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bmpr-ii (48) 48
humans (33) 33
animals (29) 29
index medicus (27) 27
mice (19) 19
pulmonary hypertension (18) 18
germline mutations (17) 17
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signal transduction (16) 16
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bone morphogenetic protein receptors, type ii (11) 11
bone morphogenetic protein receptors, type ii - genetics (11) 11
bone morphogenetic protein receptors, type ii - metabolism (11) 11
cardiac & cardiovascular systems (11) 11
proteins (11) 11
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hypertension, pulmonary - genetics (10) 10
protein-serine-threonine kinases - genetics (10) 10
respiratory system (10) 10
apoptosis (9) 9
arterial-hypertension (9) 9
bone morphogenetic proteins (9) 9
cell biology (9) 9
cells, cultured (9) 9
rats (9) 9
tgf-beta (9) 9
adult (8) 8
bone morphogenetic proteins - metabolism (8) 8
endothelial-cells (8) 8
hypertension, pulmonary - pathology (8) 8
mutations (8) 8
proliferation (8) 8
pulmonary arterial hypertension (8) 8
pulmonary arteries (8) 8
biochemistry & molecular biology (7) 7
bone morphogenetic protein (7) 7
expression (7) 7
growth-factor-beta (7) 7
hypertension, pulmonary - metabolism (7) 7
hypoxia (7) 7
morphogenetic protein-receptor (7) 7
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bone morphogenetic protein receptor type ii (6) 6
genetic aspects (6) 6
health aspects (6) 6
hereditary hemorrhagic telangiectasia (6) 6
hypertension, pulmonary - physiopathology (6) 6
ligands (6) 6
pulmonary artery - metabolism (6) 6
rats, sprague-dawley (6) 6
signal transduction - genetics (6) 6
signal transduction - physiology (6) 6
signaling pathways (6) 6
smooth-muscle-cells (6) 6
analysis (5) 5
cells (5) 5
disease models, animal (5) 5
growth (5) 5
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mice, inbred c57bl (5) 5
middle aged (5) 5
myocytes, smooth muscle - pathology (5) 5
peripheral vascular disease (5) 5
physiology (5) 5
primary pulmonary-hypertension (5) 5
pulmonary artery - physiopathology (5) 5
receptors (5) 5
signal transduction - drug effects (5) 5
smad1 protein - metabolism (5) 5
smooth muscle (5) 5
vascular remodeling (5) 5
abridged index medicus (4) 4
bone morphogenetic proteins - pharmacology (4) 4
care and treatment (4) 4
caveolin-1 (4) 4
cell line (4) 4
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child (4) 4
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dna mutational analysis (4) 4
extracellular signal-regulated map kinases - metabolism (4) 4
gene-expression (4) 4
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hematology (4) 4
hypertension, pulmonary - enzymology (4) 4
hypertension, pulmonary - etiology (4) 4
in situ hybridization (4) 4
lung - metabolism (4) 4
medicine, research & experimental (4) 4
muscle, smooth, vascular - metabolism (4) 4
muscle, smooth, vascular - pathology (4) 4
myocytes, smooth muscle - metabolism (4) 4
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The Journal of Cell Biology, ISSN 0021-9525, 9/2003, Volume 162, Issue 6, pp. 1089 - 1098
Bone morphogenetic proteins (BMPs) regulate multiple cellular processes, including cell differentiation and migration. Their signals are transduced by the... 
COS cells | Receptors | Phosphorylation | Cell lines | Actin depolymerizing factors | Actins | Antibodies | Amino acids | Physiological regulation | Cells | Cofilin | Cytoskeleton | LIM kinase 1 | F-actin | BMPR-II | cofilin | PROTEIN | cytoskeleton | PHOSPHORYLATION | ACTIN POLYMERIZATION | ZINC-FINGER | KINASE | PRIMARY PULMONARY-HYPERTENSION | CELL BIOLOGY | GROWTH | GERMLINE MUTATIONS | TGF-BETA RECEPTOR | Humans | Hypertension, Pulmonary - physiopathology | Eukaryotic Cells - metabolism | Lim Kinases | Cytoskeleton - enzymology | DNA-Binding Proteins - metabolism | Bone Morphogenetic Proteins - metabolism | Up-Regulation - physiology | Hypertension, Pulmonary - enzymology | Protein-Serine-Threonine Kinases - metabolism | Bone Morphogenetic Protein 4 | Protein-Serine-Threonine Kinases - genetics | Protein Structure, Tertiary - genetics | Pulmonary Artery - physiopathology | Signal Transduction - genetics | Mutation - genetics | Bone Morphogenetic Protein Receptors, Type II | Pulmonary Artery - enzymology | Animals | Protein Kinases | Smad Proteins | Biomarkers | Trans-Activators - metabolism | COS Cells | Proteins | Gene mutations | Cytology | Physiological aspects | Genetic aspects | Genetic transcription | Research | Genetic regulation | Cell differentiation | Cell migration | LIM kinase 1; BMPR-II; cytoskeleton; F-actin; cofilin
Journal Article
Journal Article
American journal of respiratory and critical care medicine, ISSN 1073-449X, 01/2019, Volume 199, Issue 1, pp. 9 - 11
First identified by heterozygous loss-of-function mutations in the majority of individuals with heritable PAH (HPAH), diminished BMPR2 expression and BMP... 
RESPIRATORY SYSTEM | ID1 | SMOOTH-MUSCLE-CELLS | PROLIFERATION | IDENTIFICATION | BMPR-II | CRITICAL CARE MEDICINE | Pulmonary arteries | Smooth muscle | Identification | Gene expression | Metabolism | Kinases | Medical screening | Pulmonary hypertension | Proteins | Cell growth | Hypoxia | Ligands | Mutation | Females | Growth factors | Bioinformatics | Cancer
Journal Article
American Journal of Physiology - Lung Cellular and Molecular Physiology, ISSN 1040-0605, 10/2018, Volume 315, Issue 4, pp. L502 - L516
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 05/2018, Volume 128, Issue 5, pp. 1956 - 1970
Pulmonary arterial hypertension (PAH) is characterized by a progressive accumulation of pulmonary artery smooth muscle cells (PA-SMCs) in pulmonary arterioles... 
MEDICINE, RESEARCH & EXPERIMENTAL | FIBROBLAST GROWTH FACTOR-2 | INTERLEUKIN-6 RECEPTOR | OVEREXPRESSION | SMOOTH-MUSCLE-CELLS | MICE | CYTOKINE | BMPR-II | CONTRIBUTES | IL-6 RECEPTOR | BETA | Familial Primary Pulmonary Hypertension - pathology | Up-Regulation | Vascular Remodeling | Muscle, Smooth, Vascular - metabolism | Humans | Myocytes, Smooth Muscle - pathology | Rats | Familial Primary Pulmonary Hypertension - genetics | Mice, Transgenic | Pulmonary Artery - physiopathology | Signal Transduction - genetics | Muscle, Smooth, Vascular - physiopathology | Familial Primary Pulmonary Hypertension - metabolism | Familial Primary Pulmonary Hypertension - physiopathology | Arterioles - pathology | Muscle, Smooth, Vascular - pathology | Pulmonary Artery - metabolism | Animals | Arterioles - metabolism | Arterioles - physiopathology | Cytokine Receptor gp130 - biosynthesis | Mice | Myocytes, Smooth Muscle - metabolism | Pulmonary Artery - pathology | Care and treatment | Cytokine receptors | Physiological aspects | Development and progression | Health aspects | Pulmonary artery | Pulmonary hypertension | Interleukin-6 | Cytochrome | Hypertension | Animal models | Cytokines | Arterioles | Pathogenesis | Pulmonary arteries | Smooth muscle | Cardiovascular disease | Interleukin 6 | Proteins | Signal transduction | Interleukin 6 receptors | Rodents | Medical prognosis | Hypoxia | Heart diseases | Growth factors | Glycoprotein gp130 | Veins & arteries | Life Sciences | Human health and pathology | Cellular Biology | Cardiology and cardiovascular system | Pulmonology and respiratory tract
Journal Article
The FEBS Journal, ISSN 1742-464X, 11/2009, Volume 276, Issue 21, pp. 6386 - 6398
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 1/2009, Volume 184, Issue 1, pp. 83 - 99
Mutations in bone morphogenetic protein (BMP) receptor II (BMPRII) are associated with pulmonary artery endothelial cell (PAEC) apoptosis and the loss of small... 
Angiogenesis | Cell motility | Receptors | Cell growth | Small interfering RNA | Antibodies | Pseudopodia | Mice | Gene expression regulation | Endothelial cells | SIGNAL-TRANSDUCTION | II RECEPTOR | ARTERIAL-HYPERTENSION | KINASE | PLANAR CELL POLARITY | P38 MAPK | MUTATIONS | C3H10T1/2 CELLS | BMPR-II | ENDOTHELIAL GROWTH-FACTOR | CELL BIOLOGY | Cell Proliferation | Humans | Glycogen Synthase Kinase 3 beta | rhoA GTP-Binding Protein - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Phosphoproteins - metabolism | Wnt Proteins - metabolism | Pulmonary Artery - metabolism | Hypertension - genetics | Dishevelled Proteins | Endothelial Cells - physiology | Bone Morphogenetic Protein Receptors, Type II - genetics | Signal Transduction | Endothelial Cells - metabolism | Glycogen Synthase Kinase 3 - metabolism | Bone Morphogenetic Protein 2 - physiology | beta Catenin - metabolism | Bone Morphogenetic Protein Receptors, Type II - metabolism | Hypertension - metabolism | Pulmonary Artery - cytology | Neovascularization, Physiologic - physiology | Pulmonary Artery - ultrastructure | Animals | Endothelial Cells - cytology | Smad1 Protein - metabolism | Wnt3 Protein | Bone Morphogenetic Protein Receptors, Type II - physiology | Enzyme Activation | Adaptor Proteins, Signal Transducing - metabolism | rac1 GTP-Binding Protein - metabolism | Apoptosis | Cell Movement
Journal Article