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Cloning and analysis of a disease resistance gene homolog from soybean, 2003
Conserved domains e.g. nucleotide binding site (NBS) were found in several cloned plant disease resistance genes. Based on the NBS domain, resistance gene... 
Toll-Interleukin-1 receptor | nucleotide binding site | soybean as03014 | Plant Sciences | disease resistance gene homolog
Journal
Nature, ISSN 0028-0836, 07/2011, Volume 475, Issue 7354, pp. 65 - 72
The biogenic amine histamine is an important pharmacological mediator involved in pathophysiological processes such as allergies and inflammations. Histamine... 
H1 RECEPTOR | PROTEIN-COUPLED RECEPTOR | STRUCTURE-BASED DISCOVERY | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | BINDING-SITE | ANTAGONISTS | SITE-DIRECTED MUTAGENESIS | MUTATIONAL ANALYSIS | A(2A) ADENOSINE RECEPTOR | AGONIST
Journal Article
SCIENCE, ISSN 0036-8075, 04/2011, Volume 332, Issue 6027, pp. 322 - 327
Activation of G protein-coupled receptors upon agonist binding is a critical step in the signaling cascade for this family of cell surface proteins. We report... 
SUBTYPE-SELECTIVITY | COMPLEX | CONFORMATIONAL-CHANGES | ANTAGONIST | CRYSTAL-STRUCTURE | LIGAND RECOGNITION | MULTIDISCIPLINARY SCIENCES | BINDING-SITE | ALLOSTERIC MODULATION | RESIDUES | PROTEIN-COUPLED-RECEPTOR | Adenosine | Research | Properties | Protein binding
Journal Article
07/2011
The main objective of this study was to investigate the effect of cadmium (II) and copper (II) salts concentrations on uptake, tolerance, growth pattern and... 
Cadmium | Pseudomonas aeruginosa | Copper | Pseudomonas putida | Metallothionein | Ag-binding site
Web Resource
Pharmacology and Therapeutics, ISSN 0163-7258, 10/2007, Volume 116, Issue 1, pp. 7 - 19
Controlling neuronal excitability is vitally important for maintaining a healthy central nervous system (CNS) and this relies on the activity of type A... 
GABA | Neurosteroid binding site | Binding site | Transmembrane domains | receptor
Journal Article
Development, ISSN 0950-1991, 03/2007, Volume 134, Issue 6, pp. 1141 - 1150
Journal Article
Neuropharmacology, ISSN 0028-3908, 01/2009, Volume 56, Issue 1, pp. 149 - 154
This study addresses whether the potentiation site for neurosteroids on GABA receptors is conserved amongst different GABA receptor isoforms. The neurosteroid... 
Neurosteroid binding site | Neurosteroids | GABAA receptor | α Subunits | GABA | receptor
Journal Article
by Cerisier and Petitjean and Regad and Bayard and Réau and Badel and Camproux
Molecules, ISSN 1420-3049, 07/2019, Volume 24, Issue 14, p. 2529
The literature focuses on drug promiscuity, which is a drug's ability to bind to several targets, because it plays an essential role in polypharmacology.... 
descriptors | proteochemometrics | druggable binding site | multi-targets | polypharmacology | drug promiscuity
Journal Article
NATURE CHEMISTRY, ISSN 1755-4330, 05/2017, Volume 9, Issue 5, pp. 473 - 479
Cation-pi interactions drive the self-assembly and cohesion of many biological molecules, including the adhesion proteins of several marine organisms. Although... 
MECHANICS | BENZENE | ANION | C-13 | SOLID-STATE NMR | SPECTROSCOPY | COMPLEXES | BINDING-SITE | FOOT PROTEIN | MUSSEL ADHESIVE | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 07/2018, Volume 155, pp. 171 - 182
Herein, we report a new class of dual binding site AChE inhibitor designed to exert a central cholinergic activation thanks to a redox-activation step of a... 
Acetylcholine esterase inhibitors | Dual-binding site inhibitor | Alzheimer
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 07/2017, Volume 114, Issue 27, pp. 7160 - 7165
The sigma(2) receptor is an enigmatic protein that has attracted significant attention because of its involvement in diseases as diverse as cancer and... 
TUMOR-CELL LINES | PROGESTERONE | MULTIDISCIPLINARY SCIENCES | TMEM97 | PGRMC1 PROTEIN | CANCER | sigma receptors | sigma-2 receptor | NPC1 | LIGANDS | cholesterol regulation | MAC30 | DISEASE | BINDING-SITE | MEMBRANE COMPONENT 1 | EXPRESSION
Journal Article
RSC ADVANCES, ISSN 2046-2069, 11/2014, Volume 4, Issue 19, pp. 64169 - 64173
The synthesis of pyrido[2′,1′:2,3]imidazo[4,5- c ]isoquinolines via a one-pot three-component reaction by using benzene-1,2-dicarbaldehyde,... 
IRON-OXIDE NANOPARTICLES | MULTICOMPONENT REACTIONS | ANALOGS | CHEMISTRY | BINDING-SITE | RECEPTOR | DIVERSITY | DERIVATIVES | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
International journal of molecular sciences, ISSN 1422-0067, 05/2019, Volume 20, Issue 9, p. 2352
Alternariol (AOH) is a mycotoxin produced by species. In vitro studies suggest the genotoxic, mutagenic, and endocrine disruptor effects of AOH, and an... 
alternariol | fluorescence spectroscopy | serum albumin | albumin-ligand interaction | binding site
Journal Article
International journal of molecular sciences, ISSN 1422-0067, 04/2019, Volume 20, Issue 8, p. 2048
The pathology Alzheimer's disease (AD) is associated with the self-assembly of amyloid-β (Aβ) peptides into β-sheet enriched fibrillar aggregates. A promising... 
inhibitory mechanism | amyloid protofibril | fullerene | molecular dynamics simulation | binding site
Journal Article
SCIENCE, ISSN 0036-8075, 04/2002, Volume 296, Issue 5565, pp. 151 - 155
The structural basis for the divalent cation-dependent binding of heterodimeric alphabeta integrins to their ligands, which contain the prototypical... 
MULTIDISCIPLINARY SCIENCES | CD11B A-DOMAIN | ECHISTATIN | BINDING-SITE | I-DOMAIN | SUBUNIT
Journal Article
Organic Letters, ISSN 1523-7060, 02/2011, Volume 13, Issue 4, pp. 706 - 708
The ruthenium-catalyzed oxidative vinylation of thiophene-2-carboxylic acids with alkenes efficiently proceeds through directed C-H bond cleavage to give the... 
DIRECT ORTHO-ARYLATION | ORGANIC-SYNTHESIS | CINNAMIC-ACIDS | CROSS-COUPLING REACTION | AROMATIC KETONES | HOMOGENEOUS CATALYSTS | CHEMISTRY, ORGANIC | HECK REACTIONS | GLYCINE BINDING-SITE | PALLADIUM CATALYSIS | BENZOIC-ACIDS
Journal Article
NATURE CHEMICAL BIOLOGY, ISSN 1552-4450, 11/2011, Volume 7, Issue 11, pp. 769 - 778
G protein-coupled receptors (GPCRs) are intensely studied as drug targets and for their role in signaling. With the determination of the first crystal... 
DESIGN | DATABASE | 2ND EXTRACELLULAR LOOP | BIOCHEMISTRY & MOLECULAR BIOLOGY | DRUG DISCOVERY | BINDING-SITE | ANTAGONISTS | MOLECULAR DOCKING | AGONISTS | PROTEIN-COUPLED-RECEPTOR | D3 RECEPTOR
Journal Article
by Bruno, AE and Li, L and Kalabus, JL and Pan, YZ and Yu, AM and Hu, ZH
BMC GENOMICS, ISSN 1471-2164, 01/2012, Volume 13
Background: Single nucleotide polymorphisms (SNPs) can lead to the susceptibility and onset of diseases through their effects on gene expression at the... 
GRN | POLYMORPHISMS | RISK-FACTOR | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | BINDING-SITE | CANCER
Journal Article
NATURE STRUCTURAL & MOLECULAR BIOLOGY, ISSN 1545-9985, 03/2009, Volume 16, Issue 3, pp. 334 - 342
Photosystem II ( PSII) is a large homodimeric protein-cofactor complex located in the photosynthetic thylakoid membrane that acts as light-driven water:... 
X-RAY CRYSTALLOGRAPHY | CYTOCHROME BF COMPLEX | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | OXYGEN-EVOLVING CENTER | WATER OXIDATION | CELL BIOLOGY | ANGSTROM RESOLUTION | BIOPHYSICS | THERMOSYNECHOCOCCUS-ELONGATUS | PHOTOSYNTHETIC MN4CA CLUSTER | BINDING-SITE | PROTEIN COMPLEXES
Journal Article
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