLX | DNA-BINDING | INTERACTING PROTEIN | MULTIDISCIPLINARY SCIENCES | CARBOHYDRATE-RESPONSE ELEMENT | OB/OB MICE | LIVER | SITES | BINDING PROTEIN | TRANSCRIPTION FACTOR | Reproducibility of Results | Humans | Liver - metabolism | Genetic Loci - genetics | Databases, Genetic | Molecular Sequence Data | Gene Expression Profiling | Glucose - pharmacology | Signal Transduction - genetics | DNA - metabolism | Genome, Human - genetics | Hep G2 Cells | Gene Expression Regulation - drug effects | Chromatin Immunoprecipitation | Lipogenesis - genetics | Liver - drug effects | Signal Transduction - drug effects | Base Sequence | Lipogenesis - drug effects | Protein Binding - drug effects | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics | HEK293 Cells | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Binding Sites | Chromatin | Analysis | Genes | Liver | Genomics | Genomes | Glucose | Gene expression | Fatty acids | Dextrose | Protein binding | Transcription factors | Immunoprecipitation | Target recognition | Science | Hepatocellular carcinoma | Biochemistry | Leucine | Kinases | Experiments | Gene sequencing | Proteins | Conserved sequence | Cell growth | Sterols | E coli | Rodents | Helix-loop-helix proteins | Lipogenesis | Deoxyribonucleic acid--DNA | Carbohydrates | Medical research | Gene clusters | Knowledge representation | Metabolism | Variance analysis | Leucine zipper proteins | Medicine | Polymerase chain reaction | Adenoviruses | Diabetes | Molecular biology | Bayesian analysis | Binding sites | Cancer | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Journal of Cell Biology, ISSN 0021-9525, 07/2017, Volume 216, Issue 7, pp. 2091 - 2105
Impaired nutrient sensing and dysregulated glucose homeostasis are common in diabetes. However, how nutrient-sensitive signaling components control glucose... 
RAPAMYCIN | RAG GTPASES | METABOLISM | GLUCOSE-INTOLERANCE | ER STRESS | INSULIN-SECRETION | LEUCINE SENSOR | THIOREDOXIN-INTERACTING PROTEIN | ELEMENT-BINDING PROTEIN | DIET-INDUCED OBESITY | CELL BIOLOGY | TOR Serine-Threonine Kinases - metabolism | Diabetes Mellitus, Experimental - enzymology | Humans | Middle Aged | Diabetes Mellitus, Experimental - genetics | Male | Insulin - blood | TOR Serine-Threonine Kinases - genetics | Thioredoxins - genetics | Transfection | RNA Interference | Time Factors | Adult | Thioredoxins - metabolism | Transcription, Genetic | Nuclear Proteins - genetics | Signal Transduction | Cell Survival | Tissue Culture Techniques | Mice, Inbred C57BL | Genotype | Nuclear Proteins - metabolism | Transcription Factors - genetics | Mice, Knockout | Transcription Factors - metabolism | Carrier Proteins - genetics | Phenotype | Animals | Carrier Proteins - metabolism | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics | Cell Line, Tumor | Diabetes Mellitus, Experimental - pathology | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Aged | Insulin-Secreting Cells - pathology | Blood Glucose - metabolism | Insulin-Secreting Cells - enzymology | TOR protein | Stresses | Oxidative stress | Carbohydrates | Transcription factors | Cell survival | Nutrient deficiency | Transcription | Diabetes mellitus | Homeostasis | Chemoreception | Rapamycin | Glucose | Thioredoxin | Survival | Cells | Stress | Mitochondria | Cell death | Nutrients | Diabetes | Pancreas | Index Medicus | 1 | s | 29
Journal Article
Molecular Metabolism, ISSN 2212-8778, 2016, Volume 5, Issue 12, pp. 1208 - 1215
Abstract Objective Carbohydrate-response element-binding protein (ChREBP) is the major transcription factor conferring glucose-induced gene expression in... 
Endocrinology & Metabolism | Diabetes | Carbohydrate response element binding protein | Transcription | Pancreatic islet | Glucose-induced gene expression | CARBOHYDRATE RESPONSE ELEMENT | CELL PROLIFERATION | THIOREDOXIN-INTERACTING PROTEIN | BINDING PROTEIN | DEFICIENCY | METABOLISM | INSULIN-RESISTANCE | LIVER | ENDOCRINOLOGY & METABOLISM | ADIPOSE-TISSUE | Gene Expression - drug effects | Diabetes Mellitus, Experimental - genetics | Male | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - biosynthesis | Obesity - genetics | Adipose Tissue - metabolism | Insulin-Secreting Cells - metabolism | Nuclear Proteins - biosynthesis | Diabetes Mellitus, Experimental - metabolism | Nuclear Proteins - genetics | Cell Line | Promoter Regions, Genetic | Rats | Nuclear Proteins - metabolism | Transcription Factors - biosynthesis | Glucose - pharmacology | Transcription Factors - genetics | Down-Regulation - drug effects | Obesity - metabolism | Obesity - pathology | Transcription Factors - metabolism | Feedback, Physiological | Animals | Insulin-Secreting Cells - drug effects | Protein Isoforms | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics | Diabetes Mellitus, Experimental - pathology | Glucose - metabolism | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Mice, Inbred NOD | Mice | Insulin-Secreting Cells - pathology | Index Medicus
Journal Article
Diabetes, ISSN 0012-1797, 12/2015, Volume 64, Issue 12, pp. 4158 - 4170
Carbohydrate-responsive element-binding protein (ChREBP) is a glucose-sensing transcription factor required for glucose-stimulated proliferation of pancreatic... 
ACTIVATION | REPLICATION | GENE | METABOLISM | LIPOGENESIS | TRANSCRIPTION | ENDOCRINOLOGY & METABOLISM | ELEMENT-BINDING PROTEIN | INFUSION | EXPRESSION | ADIPOSE-TISSUE | Adipocytes, White - cytology | Up-Regulation | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - antagonists & inhibitors | Cell Proliferation | Alternative Splicing | Rats, Wistar | Humans | Insulin-Secreting Cells - metabolism | Protein Isoforms - metabolism | RNA Interference | Hyperglycemia - pathology | Adult | Electrophoretic Mobility Shift Assay | Insulin-Secreting Cells - cytology | Nuclear Proteins - genetics | Recombinant Proteins - metabolism | Cells, Cultured | Rats | Recombinant Proteins - chemistry | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Transcription Factors - genetics | 3T3-L1 Cells | Hyperglycemia - metabolism | Transcription Factors - metabolism | Adipocytes, White - pathology | Animals | Hyperglycemia - blood | Nuclear Proteins - antagonists & inhibitors | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics | Cell Line, Tumor | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Mice | HeLa Cells | Insulin-Secreting Cells - pathology | Adipocytes, White - metabolism | Cadaver | Protein Isoforms - antagonists & inhibitors | Protein Isoforms - genetics | Index Medicus | Abridged Index Medicus | Islet Studies
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 04/2012, Volume 443, Issue 1, pp. 111 - 123
Journal Article